Research Topics
Genomes and Genes | J HeerenSummaryAffiliation: University of Hamburg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosisJoerg Heeren
Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Curr Pharm Biotechnol 13:365-72. 2012..In this review, we will give an overview on the characteristics of modern nanoparticles and will emphasize the current studies utilizing nanoparticles for the visualization of both lipoprotein metabolism and atherosclerosis...- Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosisJoerg Heeren
Institute for Biochemistry and Molecular Biology II, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Arterioscler Thromb Vasc Biol 26:442-8. 2006..This review summarizes the current understanding of apoE recycling and its potential role in the regulation of plasma apoE levels in the postprandial state... - Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalizationJoerg Heeren
Institute for Medical Biochemistry and Molecular Biology, The Department of Molecular Cell Biology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Biol Chem 278:14370-8. 2003..Thus, these studies provide evidence for a new intracellular link between TRL-derived apoE, cellular cholesterol transport, and HDL metabolism... - Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivoJoerg Heeren
Department of Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Mol Med (Berl) 80:576-84. 2002..In conclusion, these data demonstrate for the first time that LPL is a structural component of postprandial TRL which facilitates hepatic TRL clearance from the circulation independent of its catalytic function... - Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivoJ Heeren
Department of Medical Biochemistry and Molecular Biology, University Hospital Eppendorf, D 20246 Hamburg, Germany
J Biol Chem 276:42333-8. 2001..These results provide the first evidence that recycling of TRL-derived apoE and LPL could play an important role in the modulation of lipoproteins in vivo... - Intracellular metabolism of triglyceride-rich lipoproteinsJ Heeren
Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
Curr Opin Lipidol 12:255-60. 2001..Current concepts concerning its potential relevance with regard to lipoprotein metabolism and atherosclerosis will also be discussed... - Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulationJoerg Heeren
Institute for Biochemistry and Molecular Biology II Molecular Cell Biology and Department of Internal Medicine, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Biol Chem 279:55483-92. 2004..These studies provide initial evidence that impaired recycling of apoE4 could interfere with intracellular cholesterol transport and contribute to the pathophysiological lipoprotein profile observed in apoE4 homozygotes... 
Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast functionAndreas Niemeier
Department of Orthopaedics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Bone 43:230-7. 2008..Osteoblasts participate in CR clearance from the circulation, which has a direct impact on the secretory function of osteoblasts...- Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptorBritta Loeffler
Third Department of Internal Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Lipid Res 48:288-98. 2007..Chylomicron uptake was not affected by the LDLR genotype. We conclude that LPL-mediated cellular uptake of LDL, but not of chylomicrons, is dependent on the presence of both LDLR and proteoglycans... - Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in miceSergei Ragozin
Institute for Biochemistry and Molecular Biology II, Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Arterioscler Thromb Vasc Biol 25:1433-8. 2005..To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach... - Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BIMay Brundert
University Hospital Hamburg Eppendorf, Hamburg, Germany
J Lipid Res 47:2408-21. 2006..SR-BI KO-HDL is an inferior donor for selective CE uptake compared with WT-HDL, whereas SR-BI KO-HDL more efficiently promotes cholesterol efflux... - Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant miceLudger Scheja
Department of Biochemistry and Molecular Biology II, University Medical Center, 20246, Hamburg, Germany
Lipids 43:1039-51. 2008..Furthermore, the early and persistent rise of arachidonate and docosahexaenoate indicates that insulin resistance is not due to insufficient availability (or concentrations) of polyunsaturated fatty acids as postulated previously... - Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to boneAndreas Niemeier
Department of Orthopaedics, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Bone Miner Res 20:283-93. 2005..Here we describe the expression of the multifunctional LRP1 by human osteoblasts in vitro and in vivo. We provide evidence that LRP1 plays an important role in the uptake of postprandial lipoproteins and vitamin K1 by human osteoblasts... - Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipaseMartin Merkel
Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
J Biol Chem 280:21553-60. 2005..A direct interaction between LPL and apoAV was found by ligand blotting. It is proposed, that apoAV reduces triglyceride levels by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis... - Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystalsOliver T Bruns
IBM II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Nat Nanotechnol 4:193-201. 2009..Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging... - Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesityAlexander Bartelt
Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Bone 47:736-45. 2010..We conclude that apoE is involved in an inverse regulation of bone mass and fat mass in growing mice and that this effect is modulated by diet-induced obesity... 
Give me A5 for lipoprotein hydrolysis!Martin Merkel
Department of Internal Medicine and IBM II Molecular Cell Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Clin Invest 115:2694-6. 2005....- Brown adipose tissue activity controls triglyceride clearanceAlexander Bartelt
Institute of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Nat Med 17:200-5. 2011..Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans... - Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearanceAlexander Laatsch
Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Atherosclerosis 204:105-11. 2009..The dietary lipids are carried in chylomicron remnants (CR) which are taken up into the liver mainly via LDLR-related protein 1 (LRP1). In this study, the effect of insulin on LRP1-mediated hepatic CR uptake was investigated... - Annexin VI stimulates endocytosis and is involved in the trafficking of low density lipoprotein to the prelysosomal compartmentT Grewal
Medizinische Kernklinik und Poliklinik, Universitats Krankenhaus Eppendorf, Martinistr 52, 20246 Hamburg, Germany
J Biol Chem 275:33806-13. 2000..Thus, data presented in this study suggest that after stimulating endocytosis at the cell surface, annexin VI remains bound to endocytic vesicles to regulate entry of ligands into the prelysosomal compartment... - Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cellsLars Rellin
University Medical Center Hamburg Eppendorf, Department of Biochemistry and Molecular Biology II Molecular Cell Biology, Martinistrasse 52, Hamburg, Germany
Biochim Biophys Acta 1781:232-8. 2008..Therefore we conclude that in this neuronal cell model the reduced recycling of apoE4 does not affect cellular cholesterol metabolism... - Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in miceMay Brundert
University Hospital Hamburg-Eppendorf, Hamburg, Germany
Arterioscler Thromb Vasc Biol 25:143-8. 2005..CONCLUSIONS: SR-BI mediates selective uptake of HDL CE by the liver. In adrenals, an alternative mechanism or mechanisms can play a role in selective CE uptake... - Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cellsJanne Prawitt
Department of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Exp Cell Res 314:814-24. 2008..Despite this increased expression, the receptor-mediated endocytosis of lipoproteins was decreased in differentiated adipocytes, suggesting that these proteins may have an additional function in adipose tissue beyond lipoprotein uptake... - Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BIMay Brundert
Universitaetsklinikum Hamburg-Eppendorf, Department for Internal Medicine, Martinistrasse 52, 20246 Hamburg, Germany
J Lipid Res 44:1020-32. 2003..Proteoglycans are a requisite for the HL action on selective uptake. Results suggest that (a) pathway(s) distinct from SR-BI mediate(s) selective CE uptake from HDL... - Apoprotein A-V: an important regulator of triglyceride metabolismM Kluger
III Department of Internal Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Inherit Metab Dis 31:281-8. 2008..Thus, despite its low plasma concentration, apoA-V is a major regulator of plasma TG metabolism in humans. However, the precise mechanism of its function is not yet clear... - Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistanceA Bartelt
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Diabetologia 54:2900-10. 2011.... - High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of RasThomas Grewal
Departament de Biologia Cellular, , Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
J Biol Chem 278:16478-81. 2003..We conclude that the binding of HDL to scavenger receptor type BI activates Ras in a PKC-independent manner with subsequent induction of the MAPK signaling cascade... - Cholesterol modulates the membrane binding and intracellular distribution of annexin 6Iñaki de Diego
Departament de Biologia Cellular, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 0836 Barcelona, Spain
J Biol Chem 277:32187-94. 2002.... - Mice expressing only covalent dimeric heparin binding-deficient lipoprotein lipase: muscles inefficiently secrete dimeric enzymeE Peer Lutz
Department of Medicine, Columbia University, New York, New York 10032, USA
J Biol Chem 279:238-44. 2004..Thus, although muscle can synthesize tethered, dimeric LpL, efficient production of this enzyme leading to secretion, and physiological function appears to favor secretion of a noncovalent dimer composed of monomeric subunits... - Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storageGuenter Cichon
Department of Molecular Cell Biology, Humboldt University Berlin at the Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13125 Berlin, Germany
J Gene Med 6:166-75. 2004..Most of the vector systems currently employed for gene therapy use promoter elements which do not modulate transgene expression in a physiological manner... - Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activityThomas Grewal
Centre for Immunology, St Vincent's Hospital. University of New South Wales, Australia
Oncogene 24:5809-20. 2005..These findings demonstrate an important role for annexin A6 in regulating plasma membrane localization of p120GAP and hence Ras activity... - Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in miceRoshni R Singaraja
University of British Columbia, Vancouver, Canada
Arterioscler Thromb Vasc Biol 26:1821-7. 2006..However, the role of ABCA1 in the liver for HDL apolipoprotein and cholesteryl ester (CE) catabolism in vivo is unknown... - European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007Marten Hofker
Atherosclerosis 197:471-9. 2008 - European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006Marten Hofker
Department of Molecular Genetics, University of Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
Atherosclerosis 193:461-8. 2007