Robin Haring

Summary

Affiliation: University of Greifswald
Country: Germany

Publications

  1. ncbi request reprint Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munchen, Germany
    Hepatology 50:1403-11. 2009
  2. pmc Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, School of Medicine, Boston University, Boston, MA, USA
    Clin Endocrinol (Oxf) 78:629-34. 2013
  3. pmc Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes?
    Lisa Balbach
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Straße, Greifswald, 17475, Germany
    BMC Endocr Disord 13:12. 2013
  4. doi request reprint Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality
    R Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, Greifswald, Germany
    Andrology 1:17-23. 2013
  5. pmc A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
    J Mol Endocrinol 50:73-7. 2013
  6. pmc Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study
    R Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Medicine, Boston, MA, USA
    Int J Androl 35:775-82. 2012
  7. doi request reprint Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Gend Med 9:557-68. 2012
  8. pmc A network-based approach to visualize prevalence and progression of metabolic syndrome components
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    PLoS ONE 7:e39461. 2012
  9. doi request reprint Perspectives for metabolomics in testosterone replacement therapy
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    J Endocrinol 215:3-16. 2012
  10. ncbi request reprint Prospective inverse associations of sex hormone concentrations in men with biomarkers of inflammation and oxidative stress
    Robin Haring
    Institute of Clinical Chemistry, and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Str, Greifswald, Germany
    J Androl 33:944-50. 2012

Detail Information

Publications45

  1. ncbi request reprint Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munchen, Germany
    Hepatology 50:1403-11. 2009
    ..98; 95% CI, 1.21-3.27). Cause-specific mortality analysis by cardiovascular disease deaths confirmed the sex-specific association. Adjustment for cardiometabolic risk factors did not affect the estimates...
  2. pmc Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, School of Medicine, Boston University, Boston, MA, USA
    Clin Endocrinol (Oxf) 78:629-34. 2013
    ..The impact of longitudinal trajectory patterns from serial sex steroid and gonadotrophin measurements on the observed associations is unknown to date...
  3. pmc Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes?
    Lisa Balbach
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Straße, Greifswald, 17475, Germany
    BMC Endocr Disord 13:12. 2013
    ..To investigate potential associations of serum prolactin concentration (PRL) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), previously observed in small and selected study samples, in a large population-based cohort...
  4. doi request reprint Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality
    R Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, Greifswald, Germany
    Andrology 1:17-23. 2013
    ....
  5. pmc A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
    J Mol Endocrinol 50:73-7. 2013
    ..Genetic variants of SULT2A1 do not appear to have an effect on individual DHEA and DHEAS concentrations or the DHEA/DHEAS ratio as a marker of DHEA sulfonation capacity...
  6. pmc Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study
    R Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Medicine, Boston, MA, USA
    Int J Androl 35:775-82. 2012
    ....
  7. doi request reprint Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Gend Med 9:557-68. 2012
    ..Low total testosterone (TT) concentrations in men have been suggested as a novel CVD risk factor, but its contribution to this gender gap is less well studied...
  8. pmc A network-based approach to visualize prevalence and progression of metabolic syndrome components
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    PLoS ONE 7:e39461. 2012
    ..However, it is unclear which cardiovascular risk factors tend to cluster predominately and how individual risk factor states change over time...
  9. doi request reprint Perspectives for metabolomics in testosterone replacement therapy
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    J Endocrinol 215:3-16. 2012
    ..Finally, the scientific opportunities presented by metabolomics and other -omics as novel and promising tools for biomarker discovery and individualised testosterone replacement therapy in men will be explored...
  10. ncbi request reprint Prospective inverse associations of sex hormone concentrations in men with biomarkers of inflammation and oxidative stress
    Robin Haring
    Institute of Clinical Chemistry, and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Str, Greifswald, Germany
    J Androl 33:944-50. 2012
    ..Additional studies are warranted to elucidate potential mechanisms underlying the revealed associations...
  11. ncbi request reprint The androgen receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men
    R Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany
    Int J Androl 35:511-20. 2012
    ..The added clinical value of a combined assessment of CAG repeat length and serum TT concentrations merits further investigation...
  12. pmc Diving through the "-omics": the case for deep phenotyping and systems epidemiology
    Robin Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Medicine, Boston, Massachusetts, USA
    OMICS 16:231-4. 2012
    ..We propose systems epidemiology as a novel approach to study the complexities of human pathophysiology by integrating various population-level omic-metrics and to identify new trans-omic biomarkers...
  13. doi request reprint Sex-specific associations of serum prolactin concentrations with cardiac remodeling: longitudinal results from the Study of Health Pomerania (SHIP)
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Atherosclerosis 221:570-6. 2012
    ..The association between serum PRL and cardiac remodeling in the general population is unknown...
  14. doi request reprint Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Strasse, D 17475 Greifswald, Germany
    J Clin Endocrinol Metab 97:408-15. 2012
    ..Therefore, we aimed to establish age-specific reference ranges for serum sex hormone concentrations in women using mass spectrometry and quantile regression...
  15. pmc Relation between sex hormone concentrations, peripheral arterial disease, and change in ankle-brachial index: findings from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:3724-32. 2011
    ..Our objective was to investigate cross-sectional and longitudinal associations of sex hormone concentrations with ankle-brachial index (ABI) and peripheral arterial disease (PAD)...
  16. pmc Self-perceived quality of life predicts mortality risk better than a multi-biomarker panel, but the combination of both does best
    Robin Haring
    Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Str, Greifswald 17475, Germany
    BMC Med Res Methodol 11:103. 2011
    ..Associations between measures of subjective health and mortality risk have previously been shown. We assessed the impact and comparative predictive performance of a multi-biomarker panel on this association...
  17. doi request reprint Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany
    Am J Nephrol 33:209-17. 2011
    ..Chronic kidney disease (CKD) and low serum total testosterone (TT) concentrations are independent predictors of mortality risk in the general population, but their combined potential for improved mortality risk stratification is unknown...
  18. doi request reprint Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Greifswald, Germany
    Eur J Cardiovasc Prev Rehabil 18:86-96. 2011
    ..Whether these concentrations are prospectively associated with an adverse lipid profile and an increased risk of incident dyslipidemia has not yet been investigated...
  19. ncbi request reprint Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Eur Heart J 31:1494-501. 2010
    ..This study examined whether low serum testosterone levels are a risk factor for all-cause or cause-specific mortality in a population-based sample of men aged 20-79...
  20. ncbi request reprint Total and cardiovascular disease mortality predicted by metabolic syndrome is inferior relative to its components
    R Haring
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Exp Clin Endocrinol Diabetes 118:685-91. 2010
    ..This study examined the predictive role of metabolic syndrome (MetS) and its single components for total and cardiovascular disease (CVD) mortality...
  21. ncbi request reprint Prospective association of low serum total testosterone levels with health care utilization and costs in a population-based cohort of men
    R Haring
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Int J Androl 33:800-9. 2010
    ..Cost-effectiveness studies of available treatments are necessary to identify benefits for physicians, patients and health care system as a whole...
  22. doi request reprint Extended recruitment efforts minimize attrition but not necessarily bias
    Robin Haring
    Institute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    J Clin Epidemiol 62:252-60. 2009
    ..The aims of the present study are (1) to investigate the effectiveness of extensive multimode recruitment procedures; (2) to study their effect on attrition and bias; and (3) to determine the potential predictors of attrition...
  23. ncbi request reprint Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Strasse, Greifswald, Germany
    Aging Male 13:247-57. 2010
    ..Low total testosterone levels (TT) have been associated with increased morbidity and mortality. However, the prevalence and incidence of testosterone deficiency (TD) in association with its risk has not been assessed systematically to date...
  24. pmc Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Diabetes 58:2027-31. 2009
    ..The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men...
  25. doi request reprint Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 94:1732-9. 2009
    ..The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study...
  26. ncbi request reprint Inverse association between total testosterone concentrations, incident hypertension and blood pressure
    Sarah Torkler
    Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany
    Aging Male 14:176-82. 2011
    ..Therefore, this study investigated the prospective association of total testosterone (TT) concentrations with risk of incident hypertension and blood pressure change in 1,484 men aged 20-79 years...
  27. ncbi request reprint Low total testosterone is associated with increased risk of incident type 2 diabetes mellitus in men: results from the Study of Health in Pomerania (SHIP)
    Sabine Schipf
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Aging Male 14:168-75. 2011
    ..The aim of this study was to evaluate the association between total testosterone and incident T2DM in a large population-based cohort...
  28. ncbi request reprint The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany
    Eur J Prev Cardiol 20:1061-8. 2013
    ..The aim of this study was to further evaluate the suggested independent association of sex hormone-binding globulin (SHBG) with incident metabolic syndrome (MetS) in men...
  29. ncbi request reprint Positive association between testosterone, blood pressure, and hypertension in women: longitudinal findings from the Study of Health in Pomerania
    Benedict Ziemens
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D 17489 Greifswald, Germany
    J Hypertens 31:1106-13. 2013
    ..The association between sex hormones and blood pressure (BP) in women has been investigated mostly in cross-sectional studies yielding inconsistent results...
  30. doi request reprint Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Steroids 77:52-8. 2012
    ..The aim of the present study was to investigate the combined influence of low IGF-I and low testosterone on all-cause mortality in men...
  31. ncbi request reprint The association between fatty liver disease and blood pressure in a population-based prospective longitudinal study
    Katharina Lau
    Institute for Community Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    J Hypertens 28:1829-35. 2010
    ..The aim of the present study was to investigate the association of fatty liver disease (FLD) with blood pressure (BP) and hypertension in a general population sample with prospective 5-year follow-up examinations...
  32. ncbi request reprint Association of testosterone levels with endothelial function in men: results from a population-based study
    Klaus Empen
    Medizinische Klinik B, Friedrich Loeffler Strasse 23a, Ernst Moritz Arndt Universitat, D 17475 Greifswald, Germany
    Arterioscler Thromb Vasc Biol 32:481-6. 2012
    ....
  33. doi request reprint Decreased serum TSH levels are not associated with mortality in the adult northeast German population
    Till Ittermann
    Institute for Community Medicine, Ernst Moritz Arndt University, University of Greifswald, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Eur J Endocrinol 162:579-85. 2010
    ..Even meta-analyses revealed contradictory results. We undertook the present study to investigate the association between decreased serum TSH levels and mortality in the large population-based Study of Health in Pomerania (SHIP)...
  34. doi request reprint Missing, unreplaced teeth and risk of all-cause and cardiovascular mortality
    Christian Schwahn
    Department of Prosthetic Dentistry, Gerodontology and Biomaterials, Centre of Oral Health, University of Greifswald, 17487 Greifswald, Rotgerberstraße 8, Germany
    Int J Cardiol 167:1430-7. 2013
    ..A dentition of at least 20 teeth is associated with sufficient masticatory efficiency and is a stated health goal of the World Health Organisation. We examined whether subjects with missing, unreplaced teeth had an increased mortality risk...
  35. pmc Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania
    Till Ittermann
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Strasse 48, Greifswald, Germany
    Thyroid 22:568-74. 2012
    ..Thus, the aim of the present study was to investigate the association between thyroid function tests and sonographic as well as enzymatic criteria of liver status in a large population-based study, the Study of Health in Germany (SHIP)...
  36. doi request reprint The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Clin Endocrinol (Oxf) 75:561-6. 2011
    ....
  37. ncbi request reprint Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality
    Robin Haring
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, Greifswald 17475, Germany
    Eur Heart J 35:1215-21. 2014
    ..Increased serum prolactin (PRL) concentrations have been associated with adverse cardiovascular risk profiles, but the relation between PRL and mortality risk is unknown...
  38. doi request reprint Heart valve sclerosis predicts all-cause and cardiovascular mortality
    Henry Volzke
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    Atherosclerosis 209:606-10. 2010
    ..We further studied whether a combined presence of AVS and MAC is more strongly associated with mortality than the single items and sought to disclose possible gender differences in the investigated associations...
  39. pmc Thyroid function tests in patients taking thyroid medication in Germany: Results from the population-based Study of Health in Pomerania (SHIP)
    Anke Hannemann
    Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Ferdinand Sauerbruch Strasse, 17475 Greifswald, Germany
    BMC Res Notes 3:227. 2010
    ..Using thyroid function tests, we aim to measure the proportions of subjects, who are under- or over-treated with thyroid medication in a previously iodine-deficient area...
  40. ncbi request reprint Does response bias influence population studies of thyroid disorders?
    Henry Volzke
    Institute of Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, Greifswald, Germany
    Thyroid 18:873-8. 2008
    ..We investigated the potential role of selection bias for studies performed to monitor the iodine supply and prevalence of thyroid disorders...
  41. ncbi request reprint Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study
    Henry Volzke
    Institute of Community Medicine, University of Greifswald, D 17487 Greifswald, Germany
    J Clin Endocrinol Metab 92:4039-45. 2007
    ..The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations...
  42. doi request reprint Association between serum testosterone and sex hormone-binding globulin and exercise capacity in men: results of the Study of Health in Pomerania (SHIP)
    Beate Koch
    Medical Faculty of Ernst Moritz Arndt University, Department of Internal Medicine B, Cardiology, Pneumology, Infectious Diseases, and Intensive Care, University Hospital Ferdinand Sauerbruchstrasse, D 17475 Greifswald, Germany
    J Androl 32:135-43. 2011
    ..After adjustment for relevant influencing factors, neither total serum testosterone nor SHBG levels had any interference with peak exercise capacity, aerobic exercise capacity, or maximal power output in men...
  43. pmc Cohort profile: Greifswald approach to individualized medicine (GANI_MED)
    Hans J Grabe
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Ellernholzstraße 1 2, Greifswald 17475, Germany
    J Transl Med 12:144. 2014
    ..Herein, we describe the implementation of the scientific and clinical infrastructure that allows future translation of findings relevant to Individualized Medicine into clinical practice...
  44. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  45. pmc A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation
    Andrea D Coviello
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002805. 2012
    ..The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance...