W Hacke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    BMC Med 10:70. 2012
  2. pmc Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke
    Eric Juttler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Crit Care 11:231. 2007
  3. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
  4. ncbi request reprint European Stroke Initiative (EUSI) recommendations for stroke management. The European Stroke Initiative Writing Committee
    W Hacke
    Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Eur J Neurol 7:607-23. 2000
  5. ncbi request reprint Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke
    S Wildermuth
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:935-8. 1998
  6. ncbi request reprint Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
  7. ncbi request reprint Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
  8. ncbi request reprint Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
  9. ncbi request reprint Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    P D Schellinger
    Department of Neurology, University of Heidelberg Medical School, Germany
    Ann Neurol 49:460-9. 2001
  10. pmc Thrombolytic therapy for acute ischaemic stroke in octogenarians: selection by magnetic resonance imaging improves safety but does not improve outcome
    P A Ringleb
    Neurologische Klinik der Ruprecht Karls Universität Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Neurosurg Psychiatry 78:690-3. 2007

Collaborators

Detail Information

Publications98

  1. pmc Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke
    Werner Hacke
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    BMC Med 10:70. 2012
    ..However, the molecular pathways that are affected by the identified genetic variants are not yet pinpointed, and the observed associations apply only for some, but not all victims of a specific stroke aetiology...
  2. pmc Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke
    Eric Juttler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Crit Care 11:231. 2007
    ....
  3. doi request reprint Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    Werner Hacke
    Department of Neurology, Universitat Heidelberg, Heidelberg, Germany
    N Engl J Med 359:1317-29. 2008
    ..We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke...
  4. ncbi request reprint European Stroke Initiative (EUSI) recommendations for stroke management. The European Stroke Initiative Writing Committee
    W Hacke
    Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Eur J Neurol 7:607-23. 2000
    ..The EUSI plans to review and update the recommendations on a regular basis...
  5. ncbi request reprint Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke
    S Wildermuth
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:935-8. 1998
    ..Our purpose was to determine the feasibility of CT angiography (CTA) in patients with acute hemispheric ischemia and to evaluate its relevance for thrombolytic therapy...
  6. ncbi request reprint Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
    ..The aim of this study was to assess which type of HT independently affects clinical outcome...
  7. ncbi request reprint Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
    ..Clinical studies on moderate hypothermia in the treatment of acute ischemic stroke patients are still lacking...
  8. ncbi request reprint Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
    ..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...
  9. ncbi request reprint Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    P D Schellinger
    Department of Neurology, University of Heidelberg Medical School, Germany
    Ann Neurol 49:460-9. 2001
    ..Patients with proximal vessel occlusions have a larger amount of tissue at risk, a lower recanalization rate, and a worse outcome. Urgent recanalization seems to be of utmost importance for these patients...
  10. pmc Thrombolytic therapy for acute ischaemic stroke in octogenarians: selection by magnetic resonance imaging improves safety but does not improve outcome
    P A Ringleb
    Neurologische Klinik der Ruprecht Karls Universität Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Neurosurg Psychiatry 78:690-3. 2007
    ..Owing to the fear of an increased bleeding risk, thrombolytic therapy is withheld from many patients with acute stroke > 80 years of age...
  11. doi request reprint Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
    ..In part II of the review, surgical management options for acute stroke will be discussed in detail...
  12. doi request reprint Intracerebral hemorrhage during anticoagulation with vitamin K antagonists: a consecutive observational study
    S Horstmann
    Department of Neurology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    J Neurol 260:2046-51. 2013
    ..08). One-fourth of all ICH are related to OAC. Initial extension of ICH into the ventricles and primary IVH are more frequent in OAC-ICH. The rate of hematoma expansion in OAC-ICH patients is similar to non-anticoagulated ICH patients...
  13. doi request reprint Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 32:276-82. 2011
    ..More extensive diagnostic effort is required to detect paroxysmal AF (pxAF) than persistent AF (pAF); the prevalence of pxAF in stroke patients is unknown. We evaluated the prevalence of pAF and pxAF in ischemic stroke and TIA patients...
  14. ncbi request reprint Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours
    J Rother
    Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
    Stroke 33:2438-45. 2002
    ....
  15. ncbi request reprint Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
    ..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
  16. ncbi request reprint Association between acute cerebrovascular ischemia and chronic and recurrent infection
    A J Grau
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:1724-9. 1997
    ..We performed a case-control study to investigate whether chronic or recurrent respiratory, ear-nose-throat (ENT), and dental infections are risk factors for cerebrovascular ischemia...
  17. ncbi request reprint CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia
    T Brandt
    Department of Neurology, University of Heidelberg, Germany
    Stroke 30:606-12. 1999
    ..The usefulness of CTA for vascular diagnosis in acute basilar artery (BA) ischemia has not yet been studied...
  18. ncbi request reprint [Cognitive functions after surgery and stenting for extracranial stenosis of the carotid artery]
    C Jansen
    Neurologische Klinik, Klinikum der Ruprecht Karls Universität, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 79:1424, 1426-8, 1430-1. 2008
    ..Both techniques include risks whose effect on neuropsychological abilities remains yet unknown...
  19. ncbi request reprint Cardiovascular safety of lubeluzole (Prosynap(R)) in patients with ischemic stroke
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Cerebrovasc Dis 8:247-54. 1998
    ..In doses to 10 mg/day, lubeluzole has a favorable cardiovascular safety profile, as demonstrated by the lack of clinically relevant effects on heart rate, QT, QTc, and QTlc, and it was well tolerated by patients with ischemic stroke...
  20. ncbi request reprint [Stent and surgery for symptomatic carotid stenosis. SPACE study results]
    P A Ringleb
    Neurologische Universitatsklinik, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 78:1130-7. 2007
    ..Stent-supported angioplasty can be an alternative only in the hands of an experienced interventionalist with proven low periprocedural complication rate...
  21. ncbi request reprint A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage
    P D Schellinger
    Department of Neurology, Medical Faculty, University of Heidelberg, Germany
    Stroke 30:765-8. 1999
    ..The purpose of our study was to determine the diagnostic accuracy of a standardized, multimodal MRI (mMRI) stroke protocol in the qualitative and quantitative assessment of hyperacute ICH (<6 hours)...
  22. ncbi request reprint Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1550-5. 1998
    ..The purpose of this study was to prospectively evaluate a protocol with hypertonic saline hydroxyethyl starch (HS-HES) and mannitol in stroke patients with increased intracranial pressure (ICP)...
  23. ncbi request reprint Comparison of CT with diffusion-weighted MRI in patients with hyperacute stroke
    J Fiebach
    Department of Neuroradiology, University of Heidelberg, Medical School, Germany
    Neuroradiology 43:628-32. 2001
    ..70 and that based on CT kappa = 0.39. DWI was much more reliable than CT in the detection of early ischaemic lesions and we believe that it should be used in acute ischaemic stroke before aggressive therapeutic intervention...
  24. ncbi request reprint Thrombolytic therapy for ischemic stroke--a review. Part I--Intravenous thrombolysis
    P D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 29:1812-8. 2001
    ..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients...
  25. doi request reprint The Virtual International Stroke Trials Archive (VISTA): results and impact on future stroke trials and management of stroke patients
    C Weimar
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Int J Stroke 5:103-9. 2010
    ..The Virtual International Stroke Trials Archive was established to improve stroke care and trial design through the collation, categorization and potential access to data sets from clinical trials for the treatment of stroke...
  26. ncbi request reprint Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    H C Diener
    Department of Neurology, University Essen, Germany
    Stroke 31:2543-51. 2000
    ..5 mg followed by a daily intravenous dose of 10 mg lubeluzole for 5 days in acute ischemic stroke patients...
  27. ncbi request reprint Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarction
    E Keller
    Department of Neurology, Neurocritical Care Unit, University of Heidelberg, Heidelberg, Germany
    Neurosurg Focus 8:e4. 2000
    ..The effect of hypothermia on cerebral hemodynamics is a matter of controversial discussion in literature. Clinical studies have yet to be performed in patients with ischemic stroke after induction of hypothermia...
  28. doi request reprint Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 - a three-arm randomised-controlled clinical trial
    T Reiff
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 4:294-9. 2009
    ..In case of superiority of the interventions, a noninferiority end-point will be tested between carotid artery stenting and carotid endarterectomy. This trial is registered at Current Controlled Trials ISRCTN 78592017...
  29. doi request reprint [Intensive care management [corrected] of patients with intracerebral hemorrhage]
    J Diedler
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 82:431-2, 434-6, 438-46. 2011
    ..Whether improved intensive care can contribute to improved outcome after ICH will be shown by data obtained in the coming years...
  30. ncbi request reprint Multimodal online monitoring in middle cerebral artery territory stroke
    T Steiner
    Department of Neurology, Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2500-6. 2001
    ..Furthermore, the effects of what is considered to be standard antiedema medical treatment are not fully understood. We studied whether multimodal monitoring can help to overcome this problem...
  31. doi request reprint [Ethical and legal aspects of including patients unable to consent in acute therapy studies. Example of a medication study for the treatment of intracerebral hemorrhage--the Heidelberg procedure]
    T Steiner
    Neurologische Klinik, Universitat Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg
    Dtsch Med Wochenschr 133:787-92. 2008
    ..Translation of these prerequisites into practice needs the implementation of special inclusion procedures. These procedures will be explained using the example of the recombinant factor VIIa (rFVIIa) trials for intracerebral hemorrhage...
  32. doi request reprint Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study
    Robert Stingele
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Lancet Neurol 7:216-22. 2008
    ..Better knowledge of risk factors could improve assignment of patients to these procedures and reduce overall risk. We aimed to assess the risk of stroke or death associated with CEA and CAS in patients with different risk factors...
  33. ncbi request reprint Thrombolytic therapy for ischemic stroke--a review. Part II--Intra-arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging
    P D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 29:1819-25. 2001
    ..If applied more widely, thrombolytic therapy may result in profound cost savings in health care and reduction of long-term disability of stroke patients...
  34. doi request reprint Prevalence of atrial fibrillation in intracerebral hemorrhage
    S Horstmann
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 21:570-6. 2014
    ..The aim of this study was to determine the prevalence of AF after acute ICH in a consecutive monocenter cohort, and to document the subsequent management with respect to OAC...
  35. ncbi request reprint The Stent-Supported Percutaneous Angioplasty of the Carotid Artery vs. Endarterectomy Trial
    P A Ringleb
    Department of Neurology, Universitatsklinikum Heidelberg, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 18:66-8. 2004
    ..The definitive results of this study cannot be expected before 3-5 years...
  36. ncbi request reprint Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery
    T Steiner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2833-5. 2001
    ..However, during passive rewarming, ICP continuously rises and some patients suffer transtentorial herniation...
  37. ncbi request reprint MRI in acute subarachnoid haemorrhage; findings with a standardised stroke protocol
    J B Fiebach
    Division of Neuroradiology, Department of Neurology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Germany
    Neuroradiology 46:44-8. 2004
    ..Perfusion maps were normal in all cases. MRA and conventional angiography revealed an aneurysm in only one patient. Stroke MRI within 6 h of SAH thus shows a characteristic pattern...
  38. ncbi request reprint Bootstrap statistics of ECASS II data: just another post hoc analysis of a negative stroke trial?
    R Stingele
    Department of Neurology, University of Heidelberg, Germany
    Cerebrovasc Dis 11:30-3. 2001
    ..By reducing the number of a priori assumptions, the possibilities to modify the test result by adjusting the test procedure are minimized...
  39. ncbi request reprint Indomethacin for brain edema following stroke
    S Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg
    Cerebrovasc Dis 9:248-50. 1999
    ..Continuous infusion of indomethacin was not effective. We conclude that indomethacin may reduce elevated ICP over a short time in patients with ischemic brain edema even after conventional therapy has failed...
  40. ncbi request reprint [Recommendations of the European Stroke Initiative for the management and treatment of stroke]
    W Hacke
    Neurologische Klinik, , Im Neuenheimer Feld 400, 69120 Heidelberg
    Nervenarzt 72:807-19. 2001
    ....
  41. ncbi request reprint Prolonged low-dose thrombolysis in posterior circulation stroke
    C Hametner
    Department of Neurology, Heidelberg University, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 21:114-8. 2014
    ....
  42. doi request reprint Does the cognitive measure Cog-4 show improvement among patients treated with thrombolysis after acute stroke?
    Karim Hajjar
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Int J Stroke 8:652-6. 2013
    ..Items correspond to orientation, executive function, language, and inattention. We investigated responsiveness of Cog-4 to treatment with thrombolysis and whether it offers information that supplements modified Rankin Scale...
  43. doi request reprint Stentprotected angioplasty of symptomatic carotid artery stenoses. The European point of view
    Peter A Ringleb
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Int J Stroke 1:94-6. 2006
  44. doi request reprint Continuous monitoring versus HOLTER ECG for detection of atrial fibrillation in patients with stroke
    C Gumbinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 19:253-7. 2012
    ..Furthermore, we investigate how many additional patients with paroxysmal atrial fibrillation can be identified as a result of a longer duration of continuous monitoring...
  45. doi request reprint [European Stroke Organisation 2008 guidelines for managing acute cerebral infarction or transient ischemic attack. Part 1]
    P Ringleb
    Neurologische Klinik, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 79:936-57. 2008
  46. ncbi request reprint Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit
    T Steiner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:711-5. 1997
    ..This study was performed to prospectively assess the prognosis of stroke patients who require ventilation in a neurological intensive care unit and to determine factors that may influence outcome...
  47. ncbi request reprint [Carotid artery stenosis]
    P A Ringleb
    Neurologische Universitatsklinik, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Chirurg 78:593-4, 596-9. 2007
    ..Thus carotid endarterectomy remains the gold standard in treatment of symptomatic carotid artery stenosis. The frequently performed endovascular treatment of asymptomatic carotid stenosis is not supported by study data...
  48. ncbi request reprint Fever and infection early after ischemic stroke
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Neurol Sci 171:115-20. 1999
    ..In about half of the infected patients, infection was most probably acquired before stroke. Fever was associated with a more severe neurological deficit on admission...
  49. ncbi request reprint Effect of propentofylline (HWA 285) on focal ischemia in rats: effect of treatment and posttreatment duration on infarct size
    P Haag
    Department of Neurology, University of Heidelberg, Germany
    J Neurol Sci 175:52-6. 2000
    ..BACKGROUND AND PUROSEe: in this study we tested the potentially neuroprotective properties of propentofylline in a model of focal ischemia with long-term, repeated treatment...
  50. doi request reprint [Ten years' experience at a major stroke center]
    T Konatschnig
    Neurologische Klinik der Ruprecht Karls Universität Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Nervenarzt 80:166, 168-70, 172-3. 2009
    ..In a retrospective study we report on the changes in this patient population from 1996 to 2006, with special consideration of those suitable for intravenous thrombolysis...
  51. ncbi request reprint [Acute cerebral circulation problems]
    P D Schellinger
    Neurologische Klinik, Universitatsklinikum Heidelberg
    Internist (Berl) 46:982-93. 2005
    ....
  52. doi request reprint [New oral anticoagulants in atrial fibrillation]
    R Veltkamp
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Heidelberg, Deutschland
    Nervenarzt 82:180, 182-4, 186-9. 2011
    ..Currently unresolved issues relate to the verification of patient adherence by suitable coagulation tests and to the emergency coagulation diagnostics and therapy in acute ischemic or hemorrhagic strokes under the new OAC...
  53. ncbi request reprint [Secondary prevention of stroke]
    P Ringleb
    Neurologische Klinik der Ruprecht Karls Universität, Im Neuenheimer Feld 400, 69120 Heidelberg
    Hamostaseologie 26:334-42; quiz 343-4. 2006
    ..A prediction model which allows to identify patients in whom clopidogrel or dipyridamol plus ASA is superior to ASA for the secondary prevention of stroke is presented...
  54. ncbi request reprint Association of cervical artery dissection with recent infection
    A J Grau
    Department of Neurology, University of Heidelberg, Germany
    Arch Neurol 56:851-6. 1999
    ..Cervical artery dissection (CAD) is an important cause of ischemic stroke in younger patients. However, its cause is insufficiently understood...
  55. ncbi request reprint Serial analysis of the apparent diffusion coefficient time course in human stroke
    J B Fiebach
    Department of Neuroradiology, University of Heidelberg, Medical School, Kopfklinik, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neuroradiology 44:294-8. 2002
    ..Furthermore, the age of an ischemia can be determined and multiple strokes can be distinguished from a single progressive stroke...
  56. ncbi request reprint [Value of MRI in intracerebral and subarachnoid hemorrhage]
    P D Schellinger
    Neurologische Klinik, Universitatsklinikums Heidelberg, Kopfklinik, Im Neuenheimer Feld 400, 69120 Heidelberg
    Nervenarzt 72:907-17. 2001
    ..Further interest is focused on perihemorrhagic pathophysiologic processes, which may help to improve therapeutic decision making in patients with ICH...
  57. ncbi request reprint [Thrombolysis in cerebral ischemia. An overview]
    P D Schellinger
    Neurologische Klinik des Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, Kopfklinik, 69120 Heidelberg
    Nervenarzt 72:590-9. 2001
    ....
  58. ncbi request reprint Neuropsychiatric symptoms in active construction painters with chronic solvent exposure
    G Triebig
    Institute and Policlinic of Occupational and Social Medicine of the University Hospital Heidelberg, Germany
    Neurotoxicology 21:791-4. 2000
    ..The predictive value of these symptoms for subsequent neuropsychiatric morbidity remains to be elucidated in a future follow-up study...
  59. pmc Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus
    M Krause
    Department of Neurology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    J Neurol Neurosurg Psychiatry 70:464-70. 2001
    ..The aim of this prospective study is to compare the long term effects of GPi and STN stimulation in patients with severe Parkinson's disease...
  60. ncbi request reprint Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI
    P D Schellinger
    Department of Neuroradiology, University of Heidelberg Medical School, Germany
    Stroke 31:1318-28. 2000
    ..We studied the feasibility of stroke MRI for the initial evaluation and follow-up monitoring of patients undergoing intravenous thrombolysis...
  61. ncbi request reprint [Treatment of acute clinical stroke]
    T Steiner
    Neurologische Klinik der Universität Heidelberg
    Anaesthesist 49:2-8. 2000
    ..Complications of acute stroke comprise changes of blood pressure with hemodynamically relevant effects on cerebral perfusion pressure, acute post- ischemic brain edema, and intracerebral bleedings...
  62. ncbi request reprint Acute central nervous system (CNS) toxicity of total body irradiation (TBI) measured using neuropsychological testing of attention functions
    F Wenz
    Department of Clinical Radiology, University of Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 44:891-4. 1999
    ..The purpose of this study was to investigate acute normal tissue damage of low irradiation doses to the healthy, adult central nervous system (CNS) using neuropsychological testing of attention functions...
  63. ncbi request reprint [Continuous monitoring of patients with extensive strokes. Importance of monitoring on the neurological intensive care unit]
    T Steiner
    Universitatsklinikum Heidelberg, Neurologische Klinik, Im Neuenheimer Feld 400, 69120 Heidelberg
    Nervenarzt 73:501-7. 2002
    ..The following article attempts to explain methods of neurointensive care monitoring and its importance for the treatment of stroke. Furthermore, we describe new developments in patient monitoring...
  64. ncbi request reprint [Current concepts of intensive care of space-occupying middle cerebral artery infarct]
    S Schwarz
    Neurologische Klinik, Universität Mannheim
    Nervenarzt 73:508-18. 2002
    ..Corticoids and hemodilution are obsolete therapies in these patients...
  65. ncbi request reprint [Spectrum of neurological symptoms in dissections of brain-supplying arteries]
    M Bertram
    Neuroradiologische Klinik, Ruprecht Karls Universitat Heidelberg
    Dtsch Med Wochenschr 124:273-8. 1999
    ..This study was undertaken to demonstrate the incidence, severity and sequelae of this condition, important in both routine general and hospital practice, with particular emphasis on early signs and diagnosis...
  66. ncbi request reprint [Evaluation of stent-protected angioplasty for theray of symptomatic stenoses of the carotid artery. SPACE and other randomized trials]
    P Ringleb
    Koordinationszentrum der SPACE Studie, Neurologische Universitatsklinik, Neurologischen Klinik der Ruprect Karls Universität, Heidelberg
    Nervenarzt 74:482-8. 2003
    ..Three to 5 years are needed until these trials' final results will be published. Until then, stent-protected angioplasty should be done only under the consideration that it has not been scientifically evaluated...
  67. ncbi request reprint An integrated approach for a knowledge-based clinical workstation: architecture and experience
    B Brigl
    Department of Medical Informatics, University of Heidelberg, Germany
    Methods Inf Med 37:16-25. 1998
    ..We show that, although our approach promotes the integration of decision support into hospital information systems, the success of decision support depends above all on an adequate transformation of clinical needs...
  68. doi request reprint [Therapeutic options in malignant cerebral venous and sinus thrombosis]
    S Schönenberger
    Neurologische Klinik, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
    Nervenarzt 85:205-10. 2014
    ..Based on five cases of severe CVST treatment options will be presented...
  69. doi request reprint [Thrombolytic treatment of acute stroke]
    H Amiri
    Neurologische Klinik, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Internist (Berl) 52:1310, 1312-6. 2011
    ..Acute basilar artery occlusion should be treated in specialized centres using intra-arterial application of urokinase, rt-PA or mechanical recanalization but intravenous thrombolysis beyond the 3 h window is an acceptable alternative...
  70. doi request reprint Microalbuminuria in cerebrovascular disease: a modifiable risk factor?
    A Rocco
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Int J Stroke 5:30-4. 2010
    ..This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion...
  71. ncbi request reprint Treatment options for large hemispheric stroke
    T Steiner
    Department of Neurology, Heidelberg University Clinic, Heidelberg, Germany
    Neurology 57:S61-8. 2001
    ..Moderate hypothermia (33-36 degrees C) has recently been shown to be effective in severe MCA infarction. Hypothermia induction within 14 hours of ischemic injury and maintained for 72 hours significantly reduced ICP and mortality (44%)...
  72. ncbi request reprint Thrombolytic properties of leukocytes from peripheral blood in healthy subjects and in patients with acute cerebral ischemia
    C Lichy
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Thromb Res 98:29-37. 2000
    ..Polymorphonuclear leukocyte thrombolytic activity may not be increased in acute cerebral ischemia. Miniplasminogen may be an interesting adjunct to plasminogen activators in acute stroke models...
  73. ncbi request reprint CT and diffusion-weighted MR imaging in randomized order: diffusion-weighted imaging results in higher accuracy and lower interrater variability in the diagnosis of hyperacute ischemic stroke
    J B Fiebach
    Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany
    Stroke 33:2206-10. 2002
    ..The value of this method as a routine procedure is still being discussed. In previous studies, CT was always performed before DWI. Therefore, infarct progression could be a reason for the better result in DWI...
  74. ncbi request reprint Masking of vertebral artery dissection by severe trauma to the cervical spine
    P D Schellinger
    Department of Neurology, University of Heidelberg, Germany
    Spine (Phila Pa 1976) 26:314-9. 2001
    ..A prospective case study was performed...
  75. doi request reprint [Clinical course of cerebral sinus venous thrombosis. Data from a monocentric cohort study over 15 years]
    C Geisbüsch
    Neurologische Klinik, Universitat Heidelberg, INF 400, 69120, Heidelberg, Deutschland
    Nervenarzt 85:211-20. 2014
    ..In a monocentric retrospective cohort study the clinical characteristics, risk factors, radiological findings as well as course and prognosis of patients over the past 15 years were examined...
  76. doi request reprint Stent retriever technology: concept, application and initial results
    S Rohde
    Department of Neuroradiology, University of Heidelberg Medical Centre, Heidelberg, Germany
    J Neurointerv Surg 4:455-8. 2012
    ..This article reviews the concept and technical aspects of this new technique of endovascular stroke treatment and summarizes the first clinical results...
  77. pmc Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
    Francisco Martinez-Torres
    Department of Neurology, University of Heidelberg, Germany
    BMC Neurol 8:40. 2008
    ..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...
  78. doi request reprint Detection of paroxysmal atrial fibrillation in acute stroke patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 30:410-7. 2010
    ....
  79. ncbi request reprint Magnetic evoked potentials in neurocritical care patients with acute brainstem lesions
    S Schwarz
    Department of Neurology, University of Heidelberg, INF 400, Heidelberg, Germany
    J Neurol Sci 172:30-7. 2000
    ..We evaluated the clinical and predictive value of MEPs by magnetic transcranial stimulation in intensive care patients with acute brainstem lesions of predominantly vascular origin...
  80. ncbi request reprint Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: useful or harmful?
    P A Ringleb
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1437-41. 2002
    ....
  81. ncbi request reprint Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank
    A J Grau
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2559-66. 2001
    ..Data on risk factors for etiologic subtypes of ischemic stroke are still scant. The aim of this study was to characterize stroke subtypes regarding risk factor profile, outcome, and current treatment strategies...
  82. doi request reprint A consecutive and prospective stroke database covers the state of Baden-Wuerttemberg with 10.8 million inhabitants in Germany
    C Gumbinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Neuroepidemiology 41:161-8. 2013
    ..In 1998 Baden-Wuerttemberg (BW), a federal state in southwest Germany with 10.8 million inhabitants, implemented a structured medical concept for the treatment of acute stroke...
  83. ncbi request reprint [Stroke]
    W Hacke
    Neurologische Klinik, Universitat Heidelberg, Im Neuenheimer Feld 40, 69120, Heidelberg
    Nervenarzt 78:1123. 2007
  84. ncbi request reprint Herpes simplex virus encephalitis: cranial magnetic resonance imaging and neuropathology in a mouse model
    U Meyding-Lamade
    Department of Neurology, INF 400 Kopfklinik, Heidelberg, Germany
    Neurosci Lett 248:13-6. 1998
    ..Extent and severity of structural abnormalities increased at 6 months. MRI offers a new in vivo approach for the detection of structural changes in the disease course of experimental herpes simplex virus encephalitis...
  85. ncbi request reprint Transcranial oximetry using fast near infrared spectroscopy can detect failure of collateral blood supply in humans
    R Stingele
    Department of Neurology, Ruprecht Karls University, Heidelberg, Germany
    Comp Biochem Physiol A Mol Integr Physiol 134:539-43. 2003
    ..81+/-0.028, which was significantly different from all other groups (P<0.05, one way-ANOVA). We conclude, that transcranial pulse oximetry can detect local hypoxia if collateral blood supply fails...
  86. ncbi request reprint Systemic reperfusion therapy in acute ischemic stroke
    P Martinez-Sanchez
    Stroke Unit, Department of Neurology, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Spain
    Cerebrovasc Dis 24:143-52. 2007
    ..Recombinant tissue plasminogen activator (t-PA) is the only drug approved for systemic reperfusion in acute ischemic stroke. However, the use of intravenous t-PA is currently limited by its narrow therapeutic window...
  87. ncbi request reprint [How did the results of ECASS II influence clinical practice of treatment of acute stroke]
    W Hacke
    Ruprecht Karls Universitat, Heidelberg, Alemania
    Rev Neurol 29:638-41. 1999
    ....
  88. ncbi request reprint 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial
    P A Ringleb
    Lancet 368:1239-47. 2006
    ..Since equivalence or superiority has not been convincingly shown for either treatment, we aimed to compare the two...
  89. ncbi request reprint [Indications for treating stenoses of the carotid artery]
    P Ringleb
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg
    Chirurg 75:653-7. 2004
    ..Despite this lack of evidence, the method is used in many centers as an alternative to surgery. Especially symptomatic carotid artery stenosis should be used mainly in the setting of a randomized trial such as SPACE...
  90. ncbi request reprint The Carotid Surgery for Ischemic Stroke trial: a prospective observational study on carotid endarterectomy in the early period after ischemic stroke
    H H Eckstein
    Clinic for Vascular and Endovascular Surgery, Klinikum Ludwigsburg, Teaching Hospital of the University of Heidelberg, Germany
    J Vasc Surg 36:997-1004. 2002
    ..Endpoints were the perioperative stroke or mortality rate and the incidence rate of cerebral bleedings...
  91. doi request reprint Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials
    Inke R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Stroke 39:1821-6. 2008
    ..Herein we demonstrate the applicability of our models in an independent sample of patients from controlled clinical trials...
  92. ncbi request reprint Tolerability of NXY-059 at higher target concentrations in patients with acute stroke
    K R Lees
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK
    Stroke 34:482-7. 2003
    ....
  93. ncbi request reprint [Recommendations of the European Stroke Initiative for the diagnosis and treatment of spontaneous intracerebral haemorrhage]
    S Kulkens
    Neurologische Universitätsklinik Heidelberg für das Executive und Writing Komitee der EUSI, Heidelberg
    Nervenarzt 77:970-87. 2006
    ....
  94. ncbi request reprint [Prophylaxis of stroke]
    W Hacke
    Neurologische Klinik, Universitat Heidelberg
    Praxis (Bern 1994) 94:1171-3. 2005
  95. ncbi request reprint [Telemedicine in acute stroke care: current status and developments]
    H J Audebert
    Department of Elderly Care, Guy s and St Thomas Hospital NHS Trust, London
    Dtsch Med Wochenschr 132:431-6. 2007
  96. ncbi request reprint Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery
    D L Bhatt
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 103:363-8. 2001
    ..CONCLUSION:Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding...
  97. ncbi request reprint [Certified education in neurology. New expertise in innovative and controversial areas]
    M G Hennerici
    Nervenarzt 77:S1. 2006
  98. ncbi request reprint Anticoagulation: the present and future
    H Van Aken
    , , Germany
    Clin Appl Thromb Hemost 7:195-204. 2001
    ..Oral DTIs, such as ximelagatran, are set to provide a further breakthrough in the prophylaxis and treatment of thrombosis...