Christian Haass

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie I, Hermann A, et al. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. EMBO Rep. 2016;17:1314-25 pubmed publisher
    ..Thus, reduced hnRNPA3 expression in C9orf72 cases leads to increased levels of the repeat RNA as well as enhanced production and deposition of DPR proteins and RNA foci. ..
  2. Suárez Calvet M, Araque Caballero M, Kleinberger G, Bateman R, Fagan A, Morris J, et al. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Sci Transl Med. 2016;8:369ra178 pubmed
    ..We propose that microglial activation occurs several years before the expected symptom onset, but after amyloidosis and neuronal injury have already occurred. ..
  3. Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, et al. Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. 2017;36:583-603 pubmed publisher
    ..This novel ex vivo model provides a valuable system for identification, screening, and testing of compounds aimed to therapeutically reinforce microglial phagocytosis. ..
  4. Falcon C, Monté Rubio G, Grau Rivera O, Suarez Calvet M, Sanchez Valle R, Rami L, et al. CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals. Neuroimage Clin. 2019;23:101801 pubmed publisher
  5. Haass C, Willem M. Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?. Neuron. 2019;101:557-559 pubmed publisher
    ..In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a. ..
  6. Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, et al. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 2019;22:191-204 pubmed publisher
    ..These findings suggest that in the absence of functional Trem2, early amyloidogenesis is accelerated due to reduced phagocytic clearance of amyloid seeds despite reduced plaque-associated ApoE. ..
  7. Suarez Calvet M, Morenas Rodríguez E, Kleinberger G, Schlepckow K, Araque Caballero M, Franzmeier N, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Mol Neurodegener. 2019;14:1 pubmed publisher
    ..While tau-related neurodegeneration is associated with an increase in CSF sTREM2, Aβ pathology in the absence of downstream tau-related neurodegeneration is associated with a decrease in CSF sTREM2. ..
  8. Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
    ..The present study uncovers early and selective lysosomal dysfunctions in Grn knockout microglia/macrophages. Dysregulated lysosomal homeostasis in microglia might trigger compensatory lysosomal changes in other brain cells. ..
  9. Xiang X, Piers T, Wefers B, Zhu K, Mallach A, Brunner B, et al. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Mol Neurodegener. 2018;13:49 pubmed publisher
    ..Currently described phenotypes of Trem2 R47H knock-in mice can therefore not be translated to humans. ..

More Information

Publications16

  1. Capell A, Fellerer K, Haass C. Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression. J Biol Chem. 2014;289:25879-89 pubmed publisher
    ..In parallel the 5' UTR also affects mRNA stability; thus two independent mechanisms determine GRN expression via mRNA stability and translational efficiency. ..
  2. Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, et al. Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases. J Biol Chem. 2016;291:318-33 pubmed publisher
    ..Thus, NRG1 type III is the first protein substrate that is not only cleaved by multiple sheddases but is also processed by three different I-CLiPs. ..
  3. Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, et al. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Mol Med. 2016;8:992-1004 pubmed publisher
    ..Titration experiments revealed that reduced efficacy of amyloid plaque clearance by Trem2 knockout cells can be compensated by elevating the concentration of therapeutic antibodies. ..
  4. Suárez Calvet M, Neumann M, Arzberger T, Abou Ajram C, Funk E, Hartmann H, et al. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathol. 2016;131:587-604 pubmed publisher
    ..Our findings therefore provide additional evidence that FTLD-FUS and ALS-FUS are caused by distinct disease mechanisms although both share FUS deposits as a common denominator. ..
  5. Kleinberger G, Brendel M, Mracskó É, Wefers B, Groeneweg L, Xiang X, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017;36:1837-1853 pubmed publisher
    ..Thus, we demonstrate that a TREM2 loss-of-function mutation causes brain-wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism. ..
  6. Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler S, Steiner H, et al. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med. 2017;9:1356-1365 pubmed publisher
    ..Therefore, two seemingly opposite cellular effects of TREM2 variants, namely reduced versus enhanced shedding, result in similar phenotypic outcomes by reducing cell surface TREM2. ..
  7. Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, et al. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep. 2017;18:1186-1198 pubmed publisher
    ..The apparent lack of chemotactic stimulation upon depletion of TREM2 is consistent with a stable expression profile of genes characterizing the homoeostatic signature of microglia. ..