Affiliation: University of Erlangen-Nuremberg
Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M. Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002;118:175-8 pubmed
..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. ..
Hashemolhosseini S, Schmidt K, Kilian K, Rodriguez E, Wegner M. Conservation and variation of structure and function in a newly identified GCM homolog from chicken. J Mol Biol. 2004;336:441-51 pubmed
..Taking the extraembryonic expression of chicken GCM and mammalian GCMa into account, it is tempting to speculate that a conserved extraembryonic function exists for GCM proteins in birds and mammals. ..
Hashemolhosseini S, Wegner M. Impacts of a new transcription factor family: mammalian GCM proteins in health and disease. J Cell Biol. 2004;166:765-8 pubmed
..Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors. ..
Hashemolhosseini S, Kilian K, Kardash E, Lischka P, Stamminger T, Wegner M. Structural requirements for nuclear localization of GCMa/Gcm-1. FEBS Lett. 2003;553:315-20 pubmed
..Nuclear import was counteracted by an amino-terminal nuclear export activity. This complex regulation of subcellular localization has important implications for GCMa/Gcm-1 function. ..