Affiliation: University of Regensburg
- Alternative chromatin structures of the 35S rRNA genes in Saccharomyces cerevisiae provide a molecular basis for the selective recruitment of RNA polymerases I and IIHannah Goetze
Universitätsstr 31, D 93053 Regensburg, Germany
Mol Cell Biol 30:2028-45. 2010..Furthermore, lack of UAF leads to the loss of Sir2 from rDNA, correlating with impaired Pol II silencing. This analysis of rDNA chromatin provides a molecular basis, explaining many phenotypes observed in previous genetic analyses...
- Reduction in ribosomal protein synthesis is sufficient to explain major effects on ribosome production after short-term TOR inactivation in Saccharomyces cerevisiaeAlarich Reiter
Universitaet Regensburg, Institut fur Biochemie, Genetik und Mikrobiologie, Lehrstuhl Biochemie III, Regensburg, Germany
Mol Cell Biol 31:803-17. 2011..We suggest that shortage of newly synthesized r-proteins after short-term TOR inactivation is sufficient to explain most of the observed effects on ribosome production...
- TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA productionAnja Philippi
Institut fur Biochemie, Genetik und Mikrobiologie, Universitat Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
Nucleic Acids Res 38:5315-26. 2010..However, our analysis reveals that the dramatic reduction of rRNA synthesis in the immediate cellular response to impaired TOR signalling cannot be explained by the simple down-regulation of Rrn3p and Pol I-Rrn3p levels...
- Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone moleculesKatharina Merz
Universitaet Regensburg, Institut fur Biochemie, Genetik und Mikrobiologie, 93053 Regensburg, Germany
Genes Dev 22:1190-204. 2008..We demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1...
- Site specific phosphorylation of yeast RNA polymerase IJochen Gerber
Institut fur Biochemie, Mikrobiologie und Genetik, Universitat Regensburg, Munich, Germany
Nucleic Acids Res 36:793-802. 2008..2, suggesting a role in RNA cleavage/elongation or termination. Our results suggest that individual major or constitutively phosphorylated residues contribute to non-essential Pol I-functions...