M Heep

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. pmc Rifampin and rifabutin resistance mechanism in Helicobacter pylori
    M Heep
    Institut fur Medizinische Mikrobiologie, Universitatsklinikum Regensburg, D 93053, Regensburg, Germany
    Antimicrob Agents Chemother 43:1497-9. 1999
  2. pmc Transport and storage of fresh and frozen gastric biopsy specimens for optimal recovery of Helicobacter pylori
    M Heep
    Institute for Medical Microbiology, Uniklinik Regensburg, Regensburg, Germany
    J Clin Microbiol 37:3764-6. 1999
  3. pmc Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis
    M Heep
    Institute for Medical Microbiology, Regensburg, Germany
    Antimicrob Agents Chemother 44:1075-7. 2000
  4. pmc Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins
    M Heep
    Institut fur Medizinische Mikrobiologie, Universitat Regensburg, Regensburg, Germany
    Antimicrob Agents Chemother 44:1713-5. 2000
  5. ncbi request reprint Detection of rifabutin resistance and association of rpoB mutations with resistance to four rifamycin derivatives in Helicobacter pylori
    M Heep
    Institute for Medical Microbiology and Hygiene, Uniklinik Regensburg, Germany
    Eur J Clin Microbiol Infect Dis 21:143-5. 2002
  6. pmc Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates
    M Heep
    Institut fuer Medizinische Mikrobiologie und Hygiene, , Regensburg, Germany
    J Clin Microbiol 39:107-10. 2001

Detail Information

Publications6

  1. pmc Rifampin and rifabutin resistance mechanism in Helicobacter pylori
    M Heep
    Institut fur Medizinische Mikrobiologie, Universitatsklinikum Regensburg, D 93053, Regensburg, Germany
    Antimicrob Agents Chemother 43:1497-9. 1999
    ..All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli...
  2. pmc Transport and storage of fresh and frozen gastric biopsy specimens for optimal recovery of Helicobacter pylori
    M Heep
    Institute for Medical Microbiology, Uniklinik Regensburg, Regensburg, Germany
    J Clin Microbiol 37:3764-6. 1999
    ..Recovery rates were 94, 87, and 77% from biopsy specimens in Portagerm pylori in cooled containers after 1, 2, and 3 days of transport, respectively (n = 307), and 97% if stored and shipped in glycerol broth at -70 degrees C (n = 232)...
  3. pmc Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis
    M Heep
    Institute for Medical Microbiology, Regensburg, Germany
    Antimicrob Agents Chemother 44:1075-7. 2000
    ..In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis...
  4. pmc Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins
    M Heep
    Institut fur Medizinische Mikrobiologie, Universitat Regensburg, Regensburg, Germany
    Antimicrob Agents Chemother 44:1713-5. 2000
    ..RpoB V149X random mutations were generated and induced different levels of resistance, depending on the replacement amino acid. Mutagenesis of the rpoB gene at codon position 701 (R701H) induced low-level resistance...
  5. ncbi request reprint Detection of rifabutin resistance and association of rpoB mutations with resistance to four rifamycin derivatives in Helicobacter pylori
    M Heep
    Institute for Medical Microbiology and Hygiene, Uniklinik Regensburg, Germany
    Eur J Clin Microbiol Infect Dis 21:143-5. 2002
  6. pmc Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates
    M Heep
    Institut fuer Medizinische Mikrobiologie und Hygiene, , Regensburg, Germany
    J Clin Microbiol 39:107-10. 2001
    ..tuberculosis. We further demonstrated that heteroresistance caused by a mixture of mycobacterial subpopulations with different susceptibilities to RIF may influence the sensitivity of molecular tests for detection of resistance...