Research Topics
| W HackeSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study InvestigatorsW Hacke
Department of Neurology, University of Heidelberg, Germany
Lancet 352:1245-51. 1998..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...- Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric strokeS Wildermuth
Department of Neurology, University of Heidelberg, Germany
Stroke 29:935-8. 1998..Our purpose was to determine the feasibility of CT angiography (CTA) in patients with acute hemispheric ischemia and to evaluate its relevance for thrombolytic therapy... - Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?C Berger
Department of Neurology, University of Heidelberg, Germany
Stroke 32:1330-5. 2001..The aim of this study was to assess which type of HT independently affects clinical outcome... - Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarctionS Schwab
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 29:2461-6. 1998..BACKGROUND and.. - Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemiaP D Schellinger
Department of Neurology, University of Heidelberg Medical School, Germany
Ann Neurol 49:460-9. 2001..Patients with proximal vessel occlusions have a larger amount of tissue at risk, a lower recanalization rate, and a worse outcome. Urgent recanalization seems to be of utmost importance for these patients... - Early hemicraniectomy in patients with complete middle cerebral artery infarctionS Schwab
Department of Neurology, University of Heidelberg, Germany
Stroke 29:1888-93. 1998..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate... 
Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patientsT Rizos
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Cerebrovasc Dis 32:276-82. 2011..More extensive diagnostic effort is required to detect paroxysmal AF (pxAF) than persistent AF (pAF); the prevalence of pxAF in stroke patients is unknown. We evaluated the prevalence of pAF and pxAF in ischemic stroke and TIA patients...- Intensive care management of acute stroke: general managementJ Diedler
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
Int J Stroke 4:365-78. 2009..In part II of the review, surgical management options for acute stroke will be discussed in detail... - CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemiaT Brandt
Department of Neurology, University of Heidelberg, Germany
Stroke 30:606-12. 1999..The usefulness of CTA for vascular diagnosis in acute basilar artery (BA) ischemia has not yet been studied... - A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhageP D Schellinger
Department of Neurology, Medical Faculty, University of Heidelberg, Germany
Stroke 30:765-8. 1999..The purpose of our study was to determine the diagnostic accuracy of a standardized, multimodal MRI (mMRI) stroke protocol in the qualitative and quantitative assessment of hyperacute ICH (<6 hours)... - Cardiovascular safety of lubeluzole (Prosynap(R)) in patients with ischemic strokeW Hacke
Department of Neurology, University of Heidelberg, Germany
Cerebrovasc Dis 8:247-54. 1998..In doses to 10 mg/day, lubeluzole has a favorable cardiovascular safety profile, as demonstrated by the lack of clinically relevant effects on heart rate, QT, QTc, and QTlc, and it was well tolerated by patients with ischemic stroke... - Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after strokeS Schwarz
Department of Neurology, University of Heidelberg, Germany
Stroke 29:1550-5. 1998..The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP)... - The Virtual International Stroke Trials Archive (VISTA): results and impact on future stroke trials and management of stroke patientsC Weimar
Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
Int J Stroke 5:103-9. 2010..The Virtual International Stroke Trials Archive was established to improve stroke care and trial design through the collation, categorization and potential access to data sets from clinical trials for the treatment of stroke... - Thrombolytic therapy for ischemic stroke--a review. Part I--Intravenous thrombolysisP D Schellinger
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Crit Care Med 29:1812-8. 2001..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients... - Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placeboH C Diener
Department of Neurology, University Essen, Germany
Stroke 31:2543-51. 2000..5 mg followed by a daily intravenous dose of 10 mg lubeluzole for 5 days in acute ischemic stroke patients... - Thrombolytic therapy for ischemic stroke--a review. Part II--Intra-arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imagingP D Schellinger
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Crit Care Med 29:1819-25. 2001..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients... - Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic strokeWerner Hacke
Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
N Engl J Med 359:1317-29. 2008..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke... - Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 - a three-arm randomised-controlled clinical trialT Reiff
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Int J Stroke 4:294-9. 2009..In case of superiority of the interventions, a noninferiority end-point will be tested between carotid artery stenting and carotid endarterectomy. This trial is registered at Current Controlled Trials ISRCTN 78592017... - Association between acute cerebrovascular ischemia and chronic and recurrent infectionA J Grau
Department of Neurology, University of Heidelberg, Germany
Stroke 28:1724-9. 1997..We performed a case-control study to investigate whether chronic or recurrent respiratory, ear-nose-throat (ENT), and dental infections are risk factors for cerebrovascular ischemia... - Multimodal online monitoring in middle cerebral artery territory strokeT Steiner
Department of Neurology, Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany
Stroke 32:2500-6. 2001..Furthermore, the effects of what is considered to be standard antiedema medical treatment are not fully understood. We studied whether multimodal monitoring can help to overcome this problem... - Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarctionE Keller
Department of Neurology, Neurocritical Care Unit, University of Heidelberg, Heidelberg, Germany
Neurosurg Focus 8:e4. 2000..The effect of hypothermia on cerebral hemodynamics is a matter of controversial discussion in literature. Clinical studies have yet to be performed in patients with ischemic stroke after induction of hypothermia... - Bootstrap statistics of ECASS II data: just another post hoc analysis of a negative stroke trial?R Stingele
Department of Neurology, University of Heidelberg, Germany
Cerebrovasc Dis 11:30-3. 2001..RESULTS: If rt-PA does not improve the outcome (null hypothesis), the probability of observing a difference of modified ranking scale equal or larger than the one observed in ECASS II is 0.047. We therefore rejected the null hypothesis... - The Stent-Supported Percutaneous Angioplasty of the Carotid Artery vs. Endarterectomy TrialP A Ringleb
Department of Neurology, Universitatsklinikum Heidelberg, University of Heidelberg, Heidelberg, Germany
Cerebrovasc Dis 18:66-8. 2004..The definitive results of this study cannot be expected before 3-5 years... - Indomethacin for brain edema following strokeS Schwarz
Department of Neurology, University of Heidelberg, Heidelberg
Cerebrovasc Dis 9:248-50. 1999..Continuous infusion of indomethacin was not effective. We conclude that indomethacin may reduce elevated ICP over a short time in patients with ischemic brain edema even after conventional therapy has failed... - Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral arteryT Steiner
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 32:2833-5. 2001..However, during passive rewarming, ICP continuously rises and some patients suffer transtentorial herniation... - Continuous monitoring versus HOLTER ECG for detection of atrial fibrillation in patients with strokeC Gumbinger
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Eur J Neurol 19:253-7. 2012..Furthermore, we investigate how many additional patients with paroxysmal atrial fibrillation can be identified as a result of a longer duration of continuous monitoring... - Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hoursJ Rother
Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
Stroke 33:2438-45. 2002.... - Comparison of CT with diffusion-weighted MRI in patients with hyperacute strokeJ Fiebach
Department of Neuroradiology, University of Heidelberg, Medical School, Germany
Neuroradiology 43:628-32. 2001..70 and that based on CT kappa = 0.39. DWI was much more reliable than CT in the detection of early ischaemic lesions and we believe that it should be used in acute ischaemic stroke before aggressive therapeutic intervention... - Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unitT Steiner
Department of Neurology, University of Heidelberg, Germany
Stroke 28:711-5. 1997..This study was performed to prospectively assess the prognosis of stroke patients who require ventilation in a neurological intensive care unit and to determine factors that may influence outcome... - Effect of propentofylline (HWA 285) on focal ischemia in rats: effect of treatment and posttreatment duration on infarct sizeP Haag
Department of Neurology, University of Heidelberg, Germany
J Neurol Sci 175:52-6. 2000..BACKGROUND AND PUROSEe: in this study we tested the potentially neuroprotective properties of propentofylline in a model of focal ischemia with long-term, repeated treatment... - Fever and infection early after ischemic strokeA J Grau
Department of Neurology, University of Heidelberg, Heidelberg, Germany
J Neurol Sci 171:115-20. 1999..In about half of the infected patients, infection was most probably acquired before stroke. Fever was associated with a more severe neurological deficit on admission... - European Stroke Initiative (EUSI) recommendations for stroke management. The European Stroke Initiative Writing CommitteeW Hacke
Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
Eur J Neurol 7:607-23. 2000..The EUSI plans to review and update the recommendations on a regular basis... - Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE studyRobert Stingele
Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
Lancet Neurol 7:216-22. 2008..Better knowledge of risk factors could improve assignment of patients to these procedures and reduce overall risk. We aimed to assess the risk of stroke or death associated with CEA and CAS in patients with different risk factors... - Microalbuminuria in cerebrovascular disease: a modifiable risk factor?A Rocco
Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
Int J Stroke 5:30-4. 2010..This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion... - Stentprotected angioplasty of symptomatic carotid artery stenoses. The European point of viewPeter A Ringleb
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Int J Stroke 1:94-6. 2006 - Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemiaC Lichy
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Thromb Res 98:29-37. 2000..Polymorphonuclear leukocyte thrombolytic activity may not be increased in acute cerebral ischemia. Miniplasminogen may be an interesting adjunct to plasminogen activators in acute stroke models... - Masking of vertebral artery dissection by severe trauma to the cervical spineP D Schellinger
Department of Neurology, University of Heidelberg, Germany
Spine (Phila Pa 1976) 26:314-9. 2001..A prospective case study was performed... - MRI in acute subarachnoid haemorrhage; findings with a standardised stroke protocolJ B Fiebach
Division of Neuroradiology, Department of Neurology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Germany
Neuroradiology 46:44-8. 2004..Perfusion maps were normal in all cases. MRA and conventional angiography revealed an aneurysm in only one patient. Stroke MRI within 6 h of SAH thus shows a characteristic pattern... - An integrated approach for a knowledge-based clinical workstation: architecture and experienceB Brigl
Department of Medical Informatics, University of Heidelberg, Germany
Methods Inf Med 37:16-25. 1998..We show that, although our approach promotes the integration of decision support into hospital information systems, the success of decision support depends above all on an adequate transformation of clinical needs... - Detection of paroxysmal atrial fibrillation in acute stroke patientsT Rizos
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Cerebrovasc Dis 30:410-7. 2010.... - Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bankA J Grau
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 32:2559-66. 2001..Data on risk factors for etiologic subtypes of ischemic stroke are still scant. The aim of this study was to characterize stroke subtypes regarding risk factor profile, outcome, and current treatment strategies... - Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: useful or harmful?P A Ringleb
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 33:1437-41. 2002.... 
Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]Francisco Martinez-Torres
Department of Neurology, University of Heidelberg, Germany
BMC Neurol 8:40. 2008..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...- Magnetic evoked potentials in neurocritical care patients with acute brainstem lesionsS Schwarz
Department of Neurology, University of Heidelberg, INF 400, Heidelberg, Germany
J Neurol Sci 172:30-7. 2000..We evaluated the clinical and predictive value of MEPs by magnetic transcranial stimulation in intensive care patients with acute brainstem lesions of predominantly vascular origin... - Treatment options for large hemispheric strokeT Steiner
Department of Neurology, Heidelberg University Clinic, Heidelberg, Germany
Neurology 57:S61-8. 2001..Moderate hypothermia (33-36 degrees C) has recently been shown to be effective in severe MCA infarction. Hypothermia induction within 14 hours of ischemic injury and maintained for 72 hours significantly reduced ICP and mortality (44%)...