O Grisk

Summary

Affiliation: University of Greifswald
Country: Germany

Publications

  1. ncbi request reprint Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D 17495 Karlsburg, Germany
    J Hypertens 20:131-8. 2002
  2. doi request reprint Potential Benefits of Rho-kinase Inhibition in Arterial Hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Str 11c, 17495, Greifswald, Karlsburg, Germany
    Curr Hypertens Rep 15:506-13. 2013
  3. doi request reprint The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries
    Olaf Grisk
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    J Hypertens 30:980-9. 2012
  4. ncbi request reprint Sympatho-renal interactions in the determination of arterial pressure: role in hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D17495 Karlsburg, Germany
    Exp Physiol 90:183-7. 2005
  5. ncbi request reprint Influence of neonatal sympathectomy on proximal renal resistance artery function in spontaneously hypertensive rats
    Olaf Grisk
    Institut fur Physiologie, Universitat Greifswald, Greifswalder Strasse 11c, 17495 Karlsburg, Germany
    Pflugers Arch 449:364-71. 2005
  6. ncbi request reprint Analysis of arterial pressure regulating systems in renal post-transplantation hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Karlsburg, Germany
    J Hypertens 22:199-207. 2004
  7. ncbi request reprint Interactions between the sympathetic nervous system and the kidneys in arterial hypertension
    Olaf Grisk
    Department of Physiology, Ernst Moritz Arndt University of Greifswald, Greifswalder Str 11c, D 17495 Karlsburg, Germany
    Cardiovasc Res 61:238-46. 2004
  8. doi request reprint Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function
    Olaf Grisk
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    Pharmacogenet Genomics 19:276-88. 2009
  9. doi request reprint [Hypertension and the sympathetic nervous system - recent developments in research and treatment]
    O Grisk
    Institut fur Physiologie, Universitätsklinikum Greifswald
    Dtsch Med Wochenschr 134:2289-93. 2009
  10. ncbi request reprint Sympathetic-renal interaction in chronic arterial pressure control
    Olaf Grisk
    Department of Physiology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    Am J Physiol Regul Integr Comp Physiol 283:R441-50. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D 17495 Karlsburg, Germany
    J Hypertens 20:131-8. 2002
    ..In addition, the effect of differential genetic predisposition to hypertension of recipients of an SHR kidney on the development of post-transplantation hypertension was studied...
  2. doi request reprint Potential Benefits of Rho-kinase Inhibition in Arterial Hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Str 11c, 17495, Greifswald, Karlsburg, Germany
    Curr Hypertens Rep 15:506-13. 2013
    ..If introduction of ROCK inhibitors for the treatment of high blood pressure can significantly advance currently available options of antihypertensive pharmacotherapy awaits further experimental and clinical research. ..
  3. doi request reprint The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries
    Olaf Grisk
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    J Hypertens 30:980-9. 2012
    ..We tested whether ROCK inhibition more effectively reduced agonist-induced vasoconstriction in renal than in nonrenal resistance arteries and if SAR407899 more potently inhibits agonist-induced vasoconstriction than Y27632...
  4. ncbi request reprint Sympatho-renal interactions in the determination of arterial pressure: role in hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D17495 Karlsburg, Germany
    Exp Physiol 90:183-7. 2005
    ..Severe reduction in sympathetic tone during early ontogeny causes long-term changes in renal function that mitigate hypertension development in SHRs even when the extrarenal neuro-hormonal environment is restored...
  5. ncbi request reprint Influence of neonatal sympathectomy on proximal renal resistance artery function in spontaneously hypertensive rats
    Olaf Grisk
    Institut fur Physiologie, Universitat Greifswald, Greifswalder Strasse 11c, 17495 Karlsburg, Germany
    Pflugers Arch 449:364-71. 2005
    ..In conclusion, neonatal sympathectomy does not induce any changes in the function of isolated proximal renal resistance arteries from SHR that could explain the blood pressure lowering effect of a kidney graft from sympathectomized SHR...
  6. ncbi request reprint Analysis of arterial pressure regulating systems in renal post-transplantation hypertension
    Olaf Grisk
    Department of Physiology, University of Greifswald, Karlsburg, Germany
    J Hypertens 22:199-207. 2004
    ....
  7. ncbi request reprint Interactions between the sympathetic nervous system and the kidneys in arterial hypertension
    Olaf Grisk
    Department of Physiology, Ernst Moritz Arndt University of Greifswald, Greifswalder Str 11c, D 17495 Karlsburg, Germany
    Cardiovasc Res 61:238-46. 2004
    ..These mechanisms importantly contribute to the pathogenesis of hypertension secondary to renal artery stenosis and end-stage renal disease...
  8. doi request reprint Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function
    Olaf Grisk
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    Pharmacogenet Genomics 19:276-88. 2009
    ..Furthermore, we investigated whether a particular kidney donor ABCC2 genotype is associated with delayed graft function in patients...
  9. doi request reprint [Hypertension and the sympathetic nervous system - recent developments in research and treatment]
    O Grisk
    Institut fur Physiologie, Universitätsklinikum Greifswald
    Dtsch Med Wochenschr 134:2289-93. 2009
    ..New developments in biomedical technology allow for non-pharmacological interventions to reduce sympathetic activity and provide new options to treat hypertensive patients who are resistant to antihypertensive drug therapy...
  10. ncbi request reprint Sympathetic-renal interaction in chronic arterial pressure control
    Olaf Grisk
    Department of Physiology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    Am J Physiol Regul Integr Comp Physiol 283:R441-50. 2002
    ..Generalized reduction in sympathetic tone resets the kidney-fluid system to reduced MAP and blunts the extent of arterial pressure rise induced by an SHR kidney graft...
  11. ncbi request reprint Impaired coronary function in Wistar Ottawa Karlsburg W rats-a new model of the metabolic syndrome
    Olaf Grisk
    Department of Cardiovascular Medicine, Institute of Physiology, University of Greifswald, Greifswalder Str 11c, 17495, Karlsburg, Germany
    Pflugers Arch 454:1011-21. 2007
    ..The latter may contribute to inappropriately elevated coronary tone in insulin-resistant subjects, especially when sympathetic activity to the heart is increased...
  12. ncbi request reprint The development of post-transplantation hypertension in recipients of an SHR kidney is independent of reinnervation of the graft
    O Grisk
    Department of Physiology, Ernst Moritz Arndt University, Karlsburg, Germany
    Pflugers Arch 438:502-7. 1999
    ..001) within 6 weeks after transplantation. We conclude that post-transplantation hypertension in recipients of an SHR kidney does not depend on sympathetic reinnervation of the graft...
  13. pmc Endothelin-1-induced activation of rat renal pelvic contractions depends on cyclooxygenase-1 and Rho kinase
    Olaf Grisk
    Institute of Physiology, Univ of Greifswald, Greifswalder Str 11c, D 17495 Karlsburg, Germany
    Am J Physiol Regul Integr Comp Physiol 299:R1602-9. 2010
    ..ET-1 is a powerful ET(A) receptor-dependent activator of renal pelvic contractions. COX-1 and ROCK activity are required for the ET-1 effects on pelvic contractions, which are not significantly affected by dietary NaCl intake...
  14. ncbi request reprint Sympathetic reinnervation of rat kidney grafts
    O Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D-17495 Karlsburg, Germany
    Transplantation 72:1153-5. 2001
    ..This is not accompanied by a significant recovery of norepinephrine concentration in renal tissue indicating persistent sympathetic denervation...
  15. ncbi request reprint Sympathetic activity in early renal posttransplantation hypertension in rats
    O Grisk
    Department of Physiology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    Am J Physiol Regul Integr Comp Physiol 279:R1737-44. 2000
    ..The results suggest that elevated sympathetic activity is not a major contributor to the development of renal posttransplantation hypertension...
  16. ncbi request reprint Neonatal sympathectomy reduces NADPH oxidase activity and vascular resistance in spontaneously hypertensive rat kidneys
    Torsten Schlüter
    Institute of Physiology, University of Greifswald, Greifswalder Strasse 11c, D17495 Karlsburg, Germany
    Am J Physiol Regul Integr Comp Physiol 291:R391-9. 2006
    ....
  17. doi request reprint Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
    Torsten Schlüter
    Department of Physiology, University of Greifswald, Greifswalder Street 11C, D17495 Greifswald, Karlsburg, Germany
    Cardiovasc Res 80:271-9. 2008
    ..Further experiments were performed in normotensive rats and in NADPH oxidase subunit knock-out mice to test if apocynin-induced vasodilation depends on NADPH oxidase inhibition at all...
  18. ncbi request reprint Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis
    Barbara Peters
    Department of Cardiovascular Medicine, University of Greifswald, Greifswald, Germany
    J Hypertens 26:102-9. 2008
    ..In cyp1a1ren-2 transgenic rats, prorenin levels and arterial pressure can be increased by oral administration of indole-3-carbinol (I3C). The transgenic strain has been used as a model of malignant hypertension...
  19. ncbi request reprint Low NaCl intake elevates renal medullary endothelin-1 and endothelin A (ETA) receptor mRNA but not the sensitivity of renal Na+ excretion to ETA receptor blockade in rats
    F Klinger
    Institute of Physiology, University of Greifswald, Greifswald, Germany
    Acta Physiol (Oxf) 192:429-42. 2008
    ..We further tested for NaCl intake-dependent differences in the contribution of the ET system to renal sodium handling...
  20. ncbi request reprint Influence of arterial baroreceptors and intracerebroventricular guanabenz on synchronized renal nerve activity
    O Grisk
    Department of Physiology, Ernst Moritz Arndt University, Greifswald, Germany
    Acta Physiol Scand 163:209-18. 1998
    ....
  21. ncbi request reprint Colon ascendens stent peritonitis--a model of sepsis adopted to the rat: physiological, microcirculatory and laboratory changes
    Martina Katja Lustig
    Klinik fur Chirurgie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Shock 28:59-64. 2007
    ....
  22. ncbi request reprint The kidney as a determinant of genetic hypertension: evidence from renal transplantation studies
    Rainer Rettig
    Department of Physiology, University of Greifswald, D 17495 Karlsburg, Germany
    Hypertension 46:463-8. 2005
  23. ncbi request reprint Frequency modulation of mesenteric and renal vascular resistance
    Olaf Grisk
    Institut fur Physiologie, Ernst Moritz Arndt Universitat Greifswald, 17495 Karlsburg, Germany
    Am J Physiol Regul Integr Comp Physiol 282:R1468-76. 2002
    ..Furthermore, our data suggest that sympathetic modulation of mesenteric vascular resistance can initiate blood pressure oscillations at slightly higher frequencies than sympathetic modulation of renal vascular resistance...
  24. doi request reprint Intrarenal artery superoxide is mainly NADPH oxidase-derived and modulates endothelium-dependent dilation in elderly patients
    Torsten Schlüter
    Department of Physiology, University Clinics of Greifswald, Greifswald, Germany
    Cardiovasc Res 85:814-24. 2010
    ....
  25. doi request reprint Long-term hypothermia reduces infarct volume in aged rats after focal ischemia
    Baltromejus Florian
    Department of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487 Greifswald, Germany
    Neurosci Lett 438:180-5. 2008
    ..Conclusions: Prolonged, H(2)S-induced hypothermia is a simple and efficacious method to limit the damage inflicted by stroke in aged rats...
  26. ncbi request reprint Angiotensin II induces catecholamine release by direct ganglionic excitation
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Luebeck, Luebeck, Germany
    Hypertension 40:348-54. 2002
    ..In both the absence and presence of preganglionic sympathetic activity, this mechanism contributes significantly to ANG-induced enhancement of catecholamine release...
  27. ncbi request reprint Impact of renal transplantation on small vessel reactivity
    Gert Gabriels
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Munster, Germany
    Transplantation 75:689-97. 2003
    ..The function of large arteries is altered after renal transplantation. Whether transplantation also induces agonist-dependent functional changes in small arterial renal and extrarenal vessels has not yet been studied...
  28. ncbi request reprint Apelin and vascular dysfunction in type 2 diabetes
    Olaf Grisk
    Cardiovasc Res 74:339-40. 2007
  29. ncbi request reprint Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats
    Kari T Kivistö
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D 70376 Stuttgart, Germany
    Drug Metab Dispos 33:1593-6. 2005
    ..Furthermore, intestinal Mrp2 does not appear to play a major role in the oral absorption of pravastatin in normal rats...