P D Hardt

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Second Giessen International Workshop on Interactions of Exocrine and Endocrine Pancreatic Diseases. Castle of Rauischholzhausen of the Justus-Liebig-university, Giessen (Rauischholzhausen), Germany. March 7-8, 2008
    Ake Andren-Sandberg
    Department of Surgery, Karolinska University Hospital, Huddige, Sweden
    JOP 9:541-75. 2008
  2. ncbi request reprint Liquid pancreatic enzyme therapy for a patient with short bowel syndrome and chronic pancreatitis in a complicated case of Crohn's disease
    P D Hardt
    Third Medical Department, University of Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Eur J Med Res 4:345-6. 1999
  3. doi request reprint Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?
    Philip D Hardt
    Third Medical Department and Policlinic, University Hospital Giessen and Marburg, Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Diabetes Care 31:S165-9. 2008
  4. doi request reprint Exocrine pancreatic involvement in critically ill patients
    Philip D Hardt
    University Hospital Giessen and Marburg, Giessen Site, Third Medical Department, Giessen, Germany
    Curr Opin Clin Nutr Metab Care 12:168-74. 2009
  5. ncbi request reprint The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency
    P D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Z Gastroenterol 41:903-6. 2003
  6. ncbi request reprint Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening
    P D Hardt
    Third Medical Department, Giessen University Hospital, Rodthohl 6, D 35385 Giessen, Germany
    Anticancer Res 23:855-7. 2003
  7. ncbi request reprint Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls
    P D Hardt
    Third Medical Department, Giessen University Hospital, Rodthohl 6, D 35385 Giessen, Germany
    Anticancer Res 23:851-3. 2003
  8. pmc Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes?
    Philip D Hardt
    Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Klinikstra├če 33, 35392 Giessen, Germany
    Exp Diabetes Res 2011:761950. 2011
  9. ncbi request reprint Fecal elastase 1 measurement compared with endoscopic retrograde cholangiopancreatography for the diagnosis of chronic pancreatitis
    Philip D Hardt
    Third Medical Department, Justus Liebig University Giessen, Giessen, Germany
    Pancreas 25:e6-9. 2002
  10. ncbi request reprint Chronic pancreatitis and diabetes mellitus. A retrospective analysis of 156 ERCP investigations in patients with insulin-dependent and non-insulin-dependent diabetes mellitus
    Philip D Hardt
    Third Medical Department, Justus Liebig University Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Pancreatology 2:30-3. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Second Giessen International Workshop on Interactions of Exocrine and Endocrine Pancreatic Diseases. Castle of Rauischholzhausen of the Justus-Liebig-university, Giessen (Rauischholzhausen), Germany. March 7-8, 2008
    Ake Andren-Sandberg
    Department of Surgery, Karolinska University Hospital, Huddige, Sweden
    JOP 9:541-75. 2008
    ..The meeting resulted in several new projects that will be started by the participants in the near future...
  2. ncbi request reprint Liquid pancreatic enzyme therapy for a patient with short bowel syndrome and chronic pancreatitis in a complicated case of Crohn's disease
    P D Hardt
    Third Medical Department, University of Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Eur J Med Res 4:345-6. 1999
    ..In combination with this enzyme preparation, enteral nutrition could successfully be started again...
  3. doi request reprint Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?
    Philip D Hardt
    Third Medical Department and Policlinic, University Hospital Giessen and Marburg, Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Diabetes Care 31:S165-9. 2008
    ..Algorithms for diagnosis and therapy of diabetes should therefore address both endocrine and exocrine pancreatic function...
  4. doi request reprint Exocrine pancreatic involvement in critically ill patients
    Philip D Hardt
    University Hospital Giessen and Marburg, Giessen Site, Third Medical Department, Giessen, Germany
    Curr Opin Clin Nutr Metab Care 12:168-74. 2009
    ..To learn about the prevalence, pathophysiology, and treatment of exocrine pancreatic involvement in critically ill patients...
  5. ncbi request reprint The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency
    P D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Z Gastroenterol 41:903-6. 2003
    ..ELISA 2 should be renamed, since obviously it does react with an antigen (antigens) different from elastase 1...
  6. ncbi request reprint Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening
    P D Hardt
    Third Medical Department, Giessen University Hospital, Rodthohl 6, D 35385 Giessen, Germany
    Anticancer Res 23:855-7. 2003
    ..In this study an ELISA based on a different combination of antibodies was used to investigate stool samples of GI cancer patients...
  7. ncbi request reprint Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls
    P D Hardt
    Third Medical Department, Giessen University Hospital, Rodthohl 6, D 35385 Giessen, Germany
    Anticancer Res 23:851-3. 2003
    ..Since most GI tumors grow intraluminally, it appeared interesting to determine whether Tumor M2-PK is detectable in the feces of tumor patients...
  8. pmc Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes?
    Philip D Hardt
    Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Klinikstra├če 33, 35392 Giessen, Germany
    Exp Diabetes Res 2011:761950. 2011
    ..This paper discusses the currently available studies on this subject and tries to provide an overview of the current concepts of exocrine pancreatic insufficiency in diabetes mellitus...
  9. ncbi request reprint Fecal elastase 1 measurement compared with endoscopic retrograde cholangiopancreatography for the diagnosis of chronic pancreatitis
    Philip D Hardt
    Third Medical Department, Justus Liebig University Giessen, Giessen, Germany
    Pancreas 25:e6-9. 2002
    ..Direct tests, which are claimed to be the "gold standard" of functional diagnosis, are too complicated to be performed on great numbers of patients and are not standardized...
  10. ncbi request reprint Chronic pancreatitis and diabetes mellitus. A retrospective analysis of 156 ERCP investigations in patients with insulin-dependent and non-insulin-dependent diabetes mellitus
    Philip D Hardt
    Third Medical Department, Justus Liebig University Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Pancreatology 2:30-3. 2002
    ..Most authors tried to explain this finding as a diabetic complication. On the other hand, diabetes secondary to chronic pancreatitis (CP) might be more common than believed so far...
  11. ncbi request reprint Octreotide in the prevention of pancreatic damage induced by endoscopic sphincterotomy
    P D Hardt
    Med Klinik III und Poliklinik der JLU Giessen, Rodthohl 6, D 35385 Giessen, Germany
    Eur J Med Res 5:165-70. 2000
    ..According to these data, prophylactic octreotide application does not prevent acute pancreatic damage induced by endoscopic sphincterotomy...
  12. pmc Determinants of Exocrine Pancreatic Function as Measured by Fecal Elastase-1 Concentrations (FEC) in Patients with Diabetes mellitus
    Nils Ewald
    University Hospital of Giessen and Marburg, Giessen Site, Third Medical Department and Policlinic, Rodthohl 6, 35392 Giessen, Germany
    Eur J Med Res 14:118-22. 2009
    ..The present study was performed to further analyse the determinants of exocrine pancreatic function in patients with diabetes mellitus...
  13. ncbi request reprint Pathological pancreatic exocrine function and duct morphology in patients with cholelithiasis
    P D Hardt
    Third Medical Department, Justus-Liebig-University, Giessen, Germany
    Dig Dis Sci 46:536-9. 2001
    ..In conclusion, according to these data a pathophysiological connection between gallstones and chronic pancreatitis appears to be probable...
  14. doi request reprint Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c)
    N Ewald
    Third Medical Department and Policlinic, University Hospital Giessen and Marburg, Giessen Site, Klinikstrasse 33, Giessen, Germany
    Diabetes Metab Res Rev 28:338-42. 2012
    ..Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus due to pancreatic diseases...
  15. ncbi request reprint [Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]
    N Ewald
    Third Medical Department, University Hospital Giessen, Germany
    Z Gastroenterol 43:1313-7. 2005
    ..Therefore, evaluation of additional screening tools seems to be of great interest. Recently testing for fecal occult blood (FOBT), genetic alterations or alterations in tumor metabolism (e.g., tumor M2-PK) are under investigation...
  16. pmc Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer
    P D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Justus Liebig University of Giessen, Rodthohl 6, Giessen 35392, Germany
    Br J Cancer 91:980-4. 2004
    ..TNM and Dukes' classification of the tumours revealed a strong correlation between faecal Tumour M2-PK levels and staging. The determination of Tumour M2-PK in faeces provides a new promising screening tool for colorectal tumours...
  17. ncbi request reprint Influence of cholesterol and fat in food on indirect parameters of exocrine pancreatic function
    J Heller
    Institute of Nutrition Science, Justus Liebig University, Giessen, Germany
    Pancreatology 6:220-3. 2006
    ..The clinical parameters of fecal elastase 1 and chymotrypsin activity in stool do not seem to be significantly influenced by fat and cholesterol deriving from food...
  18. ncbi request reprint Prospective evaluation of novel system for jejunal feeding
    A Hauenschild
    Department for Internal Medicine, University Hospital Giessen, Rodthohl 6, 35392 Giessen, Germany
    Surg Endosc 17:452-6. 2003
    ..Placement of nasojejunal tubes with available techniques is unreliable...
  19. ncbi request reprint Giessen international workshop on interactions of exocrine and endocrine pancreatic diseases. Castle of Rauischholzhausen of the Justus-Liebig-University, Giessen, Germany. March 18-19, 2005
    Ake Andren-Sandberg
    Department of Gastrointestinal Surgery, Sntralsjukehuset i Rogaland, Bergen University, Stavanger, Norway
    JOP 6:382-405. 2005
    ..The meeting resulted in more cooperation and a number of new concepts for clinical study which will provide data for future developments...
  20. ncbi request reprint High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients
    Philip D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Pancreatology 3:395-402. 2003
    ..In this study we had the opportunity to study more than 1,000 diabetic patients to confirm recent observations in smaller populations...
  21. ncbi request reprint High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study
    Philip D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Dig Dis Sci 48:1688-92. 2003
    ..The fat excretion did not correlate with diabetes type, duration, or clinical symptoms. This finding is of some clinical importance and might influence pathophysiological concepts and the management of diabetic patients...
  22. ncbi request reprint Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer
    Nils Ewald
    Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Germany
    Anticancer Res 27:1949-52. 2007
    ..Colonoscopy is purportedly the best screening tool for CRC. However, the acceptance by the general population is very poor. Therefore evaluation of additional screening tools is of great interest...
  23. ncbi request reprint Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
    ..This investigation was designed to evaluate the impact of enzyme-replacement therapy on glucose metabolism and diabetes treatment in a prospective study of insulin-treated patients with diabetes mellitus...
  24. ncbi request reprint Pancreas divisum--an underestimated cause of chronic pancreatitis and relapsing episodes of acute pancreatitis?
    Nils Ewald
    Third Medical Department, Justus Liebig University Giessen, Rodthohl 6, D 35385, Giessen, Germany
    Dig Dis Sci 50:1857-9. 2005
  25. ncbi request reprint Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  26. ncbi request reprint Effects of oral fat load on insulin output and glucose tolerance in healthy control subjects and obese patients without diabetes
    Oliver Wuesten
    Third Medical Department and Policlinic, Rodthohl 6, D 35392 Giessen, Germany
    Diabetes Care 28:360-5. 2005
    ....