Affiliation: University of Heidelberg
- The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predictedBeate Grziwa
Center for Molecular Biology Heidelberg, University of Heidelberg, INF 282, D 69120 Heidelberg, Germany
J Biol Chem 278:6803-8. 2003..Moreover, the center of the TMD is positioned at the gamma-cleavage site at residue 42. Our data are consistent with a model in which gamma-secretase is a membrane protein that cleaves at the center of the membrane...