G Grunder

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Therapeutic plasma concentrations of antidepressants and antipsychotics: lessons from PET imaging
    G Grunder
    Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen University, Germany
    Pharmacopsychiatry 44:236-48. 2011
  2. ncbi request reprint [Therapeutic drug monitoring in psychiatry : A brief summary of the new consensus paper by the task force on TDM of the AGNP]
    G Grunder
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Nervenarzt 85:847-55. 2014
  3. ncbi request reprint [Basic principles of therapy with neuropsychotropic drugs]
    G Grunder
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Deutschland
    Nervenarzt 83:1193-208. 2012
  4. doi request reprint Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Psychiatry 165:988-95. 2008
  5. doi request reprint [Use of PET and SPECT in psychiatry]
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Aachen
    Nervenarzt 81:97-107; quiz 108. 2010
  6. ncbi request reprint Aripiprazole: pharmacodynamics of a dopamine partial agonist for the treatment of schizophrenia
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Germany
    Pharmacopsychiatry 39:S21-5. 2006
  7. ncbi request reprint Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression
    Gerhard Grunder
    RWTH Aachen University, Department of Psychiatry and Psychotherapy, and JARA Translational Brain Medicine, Pauwelsstrasse 30, Aachen, Germany
    Curr Opin Investig Drugs 11:823-32. 2010
  8. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
  9. ncbi request reprint The 'atypicality' of antipsychotics: a concept re-examined and re-defined
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University and JARA Brain Translational Brain Medicine, Pauwelsstr 30, 52074 Aachen, Germany
    Nat Rev Drug Discov 8:197-202. 2009
  10. ncbi request reprint Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 89:275-80. 1999

Detail Information

Publications19

  1. doi request reprint Therapeutic plasma concentrations of antidepressants and antipsychotics: lessons from PET imaging
    G Grunder
    Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen University, Germany
    Pharmacopsychiatry 44:236-48. 2011
    ..Associations between brain target occupancy, plasma concentrations, and clinical effects and adverse reactions will be discussed for the most commonly used antidepressant and antipsychotic drugs...
  2. ncbi request reprint [Therapeutic drug monitoring in psychiatry : A brief summary of the new consensus paper by the task force on TDM of the AGNP]
    G Grunder
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Deutschland
    Nervenarzt 85:847-55. 2014
    ..This article summarizes the essential statements to make them accessible to a wider readership in German speaking countries. ..
  3. ncbi request reprint [Basic principles of therapy with neuropsychotropic drugs]
    G Grunder
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Deutschland
    Nervenarzt 83:1193-208. 2012
    ..The reader will thus obtain the basis and stimulation for further study...
  4. doi request reprint Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Psychiatry 165:988-95. 2008
    ....
  5. doi request reprint [Use of PET and SPECT in psychiatry]
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Aachen
    Nervenarzt 81:97-107; quiz 108. 2010
    ..Due to its unmatched sensitivity, molecular imaging with PET and SPECT represents an important complement to magnetic resonance imaging technology in research and clinical practice...
  6. ncbi request reprint Aripiprazole: pharmacodynamics of a dopamine partial agonist for the treatment of schizophrenia
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Germany
    Pharmacopsychiatry 39:S21-5. 2006
    ..Aripiprazole provides good clinical effectiveness and a favorable profile of safety and tolerability. The special pharmacodynamics of aripiprazole are described herein...
  7. ncbi request reprint Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression
    Gerhard Grunder
    RWTH Aachen University, Department of Psychiatry and Psychotherapy, and JARA Translational Brain Medicine, Pauwelsstrasse 30, Aachen, Germany
    Curr Opin Investig Drugs 11:823-32. 2010
    ..Its activity against the cognitive deficits associated with schizophrenia has to be carefully investigated...
  8. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
    ..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding...
  9. ncbi request reprint The 'atypicality' of antipsychotics: a concept re-examined and re-defined
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University and JARA Brain Translational Brain Medicine, Pauwelsstr 30, 52074 Aachen, Germany
    Nat Rev Drug Discov 8:197-202. 2009
    ....
  10. ncbi request reprint Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 89:275-80. 1999
    ..Five patients, four of whom were females, completed the trial. Dropouts were mainly due to treatment failure. Antipsychotic effects were significantly greater in female than male patients...
  11. ncbi request reprint Occupancy of striatal D(2)-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic
    G Grunder
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Psychopharmacology (Berl) 146:81-6. 1999
    ..It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D(2) and D(3) dopamine (DA) receptors...
  12. ncbi request reprint AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011
    C Hiemke
    Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany
    Pharmacopsychiatry 44:195-235. 2011
    ..Thereby, one should never forget that TDM is an interdisciplinary task that sometimes requires the respectful discussion of apparently discrepant data so that, ultimately, the patient can profit from such a joint eff ort...
  13. doi request reprint Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study
    E M Meisenzahl
    Department of Psychiatry, LMU University of Munich, Munich, Germany
    Pharmacopsychiatry 41:169-75. 2008
    ..Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner...
  14. doi request reprint Dopamine-modulated aversive emotion processing fails in alcohol-dependent patients
    T Kienast
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pharmacopsychiatry 46:130-6. 2013
    ....
  15. doi request reprint Imaging studies - differential action of typical and atypical antipsychotics in a network perspective
    I Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Pharmacopsychiatry 41:S60-9. 2008
    ..Finally, hypotheses are proposed to explain differences between first- and second generation antipsychotics with respect of regional selectivity for dopamine and serotonin neurons...
  16. ncbi request reprint [Monoaminergic function in major depression. A possibly helpful tool for choosing treatment strategy]
    O Moeller
    Klinik fur Psychiatrie und Psychotherapie, Universitätsklinikum der RWTH Aachen
    Nervenarzt 77:800-8. 2006
    ..In conclusion, the results of serotonergic functions are still heterogeneous, but the relationship between noradrenergic function and treatment response has not been investigated in any detail yet...
  17. ncbi request reprint Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels
    R Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychobiology 46:33-40. 2002
    ..However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase...
  18. ncbi request reprint [18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors
    G Grunder
    Department of Psychiatry, University of Mainz, Germany
    Eur J Nucl Med 28:1463-70. 2001
    ....
  19. ncbi request reprint [Depression in Parkinson's disease. Assessment and treatment]
    S Brand
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, 52074 Aachen
    Nervenarzt 78:715-27; quiz 728. 2007
    ..A survey of current treatment options is provided: pharmacological, somatic, and psychological approaches are introduced and evaluated with respect to effectiveness in this special group of patients...