Christian Grefkes

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi request reprint Connectivity-based approaches in stroke and recovery of function
    Christian Grefkes
    Department of Neurology, University Hospital Cologne, Koln, Germany Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, Koln, Germany Cognitive Neuroscience, Institute of Neuroscience and Medicine INM 3, Research Centre Julich, Julich, Germany Electronic address
    Lancet Neurol 13:206-16. 2014
  2. doi request reprint Disruption of motor network connectivity post-stroke and its noninvasive neuromodulation
    Christian Grefkes
    Department of Neurology, University Hospital Cologne, Germany
    Curr Opin Neurol 25:670-5. 2012
  3. doi request reprint Noradrenergic modulation of cortical networks engaged in visuomotor processing
    Christian Grefkes
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    Cereb Cortex 20:783-97. 2010
  4. ncbi request reprint Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM
    Christian Grefkes
    Neuromodulation and Neurorehabilitation Group, Max Planck Institute for Neurological Research, Cologne, Germany
    Neuroimage 41:1382-94. 2008
  5. ncbi request reprint Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging
    Christian Grefkes
    Department of Neurology, University of Cologne, Cologne, Germany
    Ann Neurol 63:236-46. 2008
  6. doi request reprint Modulating cortical connectivity in stroke patients by rTMS assessed with fMRI and dynamic causal modeling
    Christian Grefkes
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research Cologne, Germany
    Neuroimage 50:233-42. 2010
  7. doi request reprint The effects of 1 Hz rTMS over the hand area of M1 on movement kinematics of the ipsilateral hand
    Manuel Dafotakis
    Institute of Neuroscience and Biophysics INB3 Medicine, Research Centre Julich, Julich, Germany
    J Neural Transm 115:1269-74. 2008
  8. ncbi request reprint Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke
    Mitra Ameli
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Ann Neurol 66:298-309. 2009
  9. doi request reprint Convergence of human brain mapping tools: neuronavigated TMS parameters and fMRI activity in the hand motor area
    Anna Sophia Sarfeld
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, Cologne, Germany
    Hum Brain Mapp 33:1107-23. 2012
  10. doi request reprint Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study
    Ling E Wang
    Cognitive Neurology Section, Institute of Neuroscience and Medicine INM 3, Research Centre Juelich, Germany
    Hum Brain Mapp 33:2941-56. 2012

Collaborators

Detail Information

Publications42

  1. doi request reprint Connectivity-based approaches in stroke and recovery of function
    Christian Grefkes
    Department of Neurology, University Hospital Cologne, Koln, Germany Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, Koln, Germany Cognitive Neuroscience, Institute of Neuroscience and Medicine INM 3, Research Centre Julich, Julich, Germany Electronic address
    Lancet Neurol 13:206-16. 2014
    ....
  2. doi request reprint Disruption of motor network connectivity post-stroke and its noninvasive neuromodulation
    Christian Grefkes
    Department of Neurology, University Hospital Cologne, Germany
    Curr Opin Neurol 25:670-5. 2012
    ....
  3. doi request reprint Noradrenergic modulation of cortical networks engaged in visuomotor processing
    Christian Grefkes
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    Cereb Cortex 20:783-97. 2010
    ..The data suggest that stimulating noradrenergic mechanisms may rearrange the functional network architecture within and across the hemispheres, for example, by synaptic gating, thereby optimizing motor behavior...
  4. ncbi request reprint Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM
    Christian Grefkes
    Neuromodulation and Neurorehabilitation Group, Max Planck Institute for Neurological Research, Cologne, Germany
    Neuroimage 41:1382-94. 2008
    ..Our data demonstrate that fMRI in combination with DCM allows insights into intrinsic properties of the human motor system and task-dependent modulations thereof...
  5. ncbi request reprint Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging
    Christian Grefkes
    Department of Neurology, University of Cologne, Cologne, Germany
    Ann Neurol 63:236-46. 2008
    ..This study aimed at identifying the impact of subcortical stroke on the interaction of cortical motor areas within and across hemispheres during the generation of voluntary hand movements...
  6. doi request reprint Modulating cortical connectivity in stroke patients by rTMS assessed with fMRI and dynamic causal modeling
    Christian Grefkes
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research Cologne, Germany
    Neuroimage 50:233-42. 2010
    ....
  7. doi request reprint The effects of 1 Hz rTMS over the hand area of M1 on movement kinematics of the ipsilateral hand
    Manuel Dafotakis
    Institute of Neuroscience and Biophysics INB3 Medicine, Research Centre Julich, Julich, Germany
    J Neural Transm 115:1269-74. 2008
    ..The impact on motor performance of the ipsilateral hand is most pronounced after 1 Hz rTMS over the left M1...
  8. ncbi request reprint Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke
    Mitra Ameli
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Ann Neurol 66:298-309. 2009
    ..The effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) over ipsilesional M1 on movement kinematics and neural activity were examined in patients with subcortical or cortical stroke...
  9. doi request reprint Convergence of human brain mapping tools: neuronavigated TMS parameters and fMRI activity in the hand motor area
    Anna Sophia Sarfeld
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, Cologne, Germany
    Hum Brain Mapp 33:1107-23. 2012
    ..The data show that TMS parameters assessed for the hand area of M1 do not only reflect the intrinsic properties at the stimulation site but also interactions with remote areas in the human motor system...
  10. doi request reprint Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study
    Ling E Wang
    Cognitive Neurology Section, Institute of Neuroscience and Medicine INM 3, Research Centre Juelich, Germany
    Hum Brain Mapp 33:2941-56. 2012
    ..The results suggest that degeneration of transcallosal fibers connecting higher order sensorimotor regions constitute a relevant factor influencing cortical reorganization and motor outcome after subcortical stroke...
  11. ncbi request reprint Dexterity is impaired at both hands following unilateral subcortical middle cerebral artery stroke
    Dennis A Nowak
    Department of Neurology, University of Cologne, Cologne, Germany
    Eur J Neurosci 25:3173-84. 2007
    ..These data provide evidence that dexterity is impaired at both hands after subcortical middle cerebral artery stroke...
  12. doi request reprint Dynamic causal modeling of cortical activity from the acute to the chronic stage after stroke
    Anne K Rehme
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research Cologne, Germany
    Neuroimage 55:1147-58. 2011
    ..The shift of an early, supportive role of contralesional M1 into enhanced inhibitory coupling might indicate maladaptive processes which could be a target of non-invasive brain stimulation techniques...
  13. doi request reprint Activation likelihood estimation meta-analysis of motor-related neural activity after stroke
    Anne K Rehme
    Max Planck Institute for Neurological Research, Neuromodulation and Neurorehabilitation, Cologne, Germany
    Neuroimage 59:2771-82. 2012
    ..However, a good functional outcome relies on the recruitment of the original functional network rather than on contralesional activity...
  14. ncbi request reprint Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke
    Dennis A Nowak
    Department of Neurology, University Hospital Cologne, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Arch Neurol 65:741-7. 2008
    ..Following the concept of interhemispheric competition, downregulation of the contralesional primary motor cortex (M1) may improve the dexterity of the affected hand after stroke...
  15. pmc Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty
    Simon B Eickhoff
    Institut for Neuroscience and Biophysics Medicine INB 3, Research Center Julich, Julich, Germany
    Hum Brain Mapp 30:2907-26. 2009
    ..It may thus provide a methodologically improved tool for coordinate-based meta-analyses on functional imaging data...
  16. ncbi request reprint Network dynamics engaged in the modulation of motor behavior in healthy subjects
    Eva Maria Pool
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    Neuroimage 82:68-76. 2013
    ..The results suggest that a stronger coupling, especially between contralateral premotor areas and M1, enables increased motor performance of simple unilateral hand movements. ..
  17. ncbi request reprint Network connectivity and individual responses to brain stimulation in the human motor system
    Lizbeth Cárdenas-Morales
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, 50931 Cologne, Germany, Department of Neurology, Cologne University Hospital, 50924 Cologne, Germany
    Cereb Cortex 24:1697-707. 2014
    ..Predominantly activity-dependent properties of the cortical motor system are indicative of excitability changes following induction of cortical plasticity with rTMS. ..
  18. doi request reprint Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
    ..This review critically summarizes the data supporting the use of novel electrophysiological concepts in the rehabilitation of hand function after stroke...
  19. doi request reprint Effects of rTMS on grip force control following subcortical stroke
    Manuel Dafotakis
    Department of Neurology, University Hospital Cologne, University of Cologne, Germany
    Exp Neurol 211:407-12. 2008
    ..Our data support the interhemispheric competition concept and furthermore reinforce current efforts to implement rTMS in novel approaches to stroke rehabilitation...
  20. pmc Dose-dependent effects of theta burst rTMS on cortical excitability and resting-state connectivity of the human motor system
    Charlotte Nettekoven
    Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    J Neurosci 34:6849-59. 2014
    ....
  21. ncbi request reprint The somatotopic organization of cytoarchitectonic areas on the human parietal operculum
    Simon B Eickhoff
    Institut fur Medizin, Forschungszentrum Julich, Julich, Germany
    Cereb Cortex 17:1800-11. 2007
    ....
  22. doi request reprint Dynamic interactions in the fronto-parietal network during a manual stimulus-response compatibility task
    Edna C Cieslik
    Institute of Neuroscience and Medicine, INM 2, Research Centre Julich, Julich, Germany
    Neuroimage 58:860-9. 2011
    ..Our DCM study hence provides evidence for context-dependent top-down control of right TPJ and DLPFC as well as the preSMA in stimulus-response compatibility...
  23. doi request reprint The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal FMRI
    Anne K Rehme
    Neuromodulation and Neurorehabilitation Group, Max Planck Institute for Neurological Research, 50931 Cologne, Germany
    Cereb Cortex 21:756-68. 2011
    ....
  24. ncbi request reprint Performing allocentric visuospatial judgments with induced distortion of the egocentric reference frame: an fMRI study with clinical implications
    Gereon R Fink
    Institute of Medicine, Research Centre Julich, Julich, Germany
    Neuroimage 20:1505-17. 2003
    ....
  25. ncbi request reprint A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
    Simon B Eickhoff
    Institut fur Medizin, Forschungszentrum Julich, Julich, Germany
    Neuroimage 25:1325-35. 2005
    ..This new toolbox provides an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space...
  26. doi request reprint State-dependent differences between functional and effective connectivity of the human cortical motor system
    Anne K Rehme
    Max Planck Institute for Neurological Research, Neuromodulation and Neurorehabilitation, Cologne, Germany
    Neuroimage 67:237-46. 2013
    ..Therefore, resting-state fMRI and DCM should be used as complementary measures when assessing functional brain networks...
  27. pmc Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches
    Christian Grefkes
    Neuromodulation and Neurorehabilitation, Max Planck Institute for Neurological Research, Gleueler Street 50, 50931 Koln, Germany
    Brain 134:1264-76. 2011
    ....
  28. doi request reprint Differential effects of dopaminergic medication on basic motor performance and executive functions in Parkinson's disease
    Jochen Michely
    Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931, Cologne, Germany
    Neuropsychologia 50:2506-14. 2012
    ..Specifically, we assessed how behavioral changes relate to medication, disease severity, and basic motor or cognitive deficits...
  29. ncbi request reprint The role of anterior midcingulate cortex in cognitive motor control: evidence from functional connectivity analyses
    Felix Hoffstaedter
    Institute for Neuroscience and Medicine INM 1, Research Centre Julich, Germany Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany
    Hum Brain Mapp 35:2741-53. 2014
    ..In summary, the different experiments of the present study suggest that the aMCC constitute a key region in the network realizing intentional motor control...
  30. ncbi request reprint The role of the anterior intraparietal sulcus in crossmodal processing of object features in humans: an rTMS study
    Dorothee Buelte
    Department of Neurology, RWTH Aachen University, Germany
    Brain Res 1217:110-8. 2008
    ..The differential effect of rTMS on tactile and visual encoding and recognition are not consistently explained by previous concepts of visuo-tactile integration...
  31. doi request reprint Functional localization in the human brain: Gradient-Echo, Spin-Echo, and arterial spin-labeling fMRI compared with neuronavigated TMS
    Svenja Diekhoff
    Max Planck Institute for Neurological Research, Cologne, Germany
    Hum Brain Mapp 32:341-57. 2011
    ..g., interactions between TMS-induced electric field and neural tissue. Differences between techniques should be kept in mind when using fMRI coordinates as TMS (intervention) targets...
  32. ncbi request reprint Translating working memory into action: Behavioral and neural evidence for using motor representations in encoding visuo-spatial sequences
    Robert Langner
    Institute of Neuroscience and Medicine INM 1, Research Centre Julich, Julich, Germany Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Hum Brain Mapp 35:3465-84. 2014
    ..Hum Brain Mapp 35:3465-3484, 2014. © 2013 Wiley Periodicals, Inc. ..
  33. doi request reprint Sensory-guided motor tasks benefit from mental training based on serial prediction
    ELLEN BINDER
    Department of Neurology, University Hospital Cologne, Cologne, Germany Max Planck Institute for Neurological Research, Cologne, Germany Cognitive Neurology Section, Institute of Neuroscience and Medicine INM3, Research Centre Julich, Julich, Germany Electronic address
    Neuropsychologia 54:18-27. 2014
    ..In summary, the data suggest that mental training based on the serial prediction task effectively engages sensorimotor circuits and thereby improves motor behaviour. ..
  34. pmc Cerebral network disorders after stroke: evidence from imaging-based connectivity analyses of active and resting brain states in humans
    Anne K Rehme
    Max Planck Institute for Neurological Research, Gleueler Str 50, 50931 Cologne, Germany
    J Physiol 591:17-31. 2013
    ..Connectivity analyses may hence provide new insights into the pathophysiology underlying neurological deficits and may be further used to develop novel, neurobiologically informed treatment strategies...
  35. ncbi request reprint Crossmodal processing of object features in human anterior intraparietal cortex: an fMRI study implies equivalencies between humans and monkeys
    Christian Grefkes
    Institute of Medicine, Research Center Julich, Germany
    Neuron 35:173-84. 2002
    ..Based on both the observed functional properties and the anatomical location, we suggest that this area in anterior IPS is the human equivalent of macaque area AIP...
  36. ncbi request reprint Human medial intraparietal cortex subserves visuomotor coordinate transformation
    Christian Grefkes
    Institute of Medicine, Research Center Julich, 52425 Julich, Germany
    Neuroimage 23:1494-506. 2004
    ....
  37. ncbi request reprint Regional cerebral blood flow correlations of somatosensory areas 3a, 3b, 1, and 2 in humans during rest: a PET and cytoarchitectural study
    Jeremy P Young
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Hum Brain Mapp 19:183-96. 2003
    ..This indicates that rCBF correlations between cortical areas during the rest state only partly reflect their connectivity and that this approach lacks sensitivity and is prone to reveal spurious or indirect connectivity...
  38. ncbi request reprint Subdivisions of human parietal area 5 revealed by quantitative receptor autoradiography: a parietal region between motor, somatosensory, and cingulate cortical areas
    Filip Scheperjans
    C and O Vogt Brain Research Institute, University of Dusseldorf, PO Box 10 10 07, 40001 Dusseldorf, Germany
    Neuroimage 25:975-92. 2005
    ..These findings suggest that human BA 5 constitutes a higher order cortical area, clearly distinct from the primary somatosensory and motor cortex...
  39. pmc The functional organization of the intraparietal sulcus in humans and monkeys
    Christian Grefkes
    Institute of Medicine, Research Center Julich, Germany
    J Anat 207:3-17. 2005
    ....
  40. ncbi request reprint Transmitter receptors reveal segregation of cortical areas in the human superior parietal cortex: relations to visual and somatosensory regions
    Filip Scheperjans
    C and O Vogt Brain Research Institute, University of Dusseldorf, PO Box 10 10 07, 40001 Dusseldorf, Germany
    Neuroimage 28:362-79. 2005
    ..e., the involvement of the human SPL in visuomotor and somatosensory motor transformations...
  41. ncbi request reprint Somatosensory areas engaged during discrimination of steady pressure, spring strength, and kinesthesia
    Anna Bodegård
    Division of Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Hum Brain Mapp 20:103-15. 2003
    ..SSTIFF and KIN activated the right anterior lobe of the cerebellum, the left area 4a and left area 2 more than did PRESS, likely due to a combination of active movements and muscle receptor feed-back...
  42. ncbi request reprint Dominance of the right hemisphere and role of area 2 in human kinesthesia
    Eiichi Naito
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurophysiol 93:1020-34. 2005
    ..Furthermore, our results provide evidence for a right hemisphere dominance for perception of limb movement...