Dominik Hartl

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases
    Dominik Hartl
    Childrens Hospital, Ludwig Maximilians University, Munich, Germany
    J Immunol 181:8053-67. 2008
  2. ncbi request reprint Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
    Dominik Hartl
    Children s Hospital Research Center, Ludwig Maximilians University, Munich 80337, Germany
    Nat Med 13:1423-30. 2007
  3. doi request reprint Immunological mechanisms behind the cystic fibrosis-ABPA link
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Germany
    Med Mycol 47:S183-91. 2009
  4. ncbi request reprint Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Germany
    J Allergy Clin Immunol 119:1258-66. 2007
  5. ncbi request reprint Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
    J Allergy Clin Immunol 117:204-11. 2006
  6. ncbi request reprint TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease
    Barbara Koller
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    J Immunol 181:2753-63. 2008
  7. pmc Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune response
    Nikolaus Rieber
    University Children s Hospital, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e17271. 2011
  8. doi request reprint CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
    Veronica Marcos
    Research Center, Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Nat Med 16:1018-23. 2010
  9. pmc Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases
    Veronica Marcos
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    Respir Res 11:32. 2010
  10. ncbi request reprint Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease
    Vitaliy Starosta
    Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, 80337 Munich, Germany
    Chest 132:1557-64. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases
    Dominik Hartl
    Childrens Hospital, Ludwig Maximilians University, Munich, Germany
    J Immunol 181:8053-67. 2008
    ....
  2. ncbi request reprint Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
    Dominik Hartl
    Children s Hospital Research Center, Ludwig Maximilians University, Munich 80337, Germany
    Nat Med 13:1423-30. 2007
    ....
  3. doi request reprint Immunological mechanisms behind the cystic fibrosis-ABPA link
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Germany
    Med Mycol 47:S183-91. 2009
    ..A summary and discussion of the immunological mechanism involved in the pathogenesis of ABPA with a focus on CF lung disease and the role of chemokines is presented here...
  4. ncbi request reprint Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Germany
    J Allergy Clin Immunol 119:1258-66. 2007
    ..Asthma is characterized by a T(H)2 immune response. CD4(+)CD25(hi) regulatory T cells (Tregs) have been proposed to prevent allergic diseases through suppression of T(H)2 responses...
  5. ncbi request reprint Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
    J Allergy Clin Immunol 117:204-11. 2006
    ..Studies in human peripheral blood indicate that P aeruginosa infection is associated with a predominant T(H)2 immune response, whereas T(H)1 responses are accompanied by a better pulmonary outcome...
  6. ncbi request reprint TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease
    Barbara Koller
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    J Immunol 181:2753-63. 2008
    ..This study demonstrates a novel mechanism of TLR regulation in neutrophils and suggests a critical role for TLR5 in neutrophil-P. aeruginosa interactions in CF lung disease...
  7. pmc Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune response
    Nikolaus Rieber
    University Children s Hospital, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e17271. 2011
    ..Pertussis-specific CD8(+) memory T cells may contribute to protection against clinical pertussis...
  8. doi request reprint CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
    Veronica Marcos
    Research Center, Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Nat Med 16:1018-23. 2010
    ..These studies establish CXCR2 as a receptor mediating NADPH oxidase-independent NET formation and provide evidence that this GPCR pathway is operative and druggable in cystic fibrosis lung disease...
  9. pmc Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases
    Veronica Marcos
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    Respir Res 11:32. 2010
    ..Therefore, we examined the expression, regulation and significance of sCD14 and mCD14 in pediatric lung diseases...
  10. ncbi request reprint Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease
    Vitaliy Starosta
    Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, 80337 Munich, Germany
    Chest 132:1557-64. 2007
    ....
  11. ncbi request reprint Surfactant protein D regulates chemotaxis and degranulation of human eosinophils
    Christina von Bredow
    Lung Research Group, Children s Hospital of Ludwig Maximilians University, Munich, Germany
    Clin Exp Allergy 36:1566-74. 2006
    ..Our data further support the concept of an anti-inflammatory function of SP-D in the lung of patients with allergic diseases...
  12. doi request reprint Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cells
    Christof Maucksch
    Department of Pediatrics, Ludwig Maximilians University, Munich, Germany
    J Gene Med 11:444-53. 2009
    ..Supercoiled topology of transfected plasmid DNA (pDNA) is critical for transgene expression in mammalian cells. In the present study, we analysed transgene expression of transfected supercoiled pDNA concatemers...
  13. ncbi request reprint Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    J Allergy Clin Immunol 121:375-382.e9. 2008
    ....
  14. ncbi request reprint Celiac disease and pulmonary hemosiderosis in a patient with chronic granulomatous disease
    Dominik Hartl
    Dr von Haunersches Kinderspital, Ludwig Maximilians University Munchen, Munchen, Germany
    Pediatr Pulmonol 38:344-8. 2004
    ..Lung function improved markedly by immunosuppression with daily glucocorticosteroid and azathioprine treatment...
  15. pmc Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany
    Matthias Griese
    Dr von Haunersches Kinderspital, University of Munich, Lindwurmstr 4a, D 80337 Munich, Germany
    Orphanet J Rare Dis 4:26. 2009
    ..This is due to the fact that (i) the incidence is low, and (ii) clinical presentation, (iii) disease classification and (iv) specific treatment options are largely unknown...
  16. ncbi request reprint Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women
    Susanne Krauss-Etschmann
    Clinical Cooperation Group Pediatric Immune Regulation, Children s Hospital of Ludwig Maximilians University and GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Allergy Clin Immunol 121:464-470.e6. 2008
    ..Because allergies are primed in early infancy and in utero, the fetus might be more accessible to nutritional intervention strategies...
  17. ncbi request reprint Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspring
    Susanne Krauss-Etschmann
    Childrens Hospital of the Ludwig Maximilians University, Lindwurmstr 2a, D 80337 Munich, Germany
    Clin Immunol 118:292-9. 2006
    ..42; TLR4 r = 0.58; CD14 r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14...
  18. pmc Interstitial lung disease in children -- genetic background and associated phenotypes
    Dominik Hartl
    Pediatric Pneumology, Childrens Hospital of the Ludwig Maximilians University, Munich, Germany
    Respir Res 6:32. 2005
    ..The knowledge of gene variants and associated phenotypes is crucial to identify relevant patients in clinical practice...
  19. ncbi request reprint Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
    Dominik Hartl
    Department of Pediatrics, University Hospital of Berne, Switzerland
    Am J Respir Crit Care Med 173:1370-6. 2006
    ..Mouse models suggest a critical role for the Th2 chemokines thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in ABPA...
  20. pmc A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
    Markus Woischnik
    Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
    BMC Cell Biol 11:88. 2010
    ..The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of the SP-C preprotein (proSP-C), however little is known about the cellular consequences of SP-CI73T expression...
  21. doi request reprint NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus
    Allison McCormick
    Max von Pettenkofer Institute, Ludwig Maximilians University, Pettenkoferstr 9a, D 80336, Munich, Germany
    Microbes Infect 12:928-36. 2010
    ..In summary, our data provide evidence that NETs are not sufficient to kill A. fumigatus, but might be a valuable tool to confine infection...
  22. pmc A role for MCP-1/CCR2 in interstitial lung disease in children
    Dominik Hartl
    Childrens Hospital, Ludwig Maximilians University, Munich, Germany
    Respir Res 6:93. 2005
    ..We hypothesized that pulmonary MCP-1 and CCR2+ T cells accumulate in pediatric ILD and are related to disease severity...
  23. pmc Comèl-Netherton syndrome defined as primary immunodeficiency
    Ellen D Renner
    Dr v Haunersches Kinderspital, Ludwig Maximilians Universitat, Munich, Germany
    J Allergy Clin Immunol 124:536-43. 2009
    ..Despite increased frequency of infections, the immunocompetence of patients with Comèl-Netherton syndrome has not been extensively investigated...
  24. doi request reprint Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial
    Matthias Griese
    Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Am J Respir Crit Care Med 188:83-9. 2013
    ..Objectives: We aimed to assess glutathione delivered by inhalation as a potential treatment for CF lung disease...
  25. doi request reprint Toll-like receptor heterodimer variants protect from childhood asthma
    Michael S D Kormann
    University Children s Hospital, Ludwig Maximilians Universitat, Munich, Germany
    J Allergy Clin Immunol 122:86-92, 92.e1-8. 2008
    ..Toll-like receptors (TLRs) represent a major group of receptors for the specific recognition of pathogen-associated molecular patterns of microbes capable of activating innate and adaptive immunity...
  26. doi request reprint Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
    Michael S D Kormann
    Department of Pediatrics, Ludwig Maximilian s University Munich, Munich, Germany
    Nat Biotechnol 29:154-7. 2011
    ....
  27. ncbi request reprint Chemokines in allergic aspergillosis--from animal models to human lung diseases
    Dominik Hartl
    Children s Hospital Research Center, Ludwig Maximilians University, Munich, Germany
    Inflamm Allergy Drug Targets 5:219-28. 2006
    ..This review illustrates the manifold role of chemokines in animal models of allergic aspergillosis and translates these findings to human lung diseases...
  28. doi request reprint Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccination
    Nikolaus Rieber
    University Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Vaccine 26:6929-35. 2008
    ..The higher antibody titres to pertussis toxin may indicate a more effective priming of B cell memory after primary whole-cell vaccination...
  29. ncbi request reprint Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins
    Elvira Larque
    Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 84:853-61. 2006
    ..Better understanding of the mechanisms involved in docosahexaenoic acid (DHA) transfer to the neonate may contribute to improve dietary support for infants born prematurely to mothers with placental lipid transport disorders...
  30. pmc TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation
    Carla A Da Silva
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, and
    J Immunol 181:4279-86. 2008
    ..These studies demonstrate that chitin is a size-dependent pathogen-associated molecular pattern that activates TLR-2 and MyD88 in a novel IL-17A/IL-17AR-based innate immunity pathway...
  31. ncbi request reprint Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough
    Dominik Hartl
    Children s Hospital of the Ludwig Maximilians University of Munich, Lindwurmstrasse 2a, D 80337 Munich, Germany
    J Allergy Clin Immunol 115:728-36. 2005
    ..Chemokines recruit T lymphocytes to inflamed tissues, and the corresponding chemokine receptors are differentially expressed on T H 1 and T H 2 cells...
  32. ncbi request reprint A donor splice site mutation in intron 1 of CYBA, leading to chronic granulomatous disease
    Martin de Boer
    Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
    Blood Cells Mol Dis 35:365-9. 2005
    ..This is, as far as we know, the first description of the molecular and clinical consequences of a donor splice site mutation in intron 1 of any gene reported so far...
  33. doi request reprint [Burnout Syndrome--burnout syndrome and the work climate in intensive medicine]
    Dominik Hartl
    Pneumologie 61:756. 2007
  34. ncbi request reprint Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response
    Silvia Stojanov
    Department of Infectious Diseases and Immunology, Children s Hospital, University of Munich, Germany
    Eur Cytokine Netw 17:90-7. 2006
    ....
  35. pmc Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant
    Hanna Müller
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Respir Res 8:69. 2007
    ..We hypothesized that pulmonary DMBT1 could contribute to respiratory distress syndrome in neonates by modulating surfactant function...