Christof R Hauck

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. ncbi request reprint Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria
    Arnaud Kengmo Tchoupa
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    Cell Commun Signal 12:27. 2014
  2. pmc Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens
    Maike Voges
    Lehrstuhl Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 7:e39908. 2012
  3. pmc The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria
    Stefan Pils
    Lehrstuhl Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 7:e32808. 2012
  4. pmc Neisseria meningitidis has two independent modes of recognizing its human receptor CEACAM1
    Katharina Kuespert
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 6:e14609. 2011
  5. doi request reprint Exploitation of integrin function by pathogenic microbes
    Christof R Hauck
    Lehrstuhl Zellbiologie, Fachbereich Biologie, Universitat Konstanz, Germany
    Curr Opin Cell Biol 24:637-44. 2012
  6. pmc Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria
    Kathrin Kopp
    Lehrstuhl Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 287:39158-70. 2012
  7. pmc Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections
    Alexandra Roth
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Constance, Germany
    Infect Immun 81:2358-70. 2013
  8. ncbi request reprint The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains
    Petra Muenzner
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Postfach X908, D 78457 Konstanz, Germany
    Cell Microbiol 10:1074-92. 2008
  9. pmc Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 286:9555-66. 2011
  10. pmc Opa proteins of pathogenic neisseriae initiate Src kinase-dependent or lipid raft-mediated uptake via distinct human carcinoembryonic antigen-related cell adhesion molecule isoforms
    Tim Schmitter
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Postfach X908, 78457 Konstanz, Germany
    Infect Immun 75:4116-26. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria
    Arnaud Kengmo Tchoupa
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    Cell Commun Signal 12:27. 2014
    ..The cooperation between these two receptor families provides an intriguing example of the fine tuning of cellular responses and their manipulation by specialized microorganisms. ..
  2. pmc Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens
    Maike Voges
    Lehrstuhl Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 7:e39908. 2012
    ....
  3. pmc The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria
    Stefan Pils
    Lehrstuhl Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 7:e32808. 2012
    ..Rac stimulation in turn is critical for actin cytoskeleton rearrangements that generate lamellipodial protrusions and lead to bacterial uptake...
  4. pmc Neisseria meningitidis has two independent modes of recognizing its human receptor CEACAM1
    Katharina Kuespert
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Konstanz, Germany
    PLoS ONE 6:e14609. 2011
    ..For example, Neisseria meningitidis engages these human receptors via outer membrane proteins of the colony opacity-associated (Opa) protein family triggering internalization into non-phagocytic cells...
  5. doi request reprint Exploitation of integrin function by pathogenic microbes
    Christof R Hauck
    Lehrstuhl Zellbiologie, Fachbereich Biologie, Universitat Konstanz, Germany
    Curr Opin Cell Biol 24:637-44. 2012
    ..Approaches to disrupt this connection might be an appropriate means to obtain broad-acting tools to modulate a spectrum of infectious diseases...
  6. pmc Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria
    Kathrin Kopp
    Lehrstuhl Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 287:39158-70. 2012
    ..Therefore, Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact...
  7. pmc Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections
    Alexandra Roth
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Constance, Germany
    Infect Immun 81:2358-70. 2013
    ..A failure of CEACAM3-mediated innate immune detection might be linked to the ability of gonococci to cause disseminated infections...
  8. ncbi request reprint The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains
    Petra Muenzner
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Postfach X908, D 78457 Konstanz, Germany
    Cell Microbiol 10:1074-92. 2008
    ..Together, these data argue for a functional role of lipid rafts in CEACAM1-mediated endocytosis that is promoted by the transmembrane domain of the receptor and that might be relevant for CEACAM1 function in physiologic settings...
  9. pmc Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 286:9555-66. 2011
    ..Together, our results highlight the ability of CEACAM3 to coordinate signaling events that not only mediate bacterial uptake, but also trigger the killing of internalized pathogens...
  10. pmc Opa proteins of pathogenic neisseriae initiate Src kinase-dependent or lipid raft-mediated uptake via distinct human carcinoembryonic antigen-related cell adhesion molecule isoforms
    Tim Schmitter
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Postfach X908, 78457 Konstanz, Germany
    Infect Immun 75:4116-26. 2007
    ..These results allow the subdivision of all human CEACAMs known to be utilized as pathogen receptors into functional groups and point to important consequences for bacterial engagement of distinct CEACAM isoforms...
  11. doi request reprint Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation
    Petra Muenzner
    Lehrstuhl Zellbiologie, Fachbereich Biologie, Universitat Konstanz, 78457 Konstanz, Germany
    Science 329:1197-201. 2010
    ..This manipulation of integrin inside-out signaling promotes efficient mucosal colonization and represents a potential target to prevent or cure bacterial infections...
  12. pmc CEACAM1 recognition by bacterial pathogens is species-specific
    Maike Voges
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Mailbox X908, 78457 Konstanz, Germany
    BMC Microbiol 10:117. 2010
    ..However, it is unknown whether bacterial adhesins of human pathogens can recognize CEACAM1 orthologues from other mammals...
  13. doi request reprint Integrin-mediated uptake of fibronectin-binding bacteria
    Christine Hoffmann
    Lehrstuhl Zellbiologie, Universitat Konstanz, Germany
    Eur J Cell Biol 90:891-6. 2011
    ..aureus can not only serve as a paradigm for other fibronectin-binding pathogenic bacteria, but might also reveal the physiological regulation of endocytosis of ligand-occupied integrins...
  14. ncbi request reprint Profiling of bacterial adhesin--host receptor recognition by soluble immunoglobulin superfamily domains
    Katharina Kuespert
    Lehrstuhl für Zellbiologie, Fachbereich Biologie X908, Universitätsstr 10, Universitat Konstanz, 78457 Konstanz, Germany
    J Microbiol Methods 68:478-85. 2007
    ....
  15. doi request reprint HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Germany
    Arch Biochem Biophys 524:77-83. 2012
    ....
  16. doi request reprint Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens
    Christine Hoffmann
    Lehrstuhl Zellbiologie X908, Universitat Konstanz, Universitätsstr 10, 78457 Konstanz, Germany
    J Cell Sci 123:4280-91. 2010
    ..This process might not only limit host cell invasion by integrin-binding bacterial pathogens, but might also be physiologically relevant for integrin-mediated cell adhesion...
  17. doi request reprint Characterizing host receptor recognition by individual bacterial pathogens
    Katharina Kuespert
    Department of Biology, University of Konstanz, Konstanz, Germany
    Methods Mol Biol 470:57-65. 2009
    ..Besides focusing on the receptor-binding assay, this chapter describes the production of fluorescence-tagged soluble host receptor domains required for conducting this assay...
  18. pmc Integrin-mediated internalization of Staphylococcus aureus does not require vinculin
    Marina Borisova
    Lehrstuhl Zellbiologie, Universitat Konstanz, Postfach X908, 78457 Konstanz, Germany
    BMC Cell Biol 14:2. 2013
    ..aureus...
  19. pmc Fluorescence resonance energy transfer (FRET)-based subcellular visualization of pathogen-induced host receptor signaling
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, Konstanz, Germany
    BMC Biol 7:81. 2009
    ..Here, we provide a methodological approach to exploit fluorescence resonance energy transfer (FRET) to visualize pathogen-initiated signaling events in human cells...
  20. ncbi request reprint CEACAMs: their role in physiology and pathophysiology
    Katharina Kuespert
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Curr Opin Cell Biol 18:565-71. 2006
    ..Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo...
  21. doi request reprint CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens
    Stefan Pils
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Int J Med Microbiol 298:553-60. 2008
    ....