Daniel Habermehl

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Evaluation of different fiducial markers for image-guided radiotherapy and particle therapy
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Radiat Res 54:i61-8. 2013
  2. pmc Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 8:59. 2013
  3. doi Early treatment response of a rare papillary tumor of the pineal region after primary proton-beam therapy using the raster-scanning technique at HIT
    Daniel Habermehl
    Department of Radiooncology, University Hospital of Heidelberg, Heidelberg, Germany
    Tumori 98:122e-125e. 2012
  4. pmc Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:27. 2013
  5. ncbi Chemoradiation in patients with unresectable extrahepatic and hilar cholangiocarcinoma or at high risk for disease recurrence after resection : Analysis of treatment efficacy and failure in patients receiving postoperative or primary chemoradiation
    D Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Germany
    Strahlenther Onkol 188:795-801. 2012
  6. pmc Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer
    Daniel Habermehl
    Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:28. 2012
  7. doi Defining the role of palliative radiotherapy in bone metastasis from primary liver cancer: an analysis of survival and treatment efficacy
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Tumori 97:609-13. 2011
  8. ncbi Carbon ion irradiation inhibits glioma cell migration through downregulation of integrin expression
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 83:394-9. 2012
  9. doi Assessment of early toxicity and response in patients treated with proton and carbon ion therapy at the Heidelberg ion therapy center using the raster scanning technique
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 81:e793-801. 2011
  10. pmc Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:533. 2010

Detail Information

Publications40

  1. pmc Evaluation of different fiducial markers for image-guided radiotherapy and particle therapy
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Radiat Res 54:i61-8. 2013
    ..However, a careful choice of marker, depending on the tumor localization and irradiation strategy, will need to be made. ..
  2. pmc Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 8:59. 2013
    ..Furthermore, carbon ions have an increased relative biological effectiveness (RBE) compared to photons...
  3. doi Early treatment response of a rare papillary tumor of the pineal region after primary proton-beam therapy using the raster-scanning technique at HIT
    Daniel Habermehl
    Department of Radiooncology, University Hospital of Heidelberg, Heidelberg, Germany
    Tumori 98:122e-125e. 2012
    ..We present a patient with a papillary tumor of the pineal region who was treated with highly conformal proton-beam therapy at the Heidelberg Ion Therapy Center (HIT) using the raster-scanning technique...
  4. pmc Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:27. 2013
    ..In the present retrospective analysis we analysed the therapeutic outcome of a set of patients, who were treated with chemoradiation (CRT) for recurrent pancreatic cancer (RPC) in a single institution...
  5. ncbi Chemoradiation in patients with unresectable extrahepatic and hilar cholangiocarcinoma or at high risk for disease recurrence after resection : Analysis of treatment efficacy and failure in patients receiving postoperative or primary chemoradiation
    D Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Germany
    Strahlenther Onkol 188:795-801. 2012
    ....
  6. pmc Neoadjuvant chemoradiation with Gemcitabine for locally advanced pancreatic cancer
    Daniel Habermehl
    Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:28. 2012
    ..To evaluate efficacy and secondary resectability in patients with locally advanced pancreatic cancer (LAPC) treated with neoadjuvant chemoradiotherapy (CRT)...
  7. doi Defining the role of palliative radiotherapy in bone metastasis from primary liver cancer: an analysis of survival and treatment efficacy
    Daniel Habermehl
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Tumori 97:609-13. 2011
    ..Palliative radiotherapy is the treatment of choice in symptomatic bone lesions and is usually performed as percutaneous fractionated radiotherapy...
  8. ncbi Carbon ion irradiation inhibits glioma cell migration through downregulation of integrin expression
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 83:394-9. 2012
    ..To investigate the effect of carbon ion irradiation on glioma cell migration...
  9. doi Assessment of early toxicity and response in patients treated with proton and carbon ion therapy at the Heidelberg ion therapy center using the raster scanning technique
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 81:e793-801. 2011
    ..PUROPOSE: To asses early toxicity and response in 118 patients treated with scanned ion beams to validate the safety of intensity-controlled raster scanning at the Heidelberg Ion Therapy Center...
  10. pmc Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:533. 2010
    ..First Japanese Data on the evaluation of carbon ion radiation therapy for the treatment of primary high-grade gliomas showed promising results in a small and heterogeneous patient collective...
  11. pmc Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): early treatment results and study concepts
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:41. 2012
    ..This study was set up in order to investigate toxicity and response after proton and carbon ion therapy for gliomas and meningiomas...
  12. pmc Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 13:419. 2013
    ..16 and 2.46 depending on the pancreatic cancer cell line as well as the endpoint analyzed. Japanese Data on the evaluation of carbon ion radiation therapy showed promising results for patients with pancreatic cancer...
  13. pmc In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines
    Rami A El Shafie
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Radiat Res 54:i113-9. 2013
    ....
  14. pmc Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:478. 2010
    ..Protons, however, offer an RBE which is comparable to photons. First Japanese Data on the evaluation of carbon ion radiation therapy showed promising results in a small and heterogeneous patient collective...
  15. pmc Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: the PROMETHEUS-01 trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 11:67. 2011
    ..Japanese Data on the evaluation of carbon ion radiation therapy showed promising results for patients with HCC...
  16. pmc Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:615. 2010
    ..First data obtained within the Phase I/II trial performed at GSI in Darmstadt on carbon ion radiotherapy for patients with high-risk meningiomas has shown safety, and treatment results are promising...
  17. doi Skull base meningiomas: Long-term results and patient self-reported outcome in 507 patients treated with fractionated stereotactic radiotherapy (FSRT) or intensity modulated radiotherapy (IMRT)
    Stephanie E Combs
    University Hospital of Heidelberg, Germany
    Radiother Oncol 106:186-91. 2013
    ..To evaluate long-term outcome of high-precision photon radiotherapy in 507 patients with skull base meningiomas...
  18. pmc Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Germany
    BMC Cancer 12:133. 2012
    ..The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy...
  19. doi Prospective evaluation of early treatment outcome in patients with meningiomas treated with particle therapy based on target volume definition with MRI and 68Ga-DOTATOC-PET
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Acta Oncol 52:514-20. 2013
    ..To evaluate early treatment results and toxicity in patients with meningiomas treated with particle therapy...
  20. pmc Long term toxicity and prognostic factors of radiation therapy for secreting and non-secreting pituitary adenomas
    Stefan Rieken
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 8:18. 2013
    ..This study was initiated to investigate long-term toxicity, treatment outcome and prognostic factors after radiotherapy (RT) in patients with pituitary adenomas...
  21. pmc In vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:9. 2012
    ..To evaluate the cytotoxic effect of carbon ion radiotherapy and chemotherapy in glioblastoma cells in vitro...
  22. doi Proton and carbon ion radiotherapy for primary brain tumors and tumors of the skull base
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Acta Oncol 52:1504-9. 2013
    ..To analyze clinical concepts, toxicity and treatment outcome in patients with brain and skull base tumors treated with photons and particle therapy...
  23. pmc Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells
    Stefan Rieken
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Radiat Oncol 6:132. 2011
    ..This study was set up to describe mechanisms underlying increased glioma cell migration through photon irradiation and to analyse the modifiability of photon-altered glioma cell motility by integrin inhibition...
  24. ncbi Prognostic Impact of CA 19-9 on Outcome after Neoadjuvant Chemoradiation in Patients with Locally Advanced Pancreatic Cancer
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 21:2801-7. 2014
    ..To asses the impact of CA 19-9 and weight loss/gain on outcome after neoadjuvant chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC)...
  25. pmc Analysis of inter- and intrafraction accuracy of a commercial thermoplastic mask system used for image-guided particle radiation therapy
    Dante Amelio
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    J Radiat Res 54:i69-76. 2013
    ..The magnitude of intrafraction displacements correlates with the time for short treatment sessions or during the early phase of long treatment delivery...
  26. doi Hearing preservation after radiotherapy for vestibular schwannomas is comparable to hearing deterioration in healthy adults and is accompanied by local tumor control and a highly preserved quality of life (QOL) as patients' self-reported outcome
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Radiother Oncol 106:175-80. 2013
    ..To evaluate long-term results and patients' self-reported outcome of high-precision photon radiotherapy for the treatment of patients with vestibular schwannoma (VS)...
  27. pmc Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:130. 2012
    ..To retrospectively access outcome and toxicity of whole brain radiotherapy (WBRT) in patients with multiple brain metastases (BM) from malignant melanoma (MM)...
  28. doi Outcome and prognostic factors of radiation therapy for medulloblastoma
    Stefan Rieken
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 81:e7-e13. 2011
    ..To investigate treatment outcome and prognostic factors after radiation therapy in patients with medulloblastomas (MB)...
  29. ncbi Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, 69120 Heidelberg, Germany
    Acta Oncol 49:1132-40. 2010
    ..In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications...
  30. pmc Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial
    Stephanie E Combs
    Deparment of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    BMC Cancer 12:137. 2012
    ..Moreover, these patients are likely to benefit from the enhanced biological efficacy of carbon ions...
  31. doi Long-term outcome after radiotherapy in patients with atypical and malignant meningiomas--clinical results in 85 patients treated in a single institution leading to optimized guidelines for early radiation therapy
    Sebastian Adeberg
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 83:859-64. 2012
    ..In the present work, we analyzed our long-term experience in radiotherapy for atypical and malignant meningioma diagnosed according to the most recent WHO categorization system...
  32. doi Analysis of FET-PET imaging for target volume definition in patients with gliomas treated with conformal radiotherapy
    Stefan Rieken
    University Hospital of Heidelberg, Department of Radiation Oncology, Germany Electronic address
    Radiother Oncol 109:487-92. 2013
    ....
  33. pmc Development and validation of automatic tools for interactive recurrence analysis in radiation therapy: optimization of treatment algorithms for locally advanced pancreatic cancer
    Kerstin A Kessel
    Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 8:138. 2013
    ..With the example of 9 patients with locally advanced pancreatic cancer we developed and validated interactive analysis tools to support the evaluation workflow...
  34. doi Clinical response and tumor control based on long-term follow-up and patient-reported outcomes in patients with chemodectomas of the skull base and head and neck region treated with highly conformal radiation therapy
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Head Neck 36:22-7. 2014
    ..The purpose of this study was to evaluate long-term outcome after radiation therapy (RT) for skull base or head-and-neck chemodectomas...
  35. pmc Connection of European particle therapy centers and generation of a common particle database system within the European ULICE-framework
    Kerstin A Kessel
    Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 7:115. 2012
    ....
  36. pmc Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas
    Katsura Kosaki
    Department of Radiology, Nagoya City University Hospital, Nagoya, Japan
    Radiat Oncol 7:44. 2012
    ..To examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry...
  37. pmc Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial
    Harald Rief
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 14:67. 2014
    ..Secondary endpoints were local control, pain response and survival...
  38. pmc Palliative radiation therapy in patients with metastasized pancreatic cancer - description of a rare patient group
    Daniel Habermehl
    Department of Radiation Oncology, Klinikum rechts der Isar, TU Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur J Med Res 19:24. 2014
    ....
  39. doi [Radiotherapy of soft tissue sarcoma--part of a multidisciplinary strategy]
    Hildegard Pape
    Department of Radiooncology, University of Dusseldorf, and Marien Hospital Düsseldorf, Germany
    Wien Klin Wochenschr 120:723-31. 2008
    ..Recent studies have underlined the efficiency of modern radiotherapy regimens. The different radiotherapy regimens will be highlighted against the background of tumor stage and tumor resectibility...