Carola A Haas

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy
    Carola A Haas
    Institute of Anatomy, Department of Neurosurgery, University of Freiburg, D 79001 Freiburg, Germany
    J Neurosci 22:5797-802. 2002
  2. doi Exogenous reelin prevents granule cell dispersion in experimental epilepsy
    Martin C Muller
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 216:390-7. 2009
  3. doi Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy
    Ute Haussler
    Experimental Epilepsy Research, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
    Cereb Cortex 22:26-36. 2012
  4. doi Reelin deficiency causes granule cell dispersion in epilepsy
    Carola A Haas
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Exp Brain Res 200:141-9. 2010
  5. ncbi Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients
    Alexander Fahrner
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 203:320-32. 2007
  6. ncbi Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus
    Christophe Heinrich
    Experimental Epilepsy Group, University of Freiburg, D 79106 Freiburg, Germany
    J Neurosci 26:4701-13. 2006
  7. doi Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated action
    Claus M Gross
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Freiburg, Germany
    Hippocampus 22:409-20. 2012
  8. doi Proper layering is important for precisely timed activation of hippocampal mossy cells
    Janina Kowalski
    Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    Cereb Cortex 20:2043-54. 2010
  9. doi Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus
    Mirjam Sibbe
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Eur J Neurosci 36:3643-52. 2012
  10. doi Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy
    Florian Volz
    Department of Neurosurgery, University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Epilepsia 52:1579-89. 2011

Collaborators

Detail Information

Publications25

  1. ncbi Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy
    Carola A Haas
    Institute of Anatomy, Department of Neurosurgery, University of Freiburg, D 79001 Freiburg, Germany
    J Neurosci 22:5797-802. 2002
    ..These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy...
  2. doi Exogenous reelin prevents granule cell dispersion in experimental epilepsy
    Martin C Muller
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 216:390-7. 2009
    ..Our findings highlight the crucial role of reelin for the maintenance of granule cell lamination in the dentate gyrus of adult mice and show that a reelin deficiency is causally involved in GCD development...
  3. doi Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy
    Ute Haussler
    Experimental Epilepsy Research, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
    Cereb Cortex 22:26-36. 2012
    ..In conclusion, SE stimulates neurogenesis in a position-dependent manner and coincidence of neurogenesis and stronger EA distal to the injection site suggests a proepileptogenic effect of increased neurogenesis...
  4. doi Reelin deficiency causes granule cell dispersion in epilepsy
    Carola A Haas
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Exp Brain Res 200:141-9. 2010
    ..In summary, these studies show that in epilepsy reelin dysfunction causes GCD development and that reelin is important for the maintenance of layered structures in the adult brain...
  5. ncbi Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients
    Alexander Fahrner
    Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    Exp Neurol 203:320-32. 2007
    ....
  6. ncbi Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus
    Christophe Heinrich
    Experimental Epilepsy Group, University of Freiburg, D 79106 Freiburg, Germany
    J Neurosci 26:4701-13. 2006
    ..These results show that GCD does not result from increased neurogenesis but reflects a displacement of mature granule cells, most likely caused by a local reelin deficiency...
  7. doi Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated action
    Claus M Gross
    Experimental Epilepsy Research, Neurocenter, University of Freiburg, Freiburg, Germany
    Hippocampus 22:409-20. 2012
    ..Taken together, these results show a sex-specific regulation of reelin gene expression by early life experience, most likely mediated by corticosterone...
  8. doi Proper layering is important for precisely timed activation of hippocampal mossy cells
    Janina Kowalski
    Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
    Cereb Cortex 20:2043-54. 2010
    ..Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing...
  9. doi Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus
    Mirjam Sibbe
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Eur J Neurosci 36:3643-52. 2012
    ..Furthermore, Sox2-positive cells as well as stem cell proliferation were reduced, thus pointing to a disruption of the stem cell niche in epilepsy under the present experimental conditions...
  10. doi Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy
    Florian Volz
    Department of Neurosurgery, University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Epilepsia 52:1579-89. 2011
    ..The aim of this study was to quantify mossy cell loss in two animal models of temporal lobe epilepsy, and determine whether there exists a relationship between mossy cell loss, mossy fiber sprouting, and granule cell dispersion...
  11. doi Increased leak conductance in dentate gyrus granule cells of temporal lobe epilepsy patients with Ammon's horn sclerosis
    Michael Stegen
    Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
    Epilepsia 50:646-53. 2009
    ..Granule cells survive AHS and have been proposed to be hyperexcitable in TLE. Here we studied whether the passive excitability of granule cells correlates with the severity of AHS...
  12. doi CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy
    Matthias Bechstein
    Experimental Epilepsy Research, Department of Neurosurgery, University of Freiburg, Freiburg, Germany
    Exp Neurol 236:141-50. 2012
    ....
  13. doi Role of Reelin in the development and maintenance of cortical lamination
    Michael Frotscher
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Neural Transm 116:1451-5. 2009
    ..Our results indicate that Reelin-induced stabilization of the neuronal cytoskeleton is an important component of Reelin's function in the development and maintenance of cortical architecture...
  14. ncbi Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold
    Michael Frotscher
    Anatomisches Institut, Universitat Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
    Cereb Cortex 13:634-40. 2003
    ..These findings show that the Reelin signaling pathway is essential for the correct positioning of human hippocampal neurons and that a Reelin deficiency is involved in the pathological changes associated with epilepsy...
  15. doi Altered θ coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy
    Ulrich P Froriep
    Bernstein Center Freiburg, University of Freiburg, Freiburg, Germany
    Epilepsia 53:1937-47. 2012
    ..We hypothesized that the interaction of subnetworks of the entorhinal-hippocampal loop between epileptic events should show significant signatures of these pathologic changes...
  16. doi GABA(A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?
    Michela Mantovani
    Section of Clinical Neuropharmacology, Department of Neurosurgery, University Hospital Freiburg, Breisacherstrasse 64, 79106 Freiburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:45-58. 2009
    ..We conclude that HFS in human brain neocortex leads to a specific increase of GABA release, which is mediated by facilitatory GABA(A) autoreceptors located on soma, dendrites, and axon terminals of GABAergic neurons...
  17. ncbi Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus
    Akos Kulik
    Department of Anatomy and Cell Biology, University of Freiburg, 79104 Freiburg, Germany
    J Neurosci 23:11026-35. 2003
    ....
  18. doi TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy
    Stefanie Tinnes
    Experimental Epilepsy Research, Department of Neurosurgery, University of Freiburg, Freiburg, Germany
    FASEB J 27:2542-52. 2013
    ..In summary, we present evidence that epileptic conditions inhibit MMP activity by up-regulation of endogenous TIMP-1, which in turn leads to extracellular accumulation of uncleaved and inactive Reelin and thereby to GCD...
  19. ncbi Neuronal hyperactivity induces astrocytic expression of neurocan in the adult rat hippocampus
    Stephan W Schwarzacher
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Glia 53:704-14. 2006
    ..In conclusion, our data indicate that synaptic activity regulates the astrocytic expression of neurocan in a graded manner...
  20. ncbi Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons
    Thomas Deller
    Department of Clinical Neuroanatomy, JW Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 453:33-44. 2002
    ..The intracellular sorting process, however, is independent of positional cues...
  21. ncbi Lesion-induced axonal sprouting in the central nervous system
    Thomas Deller
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goether University, Frankfurt am Main, Germany
    Adv Exp Med Biol 557:101-21. 2006
    ..Finally, we discuss both the beneficial as well as disadvantageous functional implications of axonal sprouting for the injured organism in question...
  22. ncbi Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus
    Carlos Bas Orth
    Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Comp Neurol 487:227-39. 2005
    ..We conclude, that this organelle is distributed in a region- and layer-specific manner in the mouse hippocampus and suggest that differences in the activity of afferent fiber systems could determine its distribution...
  23. ncbi Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice
    Guido J Burbach
    Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt, Germany
    J Neurosci 24:2421-30. 2004
    ..Taken together, our data demonstrate a plaque-associated upregulation of BDNF in APP23 transgenic mice and implicate this neurotrophin in the regulation of inflammatory and axonal growth processes in the plaque vicinity...
  24. ncbi A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity
    Thomas Deller
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Ann Anat 189:5-16. 2007
    ..Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity...
  25. ncbi Postnatal development of synaptopodin expression in the rodent hippocampus
    Kathrin Czarnecki
    Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 490:133-44. 2005
    ..However, no immunolabeling for synaptopodin was observed in identified interneurons, confirming that the protein is mainly present in spine-bearing principal cells...