W Hacke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
  2. ncbi request reprint Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke
    S Wildermuth
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:935-8. 1998
  3. ncbi request reprint Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
  4. ncbi request reprint Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
  5. ncbi request reprint Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    P D Schellinger
    Department of Neurology, University of Heidelberg Medical School, Germany
    Ann Neurol 49:460-9. 2001
  6. ncbi request reprint Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
  7. doi request reprint Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 32:276-82. 2011
  8. ncbi request reprint A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage
    P D Schellinger
    Department of Neurology, Medical Faculty, University of Heidelberg, Germany
    Stroke 30:765-8. 1999
  9. doi request reprint Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
  10. ncbi request reprint CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia
    T Brandt
    Department of Neurology, University of Heidelberg, Germany
    Stroke 30:606-12. 1999

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
    ..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...
  2. ncbi request reprint Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke
    S Wildermuth
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:935-8. 1998
    ..Our purpose was to determine the feasibility of CT angiography (CTA) in patients with acute hemispheric ischemia and to evaluate its relevance for thrombolytic therapy...
  3. ncbi request reprint Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
    ..The aim of this study was to assess which type of HT independently affects clinical outcome...
  4. ncbi request reprint Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
    ..BACKGROUND and..
  5. ncbi request reprint Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    P D Schellinger
    Department of Neurology, University of Heidelberg Medical School, Germany
    Ann Neurol 49:460-9. 2001
    ..Patients with proximal vessel occlusions have a larger amount of tissue at risk, a lower recanalization rate, and a worse outcome. Urgent recanalization seems to be of utmost importance for these patients...
  6. ncbi request reprint Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
    ..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
  7. doi request reprint Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 32:276-82. 2011
    ..More extensive diagnostic effort is required to detect paroxysmal AF (pxAF) than persistent AF (pAF); the prevalence of pxAF in stroke patients is unknown. We evaluated the prevalence of pAF and pxAF in ischemic stroke and TIA patients...
  8. ncbi request reprint A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage
    P D Schellinger
    Department of Neurology, Medical Faculty, University of Heidelberg, Germany
    Stroke 30:765-8. 1999
    ..The purpose of our study was to determine the diagnostic accuracy of a standardized, multimodal MRI (mMRI) stroke protocol in the qualitative and quantitative assessment of hyperacute ICH (<6 hours)...
  9. doi request reprint Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
    ..In part II of the review, surgical management options for acute stroke will be discussed in detail...
  10. ncbi request reprint CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia
    T Brandt
    Department of Neurology, University of Heidelberg, Germany
    Stroke 30:606-12. 1999
    ..The usefulness of CTA for vascular diagnosis in acute basilar artery (BA) ischemia has not yet been studied...
  11. ncbi request reprint Cardiovascular safety of lubeluzole (Prosynap(R)) in patients with ischemic stroke
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Cerebrovasc Dis 8:247-54. 1998
    ..In doses to 10 mg/day, lubeluzole has a favorable cardiovascular safety profile, as demonstrated by the lack of clinically relevant effects on heart rate, QT, QTc, and QTlc, and it was well tolerated by patients with ischemic stroke...
  12. ncbi request reprint Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1550-5. 1998
    ..The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP)...
  13. doi request reprint The Virtual International Stroke Trials Archive (VISTA): results and impact on future stroke trials and management of stroke patients
    C Weimar
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Int J Stroke 5:103-9. 2010
    ..The Virtual International Stroke Trials Archive was established to improve stroke care and trial design through the collation, categorization and potential access to data sets from clinical trials for the treatment of stroke...
  14. ncbi request reprint Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    H C Diener
    Department of Neurology, University Essen, Germany
    Stroke 31:2543-51. 2000
    ..5 mg followed by a daily intravenous dose of 10 mg lubeluzole for 5 days in acute ischemic stroke patients...
  15. ncbi request reprint Thrombolytic therapy for ischemic stroke--a review. Part I--Intravenous thrombolysis
    P D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 29:1812-8. 2001
    ..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients...
  16. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  17. ncbi request reprint Thrombolytic therapy for ischemic stroke--a review. Part II--Intra-arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging
    P D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 29:1819-25. 2001
    ..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients...
  18. ncbi request reprint Multimodal online monitoring in middle cerebral artery territory stroke
    T Steiner
    Department of Neurology, Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2500-6. 2001
    ..Furthermore, the effects of what is considered to be standard antiedema medical treatment are not fully understood. We studied whether multimodal monitoring can help to overcome this problem...
  19. doi request reprint Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 - a three-arm randomised-controlled clinical trial
    T Reiff
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 4:294-9. 2009
    ..In case of superiority of the interventions, a noninferiority end-point will be tested between carotid artery stenting and carotid endarterectomy. This trial is registered at Current Controlled Trials ISRCTN 78592017...
  20. ncbi request reprint Association between acute cerebrovascular ischemia and chronic and recurrent infection
    A J Grau
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:1724-9. 1997
    ..We performed a case-control study to investigate whether chronic or recurrent respiratory, ear-nose-throat (ENT), and dental infections are risk factors for cerebrovascular ischemia...
  21. ncbi request reprint Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarction
    E Keller
    Department of Neurology, Neurocritical Care Unit, University of Heidelberg, Heidelberg, Germany
    Neurosurg Focus 8:e4. 2000
    ..The effect of hypothermia on cerebral hemodynamics is a matter of controversial discussion in literature. Clinical studies have yet to be performed in patients with ischemic stroke after induction of hypothermia...
  22. ncbi request reprint The Stent-Supported Percutaneous Angioplasty of the Carotid Artery vs. Endarterectomy Trial
    P A Ringleb
    Department of Neurology, Universitatsklinikum Heidelberg, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 18:66-8. 2004
    ..The definitive results of this study cannot be expected before 3-5 years...
  23. ncbi request reprint Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery
    T Steiner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2833-5. 2001
    ..However, during passive rewarming, ICP continuously rises and some patients suffer transtentorial herniation...
  24. ncbi request reprint Bootstrap statistics of ECASS II data: just another post hoc analysis of a negative stroke trial?
    R Stingele
    Department of Neurology, University of Heidelberg, Germany
    Cerebrovasc Dis 11:30-3. 2001
    ..By reducing the number of a priori assumptions, the possibilities to modify the test result by adjusting the test procedure are minimized...
  25. ncbi request reprint Indomethacin for brain edema following stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg
    Cerebrovasc Dis 9:248-50. 1999
    ..Continuous infusion of indomethacin was not effective. We conclude that indomethacin may reduce elevated ICP over a short time in patients with ischemic brain edema even after conventional therapy has failed...
  26. doi request reprint Intracerebral hemorrhage during anticoagulation with vitamin K antagonists: a consecutive observational study
    S Horstmann
    Department of Neurology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany
    J Neurol 260:2046-51. 2013
    ..08). One-fourth of all ICH are related to OAC. Initial extension of ICH into the ventricles and primary IVH are more frequent in OAC-ICH. The rate of hematoma expansion in OAC-ICH patients is similar to non-anticoagulated ICH patients. ..
  27. doi request reprint Continuous monitoring versus HOLTER ECG for detection of atrial fibrillation in patients with stroke
    C Gumbinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 19:253-7. 2012
    ..Furthermore, we investigate how many additional patients with paroxysmal atrial fibrillation can be identified as a result of a longer duration of continuous monitoring...
  28. ncbi request reprint Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit
    T Steiner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:711-5. 1997
    ..This study was performed to prospectively assess the prognosis of stroke patients who require ventilation in a neurological intensive care unit and to determine factors that may influence outcome...
  29. ncbi request reprint Fever and infection early after ischemic stroke
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Neurol Sci 171:115-20. 1999
    ..In about half of the infected patients, infection was most probably acquired before stroke. Fever was associated with a more severe neurological deficit on admission...
  30. ncbi request reprint Comparison of CT with diffusion-weighted MRI in patients with hyperacute stroke
    J Fiebach
    Department of Neuroradiology, University of Heidelberg, Medical School, Germany
    Neuroradiology 43:628-32. 2001
    ..70 and that based on CT kappa = 0.39. DWI was much more reliable than CT in the detection of early ischaemic lesions and we believe that it should be used in acute ischaemic stroke before aggressive therapeutic intervention...
  31. ncbi request reprint Effect of propentofylline (HWA 285) on focal ischemia in rats: effect of treatment and posttreatment duration on infarct size
    P Haag
    Department of Neurology, University of Heidelberg, Germany
    J Neurol Sci 175:52-6. 2000
    ..BACKGROUND AND PUROSEe: in this study we tested the potentially neuroprotective properties of propentofylline in a model of focal ischemia with long-term, repeated treatment...
  32. ncbi request reprint Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours
    J Rother
    Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
    Stroke 33:2438-45. 2002
    ....
  33. ncbi request reprint MRI in acute subarachnoid haemorrhage; findings with a standardised stroke protocol
    J B Fiebach
    Division of Neuroradiology, Department of Neurology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Germany
    Neuroradiology 46:44-8. 2004
    ..Perfusion maps were normal in all cases. MRA and conventional angiography revealed an aneurysm in only one patient. Stroke MRI within 6 h of SAH thus shows a characteristic pattern...
  34. ncbi request reprint Masking of vertebral artery dissection by severe trauma to the cervical spine
    P D Schellinger
    Department of Neurology, University of Heidelberg, Germany
    Spine (Phila Pa 1976) 26:314-9. 2001
    ..A prospective case study was performed...
  35. doi request reprint Microalbuminuria in cerebrovascular disease: a modifiable risk factor?
    A Rocco
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Int J Stroke 5:30-4. 2010
    ..This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion...
  36. ncbi request reprint European Stroke Initiative (EUSI) recommendations for stroke management. The European Stroke Initiative Writing Committee
    W Hacke
    Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Eur J Neurol 7:607-23. 2000
    ..The EUSI plans to review and update the recommendations on a regular basis...
  37. doi request reprint Stentprotected angioplasty of symptomatic carotid artery stenoses. The European point of view
    Peter A Ringleb
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Int J Stroke 1:94-6. 2006
  38. ncbi request reprint Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemia
    C Lichy
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Thromb Res 98:29-37. 2000
    ..Polymorphonuclear leukocyte thrombolytic activity may not be increased in acute cerebral ischemia. Miniplasminogen may be an interesting adjunct to plasminogen activators in acute stroke models...
  39. doi request reprint Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study
    Robert Stingele
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Lancet Neurol 7:216-22. 2008
    ..Better knowledge of risk factors could improve assignment of patients to these procedures and reduce overall risk. We aimed to assess the risk of stroke or death associated with CEA and CAS in patients with different risk factors...
  40. ncbi request reprint Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2559-66. 2001
    ..Data on risk factors for etiologic subtypes of ischemic stroke are still scant. The aim of this study was to characterize stroke subtypes regarding risk factor profile, outcome, and current treatment strategies...
  41. ncbi request reprint Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: useful or harmful?
    P A Ringleb
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1437-41. 2002
    ....
  42. pmc Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
    Francisco Martinez-Torres
    Department of Neurology, University of Heidelberg, Germany
    BMC Neurol 8:40. 2008
    ..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...
  43. doi request reprint Detection of paroxysmal atrial fibrillation in acute stroke patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 30:410-7. 2010
    ....
  44. ncbi request reprint An integrated approach for a knowledge-based clinical workstation: architecture and experience
    B Brigl
    Department of Medical Informatics, University of Heidelberg, Germany
    Methods Inf Med 37:16-25. 1998
    ..We show that, although our approach promotes the integration of decision support into hospital information systems, the success of decision support depends above all on an adequate transformation of clinical needs...
  45. ncbi request reprint Magnetic evoked potentials in neurocritical care patients with acute brainstem lesions
    S Schwarz
    Department of Neurology, University of Heidelberg, INF 400, Heidelberg, Germany
    J Neurol Sci 172:30-7. 2000
    ..We evaluated the clinical and predictive value of MEPs by magnetic transcranial stimulation in intensive care patients with acute brainstem lesions of predominantly vascular origin...
  46. ncbi request reprint Treatment options for large hemispheric stroke
    T Steiner
    Department of Neurology, Heidelberg University Clinic, Heidelberg, Germany
    Neurology 57:S61-8. 2001
    ..Moderate hypothermia (33-36 degrees C) has recently been shown to be effective in severe MCA infarction. Hypothermia induction within 14 hours of ischemic injury and maintained for 72 hours significantly reduced ICP and mortality (44%)...