Research Topics
| H C GrunzeSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonismIsabella Braun
Department of Psychiatry, Division of Molecular and Clinical Neurobiology, Ludwig Maximilians University of Munich, Germany
Schizophr Res 97:254-63. 2007..Moreover, this study provides further evidence for regional differences in the response of GABAergic interneurons to NMDA receptor antagonism and antipsychotic treatment...- Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward currentH Grunze
Psychiatrische Klinik der Universitat, Nussbaumstr 7, 80336 Munchen, Germany
Brain Res 791:330-4. 1998..This may be an effective mechanism to inhibit pathological excitation... - Nefazodone in psychotic unipolar and bipolar depression: a retrospective chart analysis and open prospective study on its efficacy and safety versus combined treatment with amitriptyline and haloperidolHeinz Grunze
Department of Psychiatry, LMU Munich, Munich, Germany
Neuropsychobiology 46:31-5. 2002..The results suggest that the addition of classical antipsychotics should be reserved for those with very severe psychotic symptoms, but may not be needed in milder forms... - Lithium in the acute treatment of bipolar disorders-a stocktakingHeinz Grunze
Psychiatriche Klinik der LMU Nussbaumstr 7 80336 München, Germany
Eur Arch Psychiatry Clin Neurosci 253:115-9. 2003..In combination treatment, lithium should be applied particularly when it has already shown good prophylactic efficacy and/or in patients for whom a high suicide risk must be presumed... - Levetiracetam in the treatment of acute mania: an open add-on study with an on-off-on designHeinz Grunze
Department of Psychiatry at the University of Munich, Germany
J Clin Psychiatry 64:781-4. 2003..Levetiracetam is a novel antiepileptic drug with a broad spectrum of efficacy in epilepsy. We have tested the antimanic properties of the drug as an add-on to haloperidol in an open trial... - World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. Part I: Treatment of bipolar depressionHeinz Grunze
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
World J Biol Psychiatry 3:115-24. 2002..As these guidelines are intended for clinical use, the scientific evidence was not only graded, but also commented on by the experts of the task force to ensure practicability... - [Problem-based learning in medical education. Integrated "Nervous System and Behavior" course at the Munich Ludwig Maximilian University]H Grunze
Psychiatrische Klinik, Universitat Munchen
Nervenarzt 75:67-70. 2004..This article introduces the reader to its structure and elements as well as feedback from students... - Relevance of new and newly rediscovered anticonvulsants for atypical forms of bipolar disorderHeinz Grunze
Department of Psychiatry, LMU, Nussbaumstr 7, D 80336 Munich, Germany
J Affect Disord 72:S15-21. 2002..This review will consider our current knowledge of the benefit of these new and newly rediscovered anticonvulsants in treating bipolar disorders, with a special focus on their value in treating atypical manifestations... 
The use of atypical antipsychotics in Bipolar Spectrum disordersH Grunze
Heinz Grunze, Hans Jürgen Möller, Department of Psychiatry, Ludwig Maxmilians University, Nussbaumstrasse 7, 80336 Munich, Germany
Indian J Psychiatry 45:10-5. 2003..These combined efficacy data definitely support the use of atypical antipsychotics in bipolar disorder, and it is now the time to collect more experience with these substances in severely ill patients in clinical settings...- Clinical relevance and treatment possibilities of bipolar rapid cyclingH Grunze
Department of Psychiatry, LMU University Hospital, Munich, Germany
Neuropsychobiology 45:20-6. 2002.... - Antimanic efficacy of topiramate in 11 patients in an open trial with an on-off-on designH C Grunze
Department of Psychiatry, LMU Munich, Germany
J Clin Psychiatry 62:464-8. 2001..A series of open studies suggests that topiramate has efficacy in bipolar disorder. To further investigate the potential value of topiramate as an antimanic agent, we conducted an open trial in 11 manic patients... - Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswalH Grunze
Department of Psychiatry, LMU University Hospital, Munich, Germany
Neuropsychobiology 42:28-32. 2000.... - Tiagabine appears not to be efficacious in the treatment of acute maniaH Grunze
Department of Psychiatry, University of Munich, Germany
J Clin Psychiatry 60:759-62. 1999..Because a GABAergic hypofunction has been implied in the pathophysiology of mania, we have tested the antimanic properties of the GABA transporter 1 inhibitor tiagabine... - Renal impairment as a possible side effect of gabapentin. A single case reportH Grunze
Psychiatrische Klinik der Universitat, Munchen, Deutschland
Neuropsychobiology 38:198-9. 1998..It is suggested that the possibility of renal dysfunction should be kept in mind with the usage of gabapentin... - Modulation of calcium and potassium currents by lamotrigineH Grunze
Psychiatrische Klinik der Universitat, Munchen, Deutschland
Neuropsychobiology 38:131-8. 1998..These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder... - The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of ManiaHeinz Grunze
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
World J Biol Psychiatry 4:5-13. 2003..Key words: bipolar disorder, mania, acute treatment, evidence-based guidelines, pharmacotherapy, antipsychotics, mood stabiliser, electroconvulsive therapy... 
Efficacy of quetiapine monotherapy in rapid-cycling bipolar disorder in comparison with sodium valproateJens M Langosch
Department of Psychiatry, Albert Ludwigs University of Freiburg, Freiburg, Germany
J Clin Psychopharmacol 28:555-60. 2008..The aim of this study was to examine the long-term efficacy and safety of a monotherapy with quetiapine or sodium valproate (VPA) in patients with rapid-cycling bipolar disorder...- Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind studyClaus Normann
Department of Psychiatry, University of Freiburg, Germany
J Clin Psychiatry 63:337-44. 2002..CONCLUSION: Lamotrigine might have antidepressive properties in unipolar patients and may accelerate onset of action when given in combination with typical antidepressants... - Zotepine loading in acute and severely manic patients: a pilot studyBenedikt Amann
Department of Psychiatry, University LMU Munich, Germany
Bipolar Disord 7:471-6. 2005..The aim of this study was to test the first-generation atypical antipsychotic zotepine regarding its antimanic efficacy, tolerability and to find an adequate dosage for a loading strategy... - Anticonvulsants in the treatment of aggression in the demented elderly: an updateBenedikt Amann
Benito Menni, CASM, Research Unit, CIBERSAM, St Boi de Llobregat, Barcelona, Spain
Clin Pract Epidemiol Ment Health 5:14. 2009..At least 50% of the dramatically growing number of patients with dementia exerts aggressive and agitated symptoms during the course of clinical progression, particularly at moderate clinical severity... - Neurochemical underpinnings in bipolar disorder and epilepsyBenedikt Amann
Department of Psychiatry, University LMU Munich, Munich, Germany
Epilepsia 46:26-30. 2005..However, future research on intracellular mechanisms might become decisive for a better understanding of the similarities between the disorders... - Impact of cognitive-psychoeducational interventions in bipolar patients and their relativesBritta Bernhard
Bipolar Disorder Program, Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80806 Munich, Germany
Eur Psychiatry 21:81-6. 2006..Additionally we offered a group intervention for the patients' relatives. The objective of this study was to describe the outcome associated with our psychoeducational intervention in bipolar patients and their relatives... - Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cellsJens Benninghoff
S Raffaele Scientific Institute, Stem Cell Research Institute HSR SCRI, Milan, Italy
Neuropsychopharmacology 35:893-903. 2010..Finally, we documented a 5-HT-induced increase of ANSC migration activity. In summary, we demonstrated a powerful serotonergic impact on ANSC functional features, which was mainly mediated by 5-HT1A receptors... - A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalitiesDan Rujescu
Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Biol Psychiatry 59:721-9. 2006.... - The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatmentHeinz Grunze
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
World J Biol Psychiatry 5:120-35. 2004..As these guidelines are intended for clinical use, the scientific evidence was not only graded, but also reviewed by the experts of the task force to ensure practicality... - Antiepileptic drugs and mood stabilityBenedikt Amann
Hospital Benito Menni, Dr Antoni Pujadas 38, 08830 Sant Boi, Barcelona, Spain
Clin EEG Neurosci 38:116-23. 2007..The medications discussed in this review only partly fulfill definitions of a mood stabilizer, and we suggest that future research should focus on combined treatment strategies... - Reevaluating therapies for bipolar depressionHeinz Grunze
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
J Clin Psychiatry 66:17-25. 2005..Electroconvulsive therapy remains an option for treatment-refractory patients and those intolerant to pharmacologic treatment, as well as patients who are pregnant or at high risk of suicide... - EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjectsBenedikt L Amann
Department of Psychiatry, Section of Clinical Neurophysiology, University of Munich, Germany
Hum Psychopharmacol 18:641-6. 2003..To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects... - [Anticonvulsants in the treatment of bipolar disorder]Heinz Grunze
Klinik und Poliklinik fur Psychiatrie, Ludwig Maximilians Universitat
Neuropsychiatr 21:110-20. 2007.... - Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on designBarbara Hummel
Stanley Foundation Bipolar Network Centers, Department of Psychiatry, LMU Munich, Germany
Bipolar Disord 4:412-7. 2002..OXC is not metabolized to the 10, 11-epoxide, which seems to be responsible for several undesirable side-effects of carbamazepine and furthermore OXC has less enzyme-inducing properties... - Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual reviewHans Jurgen Moller
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
Eur Arch Psychiatry Clin Neurosci 256:1-16. 2006..In addition the regulatory requirements for licensing a drug for the indication "short-term treatment of bipolar depression" are described... - Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level?Wolfram Emanuel Severus
Department of Psychiatry, University of Munich, Germany
J Clin Psychopharmacol 25:457-62. 2005..In these trials, factors previously associated with predicting response to lithium should also be assessed... - Paroxetine in major depression: correlating plasma concentrations and clinical responseClaus Normann
Department of Psychiatry, Albert Ludwigs Universitat Freiburg, Germany
Pharmacopsychiatry 37:123-6. 2004..In analogy to tricyclic antidepressants, serum concentrations of selective serotonin reuptake inhibitors (SSRIs) are frequently measured in order to optimize treatment results. However, clinical evidence for this approach is sparse... - Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groupsMartin Schaefer
Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
Hepatology 37:443-51. 2003..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting... - The safety and tolerability of atypical antipsychotics in bipolar disorderFlorian Seemüller
Department of Psychiatry, Ludwigs Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
Expert Opin Drug Saf 4:849-68. 2005..Both tolerability, for example, extrapyramidal symptoms, and safety issues, for example, occurrence of weight gain and hyperglycaemia, will be highlighted for olanzapine, quetiapine, risperidone, ziprasidone and aripiprazole... - Risperidone monotherapy in manic inpatients: an open label, multicentre trialAnna Forsthoff
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
World J Biol Psychiatry 8:256-61. 2007..This study examined risperidone monotherapy in a sample of severe manic patients in admission ward settings... - Onset of depressive episodes is faster in patients with bipolar versus unipolar depressive disorder: evidence from a retrospective comparative studyUlrich Hegerl
Department of Psychiatry, University of Leipzig, Johannisallee 20, D 04317 Leipzig, Germany
J Clin Psychiatry 69:1075-80. 2008.... - Interferon alpha (IFNalpha) and psychiatric syndromes: a reviewMartin Schaefer
Department of Psychiatry, Charit, Humboldt University, Humboldt, Germany
Prog Neuropsychopharmacol Biol Psychiatry 26:731-46. 2002..Future research should improve our understanding of the role of IFNalpha for the etiopathology of psychiatric syndromes and has an impact on treatment of IFNalpha-induced psychiatric syndromes... - Newer prophylactic agents for bipolar disorder and their influence on suicidalityChristoph Born
Psychiatrische Klinik der LMU,
Arch Suicide Res 9:301-6. 2005..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome... - Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Clin Psychiatry 66:370-4. 2005..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness... - A 2-year, open-label pilot study of adjunctive chromium in patients with treatment-resistant rapid-cycling bipolar disorderBenedikt L Amann
J Clin Psychopharmacol 27:104-6. 2007 - A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorderGuy M Goodwin
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
J Clin Psychiatry 65:432-41. 2004..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients... - Olanzapine monotherapy and olanzapine combination therapy in the treatment of mania: 12-week results from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) observational studyEduard Vieta
Bipolar Disorders Program, Hospital Clinic, University of Barcelona IDIBAPS, Barcelona, Spain
J Affect Disord 106:63-72. 2008.... - [Olanzapine (Zyprexa)--reliable in acute treatment, prevention of recurrence and long-term mood stabilization]Heinz Grunze
Krankenpfl J 41:225. 2003 - An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)Robert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:310-9. 2003..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed... - A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depressionMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
Am J Psychiatry 164:1242-9. 2007..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue... - Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-upLori Altshuler
Stanley Bipolar Treatment Network, USA
Am J Psychiatry 160:1252-62. 2003..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode... - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - Treatment of bipolar depression: an updateKonstantinos N Fountoulakis
3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
J Affect Disord 109:21-34. 2008..Bipolar depression seems to be a more difficult condition to treat than mania. Most patients need complex combination treatment although the published evidence on this type of treatment is limited... - Stability and treatment outcome of distinct classes of maniaInge van Rossum
Medical Department, Eli Lilly Nederland, Grootslag 1 5, Houten, The Netherlands
Eur Psychiatry 23:360-7. 2008..Differential treatment course and outcome after 12 weeks of treatment were examined for three distinct classes of patients with acute mania in bipolar disorder... - A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episodeCharles Bowden
Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Int Clin Psychopharmacol 23:254-62. 2008..Adverse events were reported in 44% of patients in both groups. Valproate and lithium showed comparable efficacy and tolerability in the treatment of acute mania over 12 weeks... - Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar NetworkGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Clin Psychiatry 64:506-15. 2003..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder... - Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
Am J Psychiatry 160:883-9. 2003..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study... - Influence of sub-syndromal symptoms after remission from manic or mixed episodesMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Br J Psychiatry 189:515-9. 2006..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - An exploratory open trial on safety and efficacy of the anticonvulsant retigabine in acute manic patientsBenedikt Amann
J Clin Psychopharmacol 26:534-6. 2006 - Atypical antipsychotics in bipolar depression: potential mechanisms of actionLakshmi N Yatham
Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
J Clin Psychiatry 66:40-8. 2005..Further studies should be conducted to examine these hypotheses... - Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trialMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 162:1281-90. 2005..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence... - Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective... - Antiepileptic drugs in mood-disordered patientsPrashant Gajwani
NIMH Bipolar Research Center, Case Western Reserve University School of Medicine, Mood Disorders Program, University Hospitals of Cleveland, OH, USA
Epilepsia 46:38-44. 2005..LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders... - Reproductive function and risk for PCOS in women treated for bipolar disorderNatalie L Rasgon
Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
Bipolar Disord 7:246-59. 2005..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications... - Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenonTrisha Suppes
Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
Arch Gen Psychiatry 62:1089-96. 2005..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - Tourette's symptoms provoked by lamotrigine in a bipolar patientFlorian Seemüller
Am J Psychiatry 163:159. 2006 - A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorderCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
J Clin Psychiatry 66:111-21. 2005..To evaluate the efficacy and tolerability of quetiapine monotherapy versus placebo for the treatment of mania associated with bipolar disorder... - Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 60:1020-2. 2006..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder... - [Ergenyl chronospheres in bipolar disorders]Heinz Grunze
Krankenpfl J 43:213. 2005 - [Prophylaxis of bipolar disorder]Andrea Sterr
Psychiatr Prax 33:S47-54. 2006..This article summarises the current state of knowledge on treatment options for maintenance therapy... - New findings from the Bipolar Collaborative Network: clinical implications for therapeuticsRobert M Post
Penn State College of Medicine, Hershey, PA, USA
Curr Psychiatry Rep 8:489-97. 2006..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss... - [Official guidelines for the treatment of acute mania]Stephanie Krüger
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universitätsklinik Carl Gustav Carus, Dresden
Psychiatr Prax 33:S2-6. 2006..They categorize the scientific quality of the studies into four levels of evidence (A-D) and provide an algorithm based on the degree of severity of the acute manic episode... - Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressantsLori L Altshuler
Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
Am J Psychiatry 163:313-5. 2006..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder... - Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - The clinical use of gabapentin in bipolar spectrum disordersMauro Giovanni Carta
Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy
J Affect Disord 75:83-91. 2003..Accordingly, an extensive review on this subject has been carried out... - Correlates of overweight and obesity in 644 patients with bipolar disorderSusan L McElroy
Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
J Clin Psychiatry 63:207-13. 2002.... - [Speed of onset of depressive episodes: a clinical criterion helpful for separating uni- from bipolar affective disorders]Ulrich Hegerl
Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig
Neuropsychiatr 22:92-9. 2008..The aim of this study was to analyze speed of onset of depressive episodes in patients with unipolar depression (UD) and bipolar affective disorders (BD)...