H C Grunze

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
    Isabella Braun
    Department of Psychiatry, Division of Molecular and Clinical Neurobiology, Ludwig Maximilians University of Munich, Germany
    Schizophr Res 97:254-63. 2007
  2. ncbi Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current
    H Grunze
    Psychiatrische Klinik der Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    Brain Res 791:330-4. 1998
  3. ncbi Nefazodone in psychotic unipolar and bipolar depression: a retrospective chart analysis and open prospective study on its efficacy and safety versus combined treatment with amitriptyline and haloperidol
    Heinz Grunze
    Department of Psychiatry, LMU Munich, Munich, Germany
    Neuropsychobiology 46:31-5. 2002
  4. ncbi Lithium in the acute treatment of bipolar disorders-a stocktaking
    Heinz Grunze
    Psychiatriche Klinik der LMU Nussbaumstr 7 80336 München, Germany
    Eur Arch Psychiatry Clin Neurosci 253:115-9. 2003
  5. ncbi Levetiracetam in the treatment of acute mania: an open add-on study with an on-off-on design
    Heinz Grunze
    Department of Psychiatry at the University of Munich, Germany
    J Clin Psychiatry 64:781-4. 2003
  6. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. Part I: Treatment of bipolar depression
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 3:115-24. 2002
  7. ncbi [Problem-based learning in medical education. Integrated "Nervous System and Behavior" course at the Munich Ludwig Maximilian University]
    H Grunze
    Psychiatrische Klinik, Universitat Munchen
    Nervenarzt 75:67-70. 2004
  8. ncbi Relevance of new and newly rediscovered anticonvulsants for atypical forms of bipolar disorder
    Heinz Grunze
    Department of Psychiatry, LMU, Nussbaumstr 7, D 80336 Munich, Germany
    J Affect Disord 72:S15-21. 2002
  9. pmc The use of atypical antipsychotics in Bipolar Spectrum disorders
    H Grunze
    Heinz Grunze, Hans Jürgen Möller, Department of Psychiatry, Ludwig Maxmilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Indian J Psychiatry 45:10-5. 2003
  10. ncbi Clinical relevance and treatment possibilities of bipolar rapid cycling
    H Grunze
    Department of Psychiatry, LMU University Hospital, Munich, Germany
    Neuropsychobiology 45:20-6. 2002

Collaborators

Detail Information

Publications76

  1. ncbi Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
    Isabella Braun
    Department of Psychiatry, Division of Molecular and Clinical Neurobiology, Ludwig Maximilians University of Munich, Germany
    Schizophr Res 97:254-63. 2007
    ..Moreover, this study provides further evidence for regional differences in the response of GABAergic interneurons to NMDA receptor antagonism and antipsychotic treatment...
  2. ncbi Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current
    H Grunze
    Psychiatrische Klinik der Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    Brain Res 791:330-4. 1998
    ..This may be an effective mechanism to inhibit pathological excitation...
  3. ncbi Nefazodone in psychotic unipolar and bipolar depression: a retrospective chart analysis and open prospective study on its efficacy and safety versus combined treatment with amitriptyline and haloperidol
    Heinz Grunze
    Department of Psychiatry, LMU Munich, Munich, Germany
    Neuropsychobiology 46:31-5. 2002
    ..The results suggest that the addition of classical antipsychotics should be reserved for those with very severe psychotic symptoms, but may not be needed in milder forms...
  4. ncbi Lithium in the acute treatment of bipolar disorders-a stocktaking
    Heinz Grunze
    Psychiatriche Klinik der LMU Nussbaumstr 7 80336 München, Germany
    Eur Arch Psychiatry Clin Neurosci 253:115-9. 2003
    ..In combination treatment, lithium should be applied particularly when it has already shown good prophylactic efficacy and/or in patients for whom a high suicide risk must be presumed...
  5. ncbi Levetiracetam in the treatment of acute mania: an open add-on study with an on-off-on design
    Heinz Grunze
    Department of Psychiatry at the University of Munich, Germany
    J Clin Psychiatry 64:781-4. 2003
    ..Levetiracetam is a novel antiepileptic drug with a broad spectrum of efficacy in epilepsy. We have tested the antimanic properties of the drug as an add-on to haloperidol in an open trial...
  6. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. Part I: Treatment of bipolar depression
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 3:115-24. 2002
    ..As these guidelines are intended for clinical use, the scientific evidence was not only graded, but also commented on by the experts of the task force to ensure practicability...
  7. ncbi [Problem-based learning in medical education. Integrated "Nervous System and Behavior" course at the Munich Ludwig Maximilian University]
    H Grunze
    Psychiatrische Klinik, Universitat Munchen
    Nervenarzt 75:67-70. 2004
    ..This article introduces the reader to its structure and elements as well as feedback from students...
  8. ncbi Relevance of new and newly rediscovered anticonvulsants for atypical forms of bipolar disorder
    Heinz Grunze
    Department of Psychiatry, LMU, Nussbaumstr 7, D 80336 Munich, Germany
    J Affect Disord 72:S15-21. 2002
    ..This review will consider our current knowledge of the benefit of these new and newly rediscovered anticonvulsants in treating bipolar disorders, with a special focus on their value in treating atypical manifestations...
  9. pmc The use of atypical antipsychotics in Bipolar Spectrum disorders
    H Grunze
    Heinz Grunze, Hans Jürgen Möller, Department of Psychiatry, Ludwig Maxmilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Indian J Psychiatry 45:10-5. 2003
    ..These combined efficacy data definitely support the use of atypical antipsychotics in bipolar disorder, and it is now the time to collect more experience with these substances in severely ill patients in clinical settings...
  10. ncbi Clinical relevance and treatment possibilities of bipolar rapid cycling
    H Grunze
    Department of Psychiatry, LMU University Hospital, Munich, Germany
    Neuropsychobiology 45:20-6. 2002
    ....
  11. ncbi Antimanic efficacy of topiramate in 11 patients in an open trial with an on-off-on design
    H C Grunze
    Department of Psychiatry, LMU Munich, Germany
    J Clin Psychiatry 62:464-8. 2001
    ..A series of open studies suggests that topiramate has efficacy in bipolar disorder. To further investigate the potential value of topiramate as an antimanic agent, we conducted an open trial in 11 manic patients...
  12. ncbi Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal
    H Grunze
    Department of Psychiatry, LMU University Hospital, Munich, Germany
    Neuropsychobiology 42:28-32. 2000
    ....
  13. ncbi Tiagabine appears not to be efficacious in the treatment of acute mania
    H Grunze
    Department of Psychiatry, University of Munich, Germany
    J Clin Psychiatry 60:759-62. 1999
    ..Because a GABAergic hypofunction has been implied in the pathophysiology of mania, we have tested the antimanic properties of the GABA transporter 1 inhibitor tiagabine...
  14. ncbi Renal impairment as a possible side effect of gabapentin. A single case report
    H Grunze
    Psychiatrische Klinik der Universitat, Munchen, Deutschland
    Neuropsychobiology 38:198-9. 1998
    ..It is suggested that the possibility of renal dysfunction should be kept in mind with the usage of gabapentin...
  15. ncbi Modulation of calcium and potassium currents by lamotrigine
    H Grunze
    Psychiatrische Klinik der Universitat, Munchen, Deutschland
    Neuropsychobiology 38:131-8. 1998
    ..These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder...
  16. ncbi The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of Mania
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:5-13. 2003
    ..Key words: bipolar disorder, mania, acute treatment, evidence-based guidelines, pharmacotherapy, antipsychotics, mood stabiliser, electroconvulsive therapy...
  17. doi Efficacy of quetiapine monotherapy in rapid-cycling bipolar disorder in comparison with sodium valproate
    Jens M Langosch
    Department of Psychiatry, Albert Ludwigs University of Freiburg, Freiburg, Germany
    J Clin Psychopharmacol 28:555-60. 2008
    ..The aim of this study was to examine the long-term efficacy and safety of a monotherapy with quetiapine or sodium valproate (VPA) in patients with rapid-cycling bipolar disorder...
  18. ncbi Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study
    Claus Normann
    Department of Psychiatry, University of Freiburg, Germany
    J Clin Psychiatry 63:337-44. 2002
    ..The anticonvulsant lamotrigine has been shown to be effective for bipolar depression. This study examines putative antidepressive properties of lamotrigine in a mainly unipolar routine clinical patient population...
  19. ncbi Zotepine loading in acute and severely manic patients: a pilot study
    Benedikt Amann
    Department of Psychiatry, University LMU Munich, Germany
    Bipolar Disord 7:471-6. 2005
    ..The aim of this study was to test the first-generation atypical antipsychotic zotepine regarding its antimanic efficacy, tolerability and to find an adequate dosage for a loading strategy...
  20. pmc Anticonvulsants in the treatment of aggression in the demented elderly: an update
    Benedikt Amann
    Benito Menni, CASM, Research Unit, CIBERSAM, St Boi de Llobregat, Barcelona, Spain
    Clin Pract Epidemiol Ment Health 5:14. 2009
    ..At least 50% of the dramatically growing number of patients with dementia exerts aggressive and agitated symptoms during the course of clinical progression, particularly at moderate clinical severity...
  21. ncbi Neurochemical underpinnings in bipolar disorder and epilepsy
    Benedikt Amann
    Department of Psychiatry, University LMU Munich, Munich, Germany
    Epilepsia 46:26-30. 2005
    ..However, future research on intracellular mechanisms might become decisive for a better understanding of the similarities between the disorders...
  22. ncbi Impact of cognitive-psychoeducational interventions in bipolar patients and their relatives
    Britta Bernhard
    Bipolar Disorder Program, Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80806 Munich, Germany
    Eur Psychiatry 21:81-6. 2006
    ..Additionally we offered a group intervention for the patients' relatives. The objective of this study was to describe the outcome associated with our psychoeducational intervention in bipolar patients and their relatives...
  23. pmc Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells
    Jens Benninghoff
    S Raffaele Scientific Institute, Stem Cell Research Institute HSR SCRI, Milan, Italy
    Neuropsychopharmacology 35:893-903. 2010
    ..Finally, we documented a 5-HT-induced increase of ANSC migration activity. In summary, we demonstrated a powerful serotonergic impact on ANSC functional features, which was mainly mediated by 5-HT1A receptors...
  24. ncbi A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities
    Dan Rujescu
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 59:721-9. 2006
    ....
  25. ncbi The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatment
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 5:120-35. 2004
    ..As these guidelines are intended for clinical use, the scientific evidence was not only graded, but also reviewed by the experts of the task force to ensure practicality...
  26. ncbi Antiepileptic drugs and mood stability
    Benedikt Amann
    Hospital Benito Menni, Dr Antoni Pujadas 38, 08830 Sant Boi, Barcelona, Spain
    Clin EEG Neurosci 38:116-23. 2007
    ..The medications discussed in this review only partly fulfill definitions of a mood stabilizer, and we suggest that future research should focus on combined treatment strategies...
  27. ncbi Reevaluating therapies for bipolar depression
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Clin Psychiatry 66:17-25. 2005
    ..Electroconvulsive therapy remains an option for treatment-refractory patients and those intolerant to pharmacologic treatment, as well as patients who are pregnant or at high risk of suicide...
  28. ncbi EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects
    Benedikt L Amann
    Department of Psychiatry, Section of Clinical Neurophysiology, University of Munich, Germany
    Hum Psychopharmacol 18:641-6. 2003
    ..To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects...
  29. ncbi [Anticonvulsants in the treatment of bipolar disorder]
    Heinz Grunze
    Klinik und Poliklinik fur Psychiatrie, Ludwig Maximilians Universitat
    Neuropsychiatr 21:110-20. 2007
    ....
  30. ncbi Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on design
    Barbara Hummel
    Stanley Foundation Bipolar Network Centers, Department of Psychiatry, LMU Munich, Germany
    Bipolar Disord 4:412-7. 2002
    ..OXC is not metabolized to the 10, 11-epoxide, which seems to be responsible for several undesirable side-effects of carbamazepine and furthermore OXC has less enzyme-inducing properties...
  31. ncbi Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:1-16. 2006
    ..In addition the regulatory requirements for licensing a drug for the indication "short-term treatment of bipolar depression" are described...
  32. ncbi Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level?
    Wolfram Emanuel Severus
    Department of Psychiatry, University of Munich, Germany
    J Clin Psychopharmacol 25:457-62. 2005
    ..In these trials, factors previously associated with predicting response to lithium should also be assessed...
  33. ncbi Paroxetine in major depression: correlating plasma concentrations and clinical response
    Claus Normann
    Department of Psychiatry, Albert Ludwigs Universitat Freiburg, Germany
    Pharmacopsychiatry 37:123-6. 2004
    ..In analogy to tricyclic antidepressants, serum concentrations of selective serotonin reuptake inhibitors (SSRIs) are frequently measured in order to optimize treatment results. However, clinical evidence for this approach is sparse...
  34. ncbi Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
    Hepatology 37:443-51. 2003
    ..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting...
  35. ncbi The safety and tolerability of atypical antipsychotics in bipolar disorder
    Florian Seemüller
    Department of Psychiatry, Ludwigs Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Expert Opin Drug Saf 4:849-68. 2005
    ..Both tolerability, for example, extrapyramidal symptoms, and safety issues, for example, occurrence of weight gain and hyperglycaemia, will be highlighted for olanzapine, quetiapine, risperidone, ziprasidone and aripiprazole...
  36. ncbi Risperidone monotherapy in manic inpatients: an open label, multicentre trial
    Anna Forsthoff
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 8:256-61. 2007
    ..This study examined risperidone monotherapy in a sample of severe manic patients in admission ward settings...
  37. ncbi Onset of depressive episodes is faster in patients with bipolar versus unipolar depressive disorder: evidence from a retrospective comparative study
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Johannisallee 20, D 04317 Leipzig, Germany
    J Clin Psychiatry 69:1075-80. 2008
    ....
  38. ncbi Interferon alpha (IFNalpha) and psychiatric syndromes: a review
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Humboldt, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 26:731-46. 2002
    ..Future research should improve our understanding of the role of IFNalpha for the etiopathology of psychiatric syndromes and has an impact on treatment of IFNalpha-induced psychiatric syndromes...
  39. ncbi Newer prophylactic agents for bipolar disorder and their influence on suicidality
    Christoph Born
    Psychiatrische Klinik der LMU, Munchen
    Arch Suicide Res 9:301-6. 2005
    ..Confounding variables in more intensive care of these patients participating in a naturalistic study may blur small differences and contribute to a generally favorable outcome...
  40. ncbi Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  41. ncbi A 2-year, open-label pilot study of adjunctive chromium in patients with treatment-resistant rapid-cycling bipolar disorder
    Benedikt L Amann
    J Clin Psychopharmacol 27:104-6. 2007
  42. ncbi A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
    ..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients...
  43. ncbi Olanzapine monotherapy and olanzapine combination therapy in the treatment of mania: 12-week results from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) observational study
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona IDIBAPS, Barcelona, Spain
    J Affect Disord 106:63-72. 2008
    ....
  44. ncbi [Olanzapine (Zyprexa)--reliable in acute treatment, prevention of recurrence and long-term mood stabilization]
    Heinz Grunze
    Krankenpfl J 41:225. 2003
  45. ncbi An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  46. ncbi A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  47. ncbi Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  48. ncbi Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up
    Lori Altshuler
    Stanley Bipolar Treatment Network, USA
    Am J Psychiatry 160:1252-62. 2003
    ..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode...
  49. ncbi Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  50. ncbi Treatment of bipolar depression: an update
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 109:21-34. 2008
    ..Bipolar depression seems to be a more difficult condition to treat than mania. Most patients need complex combination treatment although the published evidence on this type of treatment is limited...
  51. doi Stability and treatment outcome of distinct classes of mania
    Inge van Rossum
    Medical Department, Eli Lilly Nederland, Grootslag 1 5, Houten, The Netherlands
    Eur Psychiatry 23:360-7. 2008
    ..Differential treatment course and outcome after 12 weeks of treatment were examined for three distinct classes of patients with acute mania in bipolar disorder...
  52. doi A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode
    Charles Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Int Clin Psychopharmacol 23:254-62. 2008
    ..Adverse events were reported in 44% of patients in both groups. Valproate and lithium showed comparable efficacy and tolerability in the treatment of acute mania over 12 weeks...
  53. ncbi Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  54. ncbi Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  55. ncbi Influence of sub-syndromal symptoms after remission from manic or mixed episodes
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Br J Psychiatry 189:515-9. 2006
    ..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life...
  56. ncbi Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  57. ncbi An exploratory open trial on safety and efficacy of the anticonvulsant retigabine in acute manic patients
    Benedikt Amann
    J Clin Psychopharmacol 26:534-6. 2006
  58. ncbi Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  59. ncbi Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 162:1281-90. 2005
    ..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
  60. ncbi Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  61. ncbi Antiepileptic drugs in mood-disordered patients
    Prashant Gajwani
    NIMH Bipolar Research Center, Case Western Reserve University School of Medicine, Mood Disorders Program, University Hospitals of Cleveland, OH, USA
    Epilepsia 46:38-44. 2005
    ..LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders...
  62. ncbi Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  63. ncbi Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  64. ncbi Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  65. ncbi Tourette's symptoms provoked by lamotrigine in a bipolar patient
    Florian Seemüller
    Am J Psychiatry 163:159. 2006
  66. ncbi A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:111-21. 2005
    ..To evaluate the efficacy and tolerability of quetiapine monotherapy versus placebo for the treatment of mania associated with bipolar disorder...
  67. ncbi Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  68. ncbi [Ergenyl chronospheres in bipolar disorders]
    Heinz Grunze
    Krankenpfl J 43:213. 2005
  69. ncbi [Prophylaxis of bipolar disorder]
    Andrea Sterr
    Psychiatrische Universitätsklinik der LMU München
    Psychiatr Prax 33:S47-54. 2006
    ..This article summarises the current state of knowledge on treatment options for maintenance therapy...
  70. ncbi New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  71. ncbi [Official guidelines for the treatment of acute mania]
    Stephanie Krüger
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universitätsklinik Carl Gustav Carus, Dresden
    Psychiatr Prax 33:S2-6. 2006
    ..They categorize the scientific quality of the studies into four levels of evidence (A-D) and provide an algorithm based on the degree of severity of the acute manic episode...
  72. ncbi Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  73. ncbi Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  74. ncbi The clinical use of gabapentin in bipolar spectrum disorders
    Mauro Giovanni Carta
    Division of Psychiatry, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy
    J Affect Disord 75:83-91. 2003
    ..Accordingly, an extensive review on this subject has been carried out...
  75. ncbi Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  76. ncbi [Speed of onset of depressive episodes: a clinical criterion helpful for separating uni- from bipolar affective disorders]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig
    Neuropsychiatr 22:92-9. 2008
    ..The aim of this study was to analyze speed of onset of depressive episodes in patients with unipolar depression (UD) and bipolar affective disorders (BD)...