Research Topics
Genomes and GenesSpecies | Florian GrabellusSummaryAffiliation: University of Essen Country: Germany Publications
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Publications
Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapyFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Virchows Arch 448:847-51. 2006..Therefore, we suggest that in patients with immunosuppression, even low malignant cancerous lesions should be carefully observed, as their local behavior may be aggressive with development of metastasis...- ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexualF Grabellus
Institute of Pathology, University Hospital of Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Breast 14:71-4. 2005..As confirmation of the histopathological diagnosis we detected the novel ETV6-NTRK3 gene fusion in this tumor... - Resolved hypersensitivity myocarditis after ventricular circulatory assistFlorian Grabellus
Institute of Pathology, University of Essen, Essen, Germany
Ann Thorac Surg 76:2102-4. 2003..Ten months later this lesion showed complete reversibility within specimens of the explanted heart, maybe as a result of the termination of inotropic therapy after implantation of the left ventricular assist device... - Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiationFlorian Grabellus
Institute of Pathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Virchows Arch 448:85-9. 2006..The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies... - [Two cystic retroperitoneal lesions mimicking adrenal cysts]F Grabellus
Institut fur Pathologie, Universitatsklinikum Essen
Pathologe 26:226-30. 2005..The histopathological investigation of the lesions revealed a foregut duplication cyst of the lesser gastric curvature and an epithelial inclusion cyst (epidermoid cyst) in an intrapancreatic accessory spleen respectively... 
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcomeKlaus Jürgen Schmitz
Institute of Pathology, University Hospital of Essen Duisburg, Essen, Germany
Breast Cancer Res 7:R194-203. 2005..In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy...
p53 modulation as a therapeutic strategy in gastrointestinal stromal tumorsJoern Henze
Department of Medical Oncology, West German Cancer Center, University Duisburg Essen Medical School, Essen, Germany
PLoS ONE 7:e37776. 2012....
Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalanFlorian Grabellus
Institute of Pathology and Neuropathology, Sarcoma Center, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
J Surg Oncol 103:371-9. 2011..Some tumors show an insufficient association between radiological and pathological response. We investigated STS after TM-ILP with a primary emphasis on histologic regression patterns...- Growth patterns of lung metastases from sarcoma: prognostic and surgical implications from histologyStefan Welter
Division of Thoracic Surgery, Ruhrlandklinik, Essen, Germany
Interact Cardiovasc Thorac Surg 15:612-7. 2012..The objective of the present study was to evaluate the prognostic impact of intrapulmonary growth patterns of sarcoma metastases... - The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancerFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
J Nucl Med 51:1191-7. 2010..We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of (18)F-FDG and tumor aggressiveness in breast cancer... - Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinomaSien Yi Sheu
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Germany
Histopathology 56:632-40. 2010..To compare the expression pattern of five microRNAs (miRNAs) (146b, -181b, -21, -221, -222) of papillary thyroid carcinoma (PTC) and hyalinizing trabecular tumour of the thyroid (HTT)... - Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatmentFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
J Surg Oncol 101:465-70. 2010..Objective of this study was to investigate the influence of MT expression on tumor responses in HILP-TM-treated soft tissue (STSs) and bone sarcomas (BS)... - Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resectionYing Yong Hou
Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany
J Gastrointest Surg 13:1583-92. 2009..To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST)... - Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheepHideo A Baba
Institut fur Pathologie, Universitat Essen, Hufelandstrasse 55, 45147 Essen, Germany
Intensive Care Med 30:1405-13. 2004..Inducible heat shock protein 72 (HSP 72) preserves myocardial function and prevents apoptosis. We investigated the expression and localization of HSP 72 and apoptosis in our previously described new model of multiple organ failure... - Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanismHideo A Baba
Institute of Pathology, University of Essen, Essen, Germany
Cardiovasc Res 59:390-9. 2003..CONCLUSION: Erks and Akt/GSK-3 beta are highly responsive to myocyte stretch in vitro and in vivo, and may be sensitive molecular parameters of 'reverse remodeling' under LVAD support... - Increased shedding of soluble TNF-receptor 1 during hyperthermic TNF-α-based isolated limb perfusionFlorian Grabellus
Institute of Pathology and Neuropathology, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Int J Hyperthermia 27:33-41. 2011..Shedding of soluble TNF-receptor (sTNF-R) negatively modulates the effects of TNF-α, whereas hyperthermia (HT) induces shedding. Here, we investigated whether sTNF-R shedding in response to HT occurs during HILP... - Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinomaFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Clin Nucl Med 37:121-7. 2012..We investigated the relationship among GLUT1 expression, proliferation, iodine concentration, and glucose uptake in different TC types, with emphasis on "poorly differentiated thyroid carcinoma" (PDTC)... - Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrencesFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, 45122 Essen, Germany
Ann Surg Oncol 16:676-86. 2009..Isolated limb perfusion (TM-ILP) is an effective limb-sparing treatment for primarily nonresectable soft tissue sarcomas (STS). Surgical margins of STS after ILP were yet not systematically studied... - The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpressionFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Thyroid 22:377-82. 2012..In this study, we hypothesized that the common BRAF V600E mutation was associated with GLUT1 overexpression and proliferation in papillary thyroid carcinomas (PTCs)... - pHH3 immunostaining improves interobserver agreement of mitotic index in thin melanomasTobias T Schimming
Department of Dermatology, Venerology and Allergology, University Duisburg Essen, Germany
Am J Dermatopathol 34:266-9. 2012..Further studies are needed to find out if higher sensitivity in the detection of mitosis by pHH3 immunostaining has additional prognostic relevance... - The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general populationFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
J Clin Pathol 64:1021-4. 2011..1621 A>C) in aggressive fibromatosis (AF) was recently determined to be 2.5-fold higher than in healthy controls. It was thus hypothesised that M541L could be associated with the development of AF... - Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathwayFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
Pathol Res Pract 203:135-43. 2007..The regulation of the vascular gelatinolytic system by MAP kinases suggests a therapeutic option against cardiovascular diseases at the level of MAPK signal transduction... - Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangementsSien Yi Sheu
Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
Mod Pathol 20:779-87. 2007..Additionally, this rare variant of papillary thyroid carcinoma may represent a tumour type susceptible to RET-targeted therapies... - MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusionsFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
Tumour Biol 31:157-63. 2010..A clear influence of polysomy 7 on MET protein expression could not be statistically demonstrated for this cohort. Moreover, gene fusions with the ability to cause MET overexpression do not occur in chordomas... - Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacementStefan Landgraeber
Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
Arch Orthop Trauma Surg 130:441-5. 2010..These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive... - Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft modelSemra Aydin
Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
Eur J Haematol 87:10-9. 2011..This model could be useful for evaluating the biological basis of CLL growth in the context of the hematopoietic microenvironment as well as preclinical testing of novel compounds... - RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α-CGRP deficiencyMax D Kauther
Department of Trauma Surgery, University of Duisburg Essen, Essen, Germany
Biomaterials 34:2911-9. 2013..CT/α-CGRP modulates bone cell activity in PIO in aged mice in a way that is distinct from young animals. This may have implications for the treatment of PIO in the periprosthetic surface of joint replacements in an aging population... - Size-based clinical response evaluation is insufficient to assess clinical response of sarcomas treated with isolated limb perfusion with TNF-α and melphalanFlorian Grabellus
Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
Ann Surg Oncol 19:3375-85. 2012..Based on our experience, we assume that anatomic radiological response criteria are insufficient to assess the degree of regression after TM-ILP... - Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysisMax D Kauther
Department of Trauma Surgery, University Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
BMC Musculoskelet Disord 12:186. 2011..This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice... - Impact of intraoperative radiotherapy (IORT) on survival of patients with unresectable hilar cholangiocarcinomaGernot Maximilian Kaiser
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
Hepatogastroenterology 55:1951-4. 2008..The aim of this study was to compare the efficacy of IORT to surgery alone in patients with unresectable hilar cholangiocarcinoma... - Growth patterns of lung metastases from sarcomasStefan Welter
Department of Thoracic Surgery, Ruhrlandklinik Essen, Essen, Germany
Virchows Arch 459:213-9. 2011..Almost half of all pulmonary sarcoma metastases could be identified with aggressive patterns of local growth, and only 17.2% are surrounded by a pseudocapsule which might allow safe resection margins... - Expression of MCSP and PRAME in conjunctival melanomaHenrike Westekemper
Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
Br J Ophthalmol 94:1322-7. 2010.... - A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the diseaseJan Dürig
Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
Cancer Res 67:8653-61. 2007..These results suggest that this model reflects the heterogeneity and important clinical characteristics of the disease, and thus may serve as a tool for preclinical drug testing and investigation of the pathophysiology of CLL... - Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CTJun Li
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
J Surg Oncol 98:438-43. 2008..The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma... - Feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissectionHolger Eggebrecht
Department of Cardiology, University of Duisburg Essen, Germany
Eur Heart J 27:613-20. 2006..Endovascular stent-graft placement for thoracic aortic disease is usually performed under X-ray guidance. The feasibility of rtMRI-guided stent-graft placement is currently not known... - Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumorsThomas Mühlenberg
Sarcoma Center, West German Cancer Center, University of Essen, Medical School, Essen, Germany
Cancer Res 69:6941-50. 2009..These results provide preclinical evidence for a disease-specific effect of HDACI in KIT-positive GIST, which could translate into therapeutic activity... - Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinibSebastian Bauer
Department of Internal Medicine (Cancer Research, University of Essen Medical School, Essen, Germany
Int J Cancer 117:316-25. 2005..Further trials investigating a combined surgical and pre/postoperative treatment with imatinib in patients with advanced metastatic GIST are warranted... - Magnetic resonance colonography without bowel cleansing: a prospective cross sectional study in a screening populationChristiane A Kuehle
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Gut 56:1079-85. 2007..To evaluate the diagnostic accuracy of magnetic resonance colonography (MRC) without bowel cleansing in a screening population and compare the results to colonoscopy as a standard of reference... - Contrast-enhanced dark lumen PET/CT and MR colonography in a rodent polyp model: initial results with histopathologic correlationChristiane A Kuehle
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
AJR Am J Roentgenol 185:1045-7. 2005..CONCLUSION: Detection of small tumors with PET/CT and MR colonography is possible in a rodent model. The technique thus warrants further evaluation in animal studies as well as in patients with suspected colorectal disease... - Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical supportFlorian Grabellus
Institute of Pathology, University of Essen, Essen, Germany
J Pathol 197:230-7. 2002..This supports the concept that restoration of cardiac normoxia by mechanical unloading, particularly in the subendocardium, may be in part responsible for the phenomenon of 'reverse remodelling'... - Melanotic schwannoma of the neck mimicking a malignant melanomaKlaus Jürgen Schmitz
Institute of Pathology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Eur Arch Otorhinolaryngol 262:182-5. 2005..Although the occurrence of multiple schwannomas points to a hereditary syndrome, our patient did not fulfill the criteria of Carney's syndrome or other known syndromes, suggesting a so far unknown genetic background... - Toluidine blue for the intraoperative staining of the ureters. Studies on the safe administration in ratsFrank Petrat
Institut fur Physiologische Chemie, Universitatsklinikum, Universitat Duisburg Essen, Hufelandstrasse 55, Essen, Germany
Langenbecks Arch Surg 397:983-93. 2012..We here assessed the minimum TB dose required, and its safest and most suitable form of intravenous administration for the intraoperative staining of the ureters in rats... - Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 casesKlaus Jürgen Schmitz
Institute of Pathology, University of Essen, Germany
Mod Pathol 17:15-21. 2004.... - Expression of GLUT1 is associated with increasing grade of malignancy in non-invasive and invasive urothelial carcinomas of the bladderHenning Reis
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Oncol Lett 2:1149-1153. 2011..The increase of GLUT1 expression may reflect a preinvasive metabolic switch in terms of enhanced cell metabolism concomitant to known genetic alterations. A further increase in invasive carcinomas may be related to hypoxic conditions... - Association between apoptotis and CD4(+)/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacementStefan Landgraeber
Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
Int J Biol Sci 5:182-91. 2009..It is possible that these findings may lead to a new understanding of particle-induced osteolysis... - [Gigantic nasal tumor]G Lehnerdt
Universitäts Hals Nasen Ohren Klinik, Hufelandstrasse 55, 45122, Essen, Deutschland
HNO 57:368-70. 2009..This discrepancy is relevant for surgical treatment, because the vessel-rich tumor tended to substantial intraoperative bleeding... - COX-2 expression in highly aggressive thyroid malignancies - indication for a possible therapeutic option?S Y Sheu
Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Horm Metab Res 41:314-9. 2009..The strong COX-2 expression observed in approximately 20% of our ATC and AST samples may thus indicate selective patients with a possible therapeutic option for an otherwise fatal disease... - Immunohistochemical differentiation of eosinophilic heart diseases using antibodies against eosinophil activation markersF Grabellus
Institute of Pathology, University Hospital of Essen, Essen, Germany
Histopathology 46:89-97. 2005..CONCLUSION: The immunohistochemical investigation of eosinophilic heart diseases using antibodies against CD69 can be a useful tool to distinguish between hypersensitivity myocarditis and endocarditis parietalis fibroplastica... - Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failureMichaela Kuhn
Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
Cardiovasc Res 64:308-14. 2004.... - Reversible activation of nuclear factor-kappaB in human end-stage heart failure after left ventricular mechanical supportFlorian Grabellus
The Gerhard-Domagk-Institute of Pathology, , Domagkstrasse 17, , Germany
Cardiovasc Res 53:124-30. 2002..CONCLUSION: LVAD support decreases the extent of NF-kappaB activation in failing human hearts, suggesting that NF-kappaB may be involved in the process of 'reverse remodeling'...