Oliver J Gruss

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc The mechanism of spindle assembly: functions of Ran and its target TPX2
    Oliver J Gruss
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany
    J Cell Biol 166:949-55. 2004
  2. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
  3. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
  4. pmc Importin alpha-regulated nucleation of microtubules by TPX2
    Christoph A Schatz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 22:2060-70. 2003
  5. ncbi request reprint The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
    Martin Hetzer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:E177-84. 2002
  6. pmc Human TPX2 is required for targeting Aurora-A kinase to the spindle
    Thomas A Kufer
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Cell Biol 158:617-23. 2002
  7. doi request reprint EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase
    Justus Tegha-Dunghu
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Cell Sci 121:1718-26. 2008
  8. pmc A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes
    Julien Dumont
    UMR7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, 75005 Paris, France
    J Cell Biol 176:295-305. 2007
  9. pmc Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex
    Sebastian Petri
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 179:451-65. 2007

Collaborators

Detail Information

Publications9

  1. pmc The mechanism of spindle assembly: functions of Ran and its target TPX2
    Oliver J Gruss
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany
    J Cell Biol 166:949-55. 2004
    ..We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division...
  2. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
    ..Our results indicate that Cdk11 is responsible for RanGTP-dependent MT stabilization around chromosomes and that this local stabilization is essential for normal rates of spindle assembly and spindle function...
  3. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
    ..This indicates that chromosome-induced microtubule production is a general requirement for the formation of functional spindles in animal cells...
  4. pmc Importin alpha-regulated nucleation of microtubules by TPX2
    Christoph A Schatz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 22:2060-70. 2003
    ..The data suggest that the critical early function in spindle formation regulated by importin alpha is TPX2-mediated microtubule nucleation...
  5. ncbi request reprint The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
    Martin Hetzer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:E177-84. 2002
    ..Ran functions in these events as a signal for chromosome position...
  6. pmc Human TPX2 is required for targeting Aurora-A kinase to the spindle
    Thomas A Kufer
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Cell Biol 158:617-23. 2002
    ..We propose that human TPX2 is required for targeting Aurora-A kinase to the spindle apparatus. In turn, Aurora-A might regulate the function of TPX2 during spindle assembly...
  7. doi request reprint EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase
    Justus Tegha-Dunghu
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Cell Sci 121:1718-26. 2008
    ..Our proteomic identification screen combined with sensitive phenotypic analysis therefore provides a reliable platform for the identification and characterisation of proteins important for correct cell division...
  8. pmc A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes
    Julien Dumont
    UMR7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, 75005 Paris, France
    J Cell Biol 176:295-305. 2007
    ..These findings suggest that a mechanism common to vertebrates promotes meiosis I spindle formation in the absence of chromatin-induced microtubule production and centriole-based microtubule organizing centers...
  9. pmc Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex
    Sebastian Petri
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 179:451-65. 2007
    ..Our data suggest that an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex...