Research Topics
Genomes and Genes | Wolfgang HartmannSummaryAffiliation: University of Bonn Country: Germany Publications
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Publications
A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control studyLutz E Lehmann
University Department of Anaesthesiology and Pain Therapy, Inselspital, CH 3010 Bern, Switzerland
J Transl Med 7:100. 2009..The purpose of the study was to analyze their association with the incidence and outcome of severe sepsis...- Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cellsAlexander Glassmann
Anatomisches Institut, Anatomie and Zellbiologie, University of Bonn, Bonn, Germany
BMC Dev Biol 7:111. 2007..Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens... 
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survivalWolfgang Hartmann
Department of Pathology and Neuropathology, University of Bonn Medical Center, Sigmund Freud St 25, Bonn D 53105, Germany
Clin Cancer Res 15:4538-45. 2009..The current study was done to analyze the role of PI3K/AKT signaling in hepatoblastoma...- p75(NTR) induces apoptosis in medulloblastoma cellsJan Küchler
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Int J Cancer 128:1804-12. 2011..In summary, our data link activated Hedgehog signaling in DMB with p75(NTR) expression and characterize p75(NTR) as a biologically relevant inductor of apoptosis in MB... 
Elevated expression of Wnt antagonists is a common event in hepatoblastomasArend Koch
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Clin Cancer Res 11:4295-304. 2005..We propose that Nkd-1 and beta-TrCP may be used as possible diagnostic markers for the activated Wnt signaling pathway in hepatoblastomas...- Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomasArend Koch
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Int J Cancer 121:284-91. 2007..These findings indicate that mutations of AXIN2 can lead to an oncogenic activation of the Wnt pathway in MBs... - Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTENWolfgang Hartmann
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Clin Cancer Res 12:3019-27. 2006..Recently, it has been shown that Sonic Hedgehog-induced formation of medulloblastoma in an animal model is significantly enhanced by activation of the phosphatidylinositol 3'-kinase (PI3K) signaling pathway... - Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcomaNicolaus Friedrichs
Department of Pathology, University of Bonn Medical Center, Bonn, Germany
Int J Cancer 129:1564-75. 2011..In summary, PI3K signaling plays an essential role in growth control of synovial sarcomas and might be successfully targeted in multimodal therapeutic strategies... - Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomasUlrich Schüller
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Int J Cancer 117:82-9. 2005..These data suggest that Cxcr4 may be involved in the pathogenesis of MBs... - Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cellsWolfgang Hartmann
Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-St. 25, D-53105 Bonn, Germany
Am J Pathol 166:1153-62. 2005..Together, our data point to an important role of IGF-II for the proliferation control of both cerebellar neural precursors and MB cells... - Surgery for spinal cord ependymomas: outcome and prognostic factorsAzize Boström
Department of Neurosurgery University Hospital Bonn Medical Center, Bonn, Germany
Neurosurgery 68:302-8; discussion 309. 2011..Spinal cord tumors account for 5% to 10% of all primary central nervous system tumors. The most common intramedullary neoplasms are ependymomas, composing 50% to 60% of spinal neuroepithelial tumors in adults... - Analysis of HIC-1 methylation and transcription in human ependymomasAnke Waha
Department of Neuropathology, University of Bonn, Bonn, Germany
Int J Cancer 110:542-9. 2004..Of 27 ependymomas, 22 (81%) showed absent or low expression of HIC-1. The elevated methylation of HIC-1 in nonspinal ependymomas supports the hypothesis that spinal and nonspinal ependymomas represent genetically distinct entities... - Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomasArend Koch
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
J Pathol 204:546-54. 2004..The overexpression of conductin mRNA in HBs reflects activation of the WNT pathway because conductin represents a target gene of WNT signalling in liver tissue... - Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cellsVolker Schick
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Brain Pathol 17:165-73. 2007..balloon cells in FCD(IIb) and provides new implications for the development of treatment strategies for these cortical malformations... - Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localizationSebastian Huss
Institute of Pathology, University of Cologne Medical Center, Cologne, Germany Institute of Pathology, University of Bonn Medical Center, Bonn, Germany
Histopathology 61:59-68. 2012..This study was performed to broaden the base of evidence of the pathogenic role of PDGFR mutations in IFP with particular regard to clinicopathological data and mutational patterns among IFP subtypes...