A Hamann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint A randomized clinical trial comparing breakfast, dinner, or bedtime administration of insulin glargine in patients with type 1 diabetes
    Andreas Hamann
    Division of Endocrinology and Metabolism, Department of Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Diabetes Care 26:1738-44. 2003
  2. ncbi request reprint [Etiology of overweight and obesity]
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitat Heidelberg
    Ther Umsch 57:482-7. 2000
  3. ncbi request reprint Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone
    A Hamann
    Universitatsklinikum Heidelberg, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:6-13. 2008
  4. ncbi request reprint [Molecular principles of obesity]
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik der Universität Heidelberg
    Herz 26:178-84. 2001
  5. ncbi request reprint A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:14-7. 2008
  6. doi request reprint The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
  7. ncbi request reprint Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 39:306-9. 2007
  8. ncbi request reprint Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activity
    G Rudofsky
    Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Horm Metab Res 39:665-71. 2007
  9. ncbi request reprint Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients
    P M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Diabetologia 50:1517-22. 2007
  10. ncbi request reprint No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 7:455-9. 2005

Detail Information

Publications46

  1. ncbi request reprint A randomized clinical trial comparing breakfast, dinner, or bedtime administration of insulin glargine in patients with type 1 diabetes
    Andreas Hamann
    Division of Endocrinology and Metabolism, Department of Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Diabetes Care 26:1738-44. 2003
    ..This open-label, randomized, parallel group, multicenter study investigated whether insulin glargine is equally effective if administered before breakfast, before dinner, or at bedtime...
  2. ncbi request reprint [Etiology of overweight and obesity]
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitat Heidelberg
    Ther Umsch 57:482-7. 2000
    ..The ongoing search for the important obesity genes should not only result in a better understanding of energy metabolism, but may also help in the development of new strategies for the treatment of obese patients...
  3. ncbi request reprint Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone
    A Hamann
    Universitatsklinikum Heidelberg, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:6-13. 2008
    ....
  4. ncbi request reprint [Molecular principles of obesity]
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik der Universität Heidelberg
    Herz 26:178-84. 2001
    ..Furthermore, the existence of a specific genetic predisposition towards the development of obesity becomes evident by marked interindividual differences in the response to caloric oversupply...
  5. ncbi request reprint A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:14-7. 2008
    ..We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes...
  6. doi request reprint The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
    ..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes...
  7. ncbi request reprint Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 39:306-9. 2007
  8. ncbi request reprint Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activity
    G Rudofsky
    Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Horm Metab Res 39:665-71. 2007
    ....
  9. ncbi request reprint Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients
    P M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Diabetologia 50:1517-22. 2007
    ....
  10. ncbi request reprint No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 7:455-9. 2005
    ..This study examined a possible association of the T/G polymorphism at nucleotide 94 in the adiponectin gene with the prevalence of diabetic complications...
  11. ncbi request reprint Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents
    J Tafel
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitatsklinikum Heidelberg, 69115 Heidelberg, Germany
    Diabetes Obes Metab 6:452-5. 2004
    ..We therefore investigated the possible association of polymorphisms in the beta-adrenergic receptor genes with early onset obesity...
  12. ncbi request reprint Identification of a deletion variant in the gene encoding the human alpha(2A)-adrenergic receptor
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitat Heidelberg, Germany
    Eur J Endocrinol 144:291-5. 2001
    ..This study was undertaken to assess whether variants in the alpha(2A)-adrenergic receptor gene are associated with body weight...
  13. ncbi request reprint [Oral diabetes treatment. Which substance is indicated at which time?]
    A Hamann
    Abteilung Innere Medizin I, Universitatsklinikum Heidelberg
    Internist (Berl) 45:1356-63. 2004
    ..This recommendation for monotherapy of overweight type 2 diabetics is supported by an endpoint study. In contrast, no equivalent evidence is available on any of the possible options for oral combination therapy...
  14. ncbi request reprint Regulation of energy balance by leptin
    A Hamann
    Department of Medicine, University of Hamburg, Germany
    Exp Clin Endocrinol Diabetes 104:293-300. 1996
    ..This review briefly summarizes the current status of the rapidly growing evidence that leptin plays an important role in the regulation of body weight and fat deposition...
  15. doi request reprint C332C genotype of glyoxalase 1 and its association with late diabetic complications
    J B Groener
    Department of Medicine, Division of Endocrinology and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany heidelberg de
    Exp Clin Endocrinol Diabetes 121:436-9. 2013
    ..Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes...
  16. ncbi request reprint Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis [seecomments]
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Kidney Int 56:860-72. 1999
    ..Because individuals with massive obesity who may exhibit increased leptin serum concentrations develop renal glomerulosclerosis, we studied whether leptin can influence renal growth and profibrogenic processes...
  17. ncbi request reprint Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial
    S Eisenhardt
    Women s University Hospital, Department of Gynecological Endocrinology and Reproductive Medicine and Department of Obstetrics and Gynecology, Vossstr 9, 69115 Heidelberg, Germany
    J Clin Endocrinol Metab 91:946-52. 2006
    ..Metformin is successfully used in the treatment of cycle disorders and anovulation in women with polycystic ovary syndrome (PCOS). No data of the exact point and the impact of insulin resistance (IR) on metformin's efficacy exist...
  18. ncbi request reprint Long-term treatment of central Cushing's syndrome with rosiglitazone
    M Morcos
    University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:292-7. 2007
    ..Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies...
  19. ncbi request reprint Tissue and serum levofloxacin concentrations in diabetic foot infection patients
    K Oberdorfer
    Institute of Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Antimicrob Chemother 54:836-9. 2004
    ..The purpose of our study was to determine the serum and tissue concentrations of levofloxacin when administered orally in patients with infected diabetic foot ulcers and to compare these values with microbiological findings...
  20. doi request reprint Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    M Morcos
    Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
    Horm Metab Res 40:752-9. 2008
    ..Most importantly, rosiglitazone effects on NFkappaB activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects...
  21. ncbi request reprint [Long-term weight reduction. Current therapy approaches in obesity]
    S Lichtenstein
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik,
    MMW Fortschr Med 143:28-30, 32-4. 2001
    ..If this basic program fails, adjunctive drug treatment is indicated. Surgical treatment may be considered when various conservative forms of treatment have proved unsuccessful over a period of years...
  22. ncbi request reprint High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men
    Maximilian von Eynatten
    Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675 Munich, Germany
    Atherosclerosis 199:123-8. 2008
    ..We therefore investigated whether HMW adiponectin is associated with the extent of coronary artery disease (CAD) in men...
  23. ncbi request reprint Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes
    Gottfried Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Diabetes Care 29:89-94. 2006
    ..We studied the association between polymorphisms in the UCP genes and diabetes complications in patients with type 1 diabetes...
  24. ncbi request reprint Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease
    Maximilian von Eynatten
    Department of Medicine I Endocrinology and Metabolism, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Clin Chem 52:853-9. 2006
    ..We examined the associations between serum adiponectin and several biomarkers related to cardiovascular disease and heart failure in a large high-risk population comprising patients with prevalent CHD...
  25. ncbi request reprint [Effect of metformin on gene expression of phosphoenolpyruvate carboxykinase]
    Li Yuan
    Department of Endocrinology in Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Nei Ke Za Zhi 41:663-6. 2002
    ....
  26. ncbi request reprint Activation of tubular epithelial cells in diabetic nephropathy
    Michael Morcos
    Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 51:3532-44. 2002
    ....
  27. doi request reprint Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
    Anne Katrin Sjølie
    Department of Ophthalmology, Odense University Hospital, Odense, Denmark
    Lancet 372:1385-93. 2008
    ..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes...
  28. ncbi request reprint Impact of rosiglitazone on beta-cell function, insulin resistance, and adiponectin concentrations: results from a double-blind oral combination study with glimepiride
    Andreas Pfutzner
    IKFE Institute for Clinical Research and Development, Mainz, Germany
    Metabolism 55:20-5. 2006
    ..In conclusion, our short-term investigation of rosiglitazone action provides further experimental support for the rationale of combining rosiglitazone with sulfonylurea drugs in patients with type 2 diabetes...
  29. ncbi request reprint Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells
    Li Yuan
    Department of Endocrinology and Metabolism in Hospital of University Heidelberg, Heidelberg 69115, Germany
    Acta Pharmacol Sin 24:55-60. 2003
    ....
  30. ncbi request reprint Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia
    Paul N Durrington
    University of Manchester, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Diabetes Res Clin Pract 64:137-51. 2004
    ....
  31. ncbi request reprint SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes
    Per M Humpert
    Medizinische Klinik 1, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Diabetes Care 28:934-6. 2005
  32. ncbi request reprint Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes
    Gottfried Rudofsky
    Department Medicine I, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 27:179-83. 2004
    ..To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications...
  33. ncbi request reprint Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance
    Maximilian von Eynatten
    Department of Medicine I Endocrinology and Metabolism, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Diabetes Care 27:2925-9. 2004
    ..Recently, dramatically increased LPL activity was reported in mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect LPL in humans...
  34. ncbi request reprint Atorvastatin improves diabetic dyslipidemia and increases lipoprotein lipase activity in vivo
    Jochen G Schneider
    Department of Internal Medicine I Endocrinology and Metabolism, University of Heidelberg, Germany
    Atherosclerosis 175:325-31. 2004
    ..Since low LPL activity indicates an increased cardiovascular risk, the statin-mediated increase in LPL activity may help to explain the reduction of CAD in diabetic patients treated with statins...
  35. ncbi request reprint The proline 12 alanine substitution in the peroxisome proliferator--activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo
    Jochen Schneider
    Department of Internal Medicine I Endocrinology, Diabetes and Metabolism, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Diabetes 51:867-70. 2002
    ..ml(-1).min(-1), P < 0.05). Our data demonstrate that the Pro12Ala substitution in PPAR-gamma2 is associated with lower LPL activity in vivo and provides a new target for the analysis of genetic influences on LPL activity and CAD risk...
  36. ncbi request reprint Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes
    Li Yuan
    Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Chin Med J (Engl) 115:1843-8. 2002
    ....
  37. ncbi request reprint Effect of thiol antioxidant on body fat and insulin reactivity
    Wulf Hildebrandt
    Division of Immunochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Mol Med (Berl) 82:336-44. 2004
    ..Supplementation of thiols plus creatine may reduce body fat without compromising glucose tolerance...
  38. ncbi request reprint New treatments for diabetic neuropathy: pathogenetically oriented treatment
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Germany
    Curr Diab Rep 3:452-8. 2003
    ....
  39. ncbi request reprint Genetics of obesity and obesity-related hypertension
    Andreas Hamann
    Department of Internal Medicine, University of Heidelberg, Germany
    Semin Nephrol 22:100-4. 2002
    ..This knowledge should help develop new strategies for the treatment of obesity and associated risk factors for hypertension and related cardiovascular disorders...
  40. ncbi request reprint Elevated plasma endothelin-1 levels in diabetes mellitus
    Jochen G Schneider
    Department of Internal Medicine I, Ruprecht Karls University of Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    Am J Hypertens 15:967-72. 2002
    ....
  41. ncbi request reprint Comment on: Lin et al. (2007) SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes: Diabetes 56: 1177-1180
    Gottfried Rudofsky
    Diabetes 56:e11; author reply e12-3. 2007
  42. ncbi request reprint Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia
    Peter Reismann
    Department Medicine I, University of Heidelberg, Germany
    J Neurol 251:853-8. 2004
    ..This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia...
  43. ncbi request reprint Microvascular alterations in diabetic mice correlate with level of hyperglycemia
    Petra Algenstaedt
    Department of Internal Medicine, University Hospital Hamburg Eppendorf, Germany
    Diabetes 52:542-9. 2003
    ..The results suggest that anti-inflammatory strategies might be able to prevent vascular deterioration in early stages of diabetes. Further investigations are required to evaluate the benefit of such therapeutic strategies...
  44. ncbi request reprint Adipocytokines as a novel target for the anti-inflammatory effect of atorvastatin in patients with type 2 diabetes
    Maximilian von Eynatten
    Diabetes Care 28:754-5. 2005
  45. ncbi request reprint Tissue factor as a link between wounding and tissue repair
    Jiang Chen
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetes 54:2143-54. 2005
    ..These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes...
  46. ncbi request reprint Chronic hyperinsulinism induced down-regulation of insulin post-receptor signaling transduction in Hep G2 cells
    Li Yuan
    Department of Endocrinology and Metabolism, University Hospital Heidelberg, Heidelberg 69115, Germany
    J Huazhong Univ Sci Technolog Med Sci 22:313-6. 2002
    ....