Research Topics
| Carola A HaasSummaryAffiliation: University of Freiburg Country: Germany Publications
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Detail Information
Publications
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsyCarola A Haas
Institute of Anatomy, Department of Neurosurgery, University of Freiburg, D 79001 Freiburg, Germany
J Neurosci 22:5797-802. 2002..These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy...
Exogenous reelin prevents granule cell dispersion in experimental epilepsyMartin C Muller
Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
Exp Neurol 216:390-7. 2009..Our findings highlight the crucial role of reelin for the maintenance of granule cell lamination in the dentate gyrus of adult mice and show that a reelin deficiency is causally involved in GCD development...- Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsyUte Haussler
Experimental Epilepsy Research, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Cereb Cortex 22:26-36. 2012..In conclusion, SE stimulates neurogenesis in a position-dependent manner and coincidence of neurogenesis and stronger EA distal to the injection site suggests a proepileptogenic effect of increased neurogenesis... - Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patientsAlexander Fahrner
Experimental Epilepsy Group, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
Exp Neurol 203:320-32. 2007.... - Reelin deficiency causes granule cell dispersion in epilepsyCarola A Haas
Experimental Epilepsy Research, Neurocenter, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
Exp Brain Res 200:141-9. 2010..In summary, these studies show that in epilepsy reelin dysfunction causes GCD development and that reelin is important for the maintenance of layered structures in the adult brain... - Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampusChristophe Heinrich
Experimental Epilepsy Group, University of Freiburg, D 79106 Freiburg, Germany
J Neurosci 26:4701-13. 2006..These results show that GCD does not result from increased neurogenesis but reflects a displacement of mature granule cells, most likely caused by a local reelin deficiency... - Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated actionClaus M Gross
Experimental Epilepsy Research, Neurocenter, University of Freiburg, Freiburg, Germany
Hippocampus 22:409-20. 2012..Taken together, these results show a sex-specific regulation of reelin gene expression by early life experience, most likely mediated by corticosterone... - Proper layering is important for precisely timed activation of hippocampal mossy cellsJanina Kowalski
Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, D 79104 Freiburg, Germany
Cereb Cortex 20:2043-54. 2010..Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing... - Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsyFlorian Volz
Department of Neurosurgery, University Medical Center, Albert Ludwigs University, Freiburg, Germany
Epilepsia 52:1579-89. 2011..The aim of this study was to quantify mossy cell loss in two animal models of temporal lobe epilepsy, and determine whether there exists a relationship between mossy cell loss, mossy fiber sprouting, and granule cell dispersion... - Increased leak conductance in dentate gyrus granule cells of temporal lobe epilepsy patients with Ammon's horn sclerosisMichael Stegen
Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
Epilepsia 50:646-53. 2009..Granule cells survive AHS and have been proposed to be hyperexcitable in TLE. Here we studied whether the passive excitability of granule cells correlates with the severity of AHS... - CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsyMatthias Bechstein
Experimental Epilepsy Research, Department of Neurosurgery, University of Freiburg, Freiburg, Germany
Exp Neurol 236:141-50. 2012.... - Role of Reelin in the development and maintenance of cortical laminationMichael Frotscher
Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
J Neural Transm 116:1451-5. 2009..Our results indicate that Reelin-induced stabilization of the neuronal cytoskeleton is an important component of Reelin's function in the development and maintenance of cortical architecture... - Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffoldMichael Frotscher
Anatomisches Institut, Universitat Freiburg, Albertstrasse 17, D 79104 Freiburg, Germany
Cereb Cortex 13:634-40. 2003..These findings show that the Reelin signaling pathway is essential for the correct positioning of human hippocampal neurons and that a Reelin deficiency is involved in the pathological changes associated with epilepsy... - Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsyUlrich P Froriep
Bernstein Center Freiburg, University of Freiburg, Freiburg, Germany
Epilepsia 53:1937-47. 2012..We hypothesized that the interaction of subnetworks of the entorhinal-hippocampal loop between epileptic events should show significant signatures of these pathologic changes... - Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrusMirjam Sibbe
Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
Eur J Neurosci 36:3643-52. 2012..Furthermore, Sox2-positive cells as well as stem cell proliferation were reduced, thus pointing to a disruption of the stem cell niche in epilepsy under the present experimental conditions... - GABA(A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?Michela Mantovani
Section of Clinical Neuropharmacology, Department of Neurosurgery, University Hospital Freiburg, Breisacherstrasse 64, 79106 Freiburg, Germany
Naunyn Schmiedebergs Arch Pharmacol 380:45-58. 2009..We conclude that HFS in human brain neocortex leads to a specific increase of GABA release, which is mediated by facilitatory GABA(A) autoreceptors located on soma, dendrites, and axon terminals of GABAergic neurons... - Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampusAkos Kulik
Department of Anatomy and Cell Biology, University of Freiburg, 79104 Freiburg, Germany
J Neurosci 23:11026-35. 2003.... - Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neuronsThomas Deller
Department of Clinical Neuroanatomy, JW Goethe University, D 60590 Frankfurt Main, Germany
J Comp Neurol 453:33-44. 2002..The intracellular sorting process, however, is independent of positional cues... - Neuronal hyperactivity induces astrocytic expression of neurocan in the adult rat hippocampusStephan W Schwarzacher
Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Glia 53:704-14. 2006..In conclusion, our data indicate that synaptic activity regulates the astrocytic expression of neurocan in a graded manner... - Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampusCarlos Bas Orth
Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
J Comp Neurol 487:227-39. 2005..We conclude, that this organelle is distributed in a region- and layer-specific manner in the mouse hippocampus and suggest that differences in the activity of afferent fiber systems could determine its distribution... - Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic miceGuido J Burbach
Institute of Clinical Neuroanatomy, J. W. Goethe University, D-60590 Frankfurt, Germany
J Neurosci 24:2421-30. 2004..Taken together, our data demonstrate a plaque-associated upregulation of BDNF in APP23 transgenic mice and implicate this neurotrophin in the regulation of inflammatory and axonal growth processes in the plaque vicinity... - Lesion-induced axonal sprouting in the central nervous systemThomas Deller
Institute of Clinical Neuroanatomy, Johann Wolfgang Goether-University, Frankfurt am Main, Germany
Adv Exp Med Biol 557:101-21. 2006..Finally, we discuss both the beneficial as well as disadvantageous functional implications of axonal sprouting for the injured organism in question... - A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticityThomas Deller
Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Ann Anat 189:5-16. 2007..Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity... - Postnatal development of synaptopodin expression in the rodent hippocampusKathrin Czarnecki
Institute of Anatomy and Cell Biology, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
J Comp Neurol 490:133-44. 2005..However, no immunolabeling for synaptopodin was observed in identified interneurons, confirming that the protein is mainly present in spine-bearing principal cells...