Research Topics
Genomes and Genes | Rainer GrobholzSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic indexRainer Grobholz
Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Germany
APMIS 110:724-32. 2002..04) and linear regression (r = 0.54, P = 0.001). Therefore, Bax seems to play a determinant role in the modulation of apoptosis in human seminoma that may be linked to a favourable outcome...- Influence of neuroendocrine tumor cells on proliferation in prostatic carcinomaRainer Grobholz
Department of Pathology, University Hospital Mannheim, Ruprecht Karls University Heidelberg, Germany
Hum Pathol 36:562-70. 2005..A significant and clustered NE differentiation in PCa may lead to an increased proliferation and earlier tumor progression, whereas few and solitary NE tumor cells have no prognostic impact... - IGF-II serum levels increase discrimination between benign prostatic hyperplasia and prostate cancer and improve the predictive value of PSA in clinical stagingLutz Trojan
Department of Urology, University Hospital Mannheim, Heidelberg University, Germany
Eur Urol 49:286-92; discussion 292. 2006..Our aim was to determine PSA and IGF-II serum levels in patients with PCa and benign prostatic hyperplasia (BPH) and to analyse the value of IGF-II as an additional predictive factor in the diagnostics of PCa... - Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancerWilko I Staiger
Department of Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
Oncol Rep 16:657-61. 2006..Since molecular targeted inhibition of transketolase enzyme reactions suppresses tumor growth and metastasis, TKTL1 could be a relevant target for anti-transketolase therapies in gastric cancer... - Correlation between neovascularisation and neuroendocrine differentiation in prostatic carcinomaR Grobholz
Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Mannheim, Germany
Pathol Res Pract 196:277-84. 2000..0006). These observations support the concept that increased neovascularisation is influenced not only by poor pathological grading but also by a high NE differentiation... - Expression of MAGE antigens and analysis of the inflammatory T-cell infiltrate in human seminomaR Grobholz
Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Germany
Urol Res 28:398-403. 2000..MAGE antigens are homogeneously expressed in most seminomas, but their presence does not appear to represent a dominant epitope responsible for the lymphocytic infiltrate... - [Regressive changes after short-term neoadjuvant antihormonal therapy in prostatic carcinoma: the value of Gleason grading]R Grobholz
Pathologisches Institut, Universitätsklinikum Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim
Pathologe 27:33-9. 2006..Compared to the preoperative needle biopsies, pretreated tumors showed a significant upgrading. After 2 weeks of neoadjuvant antihormonal therapy, regressive changes are so great, that Gleason grading can no longer be recommended... - Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsiesTina Dreher
Pathologisches Institut, , Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
Virchows Arch 444:509-17. 2004..p27kip1 and PTEN did not show a higher predictive accuracy of the tumor grade in the surgical specimen than the Gleason score. However, p27kip1 had the same predictive value as the Gleason score in needle biopsies... 
The lymphatic system and its specific growth factor vascular endothelial growth factor C in kidney tissue and in renal cell carcinomaMartin Voss
Medical Statistics, University Hospital Mannheim, Mannheim, Germany
BJU Int 104:94-9. 2009..The role of a high LVD in the tumour capsule needs to be determined. The VEGF-C staining pattern in normal kidney tissue hints at functions other than lymphangiogenesis...- Serum vascular endothelial growth factor C level in patients with prostate cancer and benign prostatic hyperplasiaMartin Voss
Department of Urology, University Hospital Mannheim, Mannheim, Germany
Anal Quant Cytol Histol 30:199-202. 2008..To compare serum vascular endothelial growth factor C (VEGF-C) levels in patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze VEGF-C levels in relation to clinicopathologic parameters... - Expression of different vascular endothelial markers in prostate cancer and BPH tissue: an immunohistochemical and clinical evaluationLutz Trojan
Department of Urology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
Anticancer Res 24:1651-6. 2004..The aim of this study was to evaluate the three most commonly used endothelial markers of microvessels, CD31, CD34 and vWF, in benign and malignant prostatic tissue... - Clinical staging error in prostate cancer: localization and relevance of undetected tumour areasChristian Bolenz
Department of Urology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
BJU Int 103:1184-9. 2009..To describe the localization and to assess the clinical implications of areas of undetected prostate cancer in radical prostatectomy (RP) specimens, focusing on patients with unilaterally negative preoperative biopsy cores... - Prognostic implications of lymphangiogenesis in muscle-invasive transitional cell carcinoma of the bladderMario I Fernández
Department of Urology, University Hospital Mannheim, Germany
Eur Urol 53:571-8. 2008..Aim of the study was to describe and evaluate the association of lymph vessel density with clinicopathological parameters and survival in patients with muscle-invasive transitional cell carcinoma (TCC) of the bladder... - Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosisJens J Kaden
1st Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
Cardiovasc Pathol 14:80-7. 2005.... - Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapyJochen Tuettenberg
Department of Neurosurgery, Universitatsmedizin Mannheim, University of Heidelberg, 68167 Mannheim, Germany
J Cancer Res Clin Oncol 135:1239-44. 2009..Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy... - The role of the lymphatic system and its specific growth factor, vascular endothelial growth factor C, for lymphogenic metastasis in prostate cancerLutz Trojan
Department of Urology, University Hospital Mannheim, Mannheim, Germany
BJU Int 98:903-6. 2006.... - Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patientsChristian G Sauer
University Hospital Mannheim, Department of Pathology, Mannheim, Germany
Virchows Arch 444:518-26. 2004..The relative expression rates in biopsies matched in 65% with those of the prostatectomies. Detection of MMP-2 in core needle biopsies seems not to be a helpful marker for diagnostic purposes... - Neuroendocrine tumor cells in prostate cancer: evaluation of the neurosecretory products serotonin, bombesin, and gastrin - impact on angiogenesis and clinical follow-upElmar Heinrich
Department of Urology, University Hospital Mannheim, Mannheim, Germany
Prostate 71:1752-8. 2011..This is the first study to systematically quantify and analyze the influence of the NETC distribution and of their secretory products, serotonin, bombesin, and gastrin, on angiogenesis and in the clinical follow-up of PCa patients... 
Differential expression of IGF components and insulin receptor isoforms in human seminoma versus normal testicular tissueTanja Pascale Neuvians
Department of Pathology, University Hospital Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
Neoplasia 7:446-56. 2005..g., IGF-1, IGF-R1, IR-A, and IGFBP-2) may reflect an involvement in spermatogenesis, but may also play a major role in tumor growth as their expression is not downregulated despite the lack of spermatogenesis in tumor tissue...- Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1)Lutz Trojan
Department of Urology, University Hospital Mannheim, Mannheim, Germany
J Urol 172:103-7. 2004..Normal blood vessels were additionally quantified in BPH and PCa... - Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancerRalf Dieter Hofheinz
Onkologisches Zentrum, III, Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 66:1384-90. 2006..To establish the feasibility and efficacy of chemotherapy with capecitabine, weekly irinotecan, cetuximab, and pelvic radiotherapy for patients with locally advanced rectal cancer... - Expression of pro-angiogenic growth factors VEGF, EGF and bFGF and their topographical relation to neovascularisation in prostate cancerLutz Trojan
Department of Urology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Urol Res 32:97-103. 2004..The relevance of VEGF and EGF is underlined by the increased number of positive cancer cells. Although previously reported to be a pro-angiogenic growth hormone, bFGF appears to play an assimilably minor role in the angiogenesis of PCa... - Genetic analysis of neuroendocrine tumor cells in prostatic carcinomaChristian G Sauer
Department of Pathology, University Hospital Mannheim, Mannheim, Germany
Prostate 66:227-34. 2006..CONCLUSIONS: Our results support the concept of transdifferentiation of exocrine tumor cells to a neuroendocrine tumor cell phenotype... - The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylationJochen Utikal
Department of Dermatology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
Int J Cancer 119:2287-93. 2006..In conclusion, we clearly demonstrate here that the expression of metastasis suppressor MIM is regulated by DNA methylation of a CpG island within its promoter region... - A new electromagnetic shock-wave generator "SLX-F2" with user-selectable dual focus size: ex vivo evaluation of renal injuryRasmus Leistner
Department of Urology, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
Urol Res 35:165-71. 2007..The renal injury caused by either regime remains comparable... - Endoscopic full-thickness gastric resection using a flexible stapler deviceGeorg F B A Kähler
University Hospital Mannheim, University of Heidelberg, Manheim, Germany
Surg Technol Int 16:61-5. 2007..In addition to early gastric adenocarcinoma with incipient infiltration of the submucosa, possible indications for this procedure include gastrointestinal stromal tumors... - Standardization strategy for quantitative PCR in human seminoma and normal testisTanja Pascale Neuvians
Department of Pathology, University Hospital Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
J Biotechnol 117:163-71. 2005..Further, we developed a standardization strategy, which is applicable to many experimental investigations... - Minimally invasive treatment of renal cell carcinoma: comparison of 4 different monopolar radiofrequency devicesAxel Häcker
Department of Urology, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, Ruprecht Karls University of Heidelberg, Germany
Eur Urol 48:584-92. 2005..Radiofrequency Ablation is an investigational treatment option for RCC. The aim of our study was to test the ablation algorithms of four different RF systems in a standardized ex vivo perfused porcine kidney model... - Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancerGiridhar Mudduluru
Department of Experimental Surgery Mannheim Molecular Oncology of Solid Tumors, Deutsches Krebsforschungszentrum and University Heidelberg, Mannheim, Germany
Cancer 110:1697-707. 2007.... - EphB4 controls blood vascular morphogenesis during postnatal angiogenesisRalf Erber
Department of Neurosurgery, Faculty for Clinical Medicine of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
EMBO J 25:628-41. 2006..This implies that both neoplastic and non-neoplastic vascularization is driven not only by a vascular initiation program but also by a vascular patterning program mediated by guidance molecules... - Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosisJens J Kaden
1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Mannheim, Germany
Atherosclerosis 170:205-11. 2003..Cell proliferation was increased by IL-1 beta as determined by bromodesoxyuridine incorporation. Thus, IL-1 beta may regulate remodeling of the extracellular matrix in calcific AS... - HIV-related and Epstein-Barr virus-associated anal Burkitt's lymphoma: report of a caseSebastian Freudenberg
Department of Surgery, University Hospital Mannheim, Ruprecht Karls University, Heidelberg, Germany
Dis Colon Rectum 48:1656-9. 2005..This article describes and discusses primary Burkitt's lymphoma of the anus which is an extremely rare site of origin... - Bipolar and multipolar radio frequency ablation with resistance controlled power output: standardized ex vivo kidney tissue evaluationAxel Häcker
Department of Urology, Teltow, Germany
J Urol 175:1122-6. 2006..We investigated a newly developed bipolar and multipolar RF ablation system with an internally cooled electrode and resistance controlled power output in a standardized model of perfused ex vivo kidney tissue... - Topical chemotherapy in human urothelial carcinoma explants: a novel translational tool for preclinical evaluation of experimental intravesical therapiesChristian Bolenz
Department of Urology, Mannheim Medical Centre, University of Heidelberg, Germany
Eur Urol 56:504-11. 2009..Urothelial carcinoma (UC) is associated with a high local recurrence rate despite intravesical therapy. There is a lack of representative preclinical models for standardized testing of novel experimental therapies... - Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosisJens J Kaden
1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Germany
J Heart Valve Dis 13:560-6. 2004..Their pathogenetic role in calcific aortic stenosis is unknown... - Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?Heinz Peter Schlemmer
Department of Oncological Diagnostics and Therapy, German Cancer Research Center, University Hospital Mannheim, Ruprecht Karls University, Heidelberg, Germany
Eur Radiol 14:309-17. 2004..Deltat was longer in high compared with low-grade tumors (p=0.025). The DCE MRI can provide important information about individual MVD in prostate cancer, which may be helpful for guiding biopsy and assessing individual prognosis... - Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcificationJens J Kaden
First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
J Mol Cell Cardiol 36:57-66. 2004..quot;Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known... - Urothelial carcinoma of the ureter, giant rectal stone and sigmoid carcinoma 55 years after ureterosigmoidostomyTorsten J Wilhelm
Department of Surgery, University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany
Scand J Urol Nephrol 40:172-3. 2006..We present the case of a unique accumulation of complications 55 years after ureterosigmoidostomy for bladder exstrophy and discuss possible implications for follow-up strategies... - Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiformeJochen Tuettenberg
Department of Neurosurgery, Klinikum Mannheim, Medical Faculty, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
J Cancer Res Clin Oncol 131:31-40. 2005..This study is indicative of an anti-angiogenic efficacy of continuous low-dose TMZ plus rofecoxib in GBMs, especially in those tumors that are characterized by a high angiogenic activity... - Investigation of the thermal tissue effects of the argon plasma coagulation modes "pulsed" and "precise" on the porcine esophagus, ex vivo and in vivoGeorg F Kähler
Section Endoscopy, Surgical University Hospital Mannheim, Mannheim, Germany
Gastrointest Endosc 70:362-8. 2009..Systematic investigations of the tissue damage ex vivo and in vivo with the new, second-generation APC modes are lacking... - Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancerYongde Liao
Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 107:676-80. 2003..0325). These data show that AKT is upregulated in prostate cancer and that expression is correlated with tumor progression... - Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancerAlexander Hermani
Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 11:5146-52. 2005.... - Up-regulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor gradeYongde Liao
Hormones and Signal Transduction Group, German Cancer Research Centre, D-69120 Heidelberg, Germany
Hum Pathol 36:1186-96. 2005..Expression of IGFs, especially IGF-II, may be predictors of the outcome of prostate cancer... - Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesisThomas M Moehler
Department of Medicine V, University of Heidelberg, Heidelberg, Germany
J Cell Physiol 215:27-36. 2008..Together, our observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis... - Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRIFabian Kiessling
Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, INF 280, Heidelberg, Germany
Eur Radiol 14:1793-801. 2004.... - Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapyFabian Kiessling
Department of Oncological Diagnostics and Therapy, German Cancer Research Center DKFZ, Heidelberg, Germany
Invest Radiol 39:34-44. 2004..To establish an experimental setting for monitoring perfusion and metabolism in orthotopic prostate cancer at 1.5 T using dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) and 1H-MR spectroscopy (MRS)... - Novel germ cell markers characterize testicular seminoma and fetal testisIsabella Gashaw
Institute of Anatomy, University of Duisburg Essen, Essen, Germany
Mol Hum Reprod 13:721-7. 2007.... - Renal embolization: feasibility of magnetic resonance-guidance using active catheter tracking and intraarterial magnetic resonance angiographyChristian Fink
Department of Radiology E010, Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
Invest Radiol 39:111-9. 2004..The objective of this study was to assess the feasibility of MR-guided renal embolization using active catheter tracking with automatic slice positioning and intraarterial contrast-enhanced MR angiography (MRA)... - Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostateOlaf Bettendorf
Institute of Pathology, University of Munster, Munster, Germany
Genes Chromosomes Cancer 47:565-72. 2008..Our results indicate that IDC-P in general follows the genetic pathway from normal epithelium over PIN lesion. IDC-P represents a separate prostatic lesion and should be graded as a poorly differentiated carcinoma... - Pathogenetic role of Chlamydia pneumoniae in calcific aortic stenosis: immunohistochemistry study and review of the literatureJens J Kaden
1st Department of Medicine (Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, University of Heidelberg, Germany
J Heart Valve Dis 12:447-53. 2003..pneumoniae in the adult population was demonstrated, irrespective of heart valve disease. Thus, C. pneumoniae is most likely not involved in the pathogenesis of calcific aortic stenosis... - High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculatureChristian Fink
Division Oncological Diagnostics and Therapy E010, Research Program Radiological Diagnostics and Therapy, Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
J Magn Reson Imaging 18:59-65. 2003..To evaluate high-resolution three-dimensional MR angiography (MRA) for the visualization and morphologic characterization of intratumoral vasculature...