Werner Hacke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Lancet Neurol 8:141-50. 2009
  2. doi request reprint Glycosylated hemoglobin A1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke
    Andrea Rocco
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 44:2134-8. 2013
  3. doi request reprint Baroreflex sensitivity to predict malignant middle cerebral artery infarction
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 43:714-9. 2012
  4. doi request reprint Fast-track intubation for accelerated interventional stroke treatment
    Oliver Herrmann
    Department of Neurology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 17:354-60. 2012
  5. doi request reprint MRI in patients with acute basilar artery occlusion - DWI lesion scoring is an independent predictor of outcome
    Simon Nagel
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 7:282-8. 2012
  6. doi request reprint Intensive care management of acute stroke: surgical treatment
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 5:170-7. 2010
  7. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
  8. doi request reprint Cerebral oxygen transport failure?: decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: STroke: RelevAnt Impact of hemoGlobin, Hematocrit and Transfusion (STRAIGHT)--an observational study
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:2832-7. 2011
  9. ncbi request reprint The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    Werner Hacke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:66-73. 2005
  10. doi request reprint Ultra-early intravenous stroke thrombolysis: do all patients benefit similarly?
    Daniel Strbian
    From the Departments of Neurology and Stroke Units, Helsinki University Central Hospital, Helsinki, Finland D S, T T Department of Neurology, University of Heidelberg, Heidelberg, Germany P R, W H Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland P M, A E Department of Neurology, Universitatsklinikum Erlangen, Erlangen, Germany L B, M K Department of Neurology, Tampere University Hospital, Tampere, Finland J O, H N Department of Neurology, University Lille Nord de France K M, D L Department of Neurology and Stroke Units, University Hospital Basel, Basel, Switzerland D J S, H G, S E Department of Neurology, University of Bern, Bern, Switzerland S J, B W, H P M Department of Neurology, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain V O, A C and Department of Neurology, Kantonsspital St Gallen
    Stroke 44:2913-6. 2013

Detail Information

Publications54

  1. pmc Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Lancet Neurol 8:141-50. 2009
    ....
  2. doi request reprint Glycosylated hemoglobin A1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke
    Andrea Rocco
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 44:2134-8. 2013
    ..Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA1c) on sICH...
  3. doi request reprint Baroreflex sensitivity to predict malignant middle cerebral artery infarction
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 43:714-9. 2012
    ..We aimed to investigate the predictive potential of baroreflex sensitivity (BRS) as a marker of autonomic balance for calculating the course of large middle cerebral artery infarction...
  4. doi request reprint Fast-track intubation for accelerated interventional stroke treatment
    Oliver Herrmann
    Department of Neurology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 17:354-60. 2012
    ..The aim of this study was to identify factors delaying door-to-treatment times, and to evaluate the effect of a fast-track intubation standard operating procedure (I-SOP) on door-to-angiography time...
  5. doi request reprint MRI in patients with acute basilar artery occlusion - DWI lesion scoring is an independent predictor of outcome
    Simon Nagel
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 7:282-8. 2012
    ..We analyzed early diffusion-weighted magnetic resonance imaging of patients with acute basilar artery occlusion by applying different lesion scoring systems and determined their predictive value for favorable outcome...
  6. doi request reprint Intensive care management of acute stroke: surgical treatment
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 5:170-7. 2010
    ..Most recently, hopeful preliminary data have emerged on new approaches in the treatment of intraventricular haemorrhage. In this article, we review the current neurosurgical options in acute ischaemic and haemorrhagic stroke...
  7. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  8. doi request reprint Cerebral oxygen transport failure?: decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: STroke: RelevAnt Impact of hemoGlobin, Hematocrit and Transfusion (STRAIGHT)--an observational study
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:2832-7. 2011
    ..Although conceivably relevant for penumbra oxygenation, the optimal levels of hemoglobin (Hb) and hematocrit (Hct) in patients with acute ischemic stroke are unknown...
  9. ncbi request reprint The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    Werner Hacke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:66-73. 2005
    ....
  10. doi request reprint Ultra-early intravenous stroke thrombolysis: do all patients benefit similarly?
    Daniel Strbian
    From the Departments of Neurology and Stroke Units, Helsinki University Central Hospital, Helsinki, Finland D S, T T Department of Neurology, University of Heidelberg, Heidelberg, Germany P R, W H Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland P M, A E Department of Neurology, Universitatsklinikum Erlangen, Erlangen, Germany L B, M K Department of Neurology, Tampere University Hospital, Tampere, Finland J O, H N Department of Neurology, University Lille Nord de France K M, D L Department of Neurology and Stroke Units, University Hospital Basel, Basel, Switzerland D J S, H G, S E Department of Neurology, University of Bern, Bern, Switzerland S J, B W, H P M Department of Neurology, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain V O, A C and Department of Neurology, Kantonsspital St Gallen
    Stroke 44:2913-6. 2013
    ..We now explored in a large multicenter cohort whether extra benefit of treatment within 90 minutes from symptom onset is uniform across predefined stroke severity subgroups, as compared with later thrombolysis...
  11. ncbi request reprint MRI versus CT-based thrombolysis treatment within and beyond the 3 h time window after stroke onset: a cohort study
    Martin Kohrmann
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Lancet Neurol 5:661-7. 2006
    ..We assessed the safety and efficacy of an MRI-based selection protocol for stroke treatment within and beyond 3 h compared with standard CT-based treatment...
  12. doi request reprint Oral anticoagulants--a frequent challenge for the emergency management of acute ischemic stroke
    Timolaos Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 34:411-8. 2012
    ..The proportion of OAC users among consecutive patients who suffer from acute IS or transient ichemic attacks (TIA) is unknown...
  13. doi request reprint Endovascular stroke therapy: tirofiban is associated with risk of fatal intracerebral hemorrhage and poor outcome
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 44:1453-5. 2013
    ..To investigate the relationship between severe bleeding complications and outcome after mechanical thrombectomy with or without glycoprotein-IIb/IIIa inhibitor tirofiban treatment...
  14. doi request reprint Selection of possible responders to thrombolytic therapy in acute ischemic stroke
    Christian Hametner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Ann N Y Acad Sci 1268:120-6. 2012
    ..This article presents clinical and imaging criteria of selecting patients reasonably, offering causal therapy to a growing number of patients...
  15. ncbi request reprint Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging
    Jochen B Fiebach
    Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 35:502-6. 2004
    ..We hypothesized that stroke MRI is accurate in the detection of ICH. To evaluate our hypotheses, we conducted a prospective multicenter trial...
  16. ncbi request reprint Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra?
    Peter D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 34:1674-9. 2003
    ..We sought to assess the presence and prognostic effect of perihemorrhagic ischemic changes and hypoperfusion in a prospective stroke MRI study...
  17. doi request reprint Point-of-care reversal treatment in phenprocoumon-related intracerebral hemorrhage
    Timolaos Rizos
    Department of Neurology, University Heidelberg, Heidelberg, Germany
    Ann Neurol 67:788-93. 2010
    ..Accuracy and effectiveness of point-of-care INR coagulometers (POCs) for INR reversal in OAC-ICH have not been evaluated...
  18. doi request reprint Stroke-related Early Tracheostomy versus Prolonged Orotracheal Intubation in Neurocritical Care Trial (SETPOINT): a randomized pilot trial
    Julian Bösel
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg D 69121, Germany
    Stroke 44:21-8. 2013
    ..Optimal timing of tracheostomy in ventilated patients with severe stroke is unclear. We aimed to investigate feasibility, safety, and potential advantages of early tracheostomy in these intensive care unit (ICU) patients...
  19. doi request reprint Benefits of early tracheostomy in ventilated stroke patients? Current evidence and study protocol of the randomized pilot trial SETPOINT (Stroke-related Early Tracheostomy vs. Prolonged Orotracheal Intubation in Neurocritical care Trial)
    Julian Bösel
    Department of Neurology, University of Heidelberg, Germany
    Int J Stroke 7:173-82. 2012
    ..It is completely unclear whether ventilated stroke patients might benefit from early tracheostomy, too...
  20. doi request reprint Safety of endovascular treatment of carotid artery stenosis compared with surgical treatment: a meta-analysis
    Peter A Ringleb
    Department of Neurology, University Clinic of the Ruprecht Karls University, Heidelberg, Germany
    J Vasc Surg 47:350-5. 2008
    ..Therefore, it is justified to update these meta-analyses...
  21. doi request reprint Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa(®): effects on cerebral oxygenation, circulation, and pressure
    Julian Bösel
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Intensive Care Med 38:1955-64. 2012
    ..We investigated the effects of isoflurane sedation on cerebral and systemic physiology parameters in neuromonitored ICU stroke patients...
  22. doi request reprint Induction of cooling with a passive head and neck cooling device: effects on brain temperature after stroke
    Sven Poli
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 44:708-13. 2013
    ..We conducted this study to investigate the relationship between surface head/neck cooling and brain temperature...
  23. ncbi request reprint Stroke: advances in therapy
    Peter D Schellinger
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400 Kopfklinik, D 69120 Heidelberg, Germany
    Lancet Neurol 4:2. 2005
  24. doi request reprint Improved prediction of poor outcome after thrombolysis using conservative definitions of symptomatic hemorrhage
    Christoph Gumbinger
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 43:240-2. 2012
    ..Direct comparison of symptomatic intracerebral hemorrhage (sICH) rates among different thrombolysis studies is complicated by the variability of definitions of sICH. The prediction of outcome still remains unclear...
  25. doi request reprint Baroreflex: a new therapeutic target in human stroke?
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:e678-82. 2009
    ....
  26. doi request reprint DESTINY II: DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY II
    Eric Juttler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 6:79-86. 2011
    ..This leads to great uncertainty in everyday clinical practice...
  27. ncbi request reprint Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status
    Peter D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 34:575-83. 2003
    ..It seems reasonable to apply improved selection criteria that allow differentiation between patients with and without a relevant indication for thrombolytic therapy...
  28. ncbi request reprint Prolonged low-dose intravenous thrombolysis in a stroke patient with distal basilar thrombus
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Germany
    Stroke 37:e9-11. 2006
    ..Patients with high-grade basilar artery stenosis secondary to thromboembolism are at high risk of developing subsequent vessel occlusion. Optimal medical management of this condition is unclear...
  29. ncbi request reprint Thrombolysis with alteplase for acute ischemic stroke: review of SITS-MOST and other Phase IV studies
    Sonja Külkens
    Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Expert Rev Neurother 7:783-8. 2007
    ..These findings should encourage wider use of thrombolytic therapies for suitable stroke patients treated in stroke centers...
  30. pmc Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke
    Eric Juttler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Crit Care 11:231. 2007
    ....
  31. ncbi request reprint In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging
    Johann Sellner
    Department of Neurology, Ruprecht Karls University Heidelberg, Germany
    J Neurovirol 10:255-9. 2004
    ..Our findings could further support the use of diffusion-weighted imaging for in vivo monitoring of acute flavivirus encephalitis and for the study of therapeutic approaches...
  32. ncbi request reprint Recommendations for the management of intracranial haemorrhage - part I: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee
    Thorsten Steiner
    Department of Neurology, Ruprecht Karls University Heidelberg Im Neuenheimer Feld 400, DE 69120 Heidelberg, Germany
    Cerebrovasc Dis 22:294-316. 2006
    ..These recommendations are endorsed by the 3 European societies which are represented in the EUSI: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
  33. doi request reprint The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?
    Hans Christoph Diener
    Department of Neurology, University Hospital Essen, Germany
    Int J Stroke 7:139-41. 2012
    ..The new oral anticoagulants substances show similar results in secondary as in primary stroke prevention in patients with AF and will on the long run replace warfarin...
  34. pmc Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
    Francisco Martinez-Torres
    Department of Neurology, University of Heidelberg, Germany
    BMC Neurol 8:40. 2008
    ..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...
  35. doi request reprint Frequency of increased blood pressure levels during systemic thrombolysis and risk of intracerebral hemorrhage
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:1702-6. 2011
    ..We aimed to investigate frequency of pre- and post-treatment elevated BP and its relation to intracerebral hemorrhage (ICH) and symptomatic ICH (sICH), respectively...
  36. ncbi request reprint Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial
    Eric Juttler
    University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Stroke 38:2518-25. 2007
    ..We report here the 30-day mortality and 6- and 12-month functional outcomes from the DESTINY trial...
  37. ncbi request reprint Stenting for carotid artery stenosis
    Rolf Kern
    Universitatsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Nat Clin Pract Neurol 3:212-20. 2007
    ..Two other randomized multicenter trials-ICSS and CREST-are ongoing. With an intended sample size of up to 7,000 patients, future meta-analyses will allow more-accurate treatment recommendations and subgroup analysis...
  38. ncbi request reprint Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events
    Peter A Ringleb
    Department of Neurology, University of Heidelberg Medical School, Heidelberg, Germany
    Stroke 35:528-32. 2004
    ....
  39. ncbi request reprint An update on thrombolytic therapy for acute stroke
    Peter D Schellinger
    Department of Neurology, University Hospital, Heidelberg, Germany
    Curr Opin Neurol 17:69-77. 2004
    ....
  40. doi request reprint Decompressive surgery for severe brain edema
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Intensive Care Med 24:168-78. 2009
    ..Although there is increasing evidence for the efficacy of decompressive surgery in reducing intracranial pressure and even mortality, a critical point remains the definition of good or acceptable outcome...
  41. doi request reprint AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke
    Wolf R Schabitz
    Department of Neurology, University of Munster, Munster, Germany
    Stroke 41:2545-51. 2010
    ..The present phase IIa study assessed safety and tolerability over a broad dose range of G-CSF doses in acute ischemic stroke patients and explored outcome data...
  42. ncbi request reprint Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia
    Peter Reismann
    Department Medicine I, University of Heidelberg, Germany
    J Neurol 251:853-8. 2004
    ..This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia...
  43. ncbi request reprint Continuous stroke unit electrocardiographic monitoring versus 24-hour Holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke
    Timolaos Rizos
    Department of Neurology, University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 43:2689-94. 2012
    ..We compared 24-hour Holter electrocardiography (ECG) with continuous stroke unit ECG monitoring (CEM) for pxAF detection...
  44. doi request reprint Fast point-of-care coagulometer guided reversal of oral anticoagulation at the bedside hastens management of acute subdural hemorrhage
    Timolaos Rizos
    Department of Neurology, University Heidelberg, INF 400, 69120, Heidelberg, Germany
    Neurocrit Care 13:321-5. 2010
    ..Moreover, repeated INR testings in central laboratories (CL) are time consuming. The usefulness of point-of-care INR coagulometers (POC) to test the success of INR reversal in OAC-SDH has not yet been investigated...
  45. ncbi request reprint Intra-arterial thrombolysis is the treatment of choice for basilar thrombosis: pro
    Peter D Schellinger
    Department of Neurology, University of Erlangen, Germany
    Stroke 37:2436-7. 2006
  46. doi request reprint Intrapulmonary right-left shunts in Guillain-Barré syndrome with severe dysautonomia
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 9:374-7. 2008
    ..To our knowledge, increased intrapulmonary shunts in association with GBS have not yet been reported...
  47. ncbi request reprint Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia
    Simone Wagner
    Department of Neurology University of Heidelberg Medical School, INF 400, 69120, Heidelberg, Germany
    Brain Res 984:63-75. 2003
    ..Laminin-5 and MMP presence relate directly to the degree of postischemic injury. Hypothermia reduces the conversion from the I(r) to ischemic core and the degree of BBB as well as MMP abundance...
  48. doi request reprint Relationship between onset-to-door time and door-to-thrombolysis time: a pooled analysis of 10 dedicated stroke centers
    Daniel Strbian
    From the Department of Neurology and Stroke Unit, Helsinki University Central Hospital, Helsinki, Finland D S, M T, T T Department of Neurology and Stroke Unit, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland P M, A E Department of Neurology and Stroke Unit, University of Heidelberg, Heidelberg, Germany P R, C G, W H Department of Neurology and Stroke Unit, Tampere University Hospital, Tampere, Finland H N, A K P Department of Neurology and Stroke Unit, Universitatsklinikum Erlangen, Erlangen, Germany L B, M K Department of Neurology and Stroke Unit, University Lille Nord de France M B, D L Department of Neurology and Stroke Unit, University Hospital Basel, Basel, Switzerland D J S, H G, S T E Department of Neurology and Stroke Unit, University of Bern, Bern, Switzerland S J, B W, H P M Department of Neurology and Stroke Unit, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Tumor Marker Oncology Research Centre
    Stroke 44:2808-13. 2013
    ..Inverse relationship between onset-to-door time (ODT) and door-to-needle time (DNT) in stroke thrombolysis was reported from various registries. We analyzed this relationship and other determinants of DNT in dedicated stroke centers...
  49. ncbi request reprint Surgical decompression of patients with large middle cerebral artery infarcts is effective
    Stefan Schwab
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 34:2304-5. 2003
  50. doi request reprint European Stroke Facilities Survey: the German and Austrian perspective
    E Bernd Ringelstein
    University Hospital Munster, Department of Neurology, Albert Schweitzer Strasse 33, Munster, Germany
    Cerebrovasc Dis 27:138-45. 2009
    ..The aim of this nested analysis was to identify the major components of stroke centers and other facilities actually available for acute stroke patients in hospitals of Germany and Austria...
  51. pmc Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    BMC Med 10:70. 2012
    ..However, the molecular pathways that are affected by the identified genetic variants are not yet pinpointed, and the observed associations apply only for some, but not all victims of a specific stroke aetiology...
  52. ncbi request reprint Treatment of acute ischemic stroke with clot retrieval devices
    Julian Bösel
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120, Heidelberg, Germany
    Curr Treat Options Cardiovasc Med 14:260-72. 2012
    ..This problem urgently needs to be addressed in a prospective randomized fashion and improvements of treatment be recognized and implemented before clot retrieval can be considered an established form of acute stroke treatment...
  53. ncbi request reprint Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis
    Francisco J Martinez-Torres
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurosci Lett 368:274-8. 2004
    ..Increased presence of MMP2 and MMP9 in chronic HSVE may contribute to ongoing damage. Inhibition of MMP2 and MMP9 might be a suitable target for therapeutic intervention...
  54. ncbi request reprint Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset
    Peter Schramm
    Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany
    Stroke 33:2426-32. 2002
    ....