Euphrosyne Gouzoulis-Mayfrank

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi [Dual diagnosis psychosis and substance use disorders: theoretical foundations and treatment]
    Euphrosyne Gouzoulis-Mayfrank
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln, Germany
    Z Kinder Jugendpsychiatr Psychother 36:245-53. 2008
  2. ncbi Deficient inhibition of return in schizophrenia-further evidence from an independent sample
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 30:42-9. 2006
  3. ncbi Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage?
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Addiction 101:348-61. 2006
  4. ncbi Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Drug Alcohol Depend 78:317-23. 2005
  5. ncbi Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Pharmacopsychiatry 38:301-11. 2005
  6. ncbi [Dual diagnosis of psychosis and addiction. From principles to practice]
    E Gouzoulis-Mayfrank
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, Aachen, Deutschland
    Nervenarzt 75:642-50. 2004
  7. ncbi The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    J Psychopharmacol 20:188-93. 2006
  8. ncbi [Doble diagnosis--psychosis and addiction]
    E Gouzoulis-Mayfrank
    ,
    Fortschr Neurol Psychiatr 74:528-44; quiz 545-6. 2006
  9. ncbi Blunted inhibition of return in schizophrenia-evidence from a longitudinal study
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University Hospital, Technical University of Aachen RWTH, Pauwelsstrasse 30, Aachen D 52057, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:389-96. 2004
  10. ncbi Orienting of attention in unmedicated patients with schizophrenia, prodromal subjects and healthy relatives
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Schizophr Res 97:35-42. 2007

Detail Information

Publications40

  1. ncbi [Dual diagnosis psychosis and substance use disorders: theoretical foundations and treatment]
    Euphrosyne Gouzoulis-Mayfrank
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln, Germany
    Z Kinder Jugendpsychiatr Psychother 36:245-53. 2008
    ..Current clinical research demonstrates that integrated treatment programmes can achieve significant improvements with regard to the social adjustment of, as well as decreased substance use by DD patients...
  2. ncbi Deficient inhibition of return in schizophrenia-further evidence from an independent sample
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 30:42-9. 2006
    ..IOR seems to be not just delayed, but rather profoundly disturbed in schizophrenia. Deficient IOR in patients with schizophrenia might be viewed as a trait or alternatively as a vulnerability marker of the disorder...
  3. ncbi Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage?
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Addiction 101:348-61. 2006
    ..Consequently, various abnormalities including psychiatric, vegetative, neuroendocrine and cognitive disorders could be expected in humans following MDMA-induced neurotoxic brain damage...
  4. ncbi Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Drug Alcohol Depend 78:317-23. 2005
    ..However, studies with user populations and controls suffer from many inherent methodological problems. Moreover, longitudinal data on memory performance after continued or discontinued ecstasy use are scarce...
  5. ncbi Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers
    E Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Pharmacopsychiatry 38:301-11. 2005
    ..However, so far, the psychological profiles of the two types of hallucinogenic drugs have never been studied directly in an experimental within-subject design...
  6. ncbi [Dual diagnosis of psychosis and addiction. From principles to practice]
    E Gouzoulis-Mayfrank
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, Aachen, Deutschland
    Nervenarzt 75:642-50. 2004
    ....
  7. ncbi The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    J Psychopharmacol 20:188-93. 2006
    ....
  8. ncbi [Doble diagnosis--psychosis and addiction]
    E Gouzoulis-Mayfrank
    ,
    Fortschr Neurol Psychiatr 74:528-44; quiz 545-6. 2006
  9. ncbi Blunted inhibition of return in schizophrenia-evidence from a longitudinal study
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University Hospital, Technical University of Aachen RWTH, Pauwelsstrasse 30, Aachen D 52057, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:389-96. 2004
    ....
  10. ncbi Orienting of attention in unmedicated patients with schizophrenia, prodromal subjects and healthy relatives
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Schizophr Res 97:35-42. 2007
    ..In conclusion, blunted IOR in schizophrenia is not secondary to medications. According to this and previous studies blunted IOR may be most probably viewed as a trait cognitive feature of the schizophrenic disorder...
  11. ncbi Inhibition of return in the human 5HT2A agonist and NMDA antagonist model of psychosis
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Neuropsychopharmacology 31:431-41. 2006
    ..Blunted IOR may underlie or predispose to different psychotic manifestations, but particularly to those with prominent positive symptoms...
  12. ncbi Semantic hyperpriming in thought-disordered patients with schizophrenia: state or trait?--a longitudinal investigation
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, Technical University of Aachen RWTH, Pauwelsstrasse 30, D 5205, Aachen, Germany
    Schizophr Res 65:65-73. 2003
    ..In conclusion, semantic hyperpriming in TD patients with schizophrenia appears to be clearly state-dependent and might be viewed as an episode marker of psychosis with TD...
  13. ncbi Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Dialogues Clin Neurosci 11:305-17. 2009
    ..In this paper, we will review the literature focusing on human studies...
  14. ncbi [Comorbidity of substance use and other psychiatric disorders--theoretical foundation and evidence based therapy]
    E Gouzoulis-Mayfrank
    Klinik fur Psychiatrie und Psychotherapie, Universitätsklinik Köln, Koln
    Fortschr Neurol Psychiatr 76:263-71. 2008
    ..The next step should be a broader application of integrated treatment programs and their adoption as standard treatment within the national health systems...
  15. ncbi Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 27:819-27. 2003
    ..Hippocampal dysfunction after ecstasy use may be a risk factor for earlier onset and/or more severe age-related memory decline in later years...
  16. ncbi Mismatch negativity generation in the human 5HT2A agonist and NMDA antagonist model of psychosis
    Karsten Heekeren
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany
    Psychopharmacology (Berl) 199:77-88. 2008
    ..Previous studies reported a significant reduction of MMN after ketamine (N-methyl-D-aspartate acid [NMDA] antagonist model) but not after psilocybin (5HT2A agonist model)...
  17. ncbi Neural mechanisms of working memory in ecstasy (MDMA) users who continue or discontinue ecstasy and amphetamine use: evidence from an 18-month longitudinal functional magnetic resonance imaging study
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne Germany
    Biol Psychiatry 56:349-55. 2004
    ..Here, we examined whether cortical activation patterns change after prolonged periods of continued use or abstinence from ecstasy and amphetamine...
  18. ncbi Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50931, Cologne, Germany
    Psychopharmacology (Berl) 180:607-11. 2005
    ..3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is neurotoxic in animal studies and its use has been associated with cognitive impairments in humans...
  19. ncbi Intensity dependence of auditory evoked dipole source activity in polydrug ecstasy users: evidence from an 18 months longitudinal study
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    J Psychopharmacol 20:236-44. 2006
    ..Thus, further research with larger sample sizes and prospective study designs are needed to definitively establish a causative link between ecstasy use and neurotoxicity-related dysfunctions in sensory processing...
  20. ncbi The impact of early-onset cannabis use on functional brain correlates of working memory
    Benjamin Becker
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:837-45. 2010
    ..The maturing brain might be more vulnerable to the harmful effects of cannabis use. However, due to a lack of a non-using control group we cannot exclude alternative interpretations...
  21. ncbi Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis--a longitudinal study
    Ulrich Meincke
    Dept of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Arch Psychiatry Clin Neurosci 254:415-21. 2004
    ....
  22. ncbi Self-reported psychopathological symptoms in recreational ecstasy (MDMA) users are mainly associated with regular cannabis use: further evidence from a combined cross-sectional/longitudinal investigation
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Psychopharmacology (Berl) 173:398-404. 2004
    ..However, exploring the origins of psychopathology in ecstasy users is hampered by the frequent polydrug use and by the cross-sectional design of all investigations, so far...
  23. ncbi Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Psychopharmacology (Berl) 200:573-83. 2008
    ..Pharmacologic challenges with hallucinogens have been used as models for psychosis...
  24. ncbi Correlation of passivity symptoms and dysfunctional visuomotor action monitoring in psychosis
    Knut Schnell
    Department of Psychiatry and Psychotherapy, Division of Medical Psychology, University Hospital of Bonn, Bonn, Germany
    Brain 131:2783-97. 2008
    ....
  25. ncbi Neural correlates of working memory in pure and polyvalent ecstasy (MDMA) users
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology RWTH, Aachen, Germany
    Neuroreport 14:1983-7. 2003
    ..Our results suggest that altered brain activation patterns during cognitive processing in ecstasy users may be mainly associated with prior MDMA use. Concomitant use of other drugs may modify this effect...
  26. ncbi Interactions between specific parameters of cannabis use and verbal memory
    Daniel Wagner
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:871-6. 2010
    ..This finding might deliver more insight into the complex mechanisms underlying the impaired memory functions observed in cannabis users...
  27. ncbi Sensitization and habituation of the acoustic startle reflex in patients with schizophrenia
    Ulrich Meincke
    Department of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Psychiatry Res 126:51-61. 2004
    ..In addition, the present data have important implications for designing startle studies to assess sensitization, habituation and prepulse inhibition in one session...
  28. ncbi Electromyographical differentiation between the acoustic blink and startle reflex. Implications for studies investigating startle behavior
    Ulrich Meincke
    Department of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:141-5. 2002
    ..This complexity should be taken into account in clinical studies of the modulation of the startle reflex...
  29. ncbi Medial prefrontal gray matter volume reductions in users of amphetamine-type stimulants revealed by combined tract-based spatial statistics and voxel-based morphometry
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Neuroimage 54:794-801. 2011
    ..Differences are likely to reflect effects of repeated ATS exposure even in recreational users. However, differences in pre-existing or confounding factors might also account for between-group differences...
  30. ncbi An fMRI approach to particularize the frontoparietal network for visuomotor action monitoring: Detection of incongruence between test subjects' actions and resulting perceptions
    Knut Schnell
    Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Neuroimage 34:332-41. 2007
    ..Different activation patterns of the PFC may reflect different frontoparietal networks for sustained action monitoring and actual detection of reafferent incongruence...
  31. ncbi The role of cannabis in cognitive functioning of patients with schizophrenia
    Thomas Schnell
    Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Psychopharmacology (Berl) 205:45-52. 2009
    ..Surprisingly, some small recent studies reported better cognitive performance in SCH patients with comorbid cannabis use disorders (SCH + CUD) compared to other SCH patients...
  32. ncbi Attentional modulation of prepulse inhibition: a new startle paradigm
    Karsten Heekeren
    Department of Psychiatry and Psychotherapy, University of Technology (RWTH, Aachen, Germany
    Neuropsychobiology 49:88-93. 2004
    ..This new paradigm offers a valuable tool for the study of attentional modulation of sensorimotor gating in humans...
  33. ncbi Altered parahippocampal functioning in cannabis users is related to the frequency of use
    Benjamin Becker
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany
    Psychopharmacology (Berl) 209:361-74. 2010
    ..These deficits have been associated with the duration, frequency, and age of onset of cannabis use. However, it remains unclear whether these parameters of use differently impact memory-related hippocampal functioning...
  34. ncbi Cerebral activation in abstinent ecstasy (MDMA) users during a working memory task: a functional magnetic resonance imaging (fMRI) study
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Brain Res Cogn Brain Res 16:479-87. 2003
    ..Our results may indicate subtle altered brain functioning associated with prior MDMA use, although alternative interpretations of these group differences must be considered...
  35. ncbi Proton magnetic resonance spectroscopy in ecstasy (MDMA) users
    Jörg Daumann
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Neurosci Lett 362:113-6. 2004
    ..Thus, compared with cognitive deficits, 1H MRS appears to be a less sensitive marker of potential neurotoxic damage in ecstasy users...
  36. ncbi Memory-related hippocampal functioning in ecstasy and amphetamine users: a prospective fMRI study
    Benjamin Becker
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Psychopharmacology (Berl) 225:923-34. 2013
    ..Functional neuroimaging studies with cross-sectional designs reported altered memory-related hippocampal functioning in ecstasy-polydrug users. However, differences might be pre-existing or related to the concomitant use of amphetamine...
  37. ncbi A prospective study of learning, memory, and executive function in new MDMA users
    Daniel Wagner
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Addiction 108:136-45. 2013
    ..The present study was conducted in order to assess the relationship between beginning MDMA use and subsequent cognitive performance and to overcome previous methodological shortcomings...
  38. ncbi Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL
    Thomas Schnell
    Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany
    Schizophr Res 138:183-7. 2012
    ..In the pooled sample gray matter density was positively associated with cognitive functioning. Results may support the hypothesis of a lower biological vulnerability in at least one subgroup of SCH+CAN patients...
  39. ncbi Plasticity of the acoustic startle reflex in currently abstinent ecstasy (MDMA) users
    Karsten Heekeren
    Department of Psychiatry and Psychotherapy, University of Technology (RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Psychopharmacology (Berl) 173:418-24. 2004
    ..Alternatively, strong sensitization might reflect a pre-existing trait predisposing to drug use. A clearer picture of the impact of ecstasy on startle plasticity may be obtained from longitudinal investigations...
  40. ncbi Neuroendocrine abnormalities in recreational ecstasy (MDMA) users: is it ecstasy or cannabis?
    Euphrosyne Gouzoulis-Mayfrank
    Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology RWTH, Aachen, Germany
    Biol Psychiatry 51:766-9. 2002
    ..The purpose of this study was to investigate neuroendocrine function in ecstasy (3,4-methylenedioxymethamphetamine = MDMA) users and controls...