Affiliation: University Hospital
Haller O, Arnheiter H, Pavlovic J, Staeheli P. The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success. Annu Rev Virol. 2018;5:33-51 pubmed publisher
..It also showed that in many species, MX proteins have activities against a broad range of viruses. To this day, Mx research continues to flourish and to provide insights into the never-ending battle between viruses and their hosts. ..
Haller O, Stertz S, Kochs G. The Mx GTPase family of interferon-induced antiviral proteins. Microbes Infect. 2007;9:1636-43 pubmed
..They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence. ..
Haller O, Staeheli P, Schwemmle M, Kochs G. Mx GTPases: dynamin-like antiviral machines of innate immunity. Trends Microbiol. 2015;23:154-63 pubmed publisher
..The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses. ..
Haller O. A tribute to Jean Lindenmann, co-discoverer of interferon (1924-2015). Cytokine. 2015;76:113-5 pubmed publisher
..Jean Lindenmann died in ZÃ¼rich on January 15, 2015, at the age of 90, after having survived Alick Isaacs (1921-1967) for almost five decades. ..
Haller O, Staeheli P, Kochs G. Interferon-induced Mx proteins in antiviral host defense. Biochimie. 2007;89:812-8 pubmed
..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles. ..
Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G. Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity. J Biol Chem. 2010;285:28419-24 pubmed publisher
..Moreover, the structural knowledge paves the way for the development of novel antiviral drugs against influenza and other highly pathogenic viruses. ..
Haller O, Kochs G. Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. J Interferon Cytokine Res. 2011;31:79-87 pubmed publisher
..Thus, MxA may form oligomeric rings around tubular nucleocapsid structures, thereby inhibiting their transcriptional and replicative function. Here we briefly review the most salient features of MxA expression and antiviral function. ..
Haller O. Dynamins are forever: MxB inhibits HIV-1. Cell Host Microbe. 2013;14:371-3 pubmed publisher
..Three recent papers, including one in this issue of Cell Host & Microbe, show that MxB inhibits human immunodeficiency virus type 1 (HIV-1) infection. ..