Oliver Gross

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 19:1716-23. 2004
  2. ncbi request reprint Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome
    Marie Louise Koepke
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, and Department of Anatomy I, University of Cologne, Germany
    Nephrol Dial Transplant 22:1062-9. 2007
  3. ncbi request reprint Meta-analysis of genotype-phenotype correlation in X-linked Alport syndrome: impact on clinical counselling
    Oliver Gross
    Medical Clinic I, Cologne City Hospital, Cologne Merheim, Germany
    Nephrol Dial Transplant 17:1218-27. 2002
  4. ncbi request reprint Novel COL4A4 splice defect and in-frame deletion in a large consanguine family as a genetic link between benign familial haematuria and autosomal Alport syndrome
    Oliver Gross
    Medical Faculty University of Cologne, Cologne General Hospital, Department of Internal Medicine I, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 18:1122-7. 2003
  5. ncbi request reprint Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688
    Oliver Gross
    Department of Internal Medicine I, Medical Faculty University of Cologne, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 68:456-63. 2005
  6. ncbi request reprint [From the molecular genetics of Alport's syndrome to principles of organo-protection in chronic renal diseases]
    Oliver Gross
    Medizinische Klinik I Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Medizinische Fakultät der Universität zu Köln, Ostmerheimer Strasse 200, 51109 Köln
    Med Klin (Munich) 100:826-31. 2005
  7. ncbi request reprint Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 63:438-46. 2003
  8. ncbi request reprint Chronic renal failure and shortened lifespan in COL4A3+/- mice: an animal model for thin basement membrane nephropathy
    Bogdan Beirowski
    Medical Faculty University of Cologne, Medicine Clinic I, Hospital Merheim, Ostmerheimer Strasse 200, D 51109 Cologne, Germany
    J Am Soc Nephrol 17:1986-94. 2006
  9. ncbi request reprint DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
  10. ncbi request reprint Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome
    Mato Nagel
    Laboratory for Molecular Diagnostic, Center for Nephrology and Metabolic Disorders, A Schweitzer Ring 32, D 02943 Weisswasser, Germany
    Hum Mutat 26:60. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 19:1716-23. 2004
    ..We used this animal model to compare the potential of ACE inhibitor vs AT1 antagonist to prevent renal fibrosis irrespective of blood pressure-dependent involvement by the renin system...
  2. ncbi request reprint Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome
    Marie Louise Koepke
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, and Department of Anatomy I, University of Cologne, Germany
    Nephrol Dial Transplant 22:1062-9. 2007
    ..The aim of this study was to examine the anti-fibrotic effect of the HMG-CoA-reductase-inhibitor, cerivastatin, in COL4A3 knockout mice, an animal model of Alport syndrome with progressive renal fibrosis...
  3. ncbi request reprint Meta-analysis of genotype-phenotype correlation in X-linked Alport syndrome: impact on clinical counselling
    Oliver Gross
    Medical Clinic I, Cologne City Hospital, Cologne Merheim, Germany
    Nephrol Dial Transplant 17:1218-27. 2002
    ..The goal of the present study was to identify the genotype-phenotype correlations that are helpful in clinical counseling. COL4A5-mutations (n=267) in males were analysed including 23 German Alport families...
  4. ncbi request reprint Novel COL4A4 splice defect and in-frame deletion in a large consanguine family as a genetic link between benign familial haematuria and autosomal Alport syndrome
    Oliver Gross
    Medical Faculty University of Cologne, Cologne General Hospital, Department of Internal Medicine I, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 18:1122-7. 2003
    ..The present study describes molecular changes of the COL4A4 gene that cause both diseases: autosomal recessive AS and BFH in a consanguine family with a 400-year-old history of haematuria...
  5. ncbi request reprint Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688
    Oliver Gross
    Department of Internal Medicine I, Medical Faculty University of Cologne, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 68:456-63. 2005
    ..In the present study, we investigated the nephroprotective potential of the vasopeptidase inhibitor AVE7688 beyond its antihypertensive effects in a mouse model of progressive renal fibrosis...
  6. ncbi request reprint [From the molecular genetics of Alport's syndrome to principles of organo-protection in chronic renal diseases]
    Oliver Gross
    Medizinische Klinik I Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Medizinische Fakultät der Universität zu Köln, Ostmerheimer Strasse 200, 51109 Köln
    Med Klin (Munich) 100:826-31. 2005
    ..Therefore, prevention of renal fibrosis is a very important topic. The hereditary type IV collagen disease Alport's syndrome is a rare, but challenging cause of chronic renal fibrosis...
  7. ncbi request reprint Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 63:438-46. 2003
    ..Molecular genetics allows early diagnosis, however, no preventive strategy can be offered. Using the COL4A3 -/- mouse, an animal model for human AS, we evaluated therapy with ramipril in mice...
  8. ncbi request reprint Chronic renal failure and shortened lifespan in COL4A3+/- mice: an animal model for thin basement membrane nephropathy
    Bogdan Beirowski
    Medical Faculty University of Cologne, Medicine Clinic I, Hospital Merheim, Ostmerheimer Strasse 200, D 51109 Cologne, Germany
    J Am Soc Nephrol 17:1986-94. 2006
    ..Therefore, the COL4A3(+/-) mouse model will help in the understanding of the pathogenesis of TBMN in humans and in the evaluation of potential therapies...
  9. ncbi request reprint DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
    ..The interaction between type IV collagen and cell surface receptors is believed important for normal renal function as well as significant in chronic renal diseases and we therefore analyzed mice with a targeted deletion of DDR1...
  10. ncbi request reprint Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome
    Mato Nagel
    Laboratory for Molecular Diagnostic, Center for Nephrology and Metabolic Disorders, A Schweitzer Ring 32, D 02943 Weisswasser, Germany
    Hum Mutat 26:60. 2005
    ..In numerous positively tested patients, genetic variations which are unknown were detected...
  11. ncbi request reprint Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
    ..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates...
  12. ncbi request reprint X-linked Alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study
    Jean Philippe Jais
    Biostatistique et Informatique Médicale, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
    J Am Soc Nephrol 14:2603-10. 2003
    ..Risk factors for developing renal failure have been identified: the occurrence and progressive increase in proteinuria, and the development of a hearing defect...
  13. ncbi request reprint Bone marrow transplantation rescues Alport mice
    Jurgen Floege
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 21:2721-3. 2006
  14. doi request reprint Understanding renal disorders as systemic diseases: the fascinating world of basement membranes beyond the glomerulus
    Oliver Gross
    Department of Nephrology and Rheumatology, University Hospital Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Nephrol Dial Transplant 23:1823-5. 2008