Christian Hagel

Summary

Affiliation: University Medical Center Hamburg-Eppendorf
Country: Germany

Publications

  1. doi request reprint Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 112:191-7. 2013
  2. doi request reprint Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuropathology 32:611-6. 2012
  3. doi request reprint Hyaluronan in intra-operative edema of NF1-associated neurofibromas
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuropathology 32:406-14. 2012
  4. ncbi request reprint Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model
    Maria Demestre
    Department of Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neurooncol 98:11-9. 2010
  5. ncbi request reprint Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up
    Reinhard E Friedrich
    Department of Oral and Cranio Maxillofacial, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anticancer Res 32:4547-51. 2012
  6. pmc Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors
    Melanie Spyra
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e21099. 2011
  7. doi request reprint Podoplanin and CD34 in peripheral nerve sheath tumours: focus on neurofibromatosis 1-associated atypical neurofibroma
    Urs Naber
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 103:239-45. 2011
  8. ncbi request reprint Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    J Neurooncol 82:187-92. 2007
  9. doi request reprint Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1
    Johannes Salamon
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur J Nucl Med Mol Imaging 40:685-92. 2013
  10. doi request reprint Comparative effectiveness of 18F-FDG PET/CT versus whole-body MRI for detection of malignant peripheral nerve sheath tumors in neurofibromatosis type 1
    Thorsten Derlin
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Nucl Med 38:e19-25. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 112:191-7. 2013
    ..However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable...
  2. doi request reprint Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuropathology 32:611-6. 2012
    ....
  3. doi request reprint Hyaluronan in intra-operative edema of NF1-associated neurofibromas
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuropathology 32:406-14. 2012
    ..Fibroblasts produced less hyaluronan than Schwann cells. The findings support the view that hyaluronan plays an important role in intra-operative swelling in neurofibroma surgery...
  4. ncbi request reprint Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model
    Maria Demestre
    Department of Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neurooncol 98:11-9. 2010
    ..001). We demonstrated that grafting human PNF tumour fragments into nude mice provides an adequate in vivo model for drug testing. Our results provide in vivo and in vitro evidence for efficacy of imatinib mesylate for PNF...
  5. ncbi request reprint Surgery for atypical plexiform neurofibromas of the trunk in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin: a long-term follow-up
    Reinhard E Friedrich
    Department of Oral and Cranio Maxillofacial, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anticancer Res 32:4547-51. 2012
    ..This marker may be useful in distinguishing different Schwann cell populations in NF1...
  6. pmc Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors
    Melanie Spyra
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e21099. 2011
    ..5 × 10(5)). These results provide evidence for the existence of cancer stem cell-like cells in malignant peripheral nerve sheath tumors...
  7. doi request reprint Podoplanin and CD34 in peripheral nerve sheath tumours: focus on neurofibromatosis 1-associated atypical neurofibroma
    Urs Naber
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 103:239-45. 2011
    ..Podoplanin expression in atypical neurofibroma was not associated with tumour progression towards MPNST...
  8. ncbi request reprint Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors
    Christian Hagel
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246, Hamburg, Germany
    J Neurooncol 82:187-92. 2007
    ..Our findings indicate the necessity for a separate grading scheme which takes into account the genetic background in NF1 patients...
  9. doi request reprint Evaluation of intratumoural heterogeneity on ¹⁸F-FDG PET/CT for characterization of peripheral nerve sheath tumours in neurofibromatosis type 1
    Johannes Salamon
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur J Nucl Med Mol Imaging 40:685-92. 2013
    ....
  10. doi request reprint Comparative effectiveness of 18F-FDG PET/CT versus whole-body MRI for detection of malignant peripheral nerve sheath tumors in neurofibromatosis type 1
    Thorsten Derlin
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Nucl Med 38:e19-25. 2013
    ....
  11. doi request reprint Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro
    Wei Jiang
    Laboratory for Tumor Genetics, Department of Neurology, University Medical Center Hamburg Eppendorf, Building O48, 4th Floor, Martinistr 52, 20246, Hamburg, Germany
    J Neurooncol 116:231-6. 2014
    ....
  12. ncbi request reprint B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice
    Jacob Gleiss
    DMD, Building O 10, Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    In Vivo 27:723-7. 2013
    ..Conventionally, these small grafts can only be monitored upon sacrificing the animals. We evaluated ultrasound biomicroscopy for monitoring such grafts in vivo...
  13. doi request reprint Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients
    Anja Harder
    Institute of Neuropathology, University Hospital Munster, Germany
    Am J Surg Pathol 36:702-9. 2012
    ..Our findings suggest that hybrid neurofibroma/schwannoma represents a common tumor type in schwannomatosis and shows a striking association with neurofibromatoses...
  14. ncbi request reprint Vascular endothelial growth factor (VEGF) in sera of oral and oropharyngeal squamous cell carcinoma patients
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1765-6. 2010
    ..VEGF serum levels varied considerably and showed no correlation to tumour size or locoregional spread. The wide variety of VEGF serum levels make this marker difficult to handle for initial diagnostics or monitoring of therapy...
  15. doi request reprint Apoptotic photoreceptor loss and altered expression of lysosomal proteins in the nclf mouse model of neuronal ceroid lipofuscinosis
    Udo Bartsch
    Department of Ophthalmology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Invest Ophthalmol Vis Sci 54:6952-9. 2013
    ..Here, we analyzed the time course of photoreceptor loss and the role of lysosomes in nclf mice, an animal model of the human CLN6 disease...
  16. ncbi request reprint Dysplasia of the orbit and adjacent bone associated with plexiform neurofibroma and ocular disease in 42 NF-1 patients
    Reinhard E Friedrich
    Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1751-64. 2010
    ..Several factors constitute the individual orbital dysplasia, including the growth of the invasive PNF...
  17. ncbi request reprint Immunohistochemical study on an epithelial-myoepithelial intercalated duct carcinoma transplanted to the nude mouse
    Reinhard E Friedrich
    Department Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1565-8. 2010
    ..These findings in EMC transplanted to the nude mouse demonstrate the feasibility of growing EMC in vivo...
  18. pmc Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2
    Victor Felix Mautner
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neuro Oncol 12:14-8. 2010
    ..Bevacizumab therapy may thus provide an effective treatment for progressive vestibular schwannomas in patients with NF2...
  19. pmc Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies
    Michael Preukschas
    Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e43468. 2012
    ..These findings suggest that pharmacological inhibition of eIF-5A may represent a novel concept to treat glioblastomas and may help to substantially improve the clinical course of this tumor entity...
  20. ncbi request reprint Osteochondroma of the mandibular condyle. Report of a case with 5-year follow-up
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 32:4553-6. 2012
    ..The tumour did not express insulin-like growth factor-1 receptor. Five years following the surgical intervention, there has been no local recurrence and dental occlusion was re-established, without further treatment...
  21. ncbi request reprint Appendices of the nipple and areola of the breast in Neurofibromatosis type 1 patients are neurofibromas
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1815-7. 2010
    ..Tumours arising in the areola and nipple area and mimicking an accessory nipple were all neurofibromas. Local excision of neurofibromas was adequate to relief patients from an often unsightly appearance...
  22. doi request reprint Macromolecule content influences proton diffusibility in gliomas
    Einar Goebell
    Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg Eppendorf UKE, Martinistrase 52, 20246 Hamburg, Germany
    Eur Radiol 21:2626-32. 2011
    ..Different compositions of the extra cellular matrix with changing concentrations of more or less hydrophilic components like proteins may have a major influence on the diffusion phenomena found in gliomas...
  23. ncbi request reprint Insulin-like growth factor-1 receptor (IGF-1R) in primary and metastatic undifferentiated carcinoma of the head and neck: a possible target of immunotherapy
    Reinhard E Friedrich
    Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany
    Anticancer Res 30:1641-3. 2010
    ..Targeting IGF-1R is a current topic of cancer research. The aim of this study was to identify IGF-1R in undifferentiated carcinomas of the head and neck...
  24. pmc Secretory meningiomas: a benign subgroup causing life-threatening complications
    Jan Regelsberger
    Departments of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neuro Oncol 11:819-24. 2009
    ..Extended perifocal edema in meningiomas is an unusual finding and should alert the neurosurgeon that surgery may aggravate edema excessively, leading to a life-threatening postoperative situation...
  25. ncbi request reprint Neuronal markers in non-neuronal tissues
    Christian Hagel
    Institute of Neuropathology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, DE 20246 Hamburg, Germany
    Prog Exp Tumor Res 39:64-77. 2007
    ..The large spectrum of neuronal antigens expressed in cancer including voltage-gated ion channels and numerous neurotrophic factors reflects the continuity from neuronal to non-neuronal differentiation...
  26. ncbi request reprint DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis
    Andre O Von Bueren
    Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neurooncol 109:415-23. 2012
    ..Low grade tumors of the pineal region differed from CNS-PNET and pineoblastoma. Due to their high biological and clinical variability, a coordinated prospective validation in future studies is necessary to establish robust risk factors...
  27. doi request reprint Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin
    Maike Ihnen
    Department of Gynaecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Pathol 64:146-52. 2011
    ..Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites...
  28. ncbi request reprint Atypical plexiform neurofibroma in NF1 with high standardised uptake value (SUV) in positron-emission tomography (PET) expressing podoplanin
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    In Vivo 24:871-6. 2010
    ..It appears likely that subtypes of Schwann cells express podoplanin. This marker may be useful in distinguishing different Schwann cell populations in neurofibromas...
  29. doi request reprint Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease
    Diego Sepulveda-Falla
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Brain Pathol 21:452-63. 2011
    ..The presence of pTau in cerebellum in PS1-E280A underscores the relevance of cerebellar involvement in AD and might be correlated to clinical phenotype...
  30. ncbi request reprint Morphometrics of the facial nerve following fractionated external irradiation: an experimental study in rats
    Reinhard E Friedrich
    Department of Maxillofacial Surgery, Eppendorf University Hospital, Hamburg, Germany
    Anticancer Res 30:1625-32. 2010
    ..A total of 54 animals were investigated and 11,193 measurements were obtained. The computer-assisted image analysing system CUE-3 Color Image Analyzer (Olympus, Japan) was used. Facial nerves from untreated animals served as controls...
  31. pmc Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring
    Rudolph Reimer
    Heinrich Pette Institute for Experimental Virology and Immunology at the University of Hamburg, Hamburg, Germany
    PLoS ONE 4:e6084. 2009
    ....
  32. ncbi request reprint Expression of doublecortin in tumours of the central and peripheral nervous system and in human non-neuronal tissues
    Christian Bernreuther
    Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Acta Neuropathol 111:247-54. 2006
    ....
  33. pmc Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis
    Melanie Thelen
    Department of Biochemistry, Children s Hospital, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e35493. 2012
    ..These data suggest that proteasomal degradation of mutant Cln6 is sufficient to prevent the accumulation of misfolded Cln6 protein, whereas lysosomal dysfunction impairs constitutive autophagy promoting neurodegeneration...
  34. ncbi request reprint Prognostic relevance of FDG PET in patients with neurofibromatosis type-1 and malignant peripheral nerve sheath tumours
    Winfried Brenner
    Department of Nuclear Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Eur J Nucl Med Mol Imaging 33:428-32. 2006
    ..Since histopathology and tumour grading are not well correlated with prognosis, we aimed to evaluate the potential of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) for prediction of patient outcome in MPNST...
  35. doi request reprint Hypophysectomy for prostate cancer: a revival of old knowledge?
    Jörg Flitsch
    Pituitary Unit, Department of Neurosurgery, Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Neurosurg 109:760-4. 2008
    ....