C Hafner

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies
    Christian Hafner
    Institute of Pathology, University of Regensburg, Germany
    Int J Cancer 101:1-6. 2002
  2. pmc Activation of the PI3K/AKT pathway in Merkel cell carcinoma
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e31255. 2012
  3. pmc A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
    Carolyn D Hurst
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Res Notes 2:66. 2009
  4. pmc Systemic epidermal nevus with involvement of the oral mucosa due to FGFR3 mutation
    Anette Bygum
    Department of Dermatology and Allergy Centre, Odense University Hospital, 5000 Odense, Denmark
    BMC Med Genet 12:79. 2011
  5. ncbi request reprint Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 19:1369-77. 2006
  6. ncbi request reprint Targeting T cells to hit B cells: successful treatment of cutaneous plasmacytosis with topical pimecrolimus
    Christian Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Germany
    Dermatology 213:163-5. 2006
  7. ncbi request reprint FGFR3 mutations in benign skin tumors
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cell Cycle 5:2723-8. 2006
  8. ncbi request reprint Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 127:1883-5. 2007
  9. ncbi request reprint FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    J Invest Dermatol 127:1572-3. 2007
  10. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007

Detail Information

Publications52

  1. ncbi request reprint Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies
    Christian Hafner
    Institute of Pathology, University of Regensburg, Germany
    Int J Cancer 101:1-6. 2002
    ..Investigation of the entire urothelial lining in patients with urothelial tumors should provide further insight into the development of multifocal urothelial carcinomas...
  2. pmc Activation of the PI3K/AKT pathway in Merkel cell carcinoma
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    PLoS ONE 7:e31255. 2012
    ..This finding together with our observation that the PI3K/AKT pathway is activated in the majority of human MCCs identifies PI3K/AKT as a potential new therapeutic target for MCC patients...
  3. pmc A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
    Carolyn D Hurst
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Res Notes 2:66. 2009
    ..CONCLUSION: The SNaPshot assay described here offers a fast, sensitive, inexpensive and specific approach to the analysis of frequent PIK3CA mutations in both fresh and archival patient samples...
  4. pmc Systemic epidermal nevus with involvement of the oral mucosa due to FGFR3 mutation
    Anette Bygum
    Department of Dermatology and Allergy Centre, Odense University Hospital, 5000 Odense, Denmark
    BMC Med Genet 12:79. 2011
    ..Epidermal nevi (EN) represent benign congenital skin lesions following the lines of Blaschko. They result from genetic mosaicism, and activating FGFR3 and PIK3CA mutations have been implicated...
  5. ncbi request reprint Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 19:1369-77. 2006
    ..EphA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer...
  6. ncbi request reprint Targeting T cells to hit B cells: successful treatment of cutaneous plasmacytosis with topical pimecrolimus
    Christian Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Germany
    Dermatology 213:163-5. 2006
    ..Our report indicates that the therapeutically induced disappearance of the plasma cells was due to indirect T-cell-mediated effects...
  7. ncbi request reprint FGFR3 mutations in benign skin tumors
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cell Cycle 5:2723-8. 2006
    ..Further studies are required to provide insights in the pathogenesis of benign skin tumors caused by FGFR3 mutations. These studies will add to new non-invasive therapeutical strategies for benign acanthotic skin tumors in dermatology...
  8. ncbi request reprint Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 127:1883-5. 2007
    ..Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots...
  9. ncbi request reprint FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    J Invest Dermatol 127:1572-3. 2007
    ..The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3 related tumors in urothelium and skin...
  10. ncbi request reprint FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 20:895-903. 2007
    ..Increased age appears to be a risk factor for these mutations. The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure...
  11. ncbi request reprint PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Hum Pathol 38:1496-500. 2007
    ..The genetic basis of this rare appendageal tumor remains elusive...
  12. ncbi request reprint Gene expression profiling of melanocytes following Q-Switched Ruby laser irradiation
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 216:6-13. 2008
    ..The Q-switched Ruby laser (QSRL) is used for the treatment of pigmented lesions. The influence of QSRL treatment on gene expression of nontransformed primary melanocytes has not been addressed in vitro...
  13. doi request reprint Nevus marginatus: a distinct type of epidermal nevus or merely a variant of nevus sebaceus?
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 216:236-8. 2008
    ..For this peculiar disorder, we propose the term 'nevus marginatus'. So far it is not clear whether nevus marginatus represents a distinct entity or merely an unusual clinical variant of nevus sebaceus...
  14. doi request reprint Somatic FGFR3 and PIK3CA mutations are present in familial seborrhoeic keratoses
    C Hafner
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Br J Dermatol 159:214-7. 2008
    ..We present a German family with at least seven affected members in two generations and occurrence of high numbers of SKs at an unusually young age, suggesting a hereditary background...
  15. doi request reprint Seborrheic keratosis
    Christian Hafner
    Clinic and Polyclinic for Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 6:664-77. 2008
    ..In the last years new molecular genetic insights into seborrheic keratoses have been gained. The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized...
  16. doi request reprint FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo
    C Hafner
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Br J Dermatol 160:546-51. 2009
    ..It has been proposed that SL may subsequently evolve into adenoid seborrhoeic keratosis (SK). However, little is known about the genetic basis of SL. In human SK, FGFR3 and PIK3CA mutations have recently been identified...
  17. doi request reprint Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Dermatology 218:278-81. 2009
    ..The results favour an independent origin of the basal cell carcinoma, although a possible clonal relationship between both lesions cannot be completely excluded on the basis of the molecular genetic findings...
  18. doi request reprint [Scabies]
    C Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Hautarzt 60:145-59, quiz 160-1. 2009
    ..In the following article, the current knowledge about epidemiology, biology, immunology, clinical appearance, diagnostic procedures and therapy of scabies is reviewed...
  19. doi request reprint FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra
    C Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Br J Dermatol 162:508-12. 2010
    ..Stucco keratosis (STK) and dermatosis papulosa nigra (DPN) are referred to as variants of seborrhoeic keratosis. However, the genetic alterations involved in the pathogenesis of these benign tumours are unknown...
  20. doi request reprint FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Cell Res 316:2008-16. 2010
    ..Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo...
  21. doi request reprint Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Exp Dermatol 19:e222-7. 2010
    ..PIK3CA and AKT1 hotspot mutations are obviously not caused by UV light exposure, the main risk factor in non-melanoma skin cancer...
  22. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
    ..The R248C mutation appears to be a hot spot for FGFR3 mutations in epidermal nevi...
  23. ncbi request reprint High frequency of FGFR3 mutations in adenoid seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:2404-7. 2006
    ..The mechanism for the high rate of somatic FGFR3 mutations in these benign skin tumors remains elusive, but UV light exposure may play a potential role, especially in the R248C mutations...
  24. doi request reprint [R248C FGFR3 mutation. Effect on cell growth, apoptosis and attachment in HaCaT keratinocytes]
    C Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg
    Pathologe 31:221-4. 2010
    ..Our results indicate that an increased cell number at confluence along with reduced apoptosis may contribute to the growth of benign acanthotic tumors in the human epidermis...
  25. ncbi request reprint Primary cutaneous cryptococcosis and secondary antigenemia in a patient with long-term corticosteroid therapy
    C Hafner
    Dept of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042, Regensburg, Germany
    Infection 33:86-9. 2005
    ..The clinical and microbiological characteristics of this patient as well as therapeutical and epidemiological aspects of primary cutaneous cryptococcosis (PCC) are discussed...
  26. ncbi request reprint Molecular genetic analysis excludes implantation metastasis of basal cell carcinomas
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Arch Pathol Lab Med 127:1221-4. 2003
    ..3. Molecular genetic analysis clearly demonstrated different genetic alterations of the two BCCs and therefore most likely excludes a mechanism of implantation metastasis...
  27. ncbi request reprint [Hemorrhagic dengue fever after trip to Malaysia]
    C Hafner
    Klinik und Poliklinik für Dermatologie der Universität Regensburg
    Hautarzt 57:705-7. 2006
    ..Patients who have previously had dengue fever and retained non-neutralizing heterotypic antibodies are more likely to develop this complication via the phenomenon of antibody-dependent enhancement...
  28. ncbi request reprint Identification of differentially expressed genes in models of melanoma progression by cDNA array analysis: SPARC, MIF and a novel cathepsin protease characterize aggressive phenotypes
    G Rumpler
    Department of Dermatology, University of Regensburg, Germany
    Exp Dermatol 12:761-71. 2003
    ....
  29. ncbi request reprint Loss of EphB6 expression in metastatic melanoma
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Int J Oncol 23:1553-9. 2003
    ....
  30. ncbi request reprint Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma
    Brigitte Coras
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Arch Dermatol 140:1504-7. 2004
    ..It accounts for 50% of all tumors reported in central African countries. Owing to the rising number of patients and the limitations of current therapies, there is an urgent demand for new strategies to treat KS...
  31. ncbi request reprint [Role of receptor tyrosine kinase in the angiogenesis]
    S Meyer
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Germany
    Hautarzt 53:629-42. 2002
  32. ncbi request reprint Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract
    C Hafner
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Oncogene 20:4910-5. 2001
    ..Intraluminal tumor cell seeding appears to be an important mechanism of multifocal occurrence and recurrence of urothelial carcinomas...
  33. ncbi request reprint Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors
    Thomas Vogt
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Cancer 98:2251-6. 2003
    ....
  34. ncbi request reprint Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting
    Bernd Becker
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 122:361-8. 2004
    ..Expression patterns of marker genes defined in unequivocal histopathologic entities may improve the diagnostic and prognostic assessment of difficult melanocytic lesions, which is still the hardest problem in dermatopathology...
  35. ncbi request reprint Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:565-72. 2005
    ..We conclude that the evaluation of phosphorylated retinoblastoma protein in melanocytic tumors could become a helpful adjunct in clinicopathological routine...
  36. ncbi request reprint Antiproliferative and proapoptotic effects of rapamycin and celecoxib in malignant melanoma cell lines
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Oncol Rep 19:547-53. 2008
    ..Both rapamycin and celecoxib represent promising drugs for the palliative therapy of metastasised malignant melanoma and should be considered for future trials...
  37. ncbi request reprint Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes
    Thomas Vogt
    Department of Dermatology, University of Regensburg, Germany
    Lancet Oncol 7:695-7. 2006
  38. ncbi request reprint Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 18:1249-57. 2005
    ..Since a direct interaction of RBP2-H1 and pRb seems possible, the loss of RBP2-H1 may possibly contribute to uncontrolled growth in malignant melanomas...
  39. ncbi request reprint Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells
    Stefanie Meyer
    Department of Dermatology, University of Regensburg, D 93042 Regensburg, Germany
    Int J Oncol 27:1197-206. 2005
    ..We conclude that ephrin-B2 can act as a major modulator of cell migration and matrix interactions of MM cells, which possibly contributes to the expansion and metastatic spread of MM in vivo...
  40. doi request reprint [Erythema scarlatiniforme desquamativum generalisatum]
    S Singer
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg
    Hautarzt 64:110-3. 2013
    ..This generalized episode may be followed by erythema scarlatiniforme desquamativum localisatum recidivans, which is a recurring variant of the disease, localized to the hands and feet...
  41. doi request reprint FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis
    L Groesser
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Br J Dermatol 166:784-8. 2012
    ..However, the genetic basis of BLK is unknown...
  42. doi request reprint Absence of BRAF and HRAS mutations in eruptive Spitz naevi
    S Gantner
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Br J Dermatol 164:873-7. 2011
    ..Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified...
  43. ncbi request reprint [Mechanisms of epithelial regeneration]
    C Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Germany
    Hautarzt 53:561-74. 2002
  44. ncbi request reprint Targeting the tumor stroma with peroxisome proliferator activated receptor (PPAR) agonists
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Agents Med Chem 9:816-21. 2009
    ..This review will focus on the stroma-mediated anticancer activities of PPAR agonists...
  45. pmc Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:13450-4. 2007
    ..The remarkable genotype-phenotype correlation as observed in this study points to a distinct etiopathogenesis of the mutations in keratinocytes occuring either during fetal development or in adult life...
  46. ncbi request reprint Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines
    Annika Bundscherer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Anticancer Res 30:4017-23. 2010
    ..The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines...
  47. ncbi request reprint Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro
    Christian Hafner
    Department of Dermatology, University of Regensburg, D 93042 Regensburg, Germany
    World J Gastroenterol 11:4024-31. 2005
    ..The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD)...
  48. ncbi request reprint Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Clin Chem 50:490-9. 2004
    ..Their role in healthy adult tissues and in human disease is still largely unknown, although diverse roles in carcinogenesis have been postulated...
  49. ncbi request reprint [Stroma-targeted palliative tumor therapy with biomodulators]
    Christian Hafner
    Klinik und Poliklinik fur Dermatologie, Universitat Regensburg
    J Dtsch Dermatol Ges 4:242-53; quiz 254-5. 2006
    ....
  50. ncbi request reprint Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 11:4511-8. 2005
    ..Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells...
  51. doi request reprint An epidermal nevus syndrome with cerebral involvement caused by a mosaic FGFR3 mutation
    Alejandro García-Vargas
    Instituto Dermatológico de Jalisco Dr José Barba Rubio, Guadalajara, Mexico
    Am J Med Genet A 146:2275-9. 2008
    ..This unusual mosaic phenotype may represent a distinct entity within the group of epidermal nevus syndromes...
  52. ncbi request reprint Lipodermatosclerosis: successful treatment with danazol
    Christian Hafner
    Acta Derm Venereol 85:365-6. 2005