Robert Grosse

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Regulation of myocardin-related transcriptional coactivators through cofactor interactions in differentiation and cancer
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Cell Cycle 8:2523-7. 2009
  2. doi request reprint Nuclear actin network assembly by formins regulates the SRF coactivator MAL
    Christian Baarlink
    Institute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, Germany
    Science 340:864-7. 2013
  3. doi request reprint SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany
    Nat Cell Biol 11:557-68. 2009
  4. pmc Cell motility through plasma membrane blebbing
    Oliver T Fackler
    Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 181:879-84. 2008
  5. pmc Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation
    Jana Stastna
    Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany
    Cell Res 22:728-45. 2012
  6. doi request reprint Nucleating actin for invasion
    Alexander Nürnberg
    Institute of Pharmacology, University of Marburg, Karl von Frisch Str 1, 35032 Marburg, Germany
    Nat Rev Cancer 11:177-87. 2011
  7. pmc Functional Interaction of SCAI with the SWI/SNF Complex for Transcription and Tumor Cell Invasion
    Camilla Kreßner
    Institute of Pharmacology, University of Marburg, Marburg, Germany
    PLoS ONE 8:e69947. 2013
  8. doi request reprint Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility
    Susanne Herroeder
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Immunity 30:708-20. 2009
  9. pmc LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Biol Cell 19:30-40. 2008
  10. doi request reprint HIV-1 Nef interferes with host cell motility by deregulation of Cofilin
    Bettina Stolp
    Department of Virology, Im Neuenheimer Feld 324, University of Heidelberg, Heidelberg 69120, Germany
    Cell Host Microbe 6:174-86. 2009

Collaborators

  • S Offermanns
  • Oliver T Fackler
  • Jianming Xu
  • Nancy Hogg
  • Erez Raz
  • Dominique T Brandt
  • Polyxeni Goulimari
  • Christian Baarlink
  • Camilla Kreßner
  • Haicui Wang
  • Jana Stastna
  • Alexander Nürnberg
  • Peter Nollau
  • Xiaoyu Pan
  • Bettina Stolp
  • Susanne Herroeder
  • Thomas M Kitzing
  • Helga Knieling
  • Stefan Kutscheidt
  • Volker Lohmann
  • Alina Kollmannsperger
  • Thomas Kitzing
  • Klaus Dieter Fischer
  • Matthias Gunzer
  • Markus W Hollmann
  • Sebastian Hannemann
  • Jana Hoeckner
  • Herbert Steinbeisser
  • Stephan Vogt
  • Peter Reichardt
  • Antonia Sassmann
  • Simone I Giese
  • Libin Abraham
  • Dagmar Jaeneke
  • Elisabeth Kremmer
  • Barbara Zimmermann
  • Johanna Ivaska
  • Michal Reichman-Fried
  • Nina Wettschureck
  • Ulrike Engel
  • Kozo Kaibuchi
  • Takashi Watanabe
  • Gareth Griffiths
  • Sabrina Marion

Detail Information

Publications13

  1. ncbi request reprint Regulation of myocardin-related transcriptional coactivators through cofactor interactions in differentiation and cancer
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Cell Cycle 8:2523-7. 2009
    ..Thus, SCAI may act in very different conditions such as during cancer progression, development or cell differentiation...
  2. doi request reprint Nuclear actin network assembly by formins regulates the SRF coactivator MAL
    Christian Baarlink
    Institute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, Germany
    Science 340:864-7. 2013
    ..Activated mDia promoted rapid and reversible nuclear actin network assembly, subsequent MAL nuclear accumulation, and SRF activity. Thus, a dynamic polymeric actin structure within the nucleus is part of the serum response...
  3. doi request reprint SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany
    Nat Cell Biol 11:557-68. 2009
    ..Functional analysis of the beta1-integrin gene strongly argues that SCAI is a novel transcriptional cofactor that controls gene expression downstream of Dia1 to dictate changes in cell invasive behaviour...
  4. pmc Cell motility through plasma membrane blebbing
    Oliver T Fackler
    Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 181:879-84. 2008
    ..The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction...
  5. pmc Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation
    Jana Stastna
    Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany
    Cell Res 22:728-45. 2012
    ..We propose that isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility...
  6. doi request reprint Nucleating actin for invasion
    Alexander Nürnberg
    Institute of Pharmacology, University of Marburg, Karl von Frisch Str 1, 35032 Marburg, Germany
    Nat Rev Cancer 11:177-87. 2011
    ..Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease...
  7. pmc Functional Interaction of SCAI with the SWI/SNF Complex for Transcription and Tumor Cell Invasion
    Camilla Kreßner
    Institute of Pharmacology, University of Marburg, Marburg, Germany
    PLoS ONE 8:e69947. 2013
    ..Moreover our data implicate a functional hierarchy between SCAI and BRM, since SCAI function is abrogated in the absence of BRM expression. ..
  8. doi request reprint Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility
    Susanne Herroeder
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Immunity 30:708-20. 2009
    ....
  9. pmc LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Biol Cell 19:30-40. 2008
    ..We propose that Galpha(12/13) proteins exert essential functions linking extracellular signals to microtubule dynamics and cell polarity via RhoGEF and formin activity...
  10. doi request reprint HIV-1 Nef interferes with host cell motility by deregulation of Cofilin
    Bettina Stolp
    Department of Virology, Im Neuenheimer Feld 324, University of Heidelberg, Heidelberg 69120, Germany
    Cell Host Microbe 6:174-86. 2009
    ..We conclude that HIV-1 Nef alters Pak2 function, which directly or indirectly inactivates cofilin, thereby restricting migration of infected T lymphocytes as part of a strategy to optimize immune evasion and HIV-1 replication...
  11. pmc Get to grips: steering local actin dynamics with IQGAPs
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    EMBO Rep 8:1019-23. 2007
    ....
  12. pmc Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    J Cell Biol 178:193-200. 2007
    ..Thus, we identify IQGAP1 as a novel component involved in the regulation of phagocytosis by mediating the localization of the actin filament nucleator Dia1...
  13. ncbi request reprint Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 280:42242-51. 2005
    ..Thus, we identified Galpha12/13-proteins as essential components linking extracellular signals to localized Rho-Dia1 function during directed cell movement...