Research Topics
Genomes and Genes
| Dominik HartlSummaryAffiliation: University of Munich Country: Germany Publications
| Collaborators
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Detail Information
Publications
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung diseaseDominik Hartl
Children s Hospital Research Center, Ludwig Maximilians University, Munich 80337, Germany
Nat Med 13:1423-30. 2007....
Immunological mechanisms behind the cystic fibrosis-ABPA linkDominik Hartl
Children s Hospital of the Ludwig Maximilians University of Munich, Germany
Med Mycol 47:S183-91. 2009..A summary and discussion of the immunological mechanism involved in the pathogenesis of ABPA with a focus on CF lung disease and the role of chemokines is presented here...- Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseasesDominik Hartl
Childrens Hospital, Ludwig Maximilians University, Munich, Germany
J Immunol 181:8053-67. 2008.... - Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthmaDominik Hartl
Children s Hospital of the Ludwig Maximilians University of Munich, Germany
J Allergy Clin Immunol 119:1258-66. 2007..Asthma is characterized by a T(H)2 immune response. CD4(+)CD25(hi) regulatory T cells (Tregs) have been proposed to prevent allergic diseases through suppression of T(H)2 responses... - Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosisDominik Hartl
Children s Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
J Allergy Clin Immunol 117:204-11. 2006..Studies in human peripheral blood indicate that P aeruginosa infection is associated with a predominant T(H)2 immune response, whereas T(H)1 responses are accompanied by a better pulmonary outcome... - TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung diseaseBarbara Koller
Children s Hospital of the Ludwig Maximilians University, Munich, Germany
J Immunol 181:2753-63. 2008..This study demonstrates a novel mechanism of TLR regulation in neutrophils and suggests a critical role for TLR5 in neutrophil-P. aeruginosa interactions in CF lung disease... - CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammationVeronica Marcos
Research Center, Children s Hospital, Ludwig Maximilians University, Munich, Germany
Nat Med 16:1018-23. 2010..These studies establish CXCR2 as a receptor mediating NADPH oxidase-independent NET formation and provide evidence that this GPCR pathway is operative and druggable in cystic fibrosis lung disease... 
Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune responseNikolaus Rieber
University Children s Hospital, Ludwig Maximilians University, Munich, Germany
PLoS ONE 6:e17271. 2011..Pertussis-specific CD8(+) memory T cells may contribute to protection against clinical pertussis...- Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseasesVeronica Marcos
Children s Hospital of the Ludwig Maximilians University, Munich, Germany
Respir Res 11:32. 2010..Therefore, we examined the expression, regulation and significance of sCD14 and mCD14 in pediatric lung diseases... - Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux diseaseVitaliy Starosta
Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, 80337 Munich, Germany
Chest 132:1557-64. 2007.... - Surfactant protein D regulates chemotaxis and degranulation of human eosinophilsChristina von Bredow
Lung Research Group, Children's Hospital of Ludwig-Maximilians-University, Munich, Germany
Clin Exp Allergy 36:1566-74. 2006..Our data further support the concept of an anti-inflammatory function of SP-D in the lung of patients with allergic diseases... - Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cellsChristof Maucksch
Department of Pediatrics, Ludwig Maximilians University, Munich, Germany
J Gene Med 11:444-53. 2009..Supercoiled topology of transfected plasmid DNA (pDNA) is critical for transgene expression in mammalian cells. In the present study, we analysed transgene expression of transfected supercoiled pDNA concatemers... - Dysregulation of innate immune receptors on neutrophils in chronic granulomatous diseaseDominik Hartl
Children s Hospital of the Ludwig Maximilians University, Munich, Germany
J Allergy Clin Immunol 121:375-382.e9. 2008.... - Celiac disease and pulmonary hemosiderosis in a patient with chronic granulomatous diseaseDominik Hartl
Dr von Haunersches Kinderspital, Ludwig Maximilians University Munchen, Munchen, Germany
Pediatr Pulmonol 38:344-8. 2004..Lung function improved markedly by immunosuppression with daily glucocorticosteroid and azathioprine treatment... - Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant womenSusanne Krauss-Etschmann
Clinical Cooperation Group Pediatric Immune Regulation, Children s Hospital of Ludwig Maximilians University and GSF National Research Center for Environment and Health, Neuherberg, Germany
J Allergy Clin Immunol 121:464-470.e6. 2008..Because allergies are primed in early infancy and in utero, the fetus might be more accessible to nutritional intervention strategies... - Incidence and classification of pediatric diffuse parenchymal lung diseases in GermanyMatthias Griese
Dr von Haunersches Kinderspital, University of Munich, Lindwurmstr 4a, D 80337 Munich, Germany
Orphanet J Rare Dis 4:26. 2009..This is due to the fact that (i) the incidence is low, and (ii) clinical presentation, (iii) disease classification and (iv) specific treatment options are largely unknown... - Association between levels of Toll-like receptors 2 and 4 and CD14 mRNA and allergy in pregnant women and their offspringSusanne Krauss-Etschmann
Childrens Hospital of the Ludwig Maximilians University, Lindwurmstr 2a, D 80337 Munich, Germany
Clin Immunol 118:292-9. 2006..42; TLR4 r = 0.58; CD14 r = 0.54). The results suggest that maternal allergy status may affect allergic risk in offspring through a decreased expression of fetal TLR2/4/CD14... - Interstitial lung disease in children -- genetic background and associated phenotypesDominik Hartl
Pediatric Pneumology, Childrens Hospital of the Ludwig Maximilians University, Munich, Germany
Respir Res 6:32. 2005..The knowledge of gene variants and associated phenotypes is crucial to identify relevant patients in clinical practice... - Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosisDominik Hartl
Department of Pediatrics, University Hospital of Berne, Switzerland
Am J Respir Crit Care Med 173:1370-6. 2006..Mouse models suggest a critical role for the Th2 chemokines thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in ABPA... - Comèl-Netherton syndrome defined as primary immunodeficiencyEllen D Renner
Dr v Haunersches Kinderspital, Ludwig Maximilians Universitat, Munich, Germany
J Allergy Clin Immunol 124:536-43. 2009..Despite increased frequency of infections, the immunocompetence of patients with Comèl-Netherton syndrome has not been extensively investigated... - A role for MCP-1/CCR2 in interstitial lung disease in childrenDominik Hartl
Childrens Hospital, Ludwig Maximilians University, Munich, Germany
Respir Res 6:93. 2005..We hypothesized that pulmonary MCP-1 and CCR2+ T cells accumulate in pediatric ILD and are related to disease severity... - NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatusAllison McCormick
Max von Pettenkofer Institute, Ludwig Maximilians University, Pettenkoferstr 9a, D 80336, Munich, Germany
Microbes Infect 12:928-36. 2010..In summary, our data provide evidence that NETs are not sufficient to kill A. fumigatus, but might be a valuable tool to confine infection... - A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signalingMarkus Woischnik
Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
BMC Cell Biol 11:88. 2010..The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of the SP-C preprotein (proSP-C), however little is known about the cellular consequences of SP-CI73T expression... - Toll-like receptor heterodimer variants protect from childhood asthmaMichael S D Kormann
University Children s Hospital, Ludwig Maximilians Universitat, Munich, Germany
J Allergy Clin Immunol 122:86-92, 92.e1-8. 2008..Toll-like receptors (TLRs) represent a major group of receptors for the specific recognition of pathogen-associated molecular patterns of microbes capable of activating innate and adaptive immunity... - Expression of therapeutic proteins after delivery of chemically modified mRNA in miceMichael S D Kormann
Department of Pediatrics, Ludwig Maximilian s University Munich, Munich, Germany
Nat Biotechnol 29:154-7. 2011.... - Differences of humoral and cellular immune response to an acellular pertussis booster in adolescents with a whole cell or acellular primary vaccinationNikolaus Rieber
University Children s Hospital, Ludwig Maximilians University, Munich, Germany
Vaccine 26:6929-35. 2008..The higher antibody titres to pertussis toxin may indicate a more effective priming of B cell memory after primary whole-cell vaccination... - Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteinsElvira Larque
Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children Hospital, Ludwig Maximilians University of Munich, Munich, Germany
Am J Clin Nutr 84:853-61. 2006..Better understanding of the mechanisms involved in docosahexaenoic acid (DHA) transfer to the neonate may contribute to improve dietary support for infants born prematurely to mothers with placental lipid transport disorders... - Chemokines in allergic aspergillosis--from animal models to human lung diseasesDominik Hartl
Children s Hospital Research Center, Ludwig Maximilians University, Munich, Germany
Inflamm Allergy Drug Targets 5:219-28. 2006..This review illustrates the manifold role of chemokines in animal models of allergic aspergillosis and translates these findings to human lung diseases... - TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammationCarla A Da Silva
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, and
J Immunol 181:4279-86. 2008..These studies demonstrate that chitin is a size-dependent pathogen-associated molecular pattern that activates TLR-2 and MyD88 in a novel IL-17A/IL-17AR-based innate immunity pathway... - Pulmonary chemokines and their receptors differentiate children with asthma and chronic coughDominik Hartl
Children's Hospital of the Ludwig-Maximilians-University of Munich, Lindwurmstrasse 2a, D-80337 Munich, Germany
J Allergy Clin Immunol 115:728-36. 2005..The analysis of these markers could facilitate the diagnostic discrimination of asthma versus other reasons for chronic cough in children... - A donor splice site mutation in intron 1 of CYBA, leading to chronic granulomatous diseaseMartin de Boer
Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
Blood Cells Mol Dis 35:365-9. 2005..This is, as far as we know, the first description of the molecular and clinical consequences of a donor splice site mutation in intron 1 of any gene reported so far... - [Burnout Syndrome--burnout syndrome and the work climate in intensive medicine]Dominik Hartl
Pneumologie 61:756. 2007 - Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory responseSilvia Stojanov
Department of Infectious Diseases and Immunology, Children s Hospital, University of Munich, Germany
Eur Cytokine Netw 17:90-7. 2006.... - Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactantHanna Müller
Division of Neonatology, Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
Respir Res 8:69. 2007..We hypothesized that pulmonary DMBT1 could contribute to respiratory distress syndrome in neonates by modulating surfactant function...