J Gosepath

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Am J Rhinol 19:111-6. 2005
  2. ncbi request reprint Current concepts in therapy of chronic rhinosinusitis and nasal polyposis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Mainz, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 67:125-36. 2005
  3. doi request reprint Characteristics of recurrent chronic rhinosinusitis after previous surgical therapy
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Acta Otolaryngol 128:778-84. 2008
  4. ncbi request reprint mRNA induction and cytokine release of inflammatory mediators during in vitro exposure of human nasal respiratory epithelia to acetaldehyde
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Inhal Toxicol 18:1083-90. 2006
  5. ncbi request reprint Epidural hematoma after cochlear implantation in a 2.5-year-old boy
    Jan Gosepath
    Department of Otolaryngology Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Otol Neurotol 26:202-4. 2005
  6. ncbi request reprint Nasal provocation testing as an international standard for evaluation of allergic and nonallergic rhinitis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Laryngoscope 115:512-6. 2005
  7. ncbi request reprint mRNA-induction and cytokine release during in vitro exposure of human nasal respiratory epithelia to methyl methacrylate
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Toxicol Lett 171:29-37. 2007
  8. ncbi request reprint Role of fungus in eosinophilic sinusitis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Curr Opin Otolaryngol Head Neck Surg 13:9-13. 2005
  9. ncbi request reprint Expression and localization of cyclooxigenases (Cox-1 and Cox-2) in nasal respiratory mucosa. Does Cox-2 play a key role in the immunology of nasal polyps?
    J Gosepath
    Department of Otolaryngology, Head and Neck Surgery University of Mainz School of Medicine, Mainz, Germany
    J Investig Allergol Clin Immunol 14:114-8. 2004
  10. ncbi request reprint Incidence of childhood cancer of the head and neck in Germany
    J Gosepath
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Mainz, Mainz, Germany
    Ann Oncol 18:1716-21. 2007

Detail Information

Publications39

  1. ncbi request reprint New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Am J Rhinol 19:111-6. 2005
    ..We hypothesize that Cox-2 also might be relevant in the etiology of nasal polyps of aspirin-tolerant patients by their effects on inflammatory mediators as well as on microvascular permeability...
  2. ncbi request reprint Current concepts in therapy of chronic rhinosinusitis and nasal polyposis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Mainz, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 67:125-36. 2005
    ..This review discusses current concepts and new developments in the diagnosis and treatment of CRS and nasal polyposis...
  3. doi request reprint Characteristics of recurrent chronic rhinosinusitis after previous surgical therapy
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Acta Otolaryngol 128:778-84. 2008
    ..Early onset of long-term aspirin desensitization can address a very predominant inflammatory stimulus in a large number of our patients in an effort to prevent recurrent chronic rhinosinusitis (CRS) after successful surgical therapy...
  4. ncbi request reprint mRNA induction and cytokine release of inflammatory mediators during in vitro exposure of human nasal respiratory epithelia to acetaldehyde
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Inhal Toxicol 18:1083-90. 2006
    ....
  5. ncbi request reprint Epidural hematoma after cochlear implantation in a 2.5-year-old boy
    Jan Gosepath
    Department of Otolaryngology Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Otol Neurotol 26:202-4. 2005
    ..Report a case of an epidural hematoma after cochlear implantation in a 2.5-year-old boy, the diagnostic and therapeutical emergency management, as well as the postinterventional course and rehabilitation of the child...
  6. ncbi request reprint Nasal provocation testing as an international standard for evaluation of allergic and nonallergic rhinitis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Laryngoscope 115:512-6. 2005
    ..The use of rhinomanometry and acoustic rhinometry as objective diagnostic tools is emphasized. For the diagnosis of allergic and occupational rhinitis, standardized NPT should be regarded as an international diagnostic standard...
  7. ncbi request reprint mRNA-induction and cytokine release during in vitro exposure of human nasal respiratory epithelia to methyl methacrylate
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Toxicol Lett 171:29-37. 2007
    ..Methyl methacrylate (MMA) has been reported to cause histopathological changes in rodent nasal epithelium after inhalation challenges. Data in humans are lacking...
  8. ncbi request reprint Role of fungus in eosinophilic sinusitis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Curr Opin Otolaryngol Head Neck Surg 13:9-13. 2005
    ..This review analyzes the available data to describe the current understanding of the role of fungus in the pathophysiology of chronic rhinosinusitis...
  9. ncbi request reprint Expression and localization of cyclooxigenases (Cox-1 and Cox-2) in nasal respiratory mucosa. Does Cox-2 play a key role in the immunology of nasal polyps?
    J Gosepath
    Department of Otolaryngology, Head and Neck Surgery University of Mainz School of Medicine, Mainz, Germany
    J Investig Allergol Clin Immunol 14:114-8. 2004
    ....
  10. ncbi request reprint Incidence of childhood cancer of the head and neck in Germany
    J Gosepath
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of Mainz, Mainz, Germany
    Ann Oncol 18:1716-21. 2007
    ..Only very limited data are available in the literature on the incidence of childhood cancer of the head and neck worldwide...
  11. ncbi request reprint Individual monitoring of aspirin desensitization
    J Gosepath
    Department of Otolaryngology Head and Neck Surgery, Mainz Medical School, Langenbeckstrasse 1, 55101 Mainz, Germany
    Arch Otolaryngol Head Neck Surg 127:316-21. 2001
    ..The exact mechanisms of this desensitization remain obscure, but modulations of the eicosanoid pathway occur and can be monitored with the help of a practicable in vitro assay on mixed leukocyte cultures...
  12. ncbi request reprint Evaluation of inflammatory reactions and genotoxic effects after exposure of nasal respiratory epithelia to benzene
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz School of Medicine, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 65:348-52. 2003
    ..The aim of this study was to identify inflammatory changes as well as genotoxic effects in cultivated human respiratory epithelial cells after in vitro exposure to benzene...
  13. ncbi request reprint Forty-one cases of congenital choanal atresia over 26 years--retrospective analysis of outcome and technique
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Rhinology 45:158-63. 2007
    ..Stenting should be abandoned as it stimulates granulation formation that frequently leads to restenosis. The intraoperative application of Mitomycin C offers a promising adjunct in achieving a stable..
  14. ncbi request reprint [Aspirin sensitivity: long term follow-up after up to 3 years of adaptive desensitization using a maintenance dose of 100 mg of aspirin a day]
    J Gosepath
    Universitäts HNO Klinik Mainz, Germany
    Laryngorhinootologie 81:732-8. 2002
    ....
  15. ncbi request reprint Aspirin intolerance in patients with chronic sinusitis
    J Gosepath
    Department of Otolaryngology, University of Mainz, School of Medicine, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 61:146-50. 1999
    ....
  16. ncbi request reprint No evidence for a correlation of glutathione S-tranferase polymorphisms and chronic rhinosinusitis
    K Fruth
    Department of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Rhinology 49:180-4. 2011
    ..In this study, we analysed the potential association of GST-polymorphisms and chronic rhinosinusitis (CRS)...
  17. ncbi request reprint Fungal DNA is present in tissue specimens of patients with chronic rhinosinusitis
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Am J Rhinol 18:9-13. 2004
    ..The aim of this study was to determine whether fungal DNA is present in tissue specimens taken from patients with polypoid CRS...
  18. ncbi request reprint [Tonsillectomy technique: bipolar scissors vs raspatory: results of a case control study in 138 patients]
    H v Heyden
    Abteilung für Hals Nasen Ohren Heilkunde, Universitätsklinikum Mainz, Mainz, Germany
    HNO 55:684-9. 2007
    ..The use of bipolar scissors versus blunt dissection tonsillectomy were compared in this study in order to evaluate postoperative bleeding and pain, as well as operative time...
  19. doi request reprint Early stress response of human nasal respiratory epithelia after exposure to 1-methoxypropanol-2
    Juergen Brieger
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Toxicol Lett 177:138-43. 2008
    ..Considering these in vitro data, existing exposure limits seem to be safe with respect to inflammatory responses of the upper respiratory tract. However, the effects of long-term exposures to MEP should be watched closely...
  20. ncbi request reprint Frequent chromosomal gains in recurrent juvenile nasopharyngeal angiofibroma
    Ulf Rüdiger Heinrich
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz School of Medicine, Langenbeckstrasse 1, 55131 Mainz, Germany
    Cancer Genet Cytogenet 175:138-43. 2007
    ..Autosomal gains in the primary tumor should be further evaluated as markers for a potentially increased risk of recurrence after surgical removal in this entity...
  21. ncbi request reprint Evaluation of microsatellite amplifications at chromosomal locus 3q26 as surrogate marker for premalignant changes in mucosa surrounding head and neck squamous cell carcinoma
    Jurgen Brieger
    Department of Otorhinolaryngology, Mainz Medical School, Building 102, Lagenbeckstrasse 1, Mainz 55101, Germany
    Cancer Genet Cytogenet 167:26-31. 2006
    ..Detection of small chromosomal aberrations is possible using the PCR-based, highly sensitive, and fast-to-perform fragment analysis technique. The value for the diagnosis and prognosis will have to be proven in follow-up studies...
  22. ncbi request reprint Vascular endothelial growth factor and basic fibroblast growth factor are released by squamous cell carcinoma cells after irradiation and increase resistance to subsequent irradiation
    Jurgen Brieger
    Department of Otorhinolaryngology, Mainz Medical School, Mainz, Germany
    Int J Mol Med 16:159-64. 2005
    ..These observations suggest that radiation might lead to unsuspected and undesired effects in tumorous tissue with possible clinical impact...
  23. doi request reprint Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin
    Juergen Brieger
    Department of Otorhinolaryngology, Head and Neck Surgery, Johannes Gutenberg University, Mainz, Germany
    APMIS 116:1050-7. 2008
    ..Our observations might reflect dysregulation of cellular pathways contributing to cellular dissemination, which might potentially result in later recurrence...
  24. ncbi request reprint Vascular endothelial growth factor expression, vascularization and proliferation in paragangliomas
    Jurgen Brieger
    Department of Otorhinolaryngology, University Hospital, School of Medicine, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 67:119-24. 2005
    ....
  25. doi request reprint Cochlear implant and hearing aid: a new approach to optimizing the fitting in this bimodal situation
    Annerose M Keilmann
    Department for ENT and Communication Disorders, Mainz Medical School, Langenbeckstr 1, 55101 Mainz, Germany
    Eur Arch Otorhinolaryngol 266:1879-84. 2009
    ..A structured bimodal fitting using loudness scaling for both the cochlear implant and the hearing aid results in a subjective and objective amelioration of the patient's hearing and speech perception...
  26. ncbi request reprint The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines
    Jurgen Brieger
    Department of Otorhinolaryngology, Mainz Medical School, Germany
    Ann N Y Acad Sci 1030:37-42. 2004
    ..We conclude that flurbiprofen is able to alter the radiation-induced secretion of these two growth factors and might be useful in decreasing the resistance of SCC to radiation...
  27. ncbi request reprint VEGF-subtype specific protection of SCC and HUVECs from radiation induced cell death
    Jurgen Brieger
    Department of Otorhinolaryngology, Laboratory of Molecular Tumour Biology, University Hospital of Mainz, 55101 Mainz, Germany
    Int J Mol Med 15:145-51. 2005
    ..We hypothesise, that the release of VEGF by the tumor protects tumor cells and endothelium resulting in increased radiation resistance...
  28. doi request reprint Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human
    Boris Rainer Haxel
    Department of Otolaryngology, Head and Neck Surgery, Johannes Gutenberg University, 55101 Mainz, Germany
    Eur Arch Otorhinolaryngol 267:443-8. 2010
    ..This is the first report showing that the use of fluorescence confocal endomicroscopy represents a promising method to examine cellular details in vivo in different oropharyngeal regions in human...
  29. ncbi request reprint Histological and radiological signs indicative for chronic sinus mucosal inflammation in Graves' ophthalmopathy
    Haralampos T Gouveris
    Department of Otolaryngology Head and Neck Surgery, The University of Mainz Hospitals, Mainz, Germany
    Rhinology 47:144-7. 2009
    ..Additionally, our data underline that CT imaging of the paranasal sinuses underestimates (29.4%) the incidence of inflammatory changes of the sinus mucosa (45.5%) of any extent in GO patients...
  30. ncbi request reprint Impact of vascular endothelial growth factor release on radiation resistance
    Juergen Brieger
    Department of Otorhinolaryngology, Head and Neck Surgery, Molecular Tumor Biology Laboratory, University Hospital of Mainz, 55101 Mainz, Germany
    Oncol Rep 18:1597-601. 2007
    ..We suggest that tumor cell survival after irradiation may be enhanced by released VEGF and that the level of released VEGF directly corresponds to the resistance of the tumor to irradiation...
  31. doi request reprint Low-dose aspirin desensitization in individuals with aspirin-exacerbated respiratory disease
    K Fruth
    Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Allergy 68:659-65. 2013
    ..The aim of this trial was to investigate the efficacy and safety of a low-dose aspirin desensitization protocol...
  32. doi request reprint No acute effects of an exposure to 50 ppm acetaldehyde on the upper airways
    A Muttray
    Institute of Occupational, Social and Environmental Medicine, University of Mainz, Mainz, Germany
    Int Arch Occup Environ Health 82:481-8. 2009
    ..The threshold value is mainly based on animal experiments. The aim of this study was to evaluate acute effects of an exposure to 50 ppm acetaldehyde on the upper airways of human subjects...
  33. ncbi request reprint Expression, localization, and significance of vascular permeability/vascular endothelial growth factor in nasal polyps
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Am J Rhinol 19:7-13. 2005
    ..Vascular permeability/vascular endothelial growth factor (VPF/VEGF) plays an important role in inducing angiogenesis and modulating capillary permeability...
  34. doi request reprint Analysis of fifty-six cochlear implant device failures
    Jan Gosepath
    Departments of Otolaryngology, Head and Neck Surgery, Dr Horst Schmidt Kliniken, Academic Teaching Hospital of the University of Mainz, DE 65199 Wiesbaden, Germany
    ORL J Otorhinolaryngol Relat Spec 71:142-7. 2009
    ..Our aim was to present a failure analysis after cochlear implant revision surgery in a large series of children and adults and to assess the outcome and audiologic performance...
  35. ncbi request reprint Topical antibiotic, antifungal, and antiseptic solutions decrease ciliary activity in nasal respiratory cells
    Jan Gosepath
    Department of Otolaryngology, University of Mainz, School of Medicine, Germany
    Am J Rhinol 16:25-31. 2002
    ..The strong dose dependence of these ciliotoxic effects indicates the need for a careful selection of the adequate concentration when using topical treatment in the nose...
  36. ncbi request reprint Yamik sinus catheter in the topical treatment of patients with acute rhinosinusitis after previous sinus surgery
    Jan Gosepath
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    Am J Rhinol 16:297-302. 2002
    ..Affecting the nasal cavity and all paranasal sinuses of one side at a time, it is used to evacuate mucous and secretions as well as and to introduce antiseptic, antibacterial, or antifungal solutions...
  37. ncbi request reprint Technical Note: minimal access surgery for cochlear implantation with MED-EL devices
    Wolf J Mann
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 68:270-2. 2006
    ..Minimally invasive techniques have been described for cochlear implant surgery, but so far this had not been the case for Med-EL devices...
  38. ncbi request reprint Inverted malignant pilomatricoma of the neck
    Simon F Preuss
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital School of Medicine, Langenbeckstr 1, 55131 Mainz, Germany
    Eur Arch Otorhinolaryngol 262:269-71. 2005
    ..Histology of the resected tumor revealed a malignant pilomatricoma. We report the clinical presentation and the management of this case and discuss the clinical and histological findings...
  39. ncbi request reprint The management of acute visual loss after sinus surgery--two cases of rhinogenic optic neuropathy
    Dietlind Haller
    Department of Otorhinolaryngology, Hanuschkrankenhaus, Vienna, Austria
    Rhinology 44:216-8. 2006
    ..Only a few cases of blindness caused by affections of the optic nerve due to inflammatory paranasal sinus disease have been described...