Research Topics
| Jan GroetznerSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Sirolimus and mycophenolate mofetil as calcineurin inhibitor-free immunosuppression in a cardiac transplant patient with chronic renal failureJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilian University Hospital Grosshadem, Munich, Germany
J Heart Lung Transplant 23:770-3. 2004..This case illustrates the beneficial potential of sirolimus and MMF as CNI-free and safe long-term immunosuppression in a patient with chronic renal failure after heart transplantation...- The new German allocation system for donated thoracic organs causes longer ischemia and increased costsJ Groetzner
Herzchirurgische Klinik, LMU, Klinikum Grosshadern, Munich, Germany
Thorac Cardiovasc Surg 50:376-9. 2002..In this study, we investigated the impact of the new allocation system on economic aspects as on clinical results... - Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppressionJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
J Heart Lung Transplant 23:632-8. 2004..Sirolimus-based immunosuppressive therapy administered immediately after lung transplantation seems to be associated with severe wound-healing complications of the bronchial anastomosis... 
Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of cautionJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
Clin Transplant 22:587-93. 2008..The aim of this prospective study was to evaluate the impact of an immunosuppressive conversion from CNIs to mycophenolate mofetil (MMF) and steroids in cardiac transplant recipients with CRF on renal and cardiac graft function...- Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failureJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Munich, Germany
Transplantation 77:568-74. 2004.... - Renal recovery after conversion to a calcineurin inhibitor-free immunosuppression in late cardiac transplant recipientsJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
Eur J Cardiothorac Surg 25:333-41. 2004..The aim of this prospective study was to evaluate the safety and efficacy of a completely CNI-free immunosuppressive regimen [mycophenolate mofetil (MMF) and sirolimus (Sir)] in HTx-recipients with late post-transplant renal impairment... - Cardiac transplantation in pediatric patients: fifteen-year experience of a single centerJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Munich Grosshadern, Munich, Germany
Ann Thorac Surg 79:53-60; discussion 61. 2005..However, it is still discussed as controversial because of uncertain long-term results. We report our experience with pediatric heart transplantation in a heterogeneous population... - Freedom from graft vessel disease in heart and combined heart- and kidney-transplanted patients treated with tacrolimus-based immunosuppressionJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Grosshadern Munich, Munich, Germany
J Heart Lung Transplant 24:1787-92. 2005..Due to the increased donor shortage, the clinical outcome of combined HKTx patients on tacrolimus-based immunosuppression was assessed and compared with a group of HTx patients... - Mechanical circulatory support in pediatric patients with the MEDOS assist deviceIngo Kaczmarek
Department Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
ASAIO J 51:498-500. 2005..Secondary organ functions improve under this pulsatile circulatory assistance. Hemorrhage and thromboembolic events are the most frequent complications... - Mechanical circulatory support in infants and adults with the MEDOS/HIA assist deviceIngo Kaczmarek
Department of Cardiac Surgery, University Hospital Grasshadern, Ludwig Maximilians University, Munich, Germany
Artif Organs 29:857-60. 2005..Secondary organ functions improve under this pulsatile circulatory assistance. Hemorrhage and thromboembolic events are the most frequent complications... - Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficaciousBruno Meiser
Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
J Heart Lung Transplant 26:598-603. 2007..97 at 1 and 2 years. The regimen was well tolerated with only 3 patients requiring a change of study medication. Mean serum creatinine increased during the first year but returned to baseline at 2 years... - Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?Bruno M Meiser
Department of Cardiac Surgery, University of Munich, Grosshadern Medical Center, Marchioninistrasse 15, 81366 Munich, Germany
Transplantation 78:591-8. 2004.... - Sirolimus impairs gonadal function in heart transplant recipientsIngo Kaczmarek
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Am J Transplant 4:1084-8. 2004..These effects were trough-level dependent. All candidates awaiting organ transplantation should be informed about these adverse effects... - New flexible polymeric heart valve prostheses for the mitral and aortic positionsSabine H Daebritz
Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
Heart Surg Forum 7:E525-32. 2004..We report in vivo and in vitro results with new polymeric valve prostheses that have a special design for the mitral and aortic positions. The aims are improved durability and elimination of the need for permanent anticoagulation... - Mycophenolate and sirolimus as calcineurin inhibitor-free immunosuppression improves renal function better than calcineurin inhibitor-reduction in late cardiac transplant recipients with chronic renal failureJan Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Grosshadern, Munich, Germany
Transplantation 87:726-33. 2009.... - Impairment of the blood-brain barrier can result in tacrolimus-induced reversible leucoencephalopathy following heart transplantationIngo Kaczmarek
Department of Cardiac Surgery, Ludwig Maximilians University, Grosshadern, Munich, Germany
Clin Transplant 17:469-72. 2003..Withdrawal of tacrolimus was not necessary while other causes of endothelial injury were treated successfully... - Impact of donor serum sodium levels on outcome after heart transplantationIngo Kaczmarek
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
J Heart Lung Transplant 24:928-31. 2005..No impact of donor serum sodium levels was seen on early post-operative results or on long-term outcome, indicating that cardiac allografts from donors with elevated sodium levels may be transplanted successfully with favorable results... - HLA-DR matching improves survival after heart transplantation: is it time to change allocation policies?Ingo Kaczmarek
Department of Cardiac Surgery, Grosshadern University Hospital, Munich, Munich, Germany
J Heart Lung Transplant 25:1057-62. 2006..The aim of this single-center study was to assess the impact of HLA matching on long- term outcome after heart transplantation... - Fas/FasL and perforin/granzyme pathway in acute rejection and diffuse alveolar damage after allogeneic lung transplantation-a human biopsy studyIris Bittmann
Ludwig Maximilians University Munich, Pathologisches Institut, Thalkirchner Strasse 36, 80337 München, Germany
Virchows Arch 445:375-81. 2004..The FasL/Fas pathway is not only important for induction of apoptosis during rejection but is also a mechanism of lung injury in the development of diffuse alveolar damage... - Introduction of a flexible polymeric heart valve prosthesis with special design for mitral positionSabine H Daebritz
Department of Cardiac Surgery, Ludwig Maximilians University, University Hospital Grosshadern, Munich, Germany
Circulation 108:II134-9. 2003..A new polycarbonaturethane (PCU) bileaflet heart valve prosthesis with special design for the mitral position is introduced, and results of animal testing are presented... - Systemic mechanical heart valve replacement in children under 16 years of ageA R Tiete
Department of Cardiac Surgery, University Hospital Grosshadern, Marchioninistr 15, 81377, Munich, Germany
Clin Res Cardiol 95:281-8. 2006..Operative mortality and the incidence of any valve-related events as endocarditis, reoperation, thromboembolism or anticoagulation related bleeding is acceptable... - The serum cortisol:cortisone ratio in the postoperative acute-phase responseM Vogeser
Institute of Clinical Chemistry, Ludwig Maximilians Universitat, Klinikum Grosshadern, Munich, Germany
Horm Res 59:293-6. 2003..The aim of the present study was to further characterize this alteration of cortisol metabolism in patients undergoing elective cardiac bypass surgery... - The controversy of donor serum sodium levels in heart transplantation--a multicenter experienceI Kaczmarek
Department of Cardiac Surgery, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Thorac Cardiovasc Surg 54:313-6. 2006..The clinical relevance on recipient outcome is less examined. We investigated the impact of elevated donor serum sodium levels (DSL) on outcome after heart transplantation in 1800 heart transplantations... - Surgicel Nu-Knit hemostat for bleeding control of fragile sternumHelmut Mair
Department of Cardiac Surgery, University of Munich, Germany
J Thorac Cardiovasc Surg 130:605-6. 2005 - Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extractionMichael Vogeser
Institute of Clinical Chemistry, Ludwig Maximilians Universitat Munchen, Klinikum Grosshadern, Munich, Germany
Clin Chem Lab Med 40:40-5. 2002..99; range 1.6-50 microg/l) and is rugged and precise with monthly CVs <7% at a sirolimus concentration of 13.1 microg/l in routine use; the instrumentation proved to be reliable and required minimal maintenance. Clin Chem.. - Free serum cortisol during the postoperative acute phase response determined by equilibrium dialysis liquid chromatography-tandem mass spectrometryMichael Vogeser
Institute of Clinical Chemistry, Hospital of the University of Munich Grosshadern, Munich, Germany
Clin Chem Lab Med 41:146-51. 2003.... - Myosplint implant and shape-change procedure: intra- and peri-operative safety and feasibilitySoren Schenk
Department of Cardiac Surgery, University Hospital Grosshadern, Munich, Germany
J Heart Lung Transplant 21:680-6. 2002..This study also suggests that Myosplints can be safely implanted in combination with mitral valve repair. The long-term effect of each procedure on cardiac function and survival will require further evaluation... - Results of pediatric cardiac transplantation -- long-term results of a 15-year experienceJ Groetzner
Department of Cardiac Surgery, Ludwig Maximilians University Hospital Munich Grosshadern, Munich, Germany
Thorac Cardiovasc Surg 53:S149-54. 2005..However, long-term outcome has been a matter of concern because of acute or chronic rejection and side effects of immunosuppression. We performed a retrospective study of up to 15-years of follow-up on this patient entity... - Lack of impact of donor sodium levels on outcome after heart transplantationI Kaczmarek
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany
Transplant Proc 35:2121-2. 2003 - Introduction of a flexible polymeric heart valve prosthesis with special design for aortic positionSabine H Daebritz
Department of Cardiac Surgery, Ludwig Maximilians University, University Hospital Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
Eur J Cardiothorac Surg 25:946-52. 2004..In this study, a respective flexible polymeric aortic valve is presented and in vitro and in vivo results are reported... - Myocardial failure caused by traumatic dissection of left coronary system--ventricular recovery with temporary circulatory supportAlexander Lauten
Department of Cardiothoracic and Vascular Surgery, Friedrich Schiller University Jena, Jena, Germany
J Card Surg 22:238-9. 2007..Surgeons should consider the device as short-term support in borderline indications... - Caspofungin as first-line therapy for the treatment of invasive aspergillosis after thoracic organ transplantationJan Groetzner
Department of Cardio Thoracic Surgery, Cologne University Hospital, Cologne, Germany
J Heart Lung Transplant 27:1-6. 2008..We report our first clinical experience with the use of caspofungin as first-line therapy in heart and lung transplant recipients with invasive aspergillosis... - Conversion to sirolimus and mycophenolate can attenuate the progression of bronchiolitis obliterans syndrome and improves renal function after lung transplantationJan Groetzner
Department of Cardiothoracic and Vascular Surgery, Friedrich Schiller University Hospital, Jena, Germany
Transplantation 81:355-60. 2006..The first clinical experience in converting LTx/HLTx-recipients with BOS from calcineurin inhibitor-(CNI)-based immunosuppression to a Sir-MMF based immunosuppression is reported herein... - Endobronchial donor pre-treatment with ventavis: is a second administration during reperfusion beneficial to optimize post-ischemic function of non-heart beating donor lungs?Thorsten Wittwer
Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany
J Surg Res 136:136-42. 2006..Berlin, Germany). Currently, there is no information whether additional application of this approach in reperfusion can further optimize immediate graft function... - Effect of induction therapy on kinetic of procalcitonin following uncomplicated heart transplantationNavid Madershahian
Department of Cardiothoracic Surgery, Cologne University Hospital, Cologne, Germany
J Card Surg 22:199-202. 2007..The aim of the study was to determine the early postoperative kinetics of serum procalcitonin (PCT) levels in uncomplicated heart transplant patients under induction therapy using antithymocyte globulin (ATG)...