J Heeren

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis
    Joerg Heeren
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Curr Pharm Biotechnol 13:365-72. 2012
  2. ncbi request reprint Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis
    Joerg Heeren
    Institute for Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 26:442-8. 2006
  3. ncbi request reprint Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization
    Joerg Heeren
    Institute for Medical Biochemistry and Molecular Biology, The Department of Molecular Cell Biology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 278:14370-8. 2003
  4. ncbi request reprint Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo
    Joerg Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 80:576-84. 2002
  5. ncbi request reprint Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivo
    J Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Eppendorf, D 20246 Hamburg, Germany
    J Biol Chem 276:42333-8. 2001
  6. ncbi request reprint Intracellular metabolism of triglyceride-rich lipoproteins
    J Heeren
    Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Lipidol 12:255-60. 2001
  7. ncbi request reprint Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
    Joerg Heeren
    Institute for Biochemistry and Molecular Biology II Molecular Cell Biology and Department of Internal Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 279:55483-92. 2004
  8. doi request reprint Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function
    Andreas Niemeier
    Department of Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone 43:230-7. 2008
  9. ncbi request reprint Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
    Britta Loeffler
    Third Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Lipid Res 48:288-98. 2007
  10. ncbi request reprint Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice
    Sergei Ragozin
    Institute for Biochemistry and Molecular Biology II, Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:1433-8. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis
    Joerg Heeren
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Curr Pharm Biotechnol 13:365-72. 2012
    ..In this review, we will give an overview on the characteristics of modern nanoparticles and will emphasize the current studies utilizing nanoparticles for the visualization of both lipoprotein metabolism and atherosclerosis...
  2. ncbi request reprint Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosis
    Joerg Heeren
    Institute for Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 26:442-8. 2006
    ..This review summarizes the current understanding of apoE recycling and its potential role in the regulation of plasma apoE levels in the postprandial state...
  3. ncbi request reprint Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization
    Joerg Heeren
    Institute for Medical Biochemistry and Molecular Biology, The Department of Molecular Cell Biology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 278:14370-8. 2003
    ..Thus, these studies provide evidence for a new intracellular link between TRL-derived apoE, cellular cholesterol transport, and HDL metabolism...
  4. ncbi request reprint Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo
    Joerg Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 80:576-84. 2002
    ..In conclusion, these data demonstrate for the first time that LPL is a structural component of postprandial TRL which facilitates hepatic TRL clearance from the circulation independent of its catalytic function...
  5. ncbi request reprint Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivo
    J Heeren
    Department of Medical Biochemistry and Molecular Biology, University Hospital Eppendorf, D 20246 Hamburg, Germany
    J Biol Chem 276:42333-8. 2001
    ..These results provide the first evidence that recycling of TRL-derived apoE and LPL could play an important role in the modulation of lipoproteins in vivo...
  6. ncbi request reprint Intracellular metabolism of triglyceride-rich lipoproteins
    J Heeren
    Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Lipidol 12:255-60. 2001
    ..Current concepts concerning its potential relevance with regard to lipoprotein metabolism and atherosclerosis will also be discussed...
  7. ncbi request reprint Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
    Joerg Heeren
    Institute for Biochemistry and Molecular Biology II Molecular Cell Biology and Department of Internal Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 279:55483-92. 2004
    ..These studies provide initial evidence that impaired recycling of apoE4 could interfere with intracellular cholesterol transport and contribute to the pathophysiological lipoprotein profile observed in apoE4 homozygotes...
  8. doi request reprint Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function
    Andreas Niemeier
    Department of Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone 43:230-7. 2008
    ..Osteoblasts participate in CR clearance from the circulation, which has a direct impact on the secretory function of osteoblasts...
  9. ncbi request reprint Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
    Britta Loeffler
    Third Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Lipid Res 48:288-98. 2007
    ..Chylomicron uptake was not affected by the LDLR genotype. We conclude that LPL-mediated cellular uptake of LDL, but not of chylomicrons, is dependent on the presence of both LDLR and proteoglycans...
  10. ncbi request reprint Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice
    Sergei Ragozin
    Institute for Biochemistry and Molecular Biology II, Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:1433-8. 2005
    ..To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach...
  11. ncbi request reprint Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI
    May Brundert
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Lipid Res 47:2408-21. 2006
    ..SR-BI KO-HDL is an inferior donor for selective CE uptake compared with WT-HDL, whereas SR-BI KO-HDL more efficiently promotes cholesterol efflux...
  12. doi request reprint Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice
    Ludger Scheja
    Department of Biochemistry and Molecular Biology II, University Medical Center, 20246, Hamburg, Germany
    Lipids 43:1039-51. 2008
    ..Furthermore, the early and persistent rise of arachidonate and docosahexaenoate indicates that insulin resistance is not due to insufficient availability (or concentrations) of polyunsaturated fatty acids as postulated previously...
  13. ncbi request reprint Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone
    Andreas Niemeier
    Department of Orthopaedics, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Bone Miner Res 20:283-93. 2005
    ..Here we describe the expression of the multifunctional LRP1 by human osteoblasts in vitro and in vivo. We provide evidence that LRP1 plays an important role in the uptake of postprandial lipoproteins and vitamin K1 by human osteoblasts...
  14. ncbi request reprint Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
    ..A direct interaction between LPL and apoAV was found by ligand blotting. It is proposed, that apoAV reduces triglyceride levels by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis...
  15. doi request reprint Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals
    Oliver T Bruns
    IBM II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Nat Nanotechnol 4:193-201. 2009
    ..Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging...
  16. doi request reprint Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity
    Alexander Bartelt
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone 47:736-45. 2010
    ..We conclude that apoE is involved in an inverse regulation of bone mass and fat mass in growing mice and that this effect is modulated by diet-induced obesity...
  17. pmc Give me A5 for lipoprotein hydrolysis!
    Martin Merkel
    Department of Internal Medicine and IBM II Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 115:2694-6. 2005
    ....
  18. doi request reprint Brown adipose tissue activity controls triglyceride clearance
    Alexander Bartelt
    Institute of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nat Med 17:200-5. 2011
    ..Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans...
  19. doi request reprint Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
    Alexander Laatsch
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Atherosclerosis 204:105-11. 2009
    ..The dietary lipids are carried in chylomicron remnants (CR) which are taken up into the liver mainly via LDLR-related protein 1 (LRP1). In this study, the effect of insulin on LRP1-mediated hepatic CR uptake was investigated...
  20. doi request reprint Increased expression of transthyretin in leptin-deficient ob/ob mice is not causative for their major phenotypic abnormalities
    C Rendenbach
    Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Neuroendocrinol 25:14-22. 2013
    ..Taken together, our data demonstrate that the increased expression of Ttr in ob/ob mice does not cause (but rather attenuates) their phenotypic abnormalities...
  21. ncbi request reprint Annexin VI stimulates endocytosis and is involved in the trafficking of low density lipoprotein to the prelysosomal compartment
    T Grewal
    Medizinische Kernklinik und Poliklinik, Universitats Krankenhaus Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Biol Chem 275:33806-13. 2000
    ..Thus, data presented in this study suggest that after stimulating endocytosis at the cell surface, annexin VI remains bound to endocytic vesicles to regulate entry of ligands into the prelysosomal compartment...
  22. ncbi request reprint Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI
    May Brundert
    Universitaetsklinikum Hamburg Eppendorf, Department for Internal Medicine, Martinistrasse 52, 20246 Hamburg, Germany
    J Lipid Res 44:1020-32. 2003
    ..Proteoglycans are a requisite for the HL action on selective uptake. Results suggest that (a) pathway(s) distinct from SR-BI mediate(s) selective CE uptake from HDL...
  23. ncbi request reprint Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice
    May Brundert
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 25:143-8. 2005
    ..Class B type I scavenger receptor (SR-BI) mediates this uptake in vitro. The role of SR-BI in HDL metabolism was explored in mice...
  24. doi request reprint Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells
    Lars Rellin
    University Medical Center Hamburg Eppendorf, Department of Biochemistry and Molecular Biology II Molecular Cell Biology, Martinistrasse 52, Hamburg, Germany
    Biochim Biophys Acta 1781:232-8. 2008
    ..Therefore we conclude that in this neuronal cell model the reduced recycling of apoE4 does not affect cellular cholesterol metabolism...
  25. ncbi request reprint Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells
    Janne Prawitt
    Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Cell Res 314:814-24. 2008
    ..Despite this increased expression, the receptor-mediated endocytosis of lipoproteins was decreased in differentiated adipocytes, suggesting that these proteins may have an additional function in adipose tissue beyond lipoprotein uptake...
  26. doi request reprint Apoprotein A-V: an important regulator of triglyceride metabolism
    M Kluger
    III Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Inherit Metab Dis 31:281-8. 2008
    ..Thus, despite its low plasma concentration, apoA-V is a major regulator of plasma TG metabolism in humans. However, the precise mechanism of its function is not yet clear...
  27. doi request reprint Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance
    A Bartelt
    Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Diabetologia 54:2900-10. 2011
    ....
  28. ncbi request reprint Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice
    Roshni R Singaraja
    University of British Columbia, Vancouver, Canada
    Arterioscler Thromb Vasc Biol 26:1821-7. 2006
    ..However, the role of ABCA1 in the liver for HDL apolipoprotein and cholesteryl ester (CE) catabolism in vivo is unknown...
  29. ncbi request reprint Cholesterol modulates the membrane binding and intracellular distribution of annexin 6
    Iñaki de Diego
    Departament de Biologia Cellular, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 0836 Barcelona, Spain
    J Biol Chem 277:32187-94. 2002
    ....
  30. ncbi request reprint High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras
    Thomas Grewal
    Departament de Biologia Cellular, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Biol Chem 278:16478-81. 2003
    ..We conclude that the binding of HDL to scavenger receptor type BI activates Ras in a PKC-independent manner with subsequent induction of the MAPK signaling cascade...
  31. ncbi request reprint Mice expressing only covalent dimeric heparin binding-deficient lipoprotein lipase: muscles inefficiently secrete dimeric enzyme
    E Peer Lutz
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:238-44. 2004
    ..Thus, although muscle can synthesize tethered, dimeric LpL, efficient production of this enzyme leading to secretion, and physiological function appears to favor secretion of a noncovalent dimer composed of monomeric subunits...
  32. ncbi request reprint Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage
    Guenter Cichon
    Department of Molecular Cell Biology, Humboldt University Berlin at the Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13125 Berlin, Germany
    J Gene Med 6:166-75. 2004
    ..Most of the vector systems currently employed for gene therapy use promoter elements which do not modulate transgene expression in a physiological manner...
  33. ncbi request reprint Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity
    Thomas Grewal
    Centre for Immunology, St Vincent s Hospital University of New South Wales, Australia
    Oncogene 24:5809-20. 2005
    ..These findings demonstrate an important role for annexin A6 in regulating plasma membrane localization of p120GAP and hence Ras activity...
  34. ncbi request reprint European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006
    Marten Hofker
    Department of Molecular Genetics, University of Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Atherosclerosis 193:461-8. 2007
  35. doi request reprint European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007
    Marten Hofker
    Atherosclerosis 197:471-9. 2008