D Gorlich

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Transport between the cell nucleus and the cytoplasm
    D Gorlich
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Annu Rev Cell Dev Biol 15:607-60. 1999
  2. ncbi Nuclear protein import
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Curr Opin Cell Biol 9:412-9. 1997
  3. pmc A novel class of RanGTP binding proteins
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 138:65-80. 1997
  4. pmc Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
    G Lipowsky
    ZMBH, 69120 Heidelberg, Germany
    EMBO J 19:4362-71. 2000
  5. ncbi Identification of a tRNA-specific nuclear export receptor
    U Kutay
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Mol Cell 1:359-69. 1998
  6. ncbi Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
    U Kutay
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Federal Republic of Germany
    Cell 90:1061-71. 1997
  7. pmc CRM1-mediated recycling of snurportin 1 to the cytoplasm
    E Paraskeva
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 145:255-64. 1999
  8. pmc The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
    A Bachi
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 6:136-58. 2000
  9. pmc The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    EMBO J 18:2411-23. 1999
  10. ncbi RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors
    F R Bischoff
    Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    FEBS Lett 419:249-54. 1997

Collaborators

  • U Kutay
  • F R Bischoff
  • N Pante
  • P Bork
  • I W Mattaj
  • H Ponstingl
  • M Stewart
  • S Jäkel
  • G Lipowsky
  • K Ribbeck
  • A Bachi
  • E Hartmann
  • E Izaurralde
  • E Paraskeva
  • R Deane
  • P Schwarzmaier
  • M Wilm
  • I C Braun
  • C von Kobbe
  • J P Rodrigues
  • S Kostka
  • M Carmo-Fonseca
  • R Kraft
  • D Doenecke
  • J Huber
  • W Albig
  • K Schwamborn
  • R Luhrmann
  • H M Kent
  • S Prehn
  • W Schafer
  • H P Zimmermann
  • L Mueller

Detail Information

Publications15

  1. ncbi Transport between the cell nucleus and the cytoplasm
    D Gorlich
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Annu Rev Cell Dev Biol 15:607-60. 1999
    ..We discuss mechanistic aspects and the energetics of transport receptor function and describe a number of pathways in detail...
  2. ncbi Nuclear protein import
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany
    Curr Opin Cell Biol 9:412-9. 1997
    ..Although an understanding of some of the steps in the import process is emerging, the molecular mechanism of the actual translocation through the NPC is still obscure...
  3. pmc A novel class of RanGTP binding proteins
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 138:65-80. 1997
    ..On the basis of these results, we propose that RanBP7 might represent a nuclear transport factor that carries an as yet unknown cargo, which could apply as well for this entire class of related RanGTP-binding proteins...
  4. pmc Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
    G Lipowsky
    ZMBH, 69120 Heidelberg, Germany
    EMBO J 19:4362-71. 2000
    ..The export signal in eIF-5A appears to be complex and to involve the hypusine modification that is unique to eIF-5A. We discuss possible cellular roles for nuclear export of eIF-5A...
  5. ncbi Identification of a tRNA-specific nuclear export receptor
    U Kutay
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Mol Cell 1:359-69. 1998
    ..RanGTP regulates the substrate-exportin-t interaction such that tRNA can be preferentially bound in the nucleus and released in the cytoplasm...
  6. ncbi Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
    U Kutay
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Federal Republic of Germany
    Cell 90:1061-71. 1997
    ..Importin alpha is released from this complex in the cytoplasm by the combined action of RanBP1 and RanGAP1. CAS binds preferentially to NLS-free importin alpha, explaining why import substrates stay in the nucleus...
  7. pmc CRM1-mediated recycling of snurportin 1 to the cytoplasm
    E Paraskeva
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 145:255-64. 1999
    ..This mechanism appears crucial for productive import cycles as it can ensure that CRM1 only exports snurportin 1 that has already released its import substrate in the nucleus...
  8. pmc The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
    A Bachi
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 6:136-58. 2000
    ....
  9. pmc The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    EMBO J 18:2411-23. 1999
    ..Its Ran-binding site is essential when operating as an autonomous import receptor, i.e. independently of Impbeta. Within the Impbeta/Imp7 heterodimer, however, Imp7 plays a more passive role than Impbeta and resembles an import adapter...
  10. ncbi RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors
    F R Bischoff
    Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    FEBS Lett 419:249-54. 1997
    ..The transiently released RanGTP x RanBP1 complex is then induced by RanGAP to hydrolyse GTP, preventing the receptor to rebind RanGTP. The efficient release of importin beta from RanGTP requires importin alpha, in addition to RanBP1...
  11. pmc Identification of different roles for RanGDP and RanGTP in nuclear protein import
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 15:5584-94. 1996
    ..Thus, binding of nucleoplasmic RanGTP to importin-beta probably triggers termination, i.e. the dissociation of importin-alpha from importin-beta and the subsequent release of the import substrate into the nucleoplasm...
  12. pmc Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 17:4491-502. 1998
    ..The presence of distinct binding sites for rpL23a and the M9 import signal in transportin, and for rpL23a and importin alpha in importin beta might explain how a single receptor can recognize very different import signals...
  13. pmc NTF2 mediates nuclear import of Ran
    K Ribbeck
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    EMBO J 17:6587-98. 1998
    ....
  14. pmc Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1
    R Deane
    Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Cell Biol 17:5087-96. 1997
    ..We propose that RanBP5 is a mediator of a nucleocytoplasmic transport pathway that is distinct from the importin-alpha-dependent import of proteins with a classical NLS...
  15. pmc Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex
    U Kutay
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 16:1153-63. 1997
    ..This suggests that mediators of these various transport events share binding sites on the NPC and/or that mechanisms exist to coordinate translocation through the NPC via different nucleocytoplasmic transport pathways...