Oliver J Gruss

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex
    Sebastian Petri
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 179:451-65. 2007
  2. pmc The centriolar satellite protein SSX2IP promotes centrosome maturation
    Felix Bärenz
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    J Cell Biol 202:81-95. 2013
  3. pmc The mechanism of spindle assembly: functions of Ran and its target TPX2
    Oliver J Gruss
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany
    J Cell Biol 166:949-55. 2004
  4. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
  5. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
  6. pmc CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation
    Simone Reber
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Deutsches Krebsforschungszentrum und Zentrum für Molekulare Biologie Heidelberg Allianz DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    J Cell Biol 183:1007-17. 2008
  7. pmc The Prp19 complex directly functions in mitotic spindle assembly
    Jennifer C Hofmann
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e74851. 2013
  8. doi request reprint EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase
    Justus Tegha-Dunghu
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Cell Sci 121:1718-26. 2008
  9. pmc The function of spliceosome components in open mitosis
    Jennifer C Hofmann
    DKFZ ZMBH Alliance, ZMBH, Im Neuenheimer Feld, Heidelberg, Germany
    Nucleus 1:447-59. 2010
  10. doi request reprint Centriolar satellites: busy orbits around the centrosome
    Felix Bärenz
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Eur J Cell Biol 90:983-9. 2011

Collaborators

Detail Information

Publications17

  1. pmc Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex
    Sebastian Petri
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 179:451-65. 2007
    ..Our data suggest that an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex...
  2. pmc The centriolar satellite protein SSX2IP promotes centrosome maturation
    Felix Bärenz
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    J Cell Biol 202:81-95. 2013
    ..It preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells. ..
  3. pmc The mechanism of spindle assembly: functions of Ran and its target TPX2
    Oliver J Gruss
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany
    J Cell Biol 166:949-55. 2004
    ..We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division...
  4. pmc Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
    Hideki Yokoyama
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    J Cell Biol 180:867-75. 2008
    ..Our results indicate that Cdk11 is responsible for RanGTP-dependent MT stabilization around chromosomes and that this local stabilization is essential for normal rates of spindle assembly and spindle function...
  5. ncbi request reprint Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
    Oliver J Gruss
    EMBL, Meyerhofstrasse 1, 69 117 Heidelberg, Germany
    Nat Cell Biol 4:871-9. 2002
    ..This indicates that chromosome-induced microtubule production is a general requirement for the formation of functional spindles in animal cells...
  6. pmc CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation
    Simone Reber
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Deutsches Krebsforschungszentrum und Zentrum für Molekulare Biologie Heidelberg Allianz DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    J Cell Biol 183:1007-17. 2008
    ..Therefore, our data demonstrate that CaMKII turns on parallel pathways to activate the APC/C and to induce microtubule depolymerization at meiotic anaphase onset...
  7. pmc The Prp19 complex directly functions in mitotic spindle assembly
    Jennifer C Hofmann
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 8:e74851. 2013
    ..Our data identify the Prp19 complex as the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase. ..
  8. doi request reprint EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase
    Justus Tegha-Dunghu
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Cell Sci 121:1718-26. 2008
    ..Our proteomic identification screen combined with sensitive phenotypic analysis therefore provides a reliable platform for the identification and characterisation of proteins important for correct cell division...
  9. pmc The function of spliceosome components in open mitosis
    Jennifer C Hofmann
    DKFZ ZMBH Alliance, ZMBH, Im Neuenheimer Feld, Heidelberg, Germany
    Nucleus 1:447-59. 2010
    ..In this review, we survey published data supporting an indirect function of splicing in open mitosis or arguing for a direct function of spliceosomal proteins in cell division...
  10. doi request reprint Centriolar satellites: busy orbits around the centrosome
    Felix Bärenz
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Eur J Cell Biol 90:983-9. 2011
    ..In this review, we summarize current knowledge about the structure, molecular composition and possible roles of the satellites that seem to surround the core of the centrosome in most animal cells...
  11. pmc Importin alpha-regulated nucleation of microtubules by TPX2
    Christoph A Schatz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 22:2060-70. 2003
    ..The data suggest that the critical early function in spindle formation regulated by importin alpha is TPX2-mediated microtubule nucleation...
  12. pmc The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
    Maren Klinger
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany Molecular Biology of Centrosomes and Cilia Group, Deutsches Krebsforschungszentrum Zentrum für Molekulare Biologie der Universität Heidelberg Alliance, 69120 Heidelberg, Germany
    Mol Biol Cell 25:495-507. 2014
    ..Our data establish SSX2IP as a novel targeting factor for ciliary membrane proteins cooperating with Cep290, the BBSome, and Rab8. ..
  13. ncbi request reprint The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation
    Hideki Yokoyama
    1 Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany 2 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Commun 5:3270. 2014
    ..Its cell cycle-dependent binding to chromatin or microtubules discriminates MEL-28 functions in interphase and mitosis, and ensures that spindle assembly occurs only after NPC breakdown. ..
  14. ncbi request reprint Phosphoregulation of the human SMN complex
    Alma Husedzinovic
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany Electronic address
    Eur J Cell Biol 93:106-17. 2014
    ..Our data suggest complex regulatory cues mediated by phosphorylation of serine/threonine and tyrosine residues, which control the subcellular localization of the SMN complex and its accumulation in nuclear CB. ..
  15. ncbi request reprint The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
    Martin Hetzer
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:E177-84. 2002
    ..Ran functions in these events as a signal for chromosome position...
  16. pmc Human TPX2 is required for targeting Aurora-A kinase to the spindle
    Thomas A Kufer
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Cell Biol 158:617-23. 2002
    ..We propose that human TPX2 is required for targeting Aurora-A kinase to the spindle apparatus. In turn, Aurora-A might regulate the function of TPX2 during spindle assembly...
  17. pmc A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes
    Julien Dumont
    UMR7622, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, 75005 Paris, France
    J Cell Biol 176:295-305. 2007
    ..These findings suggest that a mechanism common to vertebrates promotes meiosis I spindle formation in the absence of chromatin-induced microtubule production and centriole-based microtubule organizing centers...