Jochen Hampe

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Jochen Hampe
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:207-11. 2007
  2. pmc Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors
    Alexander Herrmann
    Institute of Internal Medicine I, Christian Albrechts University, Kiel, Germany
    PLoS ONE 6:e21332. 2011
  3. pmc Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
    BMC Med Genet 13:31. 2012
  4. pmc Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis
    Christian Jürgensen
    Department of Gastroenterology, Charité University Campus Mitte, Berlin, Germany
    BMC Gastroenterol 12:48. 2012
  5. pmc Comprehensive assessment of sequence variation within the copy number variable defensin cluster on 8p23 by target enriched in-depth 454 sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 12:243. 2011
  6. pmc Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 11:252. 2010
  7. pmc TassDB2 - A comprehensive database of subtle alternative splicing events
    Rileen Sinha
    Albert Ludwigs University Freiburg, Germany
    BMC Bioinformatics 11:216. 2010
  8. ncbi request reprint Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations
    Valentina Medici
    Department of General and Internal Medicine, Institute for Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstrasse 12, Kiel 24105, Germany
    Eur J Hum Genet 14:459-68. 2006
  9. doi request reprint Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Gastroenterology 135:1207-15. 2008
  10. ncbi request reprint Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
    Peter J P Croucher
    1st Department of Medicine, Christian Albrechts University, Kiel, Germany
    Eur J Hum Genet 11:6-16. 2003

Detail Information

Publications71

  1. ncbi request reprint A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Jochen Hampe
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:207-11. 2007
    ..039). Together with the lack of association between rs2241880 and ulcerative colitis (P > 0.4), these data suggest that the underlying biological process may be specific to Crohn disease...
  2. pmc Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors
    Alexander Herrmann
    Institute of Internal Medicine I, Christian Albrechts University, Kiel, Germany
    PLoS ONE 6:e21332. 2011
    ....
  3. pmc Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
    BMC Med Genet 13:31. 2012
    ..Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis...
  4. pmc Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis
    Christian Jürgensen
    Department of Gastroenterology, Charité University Campus Mitte, Berlin, Germany
    BMC Gastroenterol 12:48. 2012
    ..The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis...
  5. pmc Comprehensive assessment of sequence variation within the copy number variable defensin cluster on 8p23 by target enriched in-depth 454 sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 12:243. 2011
    ..g. by the 1000 Genomes Project is confined by an affordable sequence depth. Combining target enrichment with NGS may represent a feasible approach...
  6. pmc Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing
    Stefan Taudien
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    BMC Genomics 11:252. 2010
    ..Here, we demonstrate that amplicon sequencing of pooled individual PCR products by the 454 technology allows in-depth determination of MSV haplotypes and estimation of DEFB CNs in parallel...
  7. pmc TassDB2 - A comprehensive database of subtle alternative splicing events
    Rileen Sinha
    Albert Ludwigs University Freiburg, Germany
    BMC Bioinformatics 11:216. 2010
    ..Towards this goal we recently set up TassDB (Tandem Splice Site DataBase, version 1), which stores data about alternative splicing events at tandem splice sites separated by 3 nt in eight species...
  8. ncbi request reprint Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations
    Valentina Medici
    Department of General and Internal Medicine, Institute for Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstrasse 12, Kiel 24105, Germany
    Eur J Hum Genet 14:459-68. 2006
    ..035). The present results are consistent with an emerging pattern of a low frequency of the CARD15 variants in Northern countries where the prevalence of IBD is greatest...
  9. doi request reprint Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Gastroenterology 135:1207-15. 2008
    ..Crohn's disease (CD) and sarcoidosis (SA) are chronic inflammatory barrier diseases that share several clinical and immunological features, including the occurrence of granulomas...
  10. ncbi request reprint Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
    Peter J P Croucher
    1st Department of Medicine, Christian Albrechts University, Kiel, Germany
    Eur J Hum Genet 11:6-16. 2003
    ..This approach, in conjunction with the examination of the mutational steps in a haplotype network, allows unambiguous identification of the potentially causative mutations...
  11. ncbi request reprint Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection
    Philip Rosenstiel
    Institut für Klinische Molekularbiologie, Christian Albrechts Universitat, Kiel, Germany
    Cell Microbiol 8:1188-98. 2006
    ..6; P < 0.044]. H. pylori-induced upregulation of NOD1 and NOD2 in vivo may play a critical role in the recognition of this common pathogen. A missense mutation in the leucine-rich region of CARD15 is associated with gastric lymphoma...
  12. pmc Systematic association mapping identifies NELL1 as a novel IBD disease gene
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 2:e691. 2007
    ..Several associations were replicated in at least one independent sample, point to an involvement of ITGB6 (upstream), GRM8 (downstream), OR5V1 (downstream), PPP3R2 (downstream), NM_152575 (upstream) and HNF4G (intron)...
  13. doi request reprint Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus
    Oliver von Kampen
    Department of Internal Medicine I, Hospital Schleswig Holstein, Kiel, Germany
    Hepatology 57:2407-17. 2013
    ..hepatology 2012)...
  14. doi request reprint Systematic evaluation of the effect of common SNPs on pre-mRNA splicing
    Abdou ElSharawy
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Kiel, Germany
    Hum Mutat 30:625-32. 2009
    ..The results highlight the need for a better understanding of the sequence characteristics of functional splice-sites to improve our ability to predict in silico the splicing relevance of empirically observed DNA sequence variants...
  15. doi request reprint Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease
    Rainer Noth
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Crohns Colitis 6:464-9. 2012
    ..The aim of the present study was to investigate the influence of anti-TNF-α antibody (infliximab) treatment on the intestinal barrier function of patients with active Crohn's disease...
  16. pmc Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
    Christine M Costello
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, Christian Albrechts University of Kiel, Kiel, Germany
    PLoS Med 2:e199. 2005
    ..cDNA microarrays can be used to decipher gene regulation events at a genome-wide level and to identify novel unknown genes that might be involved in perpetuating inflammatory disease progression...
  17. ncbi request reprint Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease
    Clemens Schafmayer
    Department of General Surgery and Thoracic Surgery, Christian Albrechts University Kiel, Kiel, Germany
    Liver Int 27:910-9. 2007
    ..Two attractive positional and functional candidate genes in apolipoprotein B mRNA-editing protein (APOBEC1) and peroxisome proliferator-activated receptor gamma (PPARG) are located in this interval...
  18. ncbi request reprint GENOMIZER: an integrated analysis system for genome-wide association data
    Andre Franke
    Institute of Clinical Molecular Biology, Kiel Center of the German National Genotyping Platform, Christian Albrechts University, Kiel, Germany
    Hum Mutat 27:583-8. 2006
    ..We suggest that the use of this software will facilitate the handling and interpretation of the currently emerging genome-wide association data...
  19. pmc A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology
    Katherine L Helbig
    Institute for Experimental Medicine, Section of Epidemiology, Christian Albrechts University of Kiel, Arnold Heller Strasse 3, Haus 3, 24105 Kiel, Germany
    BMC Med Genet 13:14. 2012
    ..However, little is known about a potential interaction between these risk factors. We investigated gene-environment interactions between CD-associated NOD2 alleles and cigarette smoking in a large sample of patients with CD...
  20. ncbi request reprint Genetic variation in DLG5 is associated with inflammatory bowel disease
    Monika Stoll
    First Department of Medicine, University Hospital Schleswig Holstein, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Genet 36:476-80. 2004
    ..This is suggestive of a complex pattern of gene-gene interaction between DLG5 and CARD15, reflecting the complex nature of polygenic diseases. Further functional studies will evaluate the biological significance of DLG5 variants...
  21. ncbi request reprint SNPSplicer: systematic analysis of SNP-dependent splicing in genotyped cDNAs
    Abdou ElSharawy
    Institute of Clinical Molecular Biology at the Christian Albrechts University, Kiel, Germany
    Hum Mutat 27:1129-34. 2006
    ..We anticipate that this methodology may help in the functional annotation of SNPs in a more high-throughput fashion...
  22. pmc Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression
    Philip Rosenstiel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    BMC Genomics 8:472. 2007
    ..Tissue specific constitutive and inducible expression patterns of NOD2 have been described that result from complex regulatory events for which the molecular mechanisms are not yet fully understood...
  23. pmc Polymorphisms in the 3'-untranslated region of the CDH1 gene are a risk factor for primary gastric diffuse large B-cell lymphoma
    Gunnar Jacobs
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Haematologica 96:987-95. 2011
    ..We investigated whether germline variants in the CDH1 gene, coding for E-cadherin, genetically predispose patients to primary gastric B-cell lymphoma...
  24. pmc Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer
    Nikolaus Möckelmann
    Department of General Internal Medicine Christian Albrechts University, Kiel, Germany
    BMC Gastroenterol 9:79. 2009
    ....
  25. doi request reprint Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype
    Witigo von Schönfels
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Christian Albrechts University, Arnold Heller Str 6, 24105, Kiel, Germany
    J Gastroenterol 48:391-6. 2013
    ..As yet, variant ABCG8-D19H is the most widely recognized genetic risk factor for gallstone disease. The aim of the study is to investigate whether ABCG8-D19H is associated with gallstone recurrence after cholecystectomy...
  26. ncbi request reprint Patterns of linkage disequilibrium in the MHC region on human chromosome 6p
    Annette Stenzel
    Abteilung für Allgemeine Innere Medizin, Universitatsklinikum Schleswig Holstein, Christian Albrechts Universitat Kiel, 24105 Kiel, Germany
    Hum Genet 114:377-85. 2004
    ..The existence of large regions without any clear block structure renders the systematic and thorough construction of SNP haplotype maps a crucial prerequisite for disease-association studies...
  27. ncbi request reprint Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study
    Jochen Hampe
    Department of General Internal Medicine, Christian Albrechts University, Kiel, Germany
    Lancet 359:1661-5. 2002
    ..Crohn's disease is a heterogeneous disorder for which NOD2 (CARD 15) has been identified as a susceptibility gene. We investigate the relation between NOD2 genotype and phenotypic characteristics of patients with Crohn's disease...
  28. ncbi request reprint Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials
    Silvia Mascheretti
    Christian Albrechts University, Kiel, Germany
    Pharmacogenetics 12:509-15. 2002
    ..The subsequent negative findings in a two-cohort model exclude SNPs 8, 12 and 13 of the CARD15 gene as predictors for therapeutic response to infliximab treatment...
  29. doi request reprint Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample
    Clemens Schafmayer
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Int J Cancer 124:75-80. 2009
    ..71). Our study confirms the role of genetic variation at 8q24.21 as a risk factor for CRC and localizes the corresponding susceptibility gene to a 17 kb candidate region...
  30. ncbi request reprint Higher fetuin-A level is associated with coexistence of elevated alanine aminotransferase and the metabolic syndrome in the general population
    Manja Koch
    1 Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany
    Metab Syndr Relat Disord 11:377-84. 2013
    ..Thus, aim of the study was to investigate the association between fetuin-A level and the coexistence of elevated ALT levels and metabolic syndrome (ALT-MetS)...
  31. pmc A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways
    Philip Rosenstiel
    Institute of Clinical Molecular Biology, University Hospital Schleswig Holstein, Kiel, Germany
    Proc Natl Acad Sci U S A 103:3280-5. 2006
    ..These data unveil another level of complexicity in the regulation of intracellular innate immunity and may have important implications for the molecular understanding of NOD/NALP protein-driven disease pathophysiology...
  32. doi request reprint Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition
    Stephan Buch
    Department of Internal Medicine I, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 139:1942-1951.e2. 2010
    ..Bilirubin is a major component of gallstones so we investigated whether these variants predict gallstone bilirubin content and overall risk for gallstones...
  33. ncbi request reprint CARD15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of association
    Stefan Jenisch
    Department of Immunology, University of Kiel, Michaelisstr 5, 24105, Kiel, Germany
    Arch Dermatol Res 297:409-11. 2006
    ..All other variants including leu1007fsinsC and R702W did not show any association with psoriasis or PsA. In conclusion, a disease-causing role for CARD15 mutations could not be confirmed in German or American subjects with PsA...
  34. ncbi request reprint A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
    Stephan Buch
    First Department of Medicine, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:995-9. 2007
    ..6, P = 1.4 x 10(-14)) in the full German sample. Association was stronger in subjects with cholesterol gallstones (odds ratio = 3.3), suggesting that His19 might be associated with a more efficient transport of cholesterol into the bile...
  35. ncbi request reprint Single base-pair substitutions in exon-intron junctions of human genes: nature, distribution, and consequences for mRNA splicing
    Michael Krawczak
    Institut für Medizinische Informatik und Statistik, Christian Albrechts Universitat, Kiel, Germany
    Hum Mutat 28:150-8. 2007
    ..6% of disease-causing missense substitutions in human genes are likely to affect the mRNA splicing phenotype. Taken together, our results are consistent with correct donor splice-site recognition being a key step in exon recognition...
  36. ncbi request reprint Sarcoidosis is associated with a truncating splice site mutation in BTNL2
    Ruta Valentonyte
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Genet 37:357-64. 2005
    ..The resulting protein lacks the C-terminal IgC domain and transmembrane helix, thereby disrupting the membrane localization of the protein, as shown in experiments using green fluorescent protein and V5 fusion proteins...
  37. ncbi request reprint SGCaller: a program to call and review genotypes measured by sequencing
    Carl Manaster
    Christian Albrechts University Kiel, Kiel, Germany
    Biotechniques 38:544, 546. 2005
  38. doi request reprint Genome-wide investigation of gene-environment interactions in colorectal cancer
    Sabine Siegert
    Section of Epidemiology, Institute of Experimental Medicine, Christian Albrechts University Kiel, Kiel, Germany
    Hum Genet 132:219-31. 2013
    ..008). Notably, none of the interactions identified in our genome-wide analysis was with a previously reported CRC-associated SNP. Our study therefore highlights the potential of an "agnostic" genome-wide approach to G × E analysis...
  39. doi request reprint Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma
    Ole Ammerpohl
    Institute of Human Genetics, University Hospital Schleswig Holstein, Campus Kiel, Christian Albrechts University, Kiel, Germany
    Int J Cancer 130:1319-28. 2012
    ..0001). Cirrhosis and HCC show distinct patterns of differential methylation with regards to promoter structure, PRC2 targets and CpG islands...
  40. doi request reprint Technology-specific error signatures in the 1000 Genomes Project data
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Brunswiker Str 10, 24105 Kiel, Germany
    Hum Genet 130:505-16. 2011
    ..Our study thus highlights that different NGS platforms suit different practical applications differently well, and that NGS-based studies require stringent data quality control for their results to be valid...
  41. doi request reprint Statistical inference of allelic imbalance from transcriptome data
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany
    Hum Mutat 32:98-106. 2011
    ..Because the proposed framework can be used to assess somatic mutations and allelic imbalance in one and the same set of RNA-seq data, it will be particularly useful for the analysis of somatic genetic variation in cancer studies...
  42. pmc Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting
    Claudia Fritsch
    Department of Internal Medicine I, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Genome Res 22:2208-18. 2012
    ..The transcriptome-wide map of novel candidate TISs derived as part of the study will shed further light on the way in which human proteome diversity is influenced by alternative translation initiation and regulation...
  43. ncbi request reprint InSNP: a tool for automated detection and visualization of SNPs and InDels
    Carl Manaster
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Hum Mutat 26:11-9. 2005
    ..The Windows installer (setup) program and sample datasets are available at www.mucosa.de/insnp/...
  44. doi request reprint Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft-vs.-host disease model
    Rainer Noth
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Am J Physiol Gastrointest Liver Physiol 304:G646-54. 2013
    ..In conclusion, oral glutamine seems to have beneficial effects on the severity of inflammatory changes in the course of GvHD and might be a therapeutic option...
  45. doi request reprint Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity
    Sarah von Spiczak
    Department of Neuropediatrics, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Building 9, Kiel, Germany
    Neuromolecular Med 12:292-9. 2010
    ..Our results showed a trend toward association of TRPC4 variants and PPR/IGE. Further studies including larger samples of photosensitive probands are required to clarify the relevance of TRPC4 for PPR and IGE...
  46. ncbi request reprint Functional TLR5 genetic variants affect human colorectal cancer survival
    Sascha N Klimosch
    Authors Affiliations Department of Immunology, Interfaculty Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle Department of Pediatrics I Institute for Medical Microbiology and Hygiene, University Hospital Tubingen, Tubingen, Germany Division of Molecular Genetic Epidemiology Junior Research Group Toll Like Receptors and Cancer, German Cancer Research Center DKFZ, Heidelberg, Germany Department of General and Thoracic Surgery, University Hospital Schleswig Holstein Department of General Internal Medicine POPGEN Biobank Project, Christian Albrechts University, Kiel, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmo, Sweden
    Cancer Res 73:7232-42. 2013
    ..Our results establish an important link between TLR signaling and human colorectal cancer with relevance for biomarker and therapy development...
  47. ncbi request reprint Investigation of HLA-DPA1 genotypes as predictors of inflammatory bowel disease in the German, South African, and South Korean populations
    Annette Lantermann
    Department of General Internal Medicine, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Int J Colorectal Dis 17:238-44. 2002
    ..The HLA-DP genes play an important role in antigen presentation and are located within the chromosome 6p linkage region...
  48. ncbi request reprint Association study of a functional Toll-like receptor 4 polymorphism with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma
    Stephan Hellmig
    Klinik für Allgemeine Innere Medizin, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Leuk Lymphoma 46:869-72. 2005
    ..Further studies in larger samples are needed to confirm our findings and fully elucidate the role of TLR4 and its genetic variants in the pathophysiology of H. pylori infection and gastric lymphoma...
  49. pmc Metabolic signature of electrosurgical liver dissection
    Witigo von Schönfels
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 8:e72022. 2013
    ..Its molecular signature, i.e. the metabolites evolving from electrocauterization which may inhibit hepatic wound healing, have not been systematically studied...
  50. ncbi request reprint Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer
    Stephan Hellmig
    Department of General Internal Medicine, University Clinics of Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Immunol Lett 100:107-12. 2005
    ..pylori infection. Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease...
  51. pmc Diagnosing fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers
    Sabine Siegert
    Cologne Center for Genomics, University of Cologne, Cologne, Germany Institute of Experimental Medicine, Section of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany
    PLoS ONE 8:e76813. 2013
    ..To date, liver biopsy is the only means of reliable diagnosis for fatty liver disease (FLD). Owing to the inevitable biopsy-associated health risks, however, the development of valid noninvasive diagnostic tools for FLD is well warranted...
  52. ncbi request reprint The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population
    Inka Lindner
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
    Mol Nutr Food Res 50:270-4. 2006
    ..Additionally, the higher triglyceride and glucose levels after an oMTT support a possible functional impact of the polymorphism in vivo...
  53. ncbi request reprint Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer
    Clemens Schafmayer
    Department of General and Thoracic Surgery, Christian Albrechts University, Kiel, Germany
    Int J Cancer 121:555-8. 2007
    ..It remains to be elucidated by more systematic, large-scale experiments whether common variants in the same genes, but present across populations, represent risk factors for sporadic CRC...
  54. ncbi request reprint Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gallstone disease
    Clemens Schafmayer
    Department of General and Thoracic Surgery, Christian Albrechts University, Kiel, and Department of Internal Medicine I, University Hospital Bonn, Germany
    Hepatology 44:650-7. 2006
    ..The gallstone trait is not allelic to progressive familial cholestasis at the ABCB11 locus. Systematic fine mapping of the Lith1 region is required to identify the causative genetic variants for gallstone in mice and humans...
  55. pmc Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model
    Rainer Noth
    Department of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    BMC Gastroenterol 11:109. 2011
    ..Because surveillance and biopsies of human gastrointestinal GvHD are difficult to perform, rare information of the alterations of the gastrointestinal barrier exists resulting in a need for systematic animal models...
  56. ncbi request reprint Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
    Friederike Flachsbart
    Institute for Clinical Molecular Biology, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Exp Gerontol 41:98-102. 2006
    ..However, this does not rule out the possibility that allelic variants in direct regulators or downstream substrates of SIRT1 could play critical roles in extending lifespan in humans...
  57. doi request reprint Endoscopic endoluminal vacuum therapy in esophageal perforation
    Nils Heits
    Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Ann Thorac Surg 97:1029-35. 2014
    ..Endoscopic vacuum therapy (EVT) is a new endoscopic treatment option, which is used to treat anastomotic leakages after rectal and esophageal resections. We report on 10 patients treated with EVT for esophageal perforation...
  58. doi request reprint Lifestyle factors and health-related quality of life in colorectal cancer survivors
    Sabrina Schlesinger
    Institute of Epidemiology, Christian Albrechts University of Kiel, Campus Kiel, UKSH, Arnold Heller Str 3, Haus 1, 24105, Kiel, Germany
    Cancer Causes Control 25:99-110. 2014
    ..This study investigates the association between a postdiagnosis lifestyle score and health-related quality of life (HrQol) in long-term colorectal cancer (CRC) survivors...
  59. pmc Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
    Clemens Schafmayer
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BMC Gastroenterol 6:36. 2006
    ..This study aimed to define patterns of gallstone composition and identify demographic predictors of gallstone composition in a large sample of symptomatic gallstones from Northern Germany...
  60. doi request reprint Terminal part of thoracic duct: high-resolution US imaging
    Marcus Seeger
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Radiology 252:897-904. 2009
    ....
  61. ncbi request reprint Mutation detection and physical mapping of the CD11 gene cluster in association with inflammatory bowel disease
    Henning Frenzel
    Department of Internal Medicine I, University Hospital, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Immunogenetics 53:835-42. 2002
    ..It is unlikely that the CD11 genes play an important role in the pathogenesis of IBD. The marginally significant results could indicate a disease gene in the vicinity of the gene cluster...
  62. ncbi request reprint Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure
    Jochen Hampe
    First Department of Medicine, Christian Albrecht University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Int J Colorectal Dis 18:413-7. 2003
    ..It is presently unclear how environmental factors either trigger or modify the risk for and course of IBD in the presence of genetic susceptibility...
  63. doi request reprint Chronic portal vein thrombosis: transcapsular hepatic collateral vessels and communicating ectopic varices
    Marcus Seeger
    Department of Internal Medicine I, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Radiology 257:568-78. 2010
    ..To assess patients with chronic portal vein thrombosis (PVT) with respect to transcapsular collateral veins, the communication between these veins and ectopic varices, and the cause of PVT...
  64. doi request reprint Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis
    Hiltrud Muhle
    Department of Neuropediatrics, University Hospital of Kiel, Schwanenweg 20, 24105 Kiel, Germany
    Epilepsy Res 89:319-26. 2010
    ..3 where tentative susceptibility loci for Juvenile Myoclonic Epilepsy (JME) and Photoparoxysmal Response (PPR) have been mapped. The present candidate gene study examined if variation in GRM4 confers susceptibility to IGE...
  65. ncbi request reprint Genetics of Crohn disease, an archetypal inflammatory barrier disease
    Stefan Schreiber
    Institute for Clinical Molecular Biology, Center for Conservative Medicine, Christian Albrechts University Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Rev Genet 6:376-88. 2005
    ..These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient...
  66. ncbi request reprint Nonelectrophoretic method for high-throughput HLA-DRB1 group genotyping
    Jochen Hampe
    Christian Albrechts University Kiel, Germany
    Biotechniques 36:148-51. 2004
  67. ncbi request reprint Life-threatening chronic enteritis due to colonization of the small bowel with Stenotrophomonas maltophilia
    Stephan Hellmig
    Department of General Internal Medicine, Christian Albrechts University, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 129:706-12. 2005
    ..Future enhancements in detection techniques will show that chronic bacterial infections are more frequent as a cause of gastrointestinal malfunction than commonly thought...
  68. ncbi request reprint In vitro alterations of intestinal bacterial microbiota in fecal samples during storage
    Stephan J Ott
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Diagn Microbiol Infect Dis 50:237-45. 2004
    ..The observed alterations of fecal flora during storage point to the difficulty of the molecular analysis of the bacterial diversity and the enumeration of bacterial cells in fecal samples...
  69. ncbi request reprint Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease
    Stephan J Ott
    Institute for Clinical Molecular Biology, Department of General Internal Medicine, UKSH Campus Kiel, Kiel, Germany
    Circulation 113:929-37. 2006
    ..This study analyzes molecular phylogenies to systematically explore the presence, frequency, and diversity of bacteria in atherosclerotic lesions in patients with CHD...
  70. ncbi request reprint Entropy-based SNP selection for genetic association studies
    Jochen Hampe
    Klinik für Allgemeine Innere Medizin, Christian Albrechts Universitat Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Hum Genet 114:36-43. 2003
    ..Adoption of the method in practice is estimated to save up to 30% of genotyping load when compared with equidistant SNP localization or pair-wise LD minimization alone...
  71. pmc Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora
    Stephan J Ott
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    J Clin Microbiol 42:2566-72. 2004
    ..No significant cross-reaction was observed. The real-time PCR assays presented may facilitate understanding of the intestinal bacterial flora through a normalized global estimation of the major contributing species...