Rainer Hambrecht

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
  2. ncbi request reprint Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
    Rainer Hambrecht
    University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
    J Am Coll Cardiol 39:1175-81. 2002
  3. ncbi request reprint [Sports as therapy]
    Rainer Hambrecht
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum, Leipzig
    Herz 29:381-90. 2004
  4. ncbi request reprint [Physical exercise in older patients with chronic heart failure]
    R Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie Leipzig
    Dtsch Med Wochenschr 130:710-6. 2005
  5. ncbi request reprint Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
  6. ncbi request reprint Essay: Hunter-gatherer to sedentary lifestyle
    Rainer Hambrecht
    University of Leipzig, Heart Centre, Department of Internal Medicine Cardiology, 04289 Leipzig, Germany
    Lancet 366:S60-1. 2005
  7. ncbi request reprint Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
  8. ncbi request reprint Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
  9. ncbi request reprint Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
  10. ncbi request reprint [Stress and stress tolerance in chronic heart failure]
    Rainer Hambrecht
    Klinik für Innere Medizin Kardiologie, Herzzentrum, Universitat Leipzig
    Herz 27:179-86. 2002

Detail Information

Publications78

  1. ncbi request reprint Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
    ..This analysis was conducted, to evaluate the effects of ET on left ventricular function and haemodynamics in patients with advanced CHF (NYHA class III) fulfilling the inclusion criteria of the COPERNICUS trial...
  2. ncbi request reprint Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
    Rainer Hambrecht
    University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
    J Am Coll Cardiol 39:1175-81. 2002
    ..We sought to assess the role of insulin-like growth factor-I (IGF-I) in muscle wasting in chronic heart failure (CHF), serum concentrations and local muscular IGF-I expression were determined in patients with severe CHF...
  3. ncbi request reprint [Sports as therapy]
    Rainer Hambrecht
    Klinik für Innere Medizin Kardiologie, Universität Leipzig Herzzentrum, Leipzig
    Herz 29:381-90. 2004
    ..Considering the growing body of evidence in favor of sport as a therapy, training interventions should be considered additional/alternative therapeutic strategies as compared with established pharmacological/interventional options...
  4. ncbi request reprint [Physical exercise in older patients with chronic heart failure]
    R Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie Leipzig
    Dtsch Med Wochenschr 130:710-6. 2005
    ..Ultimately, the goal is to reduce the substantial morbidity among elderly CHF patients which constitute 79 % of all hospital admissions for heart failure...
  5. ncbi request reprint Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  6. ncbi request reprint Essay: Hunter-gatherer to sedentary lifestyle
    Rainer Hambrecht
    University of Leipzig, Heart Centre, Department of Internal Medicine Cardiology, 04289 Leipzig, Germany
    Lancet 366:S60-1. 2005
  7. ncbi request reprint Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
    ..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF...
  8. ncbi request reprint Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
    ..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)...
  9. ncbi request reprint Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
    ....
  10. ncbi request reprint [Stress and stress tolerance in chronic heart failure]
    Rainer Hambrecht
    Klinik für Innere Medizin Kardiologie, Herzzentrum, Universitat Leipzig
    Herz 27:179-86. 2002
    ....
  11. ncbi request reprint [Effects of physical training of chronic cardiac insuffciency]
    S Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig
    MMW Fortschr Med 147:26-9. 2005
    ..Training programs for patients with chronic cardiac insufficiency today represent an established auxiliary therapy for CCI with prognostic relevance...
  12. ncbi request reprint Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....
  13. ncbi request reprint Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
    ....
  14. ncbi request reprint Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
    ..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF...
  15. doi request reprint Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
    ..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers...
  16. ncbi request reprint Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Am Coll Cardiol 42:861-8. 2003
    ..The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF)...
  17. doi request reprint Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study
    Marcus Sandri
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
    Eur Heart J 33:1758-68. 2012
    ..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)...
  18. ncbi request reprint Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  19. ncbi request reprint Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  20. ncbi request reprint Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells
    Nicolle Krankel
    Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 25:698-703. 2005
    ..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function...
  21. doi request reprint Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
    ....
  22. ncbi request reprint Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Am Heart J 146:280-5. 2003
    ..It remains unclear, however, whether the degree of endothelial dysfunction caused by oxidative stress differs between CAD and CHF because of ischemic (ICM) or dilated cardiomyopathy (DCM)...
  23. ncbi request reprint Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Am Heart J 145:E3. 2003
    ..The aim of this consecutive study was to assess whether a home-based exercise program with reduced average training duration can sustain previously achieved effects on coronary endothelial function...
  24. doi request reprint Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size
    Robert Höllriegel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Int J Cardiol 167:975-80. 2013
    ....
  25. doi request reprint Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial
    Holger Thiele
    Universität Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Lancet 379:923-31. 2012
    ..However, the safety and efficacy of intracoronary versus standard intravenous bolus application in patients with ST-elevation myocardial infarction (STEMI) undergoing this intervention has not been tested in a large-scale clinical trial...
  26. doi request reprint Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training
    Volker Adams
    Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:293-9. 2008
    ..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx...
  27. ncbi request reprint Changes in myocardial perfusion due to physical exercise in patients with stable coronary artery disease
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 9a, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 32:813-9. 2005
    ..The aim of this study was to evaluate changes in myocardial stress perfusion after 1 year of exercise training in comparison with the effects of PTCA in patients with CAD...
  28. doi request reprint Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
    ..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome...
  29. ncbi request reprint Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction
    Sandra Erbs
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 23:1814-9. 2003
    ..Therefore, we aimed to determine the effects of these polymorphisms on endothelial function and endothelial response to physical exercise in patients with coronary artery disease (CAD)...
  30. doi request reprint High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Int J Cardiol 146:56-63. 2011
    ..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...
  31. ncbi request reprint Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: a 5-year follow-up
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circulation 112:3445-50. 2005
    ..Long-term follow-up data are sparse...
  32. ncbi request reprint Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease
    Volker Adams
    University Leipzig, Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Circulation 111:555-62. 2005
    ..The aim of the present study was to analyze the impact of ET on sources of ROS generation in the left internal mammary artery of patients with symptomatic coronary artery disease...
  33. ncbi request reprint Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions
    Holger Thiele
    University of Leipzig Heart Centre, Department of Internal Medicine Cardiology, Leipzig, Germany
    Int J Cardiol 135:287-95. 2009
    ..Cardiac magnetic resonance imaging (CMRI) is an excellent tool for serial assessment of underlying structural changes in perfusion, left ventricular function, and infarct size...
  34. doi request reprint Intraaortic balloon support for myocardial infarction with cardiogenic shock
    Holger Thiele
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    N Engl J Med 367:1287-96. 2012
    ..However, evidence is based mainly on registry data, and there is a paucity of randomized clinical trials...
  35. ncbi request reprint Effects of exercise training on mortality in patients with coronary heart disease
    Sandra Erbs
    Department of Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Coron Artery Dis 17:219-25. 2006
    ....
  36. ncbi request reprint Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig Heart Centre, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 26:1276-83. 2005
    ..A newly developed percutaneous left ventricular assist device (VAD) (Tandem Heart, Cardiac Assist, Pittsburgh, PA, USA) with active circulatory support might have positive haemodynamic effects and decrease mortality...
  37. ncbi request reprint Prospective randomized comparison of early and late results of 4 different stent designs
    Peter B Sick
    Heart Center, Department for Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Am Heart J 146:134-41. 2003
    ..So far, few data are available addressing the effect of stent design on this crucial variable and on early and late adverse events after stent implantation...
  38. ncbi request reprint Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions
    Stephan Gielen
    Universitat Leipzig, Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Heart Fail Monit 4:130-6. 2005
    ..In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored...
  39. ncbi request reprint Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
    ..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha...
  40. ncbi request reprint Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig Immediate versus early and late PercutaneouS coronary Intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial)
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Strümpellstr 39, 04289 Leipzig, Germany
    Eur Heart J 33:2035-43. 2012
    ..The aim of this multicentre trial was to assess whether an immediate invasive approach is superior to an early invasive or a selective invasive approach with respect to reduction of large infarction...
  41. doi request reprint Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD
    Norman Mangner
    Heart Center Leipzig, University of Leipzig, Struempellstrasse 39, D 04289 Leipzig, Germany
    Muscle Nerve 45:544-51. 2012
    ..Mice that lack both the transcription factor MyoD and dystrophin display a more pronounced myopathic phenotype when compared with mdx mice. No data on skeletal muscle function and the impact of exercise training are available...
  42. ncbi request reprint Exercise and the coronary circulation-alterations and adaptations in coronary artery disease
    Axel Linke
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Prog Cardiovasc Dis 48:270-84. 2006
    ....
  43. doi request reprint Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners
    Volker Adams
    Department of Cardiology, University Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:602-7. 2008
    ..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners...
  44. ncbi request reprint Effects of exercise training upon endothelial function in patients with cardiovascular disease
    Axel Linke
    University of Leipzig, Heart Center, Department of Cardiology, Leipzig, Germany
    Front Biosci 13:424-32. 2008
    ..Given the prognostic value of endothelial function further studies are necessary to elucidate whether the ET-induced correction of vasomotion is the key mechanism responsible for the decline in mortality in patients with CVD...
  45. ncbi request reprint Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
    ..The aim of this study was to investigate morphological, functional and electromyographical parameters of the skeletal muscle in CHF...
  46. ncbi request reprint Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia
    Karsten Lenk
    Department of Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 26:1903-9. 2005
    ..It remains unclear, however, whether an intra-arterial application of autologous CPCs in patients with infrapopliteal PAOD and CLI is safe, feasible, and of potentially beneficial effects...
  47. ncbi request reprint [Exercise training in the treatment of coronary artery disease and obesity]
    Axel Linke
    Universität Leipzig Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Herz 31:224-33. 2006
    ..Most importantly, patients should enjoy the proposed kind of physical exercise...
  48. ncbi request reprint Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression
    Nicolle Krankel
    Department of Cardiology, Heart Center, University of Leipzig, D 04289 Leipzig, Germany
    Mol Genet Metab 80:262-71. 2003
    ..The upregulation of PP2A, an important regulator in intracellular signaling and apoptosis, may be due to an increase of inflammatory cytokines...
  49. ncbi request reprint The effect of exercise training on endothelial function in cardiovascular disease in humans
    Claudia Walther
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Exerc Sport Sci Rev 32:129-34. 2004
    ..Regular exercise training is a nonpharmacological option to improve endothelial dysfunction in patients with cardiovascular disease by increasing NO bioavailability...
  50. ncbi request reprint Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging
    Holger Thiele
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    J Am Coll Cardiol 47:1641-5. 2006
    ..The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI)...
  51. ncbi request reprint Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infa
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Circulation 116:366-74. 2007
    ....
  52. ncbi request reprint Chronic heart failure and skeletal muscle catabolism: effects of exercise training
    Paul Christian Schulze
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Russenstr 19, 04289 Leipzig, Germany
    Int J Cardiol 85:141-9. 2002
    ..In concert, these beneficial effects of exercise training may help to retard the catabolic process in CHF finally leading to cardiac cachexia and death...
  53. ncbi request reprint Short- and long-term hemodynamic effects of intra-aortic balloon support in ventricular septal defect complicating acute myocardial infarction
    Holger Thiele
    Department of Internal Medicine, University of Leipzig, Heart Center, Germany
    Am J Cardiol 92:450-4. 2003
    ..In patients who can be stabilized or remain stable, there is no habituation to the effects of the intra-aortic balloon pump; thus, later surgical closure of the ventricular septal defect might be possible in some patients...
  54. ncbi request reprint Flow-mediated vasodilation partially reflects nitric oxide-mediated endothelial function
    Axel Linke
    University of Leipzig Heart Center, Department of Cardiology, Germany
    J Appl Physiol 99:1622. 2005
  55. ncbi request reprint Influence of residual stenosis after percutaneous coronary intervention with stent implantation on development of restenosis and stent thrombosis
    Peter Sick
    Department of Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Am J Cardiol 91:148-53. 2003
    ..Oversizing of stents is no longer necessary with an adequate dosage of ticlopidine and aspirin...
  56. ncbi request reprint Outcome of patients after emergency conversion from transcatheter aortic valve implantation to surgery
    Ralph Hein
    Städtisches Klinikum München GmbH, Klinikum Neuperlach, Department of Cardiology, Munich, Germany
    EuroIntervention 9:446-51. 2013
    ..To evaluate: 1) the causes of emergency conversion from transcatheter aortic valve implantation (TAVI) to surgery, 2) procedural settings, and 3) short-term outcome of converted patients...
  57. ncbi request reprint The childhood obesity epidemic: impact on endothelial function
    Stephan Gielen
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circulation 109:1911-3. 2004
  58. ncbi request reprint Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study
    Volker Adams
    University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
    Cardiovasc Res 54:95-104. 2002
    ..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression...
  59. ncbi request reprint Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  60. ncbi request reprint Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase
    Volker Adams
    Clinic of Cardiology, Leipzig Heart Center, University Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:273-7. 2003
    ..The aim of this study was to assess whether NF-kappaB is activated in skeletal muscle of patients with CHF and linked to the expression of iNOS...
  61. doi request reprint Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention: design and rationale of the Abciximab Intracoronary versus intravenously Drug Application in ST-Elevation Myocardial Infarction (AIDA ST
    Holger Thiele
    Universität Leipzig Heart Center, Department of Internal Medicine Cardiology, Germany
    Am Heart J 159:547-54. 2010
    ..The hypothesis of this trial is that abciximab bolus intracoronary in comparison to standard intravenous application will improve the outcome of patients undergoing primary PCI in STEMI...
  62. doi request reprint Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial
    Holger Thiele
    University of Leipzig Heart Center, Leipzig, Germany
    Am Heart J 163:938-45. 2012
    ..The hypothesis of this trial is that IABP in addition to early revascularization by either percutaneous coronary intervention or coronary artery bypass grafting will improve clinical outcome of patients in cardiogenic shock...
  63. ncbi request reprint Comparison of stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    Anno Diegeler
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    N Engl J Med 347:561-6. 2002
    ..Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these two procedures...
  64. ncbi request reprint Transapical approach for sutureless stent-fixed aortic valve implantation: experimental results
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 29:703-8. 2006
    ..Percutaneous aortic valve implantation has been performed in patients with severe aortic stenosis judged as nonsurgical candidates. We evaluated a facilitated transapical antegrade approach for potential use in surgical high-risk patients...
  65. ncbi request reprint Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  66. ncbi request reprint Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
    Basic Res Cardiol 98:267-74. 2003
    ....
  67. ncbi request reprint Commentary on Viewpoint: Exercise and cardiovascular risk reduction: time to update the rationale for exercise?
    Stephan Gielen
    J Appl Physiol 105:771. 2008
  68. ncbi request reprint Intracoronary administration of circulating blood-derived progenitor cells after recanalization of chronic coronary artery occlusion improves endothelial function
    Sandra Erbs
    Circ Res 98:e48. 2006
  69. ncbi request reprint Statement on cardiopulmonary exercise testing in chronic heart failure due to left ventricular dysfunction: recommendations for performance and interpretation. Part I: definition of cardiopulmonary exercise testing parameters for appropriate use in chroni
    Massimo F Piepoli
    Heart Failure Unit, Cardiac Department, G da Saliceto Polichirurgico Hospital, Cantone del Cristo, Piacenza 29100, Italy
    Eur J Cardiovasc Prev Rehabil 13:150-64. 2006
    ....
  70. ncbi request reprint Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial
    Henning Morawietz
    Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Circulation 114:I296-301. 2006
    ....
  71. ncbi request reprint Time-course of endothelial adaptation following acute and regular exercise
    Per Magnus Haram
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Cardiovasc Prev Rehabil 13:585-91. 2006
    ..Regular exercise training has emerged as a powerful tool to improve endothelium-dependent vasorelaxation. However, little is known about the magnitude of change and the permanence of exercise-induced adaptations in endothelial function...
  72. ncbi request reprint Statement on cardiopulmonary exercise testing in chronic heart failure due to left ventricular dysfunction: recommendations for performance and interpretation Part II: How to perform cardiopulmonary exercise testing in chronic heart failure
    Massimo F Piepoli
    Eur J Cardiovasc Prev Rehabil 13:300-11. 2006
    ..An example of a cardiopulmonary summary exercise test data report will be provided, defining the most important information that should be incorporated in a final report...
  73. ncbi request reprint Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    ..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction...
  74. ncbi request reprint Coronary atherosclerosis and cardiovascular risk in masters male marathon runners. Rationale and design of the "marathon study"
    Stefan Mohlenkamp
    Clinic of Cardiology, West German Heart Center Essen, University Clinic Essen, Essen, Germany
    Herz 31:575-85. 2006
    ..The predictive value of modern imaging- and non-imaging-based markers of risk that can be used for risk stratification in masters endurance athletes still deserves exploration...
  75. ncbi request reprint Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial
    Volker Schachinger
    J W Goethe Universität Frankfurt, Med Klinik III, Abt Kardiologie, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Eur Heart J 27:2775-83. 2006
    ..To investigate the clinical outcome after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI)...
  76. ncbi request reprint Treatment strategies in endothelial dysfunction: physical exercise versus pharmacological therapy
    Stephan Gielen
    Eur J Cardiovasc Prev Rehabil 12:318-20. 2005
  77. ncbi request reprint Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy?
    Georg Kojda
    Institut fur Pharmakologie und Klinische Pharmakologie, Medizinische Einrichtungen, Heinrich Heine Universitat, Moorenstr 5, 40225 Dusseldorf, Germany
    Cardiovasc Res 67:187-97. 2005
    ..Based on these observations, it appears reasonable to assume that exercise training can be viewed as an effective antioxidant and antiatherogenic therapy...
  78. ncbi request reprint [How much exercise must the heart patient have? "2,000 kilocalories per week is the minimum"]
    Rainer Hambrecht
    MMW Fortschr Med 147:8. 2005