G Gross

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..HPV-specific vaccines have been developed in the last 5 years and will be used in future for prevention and treatment of benign and malignant HPV-associated tumors of the genitoanal tract in both sexes...

..Dermatologists play a major role in the early diagnosis and effective therapy of these infections. In this paper, the latest diagnostic and therapeutic, as well as prophylactic measures and vaccines, are reviewed...

..HPV disease can be widespread, chronic and often may rapidly progress to malignant tumors. Thus, these individuals would greatly benefit from prophylactic HPV immunization...

..Aim of this post-marketing surveillance study was to generate further data on efficacy and tolerability of foscarnet sodium cream 2% in patients with recurrent herpes labialis in daily routine practice...

..Mild to moderate local reactions are of short duration. "Drug-holidays" are not necessary and the ointment does not have to be washed off. There is no contraindication for uncircumcised men with genital warts...

..Clinical efficacy and safety of Polyphenon(R) E, a defined green tea extract, in external genital warts...

..The success of HPV vaccination as a major public health prevention opportunity, however, will entirely depend on efficient infrastructures to deliver the vaccines and on the acceptance by individuals, parents and health care providers...

..In immunosuppressed organ transplant recipients and HIV-positive individuals, HPV can be widespread, chronic and often rapidly progressive to malignant tumors; thus these groups would greatly benefit from HPV immunization...

..Since high risk HPVs are more frequently found in verrucous carcinomas than in giant condylomas, HPV typing may be a helpful diagnostic step to differentiate giant condyloma from verrucous carcinoma...

..Thus early presentation to a pain therapist is recommended in specific cases...

..The current AWMF-S3-guideline "Impfprävention HPV-assoziierter Neoplasien"can be used as a decision-making basis...

..It is argued that this tumor is probably less dependent on classical carcinogens than other oral malignant tumors...

..The diagnosis and differential diagnosis of condylomata acuminata is reviewed. Combining histologic evaluation into the diagnostic approach should improve the therapeutic results...

..Careful follow-up examinations are necessary in order to recognize systemic, especially hematologic, malignancies...

..Such atypical cases often remain undetected and do not receive specific and sufficient treatment. Two case reports illustrate the importance of clinically diagnosing herpes with atypical manifestations in immunodeficient patients...

..The identification of thrombospondin 2 as a target molecule emphasizes the importance of cell-matrix interactions for the pathogenesis of malignant melanoma metastasis and may open future perspectives for treatment of this tumour...

..Functionally, H/R-induced MCP-1 production may contribute to tumour progression by committing selective pressure on tumour cells via chemoattraction and activation of tumour-infiltrating monocytes/macrophages...

..Attempts to remove the gold particles from the skin to remove the tattoo should not be undertaken because the gold is deep and widespread...

..These findings might be a feasible explanation for different OPN expression levels in metastatic tumors and may also have prognostic and therapeutic relevance...

..This may argue for a hypoxia-induced selection process during tumor progression toward melanoma cells with constitutive high Cyr61 expression...

..The lesions were diagnosed as Hailey-Hailey disease localized in the perianal areal and need to be distinguished from human papillomavirus-associated genital lesions...

..Taken together, our data demonstrate that hypoxia-induced JNK/SAPK activation appears to play a critical role in apoptosis regulation of melanoma cells in vitro and in vivo, independent of the Fas/FasL system...

..The lips were reconstructed by plastic surgery. 24 months after surgical intervention no recurrence nor metastasis to lymph nodes or distal sites were observed...

..Taken together, DNA microarray technology opens enormous perspectives for dermatologists. It may help us understand the complex pathogenesis of a wide variety of dermatologic diseases and identify their genetic background...

..Taken together, these findings not only point to new regulatory mechanisms of early melanoma development, but also may open avenues for future targeted therapies of this tumor...

..Furthermore changes in the frequency of certain diseases can be recognized to some extent. The still existing moulages of the Department of Dermatology and Venereology of Rostock offer some interesting examples...

..The genes identified in the present report and the molecular mechanisms underlying their regulation might serve as future targets for therapeutic intervention in psoriasis...

..To better understand the molecular mechanisms of malignant melanoma progression and metastasis, gene expression profiling was done of primary melanomas and melanoma metastases...

..More needs to be done to educate the general public and increase awareness among primary healthcare providers of the benefits of timely and appropriate pharmacological therapy in patients with herpes zoster...

..Within 45 analyzed VZV wild-type strains of genotypes A and D, five novel gE mutations were discovered. A statistically significant (P < 0.0001) association of certain gE mutations with VZV genotype D was found...

..We present a case of severe recalcitrant and nodular chronic actinic dermatitis responding to topically applied tacrolimus (Protopic). To avoid further relapses we continued this therapy twice a day over a period of 2 years...

..Therefore, this approach may allow us to draw a more comprehensive picture of wild-type VZV strains circulating in Germany and Central Europe by high-throughput procedures in the future...

..This study was conducted to assess the efficacy and safety of a patient-initiated, single-day regimen of famciclovir therapy, compared with placebo, in immunocompetent adult patients with recurrent genital herpes...