Benedikt Grothe

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint Dynamics of binaural processing in the mammalian sound localization pathway--the role of GABA(B) receptors
    Benedikt Grothe
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitaet Munich, Großhaderner Str 2 4, D 82152 Martinsried Planegg, Germany
    Hear Res 279:43-50. 2011
  2. doi request reprint Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem
    Anna K Magnusson
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Neuron 59:125-37. 2008
  3. doi request reprint Impaired auditory temporal selectivity in the inferior colliculus of aged Mongolian gerbils
    Leila Khouri
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University of Munich, 82152 Martinsried, Germany
    J Neurosci 31:9958-70. 2011
  4. doi request reprint Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons
    Benjamin Hassfurth
    Department Biologie II, Division of Neurobiology, Ludwig Maximilans University München, 82152 Martinsried, Germany
    Eur J Neurosci 30:1227-38. 2009
  5. doi request reprint Adaptation of binaural processing in the adult brainstem induced by ambient noise
    Ida Siveke
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munchen, 82152 Martinsried, Germany
    J Neurosci 32:462-73. 2012
  6. doi request reprint The mammalian interaural time difference detection circuit is differentially controlled by GABAB receptors during development
    Benjamin Hassfurth
    Department Biologie II, Division of Neurobiology, Ludwig Maximilans University Munich, 82152 Martinsried, Germany
    J Neurosci 30:9715-27. 2010
  7. doi request reprint Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
  8. doi request reprint NMDA currents modulate the synaptic input-output functions of neurons in the dorsal nucleus of the lateral lemniscus in Mongolian gerbils
    Christian P Porres
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 31:4511-23. 2011
  9. ncbi request reprint Inhibiting the inhibition: a neuronal network for sound localization in reverberant environments
    Michael Pecka
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitat Munich, D 82152 Martinsried, Germany
    J Neurosci 27:1782-90. 2007
  10. doi request reprint Experience-dependent refinement of the inhibitory axons projecting to the medial superior olive
    Florian Werthat
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Dev Neurobiol 68:1454-62. 2008

Collaborators

Detail Information

Publications28

  1. doi request reprint Dynamics of binaural processing in the mammalian sound localization pathway--the role of GABA(B) receptors
    Benedikt Grothe
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitaet Munich, Großhaderner Str 2 4, D 82152 Martinsried Planegg, Germany
    Hear Res 279:43-50. 2011
    ....
  2. doi request reprint Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem
    Anna K Magnusson
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Neuron 59:125-37. 2008
    ....
  3. doi request reprint Impaired auditory temporal selectivity in the inferior colliculus of aged Mongolian gerbils
    Leila Khouri
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University of Munich, 82152 Martinsried, Germany
    J Neurosci 31:9958-70. 2011
    ..These declines cannot be compensated by traditional hearing aids (that rely on amplification of sound) but may rather require pharmacological treatment...
  4. doi request reprint Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons
    Benjamin Hassfurth
    Department Biologie II, Division of Neurobiology, Ludwig Maximilans University München, 82152 Martinsried, Germany
    Eur J Neurosci 30:1227-38. 2009
    ..This type of activity-dependent homeostatic change could thus result in an augmented response to the remaining inputs...
  5. doi request reprint Adaptation of binaural processing in the adult brainstem induced by ambient noise
    Ida Siveke
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munchen, 82152 Martinsried, Germany
    J Neurosci 32:462-73. 2012
    ..Computational models of sensitivity to interaural time and level differences suggest that upregulation of inhibition in the superior olivary complex can explain the electrophysiological data...
  6. doi request reprint The mammalian interaural time difference detection circuit is differentially controlled by GABAB receptors during development
    Benjamin Hassfurth
    Department Biologie II, Division of Neurobiology, Ludwig Maximilans University Munich, 82152 Martinsried, Germany
    J Neurosci 30:9715-27. 2010
    ..This indicates not only a profound inhibitory effect of GABA(B)Rs on the major inputs to MSO neurons in neonatal animals but also a direct modulatory role of GABA(B)Rs for ITD analysis in the MSO of adult animals...
  7. doi request reprint Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
    ..Hence tonic glycine application experimentally decoupled the effect of inhibition from the timing of its inputs. We conclude that, for proper ITD processing, not only is inhibition necessary, but it must also be precisely timed...
  8. doi request reprint NMDA currents modulate the synaptic input-output functions of neurons in the dorsal nucleus of the lateral lemniscus in Mongolian gerbils
    Christian P Porres
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 31:4511-23. 2011
    ..Thus, our data show that the NMDA-dependent amplification of the postsynaptic activity contributes to the GABAergic persistent inhibition generated by DNLL neurons...
  9. ncbi request reprint Inhibiting the inhibition: a neuronal network for sound localization in reverberant environments
    Michael Pecka
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitat Munich, D 82152 Martinsried, Germany
    J Neurosci 27:1782-90. 2007
    ..Moreover, the model revealed that such response enhancement is a sufficient cue for an ideal observer to identify echoes and to exhibit echo suppression, which agrees closely with the percepts of human subjects...
  10. doi request reprint Experience-dependent refinement of the inhibitory axons projecting to the medial superior olive
    Florian Werthat
    Department Biologie II, Division of Neurobiology, LMU Munich, Grosshadernerstrasse 2, 82152 Martinsried, Germany
    Dev Neurobiol 68:1454-62. 2008
    ....
  11. doi request reprint Functional localization of neurotransmitter receptors and synaptic inputs to mature neurons of the medial superior olive
    Kiri Couchman
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munich, Germany
    J Neurophysiol 107:1186-98. 2012
    ....
  12. doi request reprint Fenestration of the calyx of Held occurs sequentially along the tonotopic axis, is influenced by afferent activity, and facilitates glutamate clearance
    Marc C Ford
    Division of Neurobiology, Ludwig Maximilians University Munich, Martinsried, Germany
    J Comp Neurol 514:92-106. 2009
    ....
  13. doi request reprint Mechanisms of sound localization in mammals
    Benedikt Grothe
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitaet, Munich, Germany
    Physiol Rev 90:983-1012. 2010
    ....
  14. doi request reprint Urocortin-expressing olivocochlear neurons exhibit tonotopic and developmental changes in the auditory brainstem and in the innervation of the cochlea
    Alexander Kaiser
    Division of Neurobiology, Department of Biology II, Ludwig Maximilians Universitaet Muenchen, 82152 Martinsried, Germany
    J Comp Neurol 519:2758-78. 2011
    ..These results suggest a possible role of urocortin in late cochlear development and in the processing of social calls in adult animals...
  15. doi request reprint Level-dependent latency shifts quantified through binaural processing
    Ida Siveke
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians Universitat Munchen, Germany
    J Neurophysiol 104:2224-35. 2010
    ..Such an adjustment of firing threshold provides a temporally accurate neural code of the temporal structure of a stimulus and its binaural disparities independent of overall sound level...
  16. ncbi request reprint Spectral composition of concurrent noise affects neuronal sensitivity to interaural time differences of tones in the dorsal nucleus of the lateral lemniscus
    Ida Siveke
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitat Munchen, Germany
    J Neurophysiol 98:2705-15. 2007
    ..A simple simulation corroborates this interpretation. Taken together, these findings suggest that the spectral composition of a concurrent sound strongly influences the spatial processing of ITD-sensitive DNLL neurons...
  17. doi request reprint Medial superior olivary neurons receive surprisingly few excitatory and inhibitory inputs with balanced strength and short-term dynamics
    Kiri Couchman
    Department of Biology II, Division of Neurobiology, Ludwig Maximilians University, Munich, D 82152 Martinsried, Germany
    J Neurosci 30:17111-21. 2010
    ..We find that the excitatory and inhibitory inputs to the MSO are well balanced both in strength and short-term dynamics, redefining this fastest of all mammalian coincidence detector circuits...
  18. doi request reprint Adaptation in sound localization: from GABA(B) receptor-mediated synaptic modulation to perception
    Annette Stange
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians Universitat Munchen, Planegg Martinsried, Germany
    Nat Neurosci 16:1840-7. 2013
    ....
  19. doi request reprint Depolarization-induced suppression of a glycinergic synapse in the superior olivary complex by endocannabinoids
    Barbara Trattner
    Department of Biology II, Division of Neurobiology, Ludwig Maximilians University Munich, Martinsried, Germany Graduate School of Systemic Neurosciences, Ludwig Maximilians University Munich, Martinsried, Germany
    J Neurochem 127:78-90. 2013
    ..Therefore, we suggest that retrograde endocannabinoid signalling has a role in adapting inputs during the functionally important switch from spontaneously generated to sound-related signals...
  20. pmc Sound localization in noise by gerbils and humans
    Andrea Lingner
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitaet Munich, Großhaderner Str 2 4, 82152 Martinsried Planegg, Germany
    J Assoc Res Otolaryngol 13:237-48. 2012
    ..e., the evaluation of signals coming from the two ears) is equally sensitive in gerbils and humans. However, the physical limitations imposed by the small head prevent the gerbil from performing equally well in the current paradigm...
  21. doi request reprint Population coding of interaural time differences in gerbils and barn owls
    Nicholas A Lesica
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
    J Neurosci 30:11696-702. 2010
    ..Together, our results support the idea that, unlike the avian brain, the mammalian brain represents ITDs in the overall activity of a homogenous population of neurons within each hemisphere...
  22. ncbi request reprint Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus
    Ida Siveke
    Division of Neurobiology, Department Biology II, Biocenter, Ludwig Maximilians University of Munich, Grosshaderner Strasse 2, D 81252 Martinsried, Germany
    J Neurophysiol 96:1425-40. 2006
    ..The large number of ITD-sensitive low-frequency neurons implicates a substantial role for the DNLL in ITD processing and promotes this nucleus as a suitable model for further studies on ITD-coding...
  23. doi request reprint Perception and neural representation of size-variant human vowels in the Mongolian gerbil (Meriones unguiculatus)
    Gabriele Schebesch
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians Universitat Munchen, Grosshadernerstr 2, D 82152 Planegg Martinsried, Germany
    Hear Res 261:1-8. 2010
    ....
  24. pmc Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset
    Anna K Magnusson
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians University, Martinsried, Germany
    J Physiol 568:497-512. 2005
    ....
  25. pmc Efficient temporal processing of naturalistic sounds
    Nicholas A Lesica
    Department of Biology II, Ludwig Maximilians University Munich, Martinsried, Germany
    PLoS ONE 3:e1655. 2008
    ....
  26. doi request reprint Dynamic spectrotemporal feature selectivity in the auditory midbrain
    Nicholas A Lesica
    Department of Biology II, Ludwig Maximilians University Munich, 82152 Martinsried, Germany
    J Neurosci 28:5412-21. 2008
    ..These results illustrate the complexity of auditory feature selectivity in the IC, but also provide encouraging evidence that the prediction of nonlinear responses to complex stimuli is a tractable problem...
  27. pmc Metabolic Maturation of Auditory Neurones in the Superior Olivary Complex
    Barbara Trattner
    Department of Biology II, Division of Neurobiology, Ludwig Maximilians University Munich, Martinsried, Germany Graduate School of Systemic Neurosciences, Ludwig Maximilians University Munich, Martinsried, Germany
    PLoS ONE 8:e67351. 2013
    ..Especially for the medial superior olive (MSO), we propose that temporally precise input integration is energetically more costly than the high firing frequencies typical for all SOC nuclei...
  28. doi request reprint Amplitude-modulation detection by gerbils in reverberant sound fields
    Andrea Lingner
    Division of Neurobiology, Department Biology II, Ludwig Maximilians Universitaet Munich, Grosshaderner Str 2 4, D 82152 Martinsried Planegg, Germany
    Hear Res 302:107-12. 2013
    ..We suggest that the lack of perceptual restoration is related to physical properties of the gerbil's ear input signals and inner-ear processing as opposed to shortcomings of their binaural neural processing...