Wolfgang Hartmann

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study
    Lutz E Lehmann
    University Department of Anaesthesiology and Pain Therapy, Inselspital, CH 3010 Bern, Switzerland
    J Transl Med 7:100. 2009
  2. pmc Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells
    Alexander Glassmann
    Anatomisches Institut, Anatomie and Zellbiologie, University of Bonn, Bonn, Germany
    BMC Dev Biol 7:111. 2007
  3. doi request reprint Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival
    Wolfgang Hartmann
    Department of Pathology and Neuropathology, University of Bonn Medical Center, Sigmund Freud St 25, Bonn D 53105, Germany
    Clin Cancer Res 15:4538-45. 2009
  4. ncbi request reprint Elevated expression of Wnt antagonists is a common event in hepatoblastomas
    Arend Koch
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Clin Cancer Res 11:4295-304. 2005
  5. doi request reprint p75(NTR) induces apoptosis in medulloblastoma cells
    Jan Küchler
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 128:1804-12. 2011
  6. ncbi request reprint Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN
    Wolfgang Hartmann
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Clin Cancer Res 12:3019-27. 2006
  7. ncbi request reprint Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
    Arend Koch
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 121:284-91. 2007
  8. ncbi request reprint Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
    Ulrich Schüller
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 117:82-9. 2005
  9. doi request reprint Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma
    Nicolaus Friedrichs
    Department of Pathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 129:1564-75. 2011
  10. pmc Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
    Wolfgang Hartmann
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud St 25, D 53105 Bonn, Germany
    Am J Pathol 166:1153-62. 2005

Collaborators

Detail Information

Publications15

  1. pmc A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study
    Lutz E Lehmann
    University Department of Anaesthesiology and Pain Therapy, Inselspital, CH 3010 Bern, Switzerland
    J Transl Med 7:100. 2009
    ..The purpose of the study was to analyze their association with the incidence and outcome of severe sepsis...
  2. pmc Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells
    Alexander Glassmann
    Anatomisches Institut, Anatomie and Zellbiologie, University of Bonn, Bonn, Germany
    BMC Dev Biol 7:111. 2007
    ..Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens...
  3. doi request reprint Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival
    Wolfgang Hartmann
    Department of Pathology and Neuropathology, University of Bonn Medical Center, Sigmund Freud St 25, Bonn D 53105, Germany
    Clin Cancer Res 15:4538-45. 2009
    ..The current study was done to analyze the role of PI3K/AKT signaling in hepatoblastoma...
  4. ncbi request reprint Elevated expression of Wnt antagonists is a common event in hepatoblastomas
    Arend Koch
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Clin Cancer Res 11:4295-304. 2005
    ..We propose that Nkd-1 and beta-TrCP may be used as possible diagnostic markers for the activated Wnt signaling pathway in hepatoblastomas...
  5. doi request reprint p75(NTR) induces apoptosis in medulloblastoma cells
    Jan Küchler
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 128:1804-12. 2011
    ..In summary, our data link activated Hedgehog signaling in DMB with p75(NTR) expression and characterize p75(NTR) as a biologically relevant inductor of apoptosis in MB...
  6. ncbi request reprint Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN
    Wolfgang Hartmann
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Clin Cancer Res 12:3019-27. 2006
    ..Recently, it has been shown that Sonic Hedgehog-induced formation of medulloblastoma in an animal model is significantly enhanced by activation of the phosphatidylinositol 3'-kinase (PI3K) signaling pathway...
  7. ncbi request reprint Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
    Arend Koch
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 121:284-91. 2007
    ..These findings indicate that mutations of AXIN2 can lead to an oncogenic activation of the Wnt pathway in MBs...
  8. ncbi request reprint Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
    Ulrich Schüller
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 117:82-9. 2005
    ..These data suggest that Cxcr4 may be involved in the pathogenesis of MBs...
  9. doi request reprint Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma
    Nicolaus Friedrichs
    Department of Pathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 129:1564-75. 2011
    ..In summary, PI3K signaling plays an essential role in growth control of synovial sarcomas and might be successfully targeted in multimodal therapeutic strategies...
  10. pmc Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
    Wolfgang Hartmann
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud St 25, D 53105 Bonn, Germany
    Am J Pathol 166:1153-62. 2005
    ..Together, our data point to an important role of IGF-II for the proliferation control of both cerebellar neural precursors and MB cells...
  11. doi request reprint Surgery for spinal cord ependymomas: outcome and prognostic factors
    Azize Boström
    Department of Neurosurgery University Hospital Bonn Medical Center, Bonn, Germany
    Neurosurgery 68:302-8; discussion 309. 2011
    ..Spinal cord tumors account for 5% to 10% of all primary central nervous system tumors. The most common intramedullary neoplasms are ependymomas, composing 50% to 60% of spinal neuroepithelial tumors in adults...
  12. ncbi request reprint Analysis of HIC-1 methylation and transcription in human ependymomas
    Anke Waha
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Int J Cancer 110:542-9. 2004
    ..Of 27 ependymomas, 22 (81%) showed absent or low expression of HIC-1. The elevated methylation of HIC-1 in nonspinal ependymomas supports the hypothesis that spinal and nonspinal ependymomas represent genetically distinct entities...
  13. ncbi request reprint Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas
    Arend Koch
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Pathol 204:546-54. 2004
    ..The overexpression of conductin mRNA in HBs reflects activation of the WNT pathway because conductin represents a target gene of WNT signalling in liver tissue...
  14. ncbi request reprint Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells
    Volker Schick
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Brain Pathol 17:165-73. 2007
    ..balloon cells in FCD(IIb) and provides new implications for the development of treatment strategies for these cortical malformations...
  15. doi request reprint Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization
    Sebastian Huss
    Institute of Pathology, University of Cologne Medical Center, Cologne, Germany Institute of Pathology, University of Bonn Medical Center, Bonn, Germany
    Histopathology 61:59-68. 2012
    ..This study was performed to broaden the base of evidence of the pathogenic role of PDGFR mutations in IFP with particular regard to clinicopathological data and mutational patterns among IFP subtypes...