Michael Groll

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Molecular machines for protein degradation
    Michael Groll
    Adolf Butenandt Institut Physiological Chemistry, LMU Munchen, Butenandtstrasse 5, Gebäude B, 81377 Munchen, Germany
    Chembiochem 6:222-56. 2005
  2. ncbi request reprint Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach
    Michael Groll
    Abteilung für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstr 5, 81377 Munchen, Germany
    Biochim Biophys Acta 1695:33-44. 2004
  3. ncbi request reprint Molecular shredders: how proteasomes fulfill their role
    Michael Groll
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstr 5, 81377 Munchen, Germany
    Curr Opin Struct Biol 13:665-73. 2003
  4. ncbi request reprint TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome
    Michael Groll
    Ludwig Maximilians University, Department for Physiological Chemistry, Butenandtstrasse 5, Building B, D 81377 Munich, Germany
    Chem Biol 13:607-14. 2006
  5. ncbi request reprint Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
    Michael Groll
    Department for Physiological Chemistry, Ludwig Maximilians University, Butenandtstrasse 5, Building B 81377, Munchen, Germany
    Structure 14:451-6. 2006
  6. pmc Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation
    Michael Groll
    Ludwig Maximilians Universitat, Adolf Butenandt Institut, Butenandtstrasse 5, Gebäude B, D 81377 Munich, Germany
    Proc Natl Acad Sci U S A 103:4576-9. 2006
  7. ncbi request reprint Purification, crystallization, and X-ray analysis of the yeast 20S proteasome
    Michael Groll
    Institute für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    Methods Enzymol 398:329-36. 2005
  8. ncbi request reprint Crystal structure of TET protease reveals complementary protein degradation pathways in prokaryotes
    Ljudmila Borissenko
    Ludwig Maximilian Universitat Munchen, Adolf Butenandt Institut, Abteilung für Physiologische Chemie, Butenandtstr 5, GebäudeB, 81377 Munich, Germany
    J Mol Biol 346:1207-19. 2005
  9. pmc Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor
    Dejana Mokranjac
    Institute for Physiological Chemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 25:4675-85. 2006
  10. ncbi request reprint 20S proteasome and its inhibitors: crystallographic knowledge for drug development
    Ljudmila Borissenko
    Charité CCM, Institut fur Biochemie, AG Strukturforschung, Monbijoustrasse 2, 10117 Berlin, Germany
    Chem Rev 107:687-717. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Molecular machines for protein degradation
    Michael Groll
    Adolf Butenandt Institut Physiological Chemistry, LMU Munchen, Butenandtstrasse 5, Gebäude B, 81377 Munchen, Germany
    Chembiochem 6:222-56. 2005
    ..Some of these compounds may find therapeutic applications in contemporary medicine...
  2. ncbi request reprint Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach
    Michael Groll
    Abteilung für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstr 5, 81377 Munchen, Germany
    Biochim Biophys Acta 1695:33-44. 2004
    ..This review summarizes the current structural knowledge of inhibitory compounds bound to the CP, showing the proteasome as a potential target for drug development in medical research...
  3. ncbi request reprint Molecular shredders: how proteasomes fulfill their role
    Michael Groll
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstr 5, 81377 Munchen, Germany
    Curr Opin Struct Biol 13:665-73. 2003
    ..The structure of the 20S proteasome and its inherent role in the regulation of proteasome function are gradually being elucidated...
  4. ncbi request reprint TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome
    Michael Groll
    Ludwig Maximilians University, Department for Physiological Chemistry, Butenandtstrasse 5, Building B, D 81377 Munich, Germany
    Chem Biol 13:607-14. 2006
    ..Our data reveal that biphenyl-ether derivatives bind noncovalently to the proteasomal tryptic-like active site in a reversible substrate-like manner without allosteric changes of active site residues...
  5. ncbi request reprint Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
    Michael Groll
    Department for Physiological Chemistry, Ludwig Maximilians University, Butenandtstrasse 5, Building B 81377, Munchen, Germany
    Structure 14:451-6. 2006
    ..This structure should enable the rational design of new boronic acid derivatives with improved affinities and specificities for individual active subunits...
  6. pmc Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation
    Michael Groll
    Ludwig Maximilians Universitat, Adolf Butenandt Institut, Butenandtstrasse 5, Gebäude B, D 81377 Munich, Germany
    Proc Natl Acad Sci U S A 103:4576-9. 2006
    ....
  7. ncbi request reprint Purification, crystallization, and X-ray analysis of the yeast 20S proteasome
    Michael Groll
    Institute für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    Methods Enzymol 398:329-36. 2005
    ..Some of these compounds may find therapeutic applications in contemporary medicine...
  8. ncbi request reprint Crystal structure of TET protease reveals complementary protein degradation pathways in prokaryotes
    Ljudmila Borissenko
    Ludwig Maximilian Universitat Munchen, Adolf Butenandt Institut, Abteilung für Physiologische Chemie, Butenandtstr 5, GebäudeB, 81377 Munich, Germany
    J Mol Biol 346:1207-19. 2005
    ..We propose that TET and TRI act as functional analogues in different organisms, with TET being more widely distributed. Thus, TET and TRI represent two evolutionarily diverged pathways of peptide degradation in prokaryotes...
  9. pmc Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor
    Dejana Mokranjac
    Institute for Physiological Chemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 25:4675-85. 2006
    ..The first crystal structure of a J domain in complex with a regulatory protein provides new insights into the function of the mitochondrial TIM23 translocase and the Hsp70 chaperone system in general...
  10. ncbi request reprint 20S proteasome and its inhibitors: crystallographic knowledge for drug development
    Ljudmila Borissenko
    Charité CCM, Institut fur Biochemie, AG Strukturforschung, Monbijoustrasse 2, 10117 Berlin, Germany
    Chem Rev 107:687-717. 2007
  11. ncbi request reprint Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycT
    Martin Locher
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 280:31149-55. 2005
    ..This interaction could maintain the protease inactive prior to secretion or could influence the secretion competence and folding of YopT...
  12. ncbi request reprint X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum
    Peter Goettig
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Biol Chem 280:33387-96. 2005
    ..Moreover, small angle x-ray scattering measurements for tricorn and inhibited F1 have been interpreted as formation of transient and substrate-induced complexes...
  13. ncbi request reprint Diversity of proteasomal missions: fine tuning of the immune response
    Ljudmila Borissenko
    Charité CCM, Institut fur Biochemie, AG Strukturforschung, Monbijoustrasse 2, D 10117 Berlin, Germany
    Biol Chem 388:947-55. 2007
    ..Both gamma-interferon-induced immunoproteasomes and peptide splicing represent two significant events providing increased diversity of antigenic peptides for flexible and fine-tuned immune response...
  14. doi request reprint A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    Michael Groll
    Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, Garching D 85747, Germany
    Nature 452:755-8. 2008
    ..It is thus possible that these bacteria are capable of producing proteasome inhibitors of the syrbactin class...
  15. ncbi request reprint Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome
    Michael Groll
    Max Planck Institut fur Biochemie, D 82152, Martinsried, Germany
    Chem Biol 9:655-62. 2002
    ..Comparisons of the CP-bound structures of MB1, MB2, and the natural products epoxomycin and TMC-95A also provide information regarding general binding modes for several classes of proteasome inhibitors...
  16. ncbi request reprint Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines
    Hannes A Braun
    Darmstadt University of Technology, Clemens Schöpf Institute for Organic Chemistry and Biochemistry, D 64287 Darmstadt, Germany
    J Biol Chem 280:28394-401. 2005
    ..Four of these compounds (7, 15, 26, and 28) induced apoptosis in HeLa cells and thus are considered as promising leads for anti-tumor drug development...
  17. ncbi request reprint RecA-like motor ATPases--lessons from structures
    Jiqing Ye
    Department of Cell Biology, Harvard Medical School, HHMI, 240 Longwood Ave, LHRRB 613, Boston, MA 02115, USA
    Biochim Biophys Acta 1659:1-18. 2004
    ..The structures determined for different RecA-like motor ATPases begin to reveal how they move macromolecules...
  18. pmc Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
    Peter Goettig
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 21:5343-52. 2002
    ..Finally, the structure of F1 suggests a possible functional complex with tricorn that allows efficient processive degradation to free amino acids for cellular recycling...
  19. ncbi request reprint Structural basis for the processive protein degradation by tricorn protease
    Hans Brandstetter
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, Martinsried, Germany
    Biol Chem 383:1157-65. 2002
    ....
  20. ncbi request reprint Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum
    Jeong Sun Kim
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Planegg Martinsried, Germany
    J Mol Biol 324:1041-50. 2002
    ..Moreover, we identified the role of Arg131-Arg132 in anchoring the substrate C terminus...
  21. pmc Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
    Patrick Schreiner
    Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Nature 453:548-52. 2008
    ..Finally, we provide a model structure of Rpn13 complexed to diubiquitin, which provides insights into how Rpn13 as a ubiquitin receptor is coupled to substrate deubiquitination by Uch37...
  22. ncbi request reprint The core structure of TMC-95A is a promising lead for reversible proteasome inhibition
    Markus Kaiser
    AG Biorganische Chemie, Max Planck Institut fur Biochemie, Am Klopferspitz 18 A, 82152 Martinsried, Germany
    Angew Chem Int Ed Engl 41:780-3. 2002
  23. ncbi request reprint Investigations on the maturation and regulation of archaebacterial proteasomes
    Michael Groll
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Planegg Martinsried, Germany
    J Mol Biol 327:75-83. 2003
    ..fulgidus leaving a pore leading into the particle with a diameter of 13A. Mutagenesis and functional studies indicate the absence of regulatory gating in the archaeal 20S proteasome...
  24. ncbi request reprint Substrate access and processing by the 20S proteasome core particle
    Michael Groll
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Planegg, Martinsried, Germany
    Int J Biochem Cell Biol 35:606-16. 2003
    ..This inhibition is relieved upon binding of the RP to the CP by formation of the 26S proteasome holoenzyme. This review summarizes the current knowledge of the structural features of 20S proteasomes...
  25. ncbi request reprint Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling
    Markus Kaiser
    Max Planck Institut fur Biochemie, AG Bioorganische Chemie, 82152 Martinsried, Germany
    Org Lett 5:3435-7. 2003
    ....
  26. ncbi request reprint Binding mode of TMC-95A analogues to eukaryotic 20S proteasome
    Markus Kaiser
    Max Planck Institut fur Biochemie, Am Klopferspitz 18, 82152 Martinsried, Germany
    Chembiochem 5:1256-66. 2004
    ....
  27. ncbi request reprint TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors
    Markus Kaiser
    Max Planck Institut fur Biochemie, AG Bioorganische Chemie, Am Klopferspilz 18A, D 82152 Martinsried
    Chem Biodivers 1:161-73. 2004
    ....
  28. ncbi request reprint ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea
    Andrew A Horwitz
    Program in Biology and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 282:22921-9. 2007
    ..Using the protease protection maps, we modeled the conformational changes associated with ATP binding and hydrolysis in PAN based on the x-ray structures of the homologous AAA ATPase, HslU...
  29. ncbi request reprint Yersinia enterocolitica type III secretion chaperone SycH. Recombinant expression, purification, characterisation, and crystallisation
    Wibke Neumayer
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 9a, D 80336 Munich, Germany
    Protein Expr Purif 35:237-47. 2004
    ..In addition, we found that YopH was enzymatically active in the presence of SycH. This implies that the function of the secretion chaperone SycH is not to keep YopH in a globally unfolded state prior to secretion...
  30. pmc Proteasome inhibition by fellutamide B induces nerve growth factor synthesis
    John Hines
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Chem Biol 15:501-12. 2008
    ..These results demonstrate an unrecognized connection between proteasome inhibition and NGF production, suggesting a possible new strategy in the development of neurotrophic agents...
  31. ncbi request reprint Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family
    Rolf Bredemeier
    Ludwig Maximilians University LMU, Department of Biology I, Menzinger Strasse 67, 80638 Munchen, Germany
    J Biol Chem 282:1882-90. 2007
    ..Based on functional and phylogenetic analysis, we suggest an evolutionary scenario that explains the origin of the contemporary translocon...