Jan Groetzner

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failure
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
    Transplantation 77:568-74. 2004
  2. ncbi request reprint Renal recovery after conversion to a calcineurin inhibitor-free immunosuppression in late cardiac transplant recipients
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
    Eur J Cardiothorac Surg 25:333-41. 2004
  3. doi request reprint Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
    Clin Transplant 22:587-93. 2008
  4. ncbi request reprint Freedom from graft vessel disease in heart and combined heart- and kidney-transplanted patients treated with tacrolimus-based immunosuppression
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern Munich, Munich, Germany
    J Heart Lung Transplant 24:1787-92. 2005
  5. ncbi request reprint Mechanical circulatory support in pediatric patients with the MEDOS assist device
    Ingo Kaczmarek
    Department Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    ASAIO J 51:498-500. 2005
  6. ncbi request reprint Mechanical circulatory support in infants and adults with the MEDOS/HIA assist device
    Ingo Kaczmarek
    Department of Cardiac Surgery, University Hospital Grasshadern, Ludwig Maximilians University, Munich, Germany
    Artif Organs 29:857-60. 2005
  7. ncbi request reprint Cardiac transplantation in pediatric patients: fifteen-year experience of a single center
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Munich Grosshadern, Munich, Germany
    Ann Thorac Surg 79:53-60; discussion 61. 2005
  8. ncbi request reprint Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious
    Bruno Meiser
    Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
    J Heart Lung Transplant 26:598-603. 2007
  9. ncbi request reprint Sirolimus impairs gonadal function in heart transplant recipients
    Ingo Kaczmarek
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Transplant 4:1084-8. 2004
  10. ncbi request reprint Sirolimus and mycophenolate mofetil as calcineurin inhibitor-free immunosuppression in a cardiac transplant patient with chronic renal failure
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilian University Hospital Grosshadem, Munich, Germany
    J Heart Lung Transplant 23:770-3. 2004

Detail Information

Publications29

  1. ncbi request reprint Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failure
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
    Transplantation 77:568-74. 2004
    ....
  2. ncbi request reprint Renal recovery after conversion to a calcineurin inhibitor-free immunosuppression in late cardiac transplant recipients
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
    Eur J Cardiothorac Surg 25:333-41. 2004
    ..The aim of this prospective study was to evaluate the safety and efficacy of a completely CNI-free immunosuppressive regimen [mycophenolate mofetil (MMF) and sirolimus (Sir)] in HTx-recipients with late post-transplant renal impairment...
  3. doi request reprint Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
    Clin Transplant 22:587-93. 2008
    ..The aim of this prospective study was to evaluate the impact of an immunosuppressive conversion from CNIs to mycophenolate mofetil (MMF) and steroids in cardiac transplant recipients with CRF on renal and cardiac graft function...
  4. ncbi request reprint Freedom from graft vessel disease in heart and combined heart- and kidney-transplanted patients treated with tacrolimus-based immunosuppression
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern Munich, Munich, Germany
    J Heart Lung Transplant 24:1787-92. 2005
    ..Due to the increased donor shortage, the clinical outcome of combined HKTx patients on tacrolimus-based immunosuppression was assessed and compared with a group of HTx patients...
  5. ncbi request reprint Mechanical circulatory support in pediatric patients with the MEDOS assist device
    Ingo Kaczmarek
    Department Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    ASAIO J 51:498-500. 2005
    ..Secondary organ functions improve under this pulsatile circulatory assistance. Hemorrhage and thromboembolic events are the most frequent complications...
  6. ncbi request reprint Mechanical circulatory support in infants and adults with the MEDOS/HIA assist device
    Ingo Kaczmarek
    Department of Cardiac Surgery, University Hospital Grasshadern, Ludwig Maximilians University, Munich, Germany
    Artif Organs 29:857-60. 2005
    ..Secondary organ functions improve under this pulsatile circulatory assistance. Hemorrhage and thromboembolic events are the most frequent complications...
  7. ncbi request reprint Cardiac transplantation in pediatric patients: fifteen-year experience of a single center
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Munich Grosshadern, Munich, Germany
    Ann Thorac Surg 79:53-60; discussion 61. 2005
    ..However, it is still discussed as controversial because of uncertain long-term results. We report our experience with pediatric heart transplantation in a heterogeneous population...
  8. ncbi request reprint Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious
    Bruno Meiser
    Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
    J Heart Lung Transplant 26:598-603. 2007
    ..97 at 1 and 2 years. The regimen was well tolerated with only 3 patients requiring a change of study medication. Mean serum creatinine increased during the first year but returned to baseline at 2 years...
  9. ncbi request reprint Sirolimus impairs gonadal function in heart transplant recipients
    Ingo Kaczmarek
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Transplant 4:1084-8. 2004
    ..These effects were trough-level dependent. All candidates awaiting organ transplantation should be informed about these adverse effects...
  10. ncbi request reprint Sirolimus and mycophenolate mofetil as calcineurin inhibitor-free immunosuppression in a cardiac transplant patient with chronic renal failure
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilian University Hospital Grosshadem, Munich, Germany
    J Heart Lung Transplant 23:770-3. 2004
    ..This case illustrates the beneficial potential of sirolimus and MMF as CNI-free and safe long-term immunosuppression in a patient with chronic renal failure after heart transplantation...
  11. ncbi request reprint Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?
    Bruno M Meiser
    Department of Cardiac Surgery, University of Munich, Grosshadern Medical Center, Marchioninistrasse 15, 81366 Munich, Germany
    Transplantation 78:591-8. 2004
    ....
  12. ncbi request reprint New flexible polymeric heart valve prostheses for the mitral and aortic positions
    Sabine H Daebritz
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Heart Surg Forum 7:E525-32. 2004
    ..We report in vivo and in vitro results with new polymeric valve prostheses that have a special design for the mitral and aortic positions. The aims are improved durability and elimination of the need for permanent anticoagulation...
  13. doi request reprint Mycophenolate and sirolimus as calcineurin inhibitor-free immunosuppression improves renal function better than calcineurin inhibitor-reduction in late cardiac transplant recipients with chronic renal failure
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Grosshadern, Munich, Germany
    Transplantation 87:726-33. 2009
    ....
  14. ncbi request reprint Impairment of the blood-brain barrier can result in tacrolimus-induced reversible leucoencephalopathy following heart transplantation
    Ingo Kaczmarek
    Department of Cardiac Surgery, Ludwig Maximilians University, Grosshadern, Munich, Germany
    Clin Transplant 17:469-72. 2003
    ..Withdrawal of tacrolimus was not necessary while other causes of endothelial injury were treated successfully...
  15. ncbi request reprint Impact of donor serum sodium levels on outcome after heart transplantation
    Ingo Kaczmarek
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Heart Lung Transplant 24:928-31. 2005
    ..No impact of donor serum sodium levels was seen on early post-operative results or on long-term outcome, indicating that cardiac allografts from donors with elevated sodium levels may be transplanted successfully with favorable results...
  16. ncbi request reprint Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression
    Jan Groetzner
    Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
    J Heart Lung Transplant 23:632-8. 2004
    ..Sirolimus-based immunosuppressive therapy administered immediately after lung transplantation seems to be associated with severe wound-healing complications of the bronchial anastomosis...
  17. ncbi request reprint HLA-DR matching improves survival after heart transplantation: is it time to change allocation policies?
    Ingo Kaczmarek
    Department of Cardiac Surgery, Grosshadern University Hospital, Munich, Munich, Germany
    J Heart Lung Transplant 25:1057-62. 2006
    ..The aim of this single-center study was to assess the impact of HLA matching on long- term outcome after heart transplantation...
  18. ncbi request reprint Fas/FasL and perforin/granzyme pathway in acute rejection and diffuse alveolar damage after allogeneic lung transplantation-a human biopsy study
    Iris Bittmann
    Ludwig Maximilians University Munich, Pathologisches Institut, Thalkirchner Strasse 36, 80337 München, Germany
    Virchows Arch 445:375-81. 2004
    ..The FasL/Fas pathway is not only important for induction of apoptosis during rejection but is also a mechanism of lung injury in the development of diffuse alveolar damage...
  19. ncbi request reprint Introduction of a flexible polymeric heart valve prosthesis with special design for mitral position
    Sabine H Daebritz
    Department of Cardiac Surgery, Ludwig Maximilians University, University Hospital Grosshadern, Munich, Germany
    Circulation 108:II134-9. 2003
    ..A new polycarbonaturethane (PCU) bileaflet heart valve prosthesis with special design for the mitral position is introduced, and results of animal testing are presented...
  20. ncbi request reprint Surgicel Nu-Knit hemostat for bleeding control of fragile sternum
    Helmut Mair
    Department of Cardiac Surgery, University of Munich, Germany
    J Thorac Cardiovasc Surg 130:605-6. 2005
  21. ncbi request reprint Free serum cortisol during the postoperative acute phase response determined by equilibrium dialysis liquid chromatography-tandem mass spectrometry
    Michael Vogeser
    Institute of Clinical Chemistry, Hospital of the University of Munich Grosshadern, Munich, Germany
    Clin Chem Lab Med 41:146-51. 2003
    ....
  22. ncbi request reprint Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction
    Michael Vogeser
    Institute of Clinical Chemistry, Ludwig Maximilians Universitat Munchen, Klinikum Grosshadern, Munich, Germany
    Clin Chem Lab Med 40:40-5. 2002
    ..99; range 1.6-50 microg/l) and is rugged and precise with monthly CVs <7% at a sirolimus concentration of 13.1 microg/l in routine use; the instrumentation proved to be reliable and required minimal maintenance. Clin Chem..
  23. ncbi request reprint Myosplint implant and shape-change procedure: intra- and peri-operative safety and feasibility
    Soren Schenk
    Department of Cardiac Surgery, University Hospital Grosshadern, Munich, Germany
    J Heart Lung Transplant 21:680-6. 2002
    ..were implanted to change the left ventricle (LV) effective radius and to reduce the LV wall stress by 20%. We conducted this study to evaluate the intra- and peri-operative safety and feasibility of LV-shape change therapy...
  24. ncbi request reprint Introduction of a flexible polymeric heart valve prosthesis with special design for aortic position
    Sabine H Daebritz
    Department of Cardiac Surgery, Ludwig Maximilians University, University Hospital Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
    Eur J Cardiothorac Surg 25:946-52. 2004
    ..In this study, a respective flexible polymeric aortic valve is presented and in vitro and in vivo results are reported...
  25. ncbi request reprint Conversion to sirolimus and mycophenolate can attenuate the progression of bronchiolitis obliterans syndrome and improves renal function after lung transplantation
    Jan Groetzner
    Department of Cardiothoracic and Vascular Surgery, Friedrich Schiller University Hospital, Jena, Germany
    Transplantation 81:355-60. 2006
    ..The first clinical experience in converting LTx/HLTx-recipients with BOS from calcineurin inhibitor-(CNI)-based immunosuppression to a Sir-MMF based immunosuppression is reported herein...
  26. doi request reprint Caspofungin as first-line therapy for the treatment of invasive aspergillosis after thoracic organ transplantation
    Jan Groetzner
    Department of Cardio Thoracic Surgery, Cologne University Hospital, Cologne, Germany
    J Heart Lung Transplant 27:1-6. 2008
    ..We report our first clinical experience with the use of caspofungin as first-line therapy in heart and lung transplant recipients with invasive aspergillosis...
  27. ncbi request reprint Myocardial failure caused by traumatic dissection of left coronary system--ventricular recovery with temporary circulatory support
    Alexander Lauten
    Department of Cardiothoracic and Vascular Surgery, Friedrich Schiller University Jena, Jena, Germany
    J Card Surg 22:238-9. 2007
    ..Surgeons should consider the device as short-term support in borderline indications...
  28. ncbi request reprint Endobronchial donor pre-treatment with ventavis: is a second administration during reperfusion beneficial to optimize post-ischemic function of non-heart beating donor lungs?
    Thorsten Wittwer
    Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany
    J Surg Res 136:136-42. 2006
    ..Berlin, Germany). Currently, there is no information whether additional application of this approach in reperfusion can further optimize immediate graft function...
  29. ncbi request reprint Effect of induction therapy on kinetic of procalcitonin following uncomplicated heart transplantation
    Navid Madershahian
    Department of Cardiothoracic Surgery, Cologne University Hospital, Cologne, Germany
    J Card Surg 22:199-202. 2007
    ..The aim of the study was to determine the early postoperative kinetics of serum procalcitonin (PCT) levels in uncomplicated heart transplant patients under induction therapy using antithymocyte globulin (ATG)...