Torsten Hain

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. pmc Universal stress proteins are important for oxidative and acid stress resistance and growth of Listeria monocytogenes EGD-e in vitro and in vivo
    Christa Seifart Gomes
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    PLoS ONE 6:e24965. 2011
  2. pmc The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophages
    Mobarak A Mraheil
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Nucleic Acids Res 39:4235-48. 2011
  3. pmc Identification of novel growth phase- and media-dependent small non-coding RNAs in Streptococcus pyogenes M49 using intergenic tiling arrays
    Nadja Patenge
    Institute of Medical Microbiology and Hospital Hygiene, University of Rostock, Schillingallee 70, 18057, Rostock, Germany
    BMC Genomics 13:550. 2012
  4. pmc Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    BMC Microbiol 8:20. 2008
  5. pmc Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Bacteriol 188:7405-15. 2006
  6. ncbi request reprint Pathogenomics of Listeria spp
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Int J Med Microbiol 297:541-57. 2007
  7. pmc Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes
    Torsten Hain
    Institute of Medical Microbiology, Justus Liebig University, Schubertstrasse 81, Giessen, D 35392, Germany
    BMC Genomics 13:144. 2012
  8. ncbi request reprint Invasiveness is a variable and heterogeneous phenotype in Listeria monocytogenes serotype strains
    Som S Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Str 107, D 35392 Giessen, Germany
    Int J Med Microbiol 296:277-86. 2006
  9. pmc Intracellular gene expression profile of Listeria monocytogenes
    Som Subhra Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Infect Immun 74:1323-38. 2006
  10. pmc Complete genome sequence of Listeria seeligeri, a nonpathogenic member of the genus Listeria
    Christiane Steinweg
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Bacteriol 192:1473-4. 2010

Collaborators

Detail Information

Publications37

  1. pmc Universal stress proteins are important for oxidative and acid stress resistance and growth of Listeria monocytogenes EGD-e in vitro and in vivo
    Christa Seifart Gomes
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    PLoS ONE 6:e24965. 2011
    ..As part of this, the universal stress protein A (UspA) and its homologues, initially discovered in Escherichia coli K-12 were shown to possess an important role in stress resistance and growth in several bacterial species...
  2. pmc The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophages
    Mobarak A Mraheil
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Nucleic Acids Res 39:4235-48. 2011
    ..Our analyses reveal extensive sRNA expression as an important feature of bacterial regulation during intracellular growth...
  3. pmc Identification of novel growth phase- and media-dependent small non-coding RNAs in Streptococcus pyogenes M49 using intergenic tiling arrays
    Nadja Patenge
    Institute of Medical Microbiology and Hospital Hygiene, University of Rostock, Schillingallee 70, 18057, Rostock, Germany
    BMC Genomics 13:550. 2012
    ..GAS is an important pathogen that causes diseases ranging from mild superficial infections of the skin and mucous membranes of the naso-pharynx, to severe toxic and invasive diseases...
  4. pmc Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    BMC Microbiol 8:20. 2008
    ..monocytogenes EGD-e. Whole genome-based transcriptional profiling was used to identify sigmaB-dependent genes at different growth phases...
  5. pmc Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Bacteriol 188:7405-15. 2006
    ..The species L. welshimeri appears to have been derived from early evolutionary events and an ancestor more compact than L. monocytogenes that led to the emergence of nonpathogenic Listeria spp...
  6. ncbi request reprint Pathogenomics of Listeria spp
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Int J Med Microbiol 297:541-57. 2007
    ..to understand genome evolution and diversity, as well as physiological aspects of metabolism utilized by the bacteria when growing in diverse and varied environments...
  7. pmc Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes
    Torsten Hain
    Institute of Medical Microbiology, Justus Liebig University, Schubertstrasse 81, Giessen, D 35392, Germany
    BMC Genomics 13:144. 2012
    ..monocytogenes. Lineage III, represented by the 4a L99 genome is known to contain strains less virulent for humans...
  8. ncbi request reprint Invasiveness is a variable and heterogeneous phenotype in Listeria monocytogenes serotype strains
    Som S Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Str 107, D 35392 Giessen, Germany
    Int J Med Microbiol 296:277-86. 2006
    ..Data presented here also suggest that the inlAB locus was introduced into L. monocytogenes by horizontal gene transfer with subsequent deletion and rearrangements occurring during evolution of this species...
  9. pmc Intracellular gene expression profile of Listeria monocytogenes
    Som Subhra Chatterjee
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Infect Immun 74:1323-38. 2006
    ..monocytogenes in host cells. Overall, our study provides crucial insights into the strategy of intracellular survival and measures taken by L. monocytogenes to escape the host cell responses...
  10. pmc Complete genome sequence of Listeria seeligeri, a nonpathogenic member of the genus Listeria
    Christiane Steinweg
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Bacteriol 192:1473-4. 2010
    ..We report the complete and annotated genome sequence of the nonpathogenic Listeria seeligeri SLCC3954 serovar 1/2b type strain harboring the smallest completely sequenced genome of the genus Listeria...
  11. pmc Novel bacterial artificial chromosome vector pUvBBAC for use in studies of the functional genomics of Listeria spp
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Appl Environ Microbiol 74:1892-901. 2008
    ....
  12. pmc Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome
    Carsten Kuenne
    Institute of Medical Microbiology, German Centre for Infection Research, Justus Liebig University, D 35392, Giessen, Germany
    BMC Genomics 14:47. 2013
    ..These were comparatively analyzed in conjunction with publicly available data and assessed for pathogenicity in the Galleria mellonella insect model...
  13. pmc Conjugative IncFI plasmids carrying CTX-M-15 among Escherichia coli ESBL producing isolates at a University hospital in Germany
    Stephen E Mshana
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    BMC Infect Dis 9:97. 2009
    ..Little data on the molecular epidemiology of ESBL producing Escherichia coli is available in Germany. Here we describe the prevalence and molecular epidemiology of ESBL producing-Escherichia coli isolates at a German University hospital...
  14. ncbi request reprint Comparative genomic analysis for the presence of potential enterococcal virulence factors in the probiotic Enterococcus faecalis strain Symbioflor 1
    Eugen Domann
    Institute of Medical Microbiology, University of Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Int J Med Microbiol 297:533-9. 2007
    ..The presence of these traits may be advantageous for the strain Symbioflor 1 since they potentially enable colonization and proliferation of the bacterium on mucosal surfaces thereby conferring on it probiotic traits...
  15. pmc Antibody targeting the ferritin-like protein controls Listeria infection
    Walid Mohamed
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Str 107, Giessen, Germany
    Infect Immun 78:3306-14. 2010
    ..In vitro studies revealed that the antilisterial resistance is due to increased listerial phagocytosis...
  16. pmc Complete sequences of plasmids from the hemolytic-uremic syndrome-associated Escherichia coli strain HUSEC41
    Carsten Künne
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    J Bacteriol 194:532-3. 2012
    ..The complete and annotated sequences of four plasmids from a historical enteroaggregative Shiga toxin-producing Escherichia coli (HUSEC) serotype O104:H4 strain, HUSEC41/01-09591, isolated in 2001 in Germany are reported...
  17. pmc Highly specific and quick detection of Mycobacterium avium subsp. paratuberculosis in feces and gut tissue of cattle and humans by multiple real-time PCR assays
    Can Imirzalioglu
    Institute of Medical Microbiology, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Clin Microbiol 49:1843-52. 2011
    ..avium subsp. paratuberculosis bacteria per gram of stool in assay-positive samples. Thus, the methods described here are useful for rapid and specific detection of M. avium subsp. paratuberculosis in clinical samples...
  18. doi request reprint Adaptation of Listeria monocytogenes to oxidative and nitrosative stress in IFN-γ-activated macrophages
    Mobarak Abu Mraheil
    Institute for Medical Microbiology, Justus Liebig University, Giessen, Germany
    Int J Med Microbiol 301:547-55. 2011
    ..Indeed we found enhanced activation of host cell genes involved in the kynurenine pathway indicating an increased need of L. monocytogenes for tryptophan during replication in IFN-γ-activated macrophages...
  19. pmc Anti-Listeria activities of Galleria mellonella hemolymph proteins
    Krishnendu Mukherjee
    Institute of Phytopathology and Applied Zoology, Justus Liebig University, Heinrich Buff Ring 26 32, 35392 Giessen, Germany
    Appl Environ Microbiol 77:4237-40. 2011
    ..We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria...
  20. ncbi request reprint Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation
    Silke Machata
    Institute of Medical Microbiology, Justus Liebig University, Giessen, Germany
    J Immunol 181:2028-35. 2008
    ....
  21. pmc Brain infection and activation of neuronal repair mechanisms by the human pathogen Listeria monocytogenes in the lepidopteran model host Galleria mellonella
    Krishnendu Mukherjee
    Institute of Phytopathology and Applied Zoology, Justus Liebig University of Giessen, Giessen, Germany
    Virulence 4:324-32. 2013
    ..Our data extend the utility of G. mellonella larvae as an ideal model for the high-throughput in vivo testing of potential compounds against listeriosis. ..
  22. pmc Predominance of Klebsiella pneumoniae ST14 carrying CTX-M-15 causing neonatal sepsis in Tanzania
    Stephen E Mshana
    Institute of Medical Microbiology, Justus Liebig University, Schubertstrasse 81, Giessen D 35392, Germany
    BMC Infect Dis 13:466. 2013
    ..Here we describe the molecular epidemiology of these isolates in a tertiary hospital in Tanzania, as potential pathogens for neonatal infections...
  23. ncbi request reprint Expression of the reporter genes lacZ and EGFP in human glioblastoma cells using Listeria monocytogenes as vector for gene transfer
    Ulf Nestler
    Department of Neurosurgery, Justus Liebig University, Giessen, Germany
    Neurol Res 31:859-68. 2009
    ..Glioblastoma has become a model target for viral gene therapy approaches. To circumvent some of the inherent problems of viral vectors, we examined the feasibility of Listeria monocytogenes for foreign gene expression in glioblastoma cells...
  24. ncbi request reprint Comparative and functional genomics of Listeria spp
    Torsten Hain
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Biotechnol 126:37-51. 2006
    ..There were 25 genes that are strain-specific i.e. absent from the genome of the L. monocytogenes F2365 serotype 4b strain suggesting heterogeneity in the gene pool required for intracellular survival of L. monocytogenes in host cells...
  25. pmc sRNAdb: a small non-coding RNA database for gram-positive bacteria
    Jordan Pischimarov
    Institute of Medical Microbiology, Justus Liebig University, Schubertstrasse 81, Giessen, D 35392, Germany
    BMC Genomics 13:384. 2012
    ..To the best of the authors' knowledge no database focusing on sRNAs from gram-positive bacteria is publicly available so far...
  26. pmc Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
    Christian Krawitz
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    BMC Complement Altern Med 11:16. 2011
    ....
  27. pmc Galleria mellonella as a model system for studying Listeria pathogenesis
    Krishnendu Mukherjee
    Institute for Phytopathology and Applied Zoology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Appl Environ Microbiol 76:310-7. 2010
    ..isolated from a wide variety of settings from both the clinic and the environment...
  28. pmc Rapid identification and typing of listeria species by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    Sukhadeo B Barbuddhe
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Appl Environ Microbiol 74:5402-7. 2008
    ..MALDI-TOF MS fingerprinting may have potential for Listeria identification and subtyping and may improve infection control measures...
  29. pmc Simultaneous deficiency of both MurA and p60 proteins generates a rough phenotype in Listeria monocytogenes
    Silke Machata
    Institut fur Medizinische Mikrobiologie, Justus Liebig Universitat, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Bacteriol 187:8385-94. 2005
    ..monocytogenes. We also identified homologous MurA and SecA2 proteins in other Listeria species. The muramidase in two species, L. innocua and L. welshimeri, shows activity similar to that of the MurA protein in L. monocytogenes...
  30. pmc Distinct polymicrobial populations in a chronic foot ulcer with implications for diagnostics and anti-infective therapy
    Can Imirzalioglu
    Institute of Medical Microbiology, Justus Liebig University Giessen, Schubertstrasse 81, D 35392 Giessen, Germany
    BMC Res Notes 7:196. 2014
    ..Here, we utilized denaturing high-performance liquid chromatography (DHPLC) as a diagnostic tool for identifying different bacterial species in complex clinical samples of a patient with a chronic foot ulcer...
  31. pmc Erythema caused by a localised skin infection with Arthrobacter mysorens
    Can Imirzalioglu
    Institute of Medical Microbiology, Justus Liebig University Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    BMC Infect Dis 10:352. 2010
    ..Skin erythemas of unknown origin are a frequent reason for consulting the general practitioner or dermatologist...
  32. pmc GenomeViz: visualizing microbial genomes
    Rohit Ghai
    Institute of Medical Microbiology, Faculty of Medicine, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    BMC Bioinformatics 5:198. 2004
    ..We have developed GenomeViz to enable rapid visualization and subsequent comparisons of several microbial genomes in an interactive environment...
  33. pmc Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application
    Mobarak A Mraheil
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Microb Biotechnol 3:658-76. 2010
    ..Finally, we discuss the use of modified peptide nucleic acids (PNAs) as a novel tool to inactivate potential sRNA and their applications in rapid and specific detection of pathogenic bacteria...
  34. pmc microRNA Response to Listeria monocytogenes Infection in Epithelial Cells
    Benjamin Izar
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, Giessen D 35392, Germany E Mails B I G K M M A M T C
    Int J Mol Sci 13:1173-85. 2012
    ..We provide first evidence that L. monocytogenes infection leads to deregulation of a set of microRNAs with important roles in host response. Distinct microRNA expression depends on both LLO and pathogen localization...
  35. pmc Culture-independent identification of pathogenic bacteria and polymicrobial infections in the genitourinary tract of renal transplant recipients
    Eugen Domann
    Institute of Medical Microbiology, Hospital of the Justus Liebig University Giessen, D 35392 Giessen, Germany
    J Clin Microbiol 41:5500-10. 2003
    ..A detailed understanding of infections found in recipients of renal transplants will guide antibiotic therapy regimens and provide new perspectives for decreasing the risk of graft rejection...
  36. pmc Identification and role of regulatory non-coding RNAs in Listeria monocytogenes
    Benjamin Izar
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, Giessen 35392, Germany E Mails B I M A M
    Int J Mol Sci 12:5070-9. 2011
    ..In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes...
  37. pmc Ultra deep sequencing of Listeria monocytogenes sRNA transcriptome revealed new antisense RNAs
    Sebastian Behrens
    Department für Computational Systems Biology, Universitat Wien, Wien, Austria Institute für Medizinische Mikrobiologie, Justus Liebig Universitat Giessen, Giessen, Germany
    PLoS ONE 9:e83979. 2014
    ..monocytogenes. ..