Christoph G Grevelding
Affiliation: University of Giessen
Lu Z, Quack T, Hahnel S, Gelmedin V, Pouokam E, Diener M, et al
. Isolation, enrichment and primary characterisation of vitelline cells from Schistosoma mansoni obtained by the organ isolation method. Int J Parasitol. 2015;45:663-72 pubmed publisher
Mader P, Blohm A, Quack T, Lange Grünweller K, Grünweller A, Hartmann R, et al
. Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents. ChemMedChem. 2016;11:1459-68 pubmed publisher
..The present study provides detailed insight into the structure-activity relationships of biarylalkyl carboxylic acid derivatives and thereby paves the way for a new drug-hit moiety for fighting schistosomiasis. ..
Blohm A, Mader P, Quack T, Lu Z, Hahnel S, Schlitzer M, et al
. Derivatives of biarylalkyl carboxylic acid induce pleiotropic phenotypes in adult Schistosoma mansoni in vitro. Parasitol Res. 2016;115:3831-42 pubmed publisher
..The variety of observed phenotypes suggested that different targets were hit. The results demonstrated that BACADs are interesting substances with respect to their anti-schistosomal effects. ..
Grevelding C, Langner S, Dissous C. Kinases: Molecular Stage Directors for Schistosome Development and Differentiation. Trends Parasitol. 2018;34:246-260 pubmed publisher
..Due to their importance for schistosome biology, kinases represent Achilles' heels and are therefore of high value also for translational research. ..
Buro C, Burmeister C, Quack T, Grevelding C. Identification and first characterization of SmEps8, a potential interaction partner of SmTK3 and SER transcribed in the gonads of Schistosoma mansoni. Exp Parasitol. 2017;180:55-63 pubmed publisher
..mansoni. The results of this study provide first evidence for a SER-SmEps8-SmTK3-SmDia signal transduction pathway controlling differentiation processes in the gonads of S. mansoni. ..
Hahnel S, Parker Manuel R, Dissous C, Cailliau K, Grevelding C. First characterization of SmOPG1, a novel protein involved in gonad-associated processes in Schistosoma mansoni. Mol Biochem Parasitol. 2017;213:22-25 pubmed publisher
..mansoni. Finally, SmOPG1 knock-down provided first hints for a function in the ovary. ..