Robert Grosse

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    J Cell Biol 178:193-200. 2007
  2. ncbi request reprint Regulation of myocardin-related transcriptional coactivators through cofactor interactions in differentiation and cancer
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Cell Cycle 8:2523-7. 2009
  3. pmc LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Biol Cell 19:30-40. 2008
  4. ncbi request reprint Nuclear actin network assembly by formins regulates the SRF coactivator MAL
    Christian Baarlink
    Institute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, Germany
    Science 340:864-7. 2013
  5. doi request reprint SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany
    Nat Cell Biol 11:557-68. 2009
  6. pmc Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation
    Jana Stastna
    Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany
    Cell Res 22:728-45. 2012
  7. doi request reprint Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility
    Susanne Herroeder
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Immunity 30:708-20. 2009
  8. pmc Functional interaction of SCAI with the SWI/SNF complex for transcription and tumor cell invasion
    Camilla Kreßner
    Institute of Pharmacology, University of Marburg, Marburg, Germany
    PLoS ONE 8:e69947. 2013
  9. doi request reprint Nucleating actin for invasion
    Alexander Nürnberg
    Institute of Pharmacology, University of Marburg, Karl von Frisch Str 1, 35032 Marburg, Germany
    Nat Rev Cancer 11:177-87. 2011
  10. doi request reprint HIV-1 Nef interferes with host cell motility by deregulation of Cofilin
    Bettina Stolp
    Department of Virology, Im Neuenheimer Feld 324, University of Heidelberg, Heidelberg 69120, Germany
    Cell Host Microbe 6:174-86. 2009

Collaborators

Detail Information

Publications18

  1. pmc Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    J Cell Biol 178:193-200. 2007
    ..Thus, we identify IQGAP1 as a novel component involved in the regulation of phagocytosis by mediating the localization of the actin filament nucleator Dia1...
  2. ncbi request reprint Regulation of myocardin-related transcriptional coactivators through cofactor interactions in differentiation and cancer
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Cell Cycle 8:2523-7. 2009
    ..Thus, SCAI may act in very different conditions such as during cancer progression, development or cell differentiation...
  3. pmc LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Biol Cell 19:30-40. 2008
    ..We propose that Galpha(12/13) proteins exert essential functions linking extracellular signals to microtubule dynamics and cell polarity via RhoGEF and formin activity...
  4. ncbi request reprint Nuclear actin network assembly by formins regulates the SRF coactivator MAL
    Christian Baarlink
    Institute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, Germany
    Science 340:864-7. 2013
    ..Activated mDia promoted rapid and reversible nuclear actin network assembly, subsequent MAL nuclear accumulation, and SRF activity. Thus, a dynamic polymeric actin structure within the nucleus is part of the serum response...
  5. doi request reprint SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany
    Nat Cell Biol 11:557-68. 2009
    ..Functional analysis of the beta1-integrin gene strongly argues that SCAI is a novel transcriptional cofactor that controls gene expression downstream of Dia1 to dictate changes in cell invasive behaviour...
  6. pmc Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation
    Jana Stastna
    Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany
    Cell Res 22:728-45. 2012
    ..We propose that isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility...
  7. doi request reprint Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility
    Susanne Herroeder
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Immunity 30:708-20. 2009
    ....
  8. pmc Functional interaction of SCAI with the SWI/SNF complex for transcription and tumor cell invasion
    Camilla Kreßner
    Institute of Pharmacology, University of Marburg, Marburg, Germany
    PLoS ONE 8:e69947. 2013
    ..Moreover our data implicate a functional hierarchy between SCAI and BRM, since SCAI function is abrogated in the absence of BRM expression. ..
  9. doi request reprint Nucleating actin for invasion
    Alexander Nürnberg
    Institute of Pharmacology, University of Marburg, Karl von Frisch Str 1, 35032 Marburg, Germany
    Nat Rev Cancer 11:177-87. 2011
    ..Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease...
  10. doi request reprint HIV-1 Nef interferes with host cell motility by deregulation of Cofilin
    Bettina Stolp
    Department of Virology, Im Neuenheimer Feld 324, University of Heidelberg, Heidelberg 69120, Germany
    Cell Host Microbe 6:174-86. 2009
    ..We conclude that HIV-1 Nef alters Pak2 function, which directly or indirectly inactivates cofilin, thereby restricting migration of infected T lymphocytes as part of a strategy to optimize immune evasion and HIV-1 replication...
  11. pmc Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion
    Thomas M Kitzing
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Genes Dev 21:1478-83. 2007
    ..Our results reveal that Dia1 is necessary for LPA-stimulated Rho/ROCK signaling and bleb-associated cancer cell invasion. Thus, Dia1-dependent RhoA activation constitutes a positive feedback mechanism to modulate cell behavior...
  12. pmc Cell motility through plasma membrane blebbing
    Oliver T Fackler
    Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 181:879-84. 2008
    ..The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction...
  13. pmc Get to grips: steering local actin dynamics with IQGAPs
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    EMBO Rep 8:1019-23. 2007
    ....
  14. doi request reprint Detection of activated Rho in fixed Xenopus tissue
    Corinna D Berger
    Institute of Human Genetics, Section Developmental Genetics, University Heidelberg, Heidelberg, Germany
    Dev Dyn 238:1407-11. 2009
    ..This technique allows a temporal and spatial analysis of Rho signaling in the developing embryo. Developmental Dynamics 238:1407-1411, 2009. (c) 2009 Wiley-Liss, Inc...
  15. ncbi request reprint Pharmacological inhibition of actin assembly to target tumor cell motility
    Alexander Nürnberg
    Institute of Pharmacology, University of Marburg, Marburg, 35032, Germany
    Rev Physiol Biochem Pharmacol 166:23-42. 2014
    ..In this chapter, we summarize reports on newly identified small-molecule inhibitors that target a growing number of actin nucleation and assembly factors relevant for human disease. ..
  16. ncbi request reprint Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function
    Polyxeni Goulimari
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 280:42242-51. 2005
    ..Thus, we identified Galpha12/13-proteins as essential components linking extracellular signals to localized Rho-Dia1 function during directed cell movement...
  17. doi request reprint The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing
    Sebastian Hannemann
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    J Biol Chem 283:27891-903. 2008
    ..These results define a role for endogenous FHOD1 in SH4 domain-induced blebbing and suggest that its activity is regulated by ROCK1 in a Src-dependent manner...
  18. pmc Formin' actin in the nucleus
    Christian Baarlink
    Institute of Pharmacology, Biochemical Pharmacological Center BPC Marburg University of Marburg Marburg, Germany
    Nucleus 5:15-20. 2014
    ..Here we discuss our findings that specific diaphanous-related formins can promote nuclear actin assembly in a signal-dependent manner. ..