J Hebebrand

Summary

Affiliation: University of Duisburg-Essen
Country: Germany

Publications

  1. ncbi request reprint Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, D 35039 Marburg, Germany
    J Clin Endocrinol Metab 88:4258-67. 2003
  2. ncbi request reprint A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 11:196-205. 2006
  3. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
  4. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
  5. doi request reprint Child and adolescent psychiatric genetics
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:259-79. 2010
  6. pmc Axis I comorbidity in adolescent inpatients referred for treatment of substance use disorders
    Tobias Langenbach
    LVR Klinikum Essen Kliniken Institut der Universität Duisburg Essen Klinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters Virchowstraße 174 45147 Essen, Germany
    Child Adolesc Psychiatry Ment Health 4:25. 2010
  7. pmc Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    BMC Med Genet 7:50. 2006
  8. pmc Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents
    Katja Holter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    BMC Med Genet 8:21. 2007
  9. pmc Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
    Susanne Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    BMC Cancer 8:85. 2008
  10. doi request reprint Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Int J Eat Disord 44:665-78. 2011

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, D 35039 Marburg, Germany
    J Clin Endocrinol Metab 88:4258-67. 2003
    ..8% (P = 0.033; exact one-sided McNemar test). These results support the hypothesis that these MC4R mutations represent major gene effects for obesity...
  2. ncbi request reprint A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 11:196-205. 2006
    ..Despite differences in ethnicity, ascertainment and phenotyping schemes, linkage results in ADHD appear remarkably consistent...
  3. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
    ..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies...
  4. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
    ..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS...
  5. doi request reprint Child and adolescent psychiatric genetics
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:259-79. 2010
    ..This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry...
  6. pmc Axis I comorbidity in adolescent inpatients referred for treatment of substance use disorders
    Tobias Langenbach
    LVR Klinikum Essen Kliniken Institut der Universität Duisburg Essen Klinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters Virchowstraße 174 45147 Essen, Germany
    Child Adolesc Psychiatry Ment Health 4:25. 2010
    ..To assess comorbid DSM-IV-TR Axis I disorders in adolescent inpatients referred for treatment of substance use disorders...
  7. pmc Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    BMC Med Genet 7:50. 2006
    ..Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques...
  8. pmc Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents
    Katja Holter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    BMC Med Genet 8:21. 2007
    ..We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents...
  9. pmc Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
    Susanne Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    BMC Cancer 8:85. 2008
    ..We tested if cancer patients that are homo-/heterozygous for the Val103Ile polymorphism are more likely to develop cachexia and/or a loss of appetite than non-carriers of the 103Ile-allele...
  10. doi request reprint Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Int J Eat Disord 44:665-78. 2011
    ....
  11. ncbi request reprint The role of leptin in anorexia nervosa: clinical implications
    J Hebebrand
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:23-35. 2007
    ..The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial...
  12. ncbi request reprint [Memorandum for improving research performance and for supporting the future medical generation in child and adolescent psychiatry, psychosomatic medicine and psychotherapy]
    Johannes Hebebrand
    Klinik für Kinder und Jugendpsychiatrie und psychotherapie der Rheinischen Kliniken der Universität Duisburg Essen
    Z Kinder Jugendpsychiatr Psychother 34:169-76. 2006
  13. ncbi request reprint Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
    J Neural Transm 114:513-21. 2007
    ..We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD...
  14. doi request reprint Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    J Clin Pharm Ther 35:207-11. 2010
    ..We aim to study this further by including patients treated with the atypical antipsychotics olanzapine or risperidone as well as opposite-sex sib pairs...
  15. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  16. ncbi request reprint Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder
    S Friedel
    Clinical Research Group, Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, 35039 Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 132:96-9. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  17. ncbi request reprint No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 114:523-6. 2007
    ..We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample...
  18. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 10:1126-32. 2005
    ..064). Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes...
  19. ncbi request reprint Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    J Neural Transm 114:1091-5. 2007
    ..To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs)...
  20. ncbi request reprint Prospective 10-year follow-up in adolescent anorexia nervosa--course, outcome, psychiatric comorbidity, and psychosocial adaptation
    B Herpertz-Dahlmann
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Germany
    J Child Psychol Psychiatry 42:603-12. 2001
    ..Those who achieve complete recovery from the eating disorder have a good chance of overcoming other psychiatric disorders and to adapt to social requirements...
  21. ncbi request reprint High serum leptin levels subsequent to weight gain predict renewed weight loss in patients with anorexia nervosa
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, Neuenhofer Weg 21, D 52074 Aachen, Germany
    Psychoneuroendocrinology 29:791-7. 2004
    ..In conclusion, high serum leptin levels at discharge from inpatient treatment may indicate a risk for renewed weight loss and an unfavorable 1 yr outcome in AN...
  22. doi request reprint Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites
    M Föcker
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg Essen, Wickenburgstr 21, 45147 Essen, Germany
    J Psychiatr Res 46:1600-9. 2012
    ..Further studies are warranted to distinguish between state and trait related alterations and to establish diagnostic sensitivity and specificity of the thus altered metabolites...
  23. ncbi request reprint No evidence for involvement of the promoter polymorphism -866 G/A of the UCP2 gene in childhood-onset obesity in humans
    N Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Marburg, Germany
    Exp Clin Endocrinol Diabetes 111:73-6. 2003
    ..Allele and genotype frequencies did not differ between the extremely obese and never-obese subjects. In conclusion, we cannot confirm the results of ) in our young sample...
  24. ncbi request reprint Molecular genetic aspects of attention-deficit/hyperactivity disorder
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Neurosci Biobehav Rev 28:625-41. 2004
    ..The molecular results mentioned above are presented and discussed in detail, thus providing both clinicians and geneticists with an overview of the current research status of this important child and adolescent psychiatric disorder...
  25. ncbi request reprint Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    J Psychiatr Res 35:339-45. 2001
    ..Together with other published findings in adults, these results suggest an increased prevalence of obesity among young patients with schizophrenia and especially among patients chronically treated with atypical antipsychotics...
  26. doi request reprint Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention
    A L Volckmar
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    Exp Clin Endocrinol Diabetes 121:334-7. 2013
    ..The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention...
  27. ncbi request reprint The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, Neuenhofer Weg 21, D 52074, Aachen, Germany
    J Psychiatr Res 37:165-9. 2003
    ..001) and lg10 leptin level at admission (P=0.002). In conclusion, we confirmed weight gain induced hyperleptinemia in AN. Further research is required to assess if this phenomenon contributes to renewed weight loss...
  28. doi request reprint Exploring the genetic link between RLS and ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Klinikun Essen, Virchowstr 174, 45147 Essen, Germany
    J Psychiatr Res 43:941-5. 2009
    ..Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD...
  29. ncbi request reprint Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Mol Psychiatry 2:330-4. 1997
    ..Peak leptin levels reached after weight gain are possibly the cause of increased energy expenditure during this stage of the disorder...
  30. ncbi request reprint Overweight and obesity in children with Attention-Deficit/Hyperactivity Disorder
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Germany
    Int J Obes Relat Metab Disord 28:685-9. 2004
    ..The aim of our study was to assess if the prevalence of overweight and obesity is lower in a population of boys with ADHD in comparison with the German healthy male reference population of the same age...
  31. doi request reprint Screening for anorexia nervosa via measurement of serum leptin levels
    M Föcker
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147, Essen, Germany
    J Neural Transm 118:571-8. 2011
    ..Hypoleptinemia represents a state marker of acute AN and is useful for a laboratory-based diagnostic screening...
  32. ncbi request reprint Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm 111:817-25. 2004
    ..We did not detect transmission disequilibrium of the investigated polymorphisms in OCD. Hence, these polymorphisms do not play a major role in the genetic predisposition to early onset OCD...
  33. doi request reprint The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents
    N Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Horm Metab Res 44:75-7. 2012
    ..As the length (1 year as compared to 3 months) and mode of treatment (hypocaloric diet in adults vs. physical activity plus balanced meals) of the interventions varied, these parameters might have influenced the inconsistent results...
  34. ncbi request reprint Prediction of low body weight at long-term follow-up in acute anorexia nervosa by low body weight at referral
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Am J Psychiatry 154:566-9. 1997
    ..The authors investigated the hypothesis that in acute anorexia nervosa a low body weight predicts a poor weight prognosis for the future...
  35. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 7:1054-7. 2002
    ..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD...
  36. ncbi request reprint Social class, parental education, and obesity prevalence in a study of six-year-old children in Germany
    A Lamerz
    Department of Child and Adolescent Psychiatry, University Hospital Aachen, Neuenhofer Weg 21, Aachen, Germany
    Int J Obes (Lond) 29:373-80. 2005
    ..To assess the association between socioeconomic status (SES) and childhood obesity, and which factor in particular stands out in relation to obesity...
  37. ncbi request reprint Perspectives: molecular genetic research in human obesity
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Obes Rev 4:139-46. 2003
    ..We recommend that the procedure via which a consensus is reached as to what constitutes a true positive association finding requires formalization...
  38. ncbi request reprint Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia
    J Hebebrand
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Hans Sachs Strasse 6, 35033 Marburg, Germany
    Physiol Behav 79:25-37. 2003
    ..In the first and second parts of our review, we will summarize the relevant findings pertaining to hyperactivity in AN patients and in the rat model, respectively. We conclude with a synopsis and implications for future research...
  39. ncbi request reprint Candidate gene polymorphisms in eating disorders
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Str 6, D 35033, Marburg, Germany
    Eur J Pharmacol 410:147-159. 2000
    ..This kind of approach has already been initiated for anorexia nervosa. Genetic research on eating disorders will hopefully lead to new pharmacological treatment strategies...
  40. ncbi request reprint Reproductive function during weight gain in anorexia nervosa. Leptin represents a metabolic gate to gonadotropin secretion
    K Holtkamp
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Germany
    J Neural Transm 110:427-35. 2003
    ..Once this is exceeded other biological mechanisms seem to be important for the complete recovery of the reproductive function and the resumption of menses...
  41. ncbi request reprint No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Pharmacogenomics J 7:275-81. 2007
    ..In conclusion, we have not identified a novel binding site of the two investigated atypical AP that could contribute to the induced weight gain...
  42. pmc Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
    Susann Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Genet 8:17. 2007
    ..Additionally, we tested for linkage and performed family based association studies at four common variants in the 165 families of our initial genome scan...
  43. ncbi request reprint A prospective study of serum ghrelin levels in patients treated with clozapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 112:1411-6. 2005
    ..Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain...
  44. doi request reprint Genetic aspects in attention-deficit/hyperactivity disorder
    O Albayrak
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 115:305-15. 2008
    ..This article comprehensively reviews the latest findings on the genetics of ADHD...
  45. ncbi request reprint A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity
    E Rettenbacher
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Germany
    Exp Clin Endocrinol Diabetes 115:7-12. 2007
    ..Functionally relevant mutations in the melanocortin-4 receptor gene ( MC4R) currently display the most common major gene/allele effect on extreme obesity...
  46. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    ..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism...
  47. ncbi request reprint Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:1761-9. 2006
    ..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals...
  48. ncbi request reprint Genetic factors for overweight and CAD
    Günter Brönner
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, and Medical Clinic II, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Herz 31:189-99. 2006
    ..g., animal models, linkage studies, association studies, etc.). These methods are discussed either in the paragraphs on obesity or on CAD; the described principles apply to both phenotypes...
  49. ncbi request reprint The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels
    Günter Brönner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:535-8. 2006
    ..Recently, the V103I polymorphism of MC4R has been shown to be negatively associated with body mass index. This suggests that serum lipids and blood pressure in individuals carrying the 103I allele might be influenced as well...
  50. doi request reprint Megalographia in children with cerebellar lesions and in children with attention-deficit/hyperactivity disorder
    Markus Frings
    Department of Neurology, University of Duisburg Essen, Hufelandstrase 55, 45122 Essen, Germany
    Cerebellum 9:429-32. 2010
    ..However, an involvement of non-cerebellar dysfunctions in ADHD cannot be excluded...
  51. pmc From monogenic to polygenic obesity: recent advances
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:297-310. 2010
    ..The development of new strategies for diagnosis, treatment and prevention of obesity can be anticipated...
  52. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
    ..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity...
  53. doi request reprint Timing of conditioned eyeblink responses is impaired in children with attention-deficit/hyperactivity disorder
    Markus Frings
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Exp Brain Res 201:167-76. 2010
    ..Cerebellar malfunction may contribute to disordered eyeblink conditioning in ADHD. However, because CR abnormalities differed between ADHD and cerebellar subjects, dysfunction of non-cerebellar structures cannot be excluded...
  54. ncbi request reprint The need to revise the diagnostic criteria for anorexia nervosa
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 111:827-40. 2004
    ..We propose alternative criteria which allow a better integration of biologically derived hypotheses addressing the nosology and the symptomatology of AN...
  55. ncbi request reprint No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 109:402-5. 2001
    ..35; underweight: 0.32). Similarly, genotype frequencies did not differ between the groups. We concluded that the 825-T allele of the GNB3 does not play a major role in weight regulation in German children, adolescents and young adults...
  56. ncbi request reprint Objective measurement of hyperactivity, impulsivity, and inattention in children with hyperkinetic disorders before and after treatment with methylphenidate
    P Heiser
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Strasse 6, 35037 Marburg, Germany
    Eur Child Adolesc Psychiatry 13:100-4. 2004
    ....
  57. pmc Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:14. 2009
    ..We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity...
  58. doi request reprint Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 3:294-303. 2010
    ..The identified variants mostly have small to very small effect sizes; only 1-2% of the BMI variance is explained. Currently, a consensus explanation for this 'missing heritability' in complex diseases has not yet emerged...
  59. ncbi request reprint No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    ..In addition, we confirmed the presence of rs1049353. As these variants could not explain the initial TDT, we conclude that there is no evidence for an association of CNR1 alleles with obesity in our study groups...
  60. doi request reprint Environmental and genetic risk factors in obesity
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstr, 174, D 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:83-94. 2009
    ..Important factors are socioeconomic status and television consumption. The authors conclude by briefly assessing implications for treatment and prevention of childhood obesity...
  61. doi request reprint Procolipase gene: no association with early-onset obesity or fat intake
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Obes Facts 2:40-4. 2009
    ..We explored the relationship between genetic variation in CLPS, early-onset obesity and fat intake in humans...
  62. pmc Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
    Anke Hinney
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    PLoS ONE 2:e1361. 2007
    ..Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity...
  63. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
    ..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults...
  64. ncbi request reprint Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Psychiatr Genet 14:139-42. 2004
    ..Further pharmacogenetic studies pertaining to antipsychotic-induced weight gain are warranted...
  65. ncbi request reprint Prevalence of obesity, binge eating, and night eating in a cross-sectional field survey of 6-year-old children and their parents in a German urban population
    Andreas Lamerz
    Department of Child and Adolescent Psychiatry, University Hospital of the Technical University of Aachen, Germany
    J Child Psychol Psychiatry 46:385-93. 2005
    ..To assess the prevalence of obesity, obesity-related binge eating, non-obesity-related binge eating, and night eating in five- to six-year-old children and to examine the impact of parental eating disturbances...
  66. doi request reprint Social cognition in attention-deficit hyperactivity disorder (ADHD)
    J Uekermann
    LVR Clinics Essen, University of Duisburg Essen, Department of Psychiatry and Psychotherapy, Essen, Germany
    Neurosci Biobehav Rev 34:734-43. 2010
    ..So far only few studies have addressed the issue of social cognition deficits in ADHD...
  67. doi request reprint Evaluating strategies for marker ranking in genome-wide association studies of complex traits
    A Scherag
    André Scherag, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Methods Inf Med 49:632-40. 2010
    ..Thus, several methods to sort marker data have been proposed which will be evaluated here...
  68. ncbi request reprint Lower serum leptin levels in female students of the nutritional sciences with eating disorders
    Joachim Frey
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Eur J Nutr 42:142-8. 2003
    ..It is unknown if these lower leptin levels represent a state or trait marker...
  69. pmc Eating disorders: the current status of molecular genetic research
    Susann Scherag
    Department of Child and Adolescent Psychiatry and Psychotherapy, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:211-26. 2010
    ..The elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches...
  70. ncbi request reprint Mutation analysis of the MCHR1 gene in human obesity
    Anne Kathrin Wermter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, 45147 Essen, Germany
    Eur J Endocrinol 152:851-62. 2005
    ..The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity...
  71. ncbi request reprint Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity
    Nadine Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    J Nutr 135:1387-92. 2005
    ..244G-->A revealed no transmission disequilibrium. We conclude that the analyzed SNPs in GAL and GALR1 do not play a major role in early onset obesity or dietary fat intake in the obese children and adolescents of our study groups...
  72. ncbi request reprint DSM-IV-TR Axes-I and II mental disorders in a representative and referred sample of unemployed youths - Results from a psychiatric liaison service in a job centre
    V Reissner
    University of Duisburg Essen, Department of Child and Adolescent Psychiatry and Psychotherapy, Wickenburgstr 21, 45147 Essen, Germany Electronic address
    Eur Psychiatry 29:239-45. 2014
    ..This study compares both DSM-IV-TR Axis-I and Axis-II mental disorders between a representative and a referred sample of unemployed youths aged 16.0 to 24.9...
  73. ncbi request reprint Does obesity surgery improve psychosocial functioning? A systematic review
    S Herpertz
    Clinic of Psychosomatic Medicine and Psychotherapy, University of Essen, Essen, Germany
    Int J Obes Relat Metab Disord 27:1300-14. 2003
    ....
  74. doi request reprint A prospective study of body weight and serum leptin levels in patients treated with topiramate
    Frank M Theisen
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Clin Neuropharmacol 31:226-30. 2008
    ..We prospectively studied 26 (10 women) patients (age, 37.4 +/- 10.3 years) with different types of refractory focal epilepsy who received topiramate as adjunctive treatment...
  75. doi request reprint Diagnostic issues in eating disorders and obesity
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:1-16. 2009
    ..85 % of expected weight is approximately equivalent to the 10(th) BMI centile...
  76. doi request reprint Psychological and psychiatric aspects of pediatric obesity
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:49-65. 2009
    ..Sources include peers, teachers, parents, and health care providers. It would indeed seem peculiar if this ongoing and intense stigmatization did not affect mental well-being at a very early stage of life...
  77. doi request reprint Postural and gait performance in children with attention deficit/hyperactivity disorder
    Paul Buderath
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Gait Posture 29:249-54. 2009
    ..However, the observed abnormalities were minor. It needs to be examined whether balance problems become more pronounced in ADHD children exhibiting more prominent signs of clumsiness...
  78. ncbi request reprint Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, 35033 Marburg, Germany
    J Clin Endocrinol Metab 87:2716. 2002
    ..A frameshift mutation was detected in a normal weight individual. None of the variants seem to influence weight regulation...
  79. ncbi request reprint Secular trends in body mass index measurements in preschool children from the City of Aachen, Germany
    Beate Herpertz-Dahlmann
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Neuenhofer Weg 21, 52074 Aachen, Germany
    Eur J Pediatr 162:104-9. 2003
    ..While significant increases occurred for any given BMI percentile, the annual increase for both sexes was most prominent in the upper range. No change in body height was observed during the study period...
  80. pmc School avoidance from the point of view of child and adolescent psychiatry: symptomatology, development, course, and treatment
    Martin Knollmann
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, LVR Klinikum Essen, Universitat Duisburg Essen, Germany
    Dtsch Arztebl Int 107:43-9. 2010
    ..A considerable percentage of children and adolescents who avoid school have mental illnesses. This article reviews the typical manifestations, classification, development, course, and treatment of school-avoiding behavior...
  81. doi request reprint Leptin-mediated neuroendocrine alterations in anorexia nervosa: somatic and behavioral implications
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:117-29. 2009
    ..During therapeutically induced weight gain, leptin levels can intermittently increase above normal concentrations. This hyperleptinemia could predispose to renewed weight loss...
  82. ncbi request reprint Clozapine-induced weight gain: a study in monozygotic twins and same-sex sib pairs
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, D 35039 Marburg, Germany
    Psychiatr Genet 15:285-9. 2005
    ..An important caveat is that, owing to the sample size, the heritability estimates have a large standard error and thus have to be interpreted with caution...
  83. ncbi request reprint The contribution of anxiety and food restriction on physical activity levels in acute anorexia nervosa
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University Aachen, Neuenhofer Weg 21, D 52074 Aachen, Germany
    Int J Eat Disord 36:163-71. 2004
    ..Interconnections among caloric restriction, psychopathology, and physical activity in humans with AN are poorly investigated...
  84. ncbi request reprint Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Eur J Hum Genet 16:1126-34. 2008
    ..Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep...
  85. doi request reprint Serum levels of S100B are decreased in chronic starvation and normalize with weight gain
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Neural Transm 115:937-40. 2008
    ..We found that nutritional status was an important factor influencing serum levels of S100B...
  86. ncbi request reprint Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Biol Psychiatry 60:311-3. 2006
    ..Leptin ameliorates anxiety-related movement in ob/ob mice. In this study, we assessed the relationship between leptin and qualities of physical activity and restlessness in acute anorexia nervosa (AN)...
  87. ncbi request reprint Twin study on heritability of activity, attention, and impulsivity as assessed by objective measures
    Philip Heiser
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    J Atten Disord 9:575-81. 2006
    ..The purpose of this study was to assess heritability of activity, attention, and impulsivity by comparing young monozygotic (MZ) twins with dizygotic (DZ) twins using objective measures...
  88. doi request reprint Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study
    Iris M Heid
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Obesity (Silver Spring) 16:369-76. 2008
    ..This study aims to provide epidemiological evidence for showing the association of this polymorphism with features of the metabolic syndrome and with parameters related to energy expenditure and dietary habits as potential mediators...
  89. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  90. ncbi request reprint Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Eur J Hum Genet 13:428-34. 2005
    ..These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI...
  91. ncbi request reprint Genome scan for childhood and adolescent obesity in German families
    Kathrin Saar
    Molecular Genetics and Gene Mapping Center, Max Delbruck Center, Berlin, Germany
    Pediatrics 111:321-7. 2003
    ....
  92. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  93. ncbi request reprint [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]
    Benno Graf Schimmelmann
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitat Duisburg Essen, Rheinische Kliniken Essen, Virchowstrasse 174, DE 45147 Essen
    Z Kinder Jugendpsychiatr Psychother 34:425-33. 2006
    ..The understanding of ADHD's neurobiology may be advanced by new technologies, such as SNP-based genome scans performed with gene chips comprising 10,000-1,000,000 SNPs, as well as using more sophisticated animal model designs...
  94. pmc Possible genomic imprinting of three human obesity-related genetic loci
    Chuanhui Dong
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Am J Hum Genet 76:427-37. 2005
    ..79; multipoint LOD of 3.72 for BMI) in region 13q32, in the European American sample. The results suggest that parent-of-origin effects, perhaps including genomic imprinting, may play a role in human obesity...
  95. ncbi request reprint Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
    ..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population...
  96. ncbi request reprint Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Hum Mol Genet 13:1205-12. 2004
    ..These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors...
  97. ncbi request reprint Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene
    Dorothea Gadzicki
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany
    Am J Med Genet B Neuropsychiatr Genet 127:97-103. 2004
    ..We conclude that genetic variations of the CNR1 gene are not a plausible explanation for the clinically observed relation between the cannabinoid system and TS...
  98. pmc Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
    Am J Hum Genet 74:572-81. 2004
    ..The respective protective effect against obesity implies that variation in the MC4R gene entails both loss and gain of function...
  99. ncbi request reprint Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
    Hai Jun Wang
    Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
    J Clin Endocrinol Metab 89:157-62. 2004
    ..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups...
  100. ncbi request reprint HLA-DRB genotyping in Gilles de la Tourette patients and their parents
    Sarah Schoenian
    Department of Neurology, Philipps University Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 119:60-4. 2003
    ..741, Monte Carlo P = 0.4998). Our results imply that the HLA-DRB locus does not confer genetic susceptibility to GTS...