Research Topics
Genomes and GenesSpecies | Hans Jörgen GrabeSummaryAffiliation: University of Greifswald Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sampleHans Jörgen Grabe
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Am J Med Genet B Neuropsychiatr Genet 159:298-309. 2012..05). Childhood abuse and adult traumatic events may act synergistically in interaction with the s allele of the 5-HTTLPR to increase the risk for depressive symptoms independently from the lifetime diagnosis of PTSD...- Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuseHans Jörgen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
Prog Neuropsychopharmacol Biol Psychiatry 36:264-70. 2012..We tested the hypothesis of a three-way interaction with respect to depressive symptoms... 
A telephone- and text-message based telemedical care concept for patients with mental health disorders--study protocol for a randomized, controlled study designNeeltje van den Berg
Institute for Community Medicine University of Greifswald Ellernholzstr, 1 2 17487 Greifswald, Germany
BMC Psychiatry 11:30. 2011..The interventions will be conducted during a time period of 6 months. TRIAL REGISTRATION: This study is registered in the German Clinical Trials Register (DRKS00000662)...- Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorderRichard Delorme
INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
BMC Med Genet 11:100. 2010..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients... - The German version of the Toronto Structured Interview for Alexithymia: factor structure, reliability, and concurrent validity in a psychiatric patient sampleHans Joergen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
Compr Psychiatry 50:424-30. 2009..The aim of this study was to evaluate the psychometric properties of a German language translation of the TSIA in a psychiatric patient sample... - Tooth loss and cognitive impairmentHans Joergen Grabe
Department of Psychiatry and Psychotherapy, HANSE Klinikum Stralsund, Ernst Moritz Arndt University of Greifswald, Stralsund, Germany
J Clin Periodontol 36:550-7. 2009..The hypothesis was tested that periodontitis and tooth loss as a proxy of chronic periodontitis is associated with cognitive impairment in the elderly... - Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general populationHans Jörgen Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, HANSE Klinikum Stralsund, Rostocker Chaussee 70, Stralsund, Germany
Am J Psychiatry 166:926-33. 2009..The authors investigated 5-HTTLPR genotypes and their interaction with the number of traumatic events in the prediction of PTSD in a general population sample... 
Obsessive-compulsive disorder and posttraumatic stress disorderHans Joergen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
Psychopathology 41:129-34. 2008..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD...- Alexithymia in obsessive-compulsive disorder - results from a family studyHans Joergen Grabe
Department of Psychiatry, University of Greifswald, Greifswald, Germany
Psychother Psychosom 75:312-8. 2006..This study investigates the hypotheses of an elevated level of alexithymia in subjects with OCD and their first-degree relatives compared to controls and their first-degree relatives... - Familiality of obsessive-compulsive disorder in nonclinical and clinical subjectsHans Joergen Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
Am J Psychiatry 163:1986-92. 2006..This study compared the familial aggregation of OCD in first-degree relatives of community subjects with never-treated OCD, outpatients with OCD, and comparison subjects... - Association of mental distress with health care utilization and costs: a 5-year observation in a general populationHans Jörgen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Rostocker Chaussee 70, 18437, Stralsund, Germany
Soc Psychiatry Psychiatr Epidemiol 44:835-44. 2009..Previous studies have associated mental distress and disorders with increased health care utilization and costs. However, most studies have selected subjects from treatment facilities or have applied retrospective designs... - [The "AMDP-rating scale for obsessive-compulsive symptoms": The 2nd version]H J Grabe
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Ernst Moritz Arndt Universität Greifswald im Klinikum der Hansestadt Stralsund, Germany
Fortschr Neurol Psychiatr 70:227-33. 2002..The results are presented and their implications on the final steps of the development of the scale will be discussed... - [Mental distress and the use of psychiatric and psychotherapeutic treatments services: results of the Study of Health in Pomerania]Hans Jörgen Grabe
Klinik fur Psychiatrie und Psychotherapie, Ernst Moritz Arndt Universitat Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
Psychiatr Prax 32:299-303. 2005.... - Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burdenH J Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
Mol Psychiatry 10:220-4. 2005..The relevance of this finding is sustained by the fact that the sample characteristics and the risk structure were highly different from previous studies... - Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general populationHans Jörgen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
Am J Med Genet B Neuropsychiatr Genet 153:1483-93. 2010..2010 Wiley-Liss, Inc... - Alexithymia, hypertension, and subclinical atherosclerosis in the general populationHans Joergen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
J Psychosom Res 68:139-47. 2010..Therefore, we hypothesize that alexithymia is associated with hypertension and carotid atherosclerosis in the general population... - Somatoform pain disorder in the general populationHans Joergen Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Stralsund, Germany
Psychother Psychosom 72:88-94. 2003..Chronic pain disorder is assumed to represent a frequent and disabling condition. However, data on the prevalence of somatoform pain symptoms and somatoform pain disorder in the community are limited to date... - Interhemispheric transfer in alexithymia: a transcallosal inhibition studyHans Joergen Grabe
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald Stralsund, Germany
Psychother Psychosom 73:117-23. 2004..This study investigates the hypothesis that alexithymia is associated with an interhemispheric transfer deficit via the corpus callosum (CC)... - Alexithymia and personality in relation to dimensions of psychopathologyHans Joergen Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
Am J Psychiatry 161:1299-301. 2004..The authors examined the capacity of alexithymia to predict a broad range of psychiatric symptoms relative to that of other personality dimensions, age, and gender... - No association of seropositivity for anti-Borrelia IgG antibody with mental and physical complaintsHans Joergen Grabe
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University Greifswald, Germany
Nord J Psychiatry 62:386-91. 2008..Therefore, clinicians should not overvalue seropositivity for anti-Borrelia IgG as a medical cause for unexplained mental or physical complaints... - A more proximal impact of dissociation than of trauma and posttraumatic stress disorder on schneiderian symptoms in patients diagnosed with schizophreniaMatthias Vogel
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Stralsund, Germany
Compr Psychiatry 50:128-34. 2009..Dissociation and schneiderian symptoms may reflect posttraumatic symptomatology in some patients diagnosed with schizophrenia who might not develop PTSD... - Gender-dependent associations between socioeconomic status and tooth loss in working age people in the Study of Health in Pomerania (SHIP), GermanyTorsten Mundt
Department of Prosthodontics, Gerodontology and Dental Materials, Center of Oral Health, University of Greifswald, Rotgerberstraße 8, Greifswald, Germany
Community Dent Oral Epidemiol 39:398-408. 2011..Using the 5-year follow-up of this study, we aimed at verifying these findings and at investigating the gender-dependent impact of key socioeconomic indicators on tooth loss... - Transcallosal inhibition in patients with and without alexithymiaJan Richter
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald Stralsund, Germany
Neuropsychobiology 53:101-7. 2006..Previous results indicated a facilitated transcallosal inhibition via the corpus callosum (CC) in alexithymic male students. This study investigates transcallosal inhibition in alexithymic and nonalexithymic psychiatric inpatients... - Association of childhood neglect with adult dissociation in schizophrenic inpatientsMatthias Vogel
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald, Germany
Psychopathology 42:124-30. 2009..Dissociation is often related to previous trauma and also occurs frequently in schizophrenia. Dissociation and psychosis may reflect a posttraumatic syndrome in some patients with schizophrenia... - The role of trauma and PTSD-related symptoms for dissociation and psychopathological distress in inpatients with schizophreniaMatthias Vogel
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald, Germany
Psychopathology 39:236-42. 2006..To investigate the relationship between dissociative experiences, psychopathological distress, a history of trauma and posttraumatic symptoms in adult schizophrenia... - Socioeconomic indicators and prosthetic replacement of missing teeth in a working-age population--results of the Study of Health in Pomerania (SHIP)Torsten Mundt
Department of Prosthodontics, Gerodontology and Biomaterials, Center of Oral Health, University of Greifswald, Germany
Community Dent Oral Epidemiol 37:104-15. 2009..To analyse the possible effects of the socioeconomic status (SES) on the prosthetic replacement of missing teeth in working-age people and to explore the role of potential confounders... - Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in PomeraniaRobin Haring
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand Sauerbruch Strasse, Greifswald, Germany
Aging Male 13:247-57. 2010..Low total testosterone levels (TT) have been associated with increased morbidity and mortality. However, the prevalence and incidence of testosterone deficiency (TD) in association with its risk has not been assessed systematically to date... - Decreased levels of dopamine D3 receptor mRNA in schizophrenic and bipolar patientsMatthias Vogel
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald, Germany
Neuropsychobiology 50:305-10. 2004..The observed diminution was not specific for schizophrenia but also for bipolar disorder requiring further analysis of the regulatory factors involved in dopamine receptor subtype expression... - Depressive and anxiety symptoms as risk factors for temporomandibular joint pain: a prospective cohort study in the general populationStefan Kindler
Department of Oral and Maxillofacial Surgery Plastic Surgery, University of Greifswald, Greifswald, Germany Electronic address
J Pain 13:1188-97. 2012..Depressive symptoms are specific for joint pain whereas anxiety symptoms are specific for muscle pain, findings that deserve detailed examination. These findings may support decision-making in treating TMD... - Dissociative experiences and psychopathology in conversion disordersC Spitzer
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald, Germany
J Psychosom Res 46:291-4. 1999..There were no differences in the SCL-90-R scores between the two groups. Our findings support the theory of similar psychological processes underlying conversion and dissociative disorders despite their descriptive differences... - Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in Northern GermanyH J Grabe
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt Universität Greifswald im Klinikum der Hansestadt Stralsund, Germany
Eur Arch Psychiatry Clin Neurosci 251:130-5. 2001..Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population... - Alexithymia and the temperament and character model of personalityH J Grabe
Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Germany
Psychother Psychosom 70:261-7. 2001.... - Prevalence, quality of life and psychosocial function in obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern GermanyH J Grabe
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt Universitat Greifswald, Klinikum der Hansestadt Stralsund, Germany
Eur Arch Psychiatry Clin Neurosci 250:262-8. 2000..Moreover, data on quality of life and on psychosocial function of subjects with OCD and subclinical OCD in the general population are missing to date... - Relation between psychological strain and carotid atherosclerosis in a general populationB Wolff
Klinik für Innere Medizin B, Ernst Moritz Arndt Universitat Greifswald, Friedrich Loeffler Strasse 23 a, 17487 Greifswald, Germany
Heart 91:460-4. 2005..To investigate the hypothesis that psychological strain is related to carotid atherosclerosis in a large general population sample... - Association between depression and subclinical carotid atherosclerosis in patients with Type 1 diabetesC Spitzer
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald Stralsund, Gerrmany
Diabet Med 25:349-54. 2008..Given the high prevalence of depression in patients with Type 1 diabetes and the diabetes-related risk factors for atherosclerosis, we hypothesized that this relation might also be of special relevance in Type 1 diabetic patients... - Estimation of psycholeptic and psychoanaleptic medicine use in an adult general population sample using the Anatomical Therapeutic Chemical classificationU John
Medical Faculty, Institute of Epidemiology and Social Medicine, University of Greifswald, Greifswald, Germany
Int J Methods Psychiatr Res 17:220-31. 2008..It is concluded that considerable proportions of individuals with current PM use exist although lower than may be expected on the basis of the number of individuals with mental disorder in the general population... - Impulsiveness in obsessive-compulsive disorder: results from a family studyS Ettelt
Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
Acta Psychiatr Scand 115:41-7. 2007..The purpose of this study was to assess impulsiveness in OCD families and compare it to control families... - [Categorical versus dimensional classification of personality disorders: are dimensional models the future?]S Barnow
Klinik und Poliklinik fur Psychiatrie, Psychosomatische Medizin und Psychotherapie der Ernst Moritz Arndt Universität Greifswald, Germany
Fortschr Neurol Psychiatr 74:706-13. 2006..Our results show that the Seven-Factor model discriminates well between PDs and healthy controls, as well as between PDs and Axis-I disorders. We discuss our findings and present a modified scheme to diagnose PDs... - Tele-electrocardiography in the epidemiological 'Study of Health in Pomerania' (SHIP)Dietrich Alte
Ernst Moritz Arndt Universitat Greifswald, Institut für Epidemiologie und Sozialmedizin Institute of Epidemiology and Social Medicine, Germany
J Telemed Telecare 12:103-7. 2006..Physicians required about 1.5 h to read approximately 100 ECGs daily. The functionality and ergonomics of ECG cards appear to be sufficiently developed for large-scale use in epidemiological studies... - DIRAS2 is associated with adult ADHD, related traits, and co-morbid disordersAndreas Reif
Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 36:2318-27. 2011..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders... - Life- and person-centred help in Mecklenburg-Western Pomerania, Germany (DelpHi): study protocol for a randomised controlled trialJochen René Thyrian
German Center for Neurodegenerative Diseases DZNE Greifswald, Ellernholzstrasse 1 2, Greifswald, D 17487, Germany
Trials 13:56. 2012..abstract:.. - Dopamine D3 receptor and schizophrenia: a widened scope for the immune hypothesisMatthias Vogel
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University, Greifswald, Rostocker Chaussee 70, D 18437 Stralsund, Germany
Med Hypotheses 67:354-8. 2006..This mechanism could result in a decrease of D3R and a consecutive relative preponderance of D2R and thereby connect immune alterations and schizophrenia... - Mental and physical complaints in thyroid disorders in the general populationH J Grabe
Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University Greifswald, Stralsund, Germany
Acta Psychiatr Scand 112:286-93. 2005..To test the hypothesis that untreated overt and subclinical thyroid disorders and autoimmune thyroiditis (AIT) are associated with mental and physical complaints in the general population... - Neurotrophic factor S100 beta in major depressionH J Grabe
Department of Psychiatry, Klinikum der Hansestadt Stralsund, Ernst Moritz Arndt University of Greifswald, Stralsund, Germany
Neuropsychobiology 44:88-90. 2001..6, d.f. = 10, p = 0.024). Replications of this finding in severely depressed patients are necessary to confirm the association between neurotrophic factor S100 beta and depressive disorders... - Perceived parental rearing in subjects with obsessive-compulsive disorder and their siblingsL Lennertz
Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Acta Psychiatr Scand 121:280-8. 2010..In addition, we included data from unaffected siblings to corroborate information on parental rearing...