O Golubnitschaja

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    J Glaucoma 13:66-72. 2004
  2. pmc Chromium-picolinate therapy in diabetes care: molecular and subcellular profiling revealed a necessity for individual outcome prediction, personalised treatment algorithms and new guidelines
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Infect Disord Drug Targets 11:188-95. 2011
  3. pmc Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes
    Kristina Yeghiazaryan
    Department of Radiology, University of Bonn, Germany
    Mol Vis 15:2339-48. 2009
  4. pmc Degenerative valve disease and bioprostheses: risk assessment, predictive diagnosis, personalised treatments
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, Bonn, 53105 Germany
    EPMA J 2:91-105. 2011
  5. pmc Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    EPMA J 2:197-210. 2011
  6. pmc Time for new guidelines in advanced diabetes care: Paradigm change from delayed interventional approach to predictive, preventive & personalized medicine
    Olga Golubnitschaja
    European Association for Predictive, Preventive and Personalised Medicine, Bonn, Germany Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 1:3-12. 2010
  7. pmc European strategies in predictive, preventive and personalised medicine: highlights of the EPMA World Congress 2011
    Olga Golubnitschaja
    European Association for Predictive, Preventive and Personalised Medicine EPMA, Brussels, Belgium Department of Radiology, Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 2:315-32. 2011
  8. pmc Neurodegeneration: accelerated ageing or inadequate healthcare?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany European Association for Predictive, Preventive and Personalised Medicine, Brussels, Belgium
    EPMA J 1:211-5. 2010
  9. pmc Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany European Association for Predictive, Preventive and Personalised Medicine, www epmanet eu
    EPMA J 1:237-44. 2010
  10. pmc Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures
    Melanie Cebioglu
    Division of Molecular Experimental Radiology, Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 1:130-7. 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    J Glaucoma 13:66-72. 2004
    ..In this study we investigated MMP gene expression in circulating leukocytes isolated from normal tension glaucoma (NTG) patients in comparison to healthy controls...
  2. pmc Chromium-picolinate therapy in diabetes care: molecular and subcellular profiling revealed a necessity for individual outcome prediction, personalised treatment algorithms and new guidelines
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Infect Disord Drug Targets 11:188-95. 2011
    ....
  3. pmc Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes
    Kristina Yeghiazaryan
    Department of Radiology, University of Bonn, Germany
    Mol Vis 15:2339-48. 2009
    ..The goal of this study was to look for possible similarities in gene expression profiles of circulating leukocytes in vasospastic individuals and glaucoma patients...
  4. pmc Degenerative valve disease and bioprostheses: risk assessment, predictive diagnosis, personalised treatments
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, Bonn, 53105 Germany
    EPMA J 2:91-105. 2011
    ..Molecular signature of valvular degeneration is reviewed here with emphases on clinical meaning, risk-assessment, predictive diagnosis, individualised treatments...
  5. pmc Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    EPMA J 2:197-210. 2011
    ....
  6. pmc Time for new guidelines in advanced diabetes care: Paradigm change from delayed interventional approach to predictive, preventive & personalized medicine
    Olga Golubnitschaja
    European Association for Predictive, Preventive and Personalised Medicine, Bonn, Germany Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 1:3-12. 2010
    ..The ultimate mission of the "European Association for Predictive, Preventive & Personalised Medicine" is to promote this process in Europe and across the globe...
  7. pmc European strategies in predictive, preventive and personalised medicine: highlights of the EPMA World Congress 2011
    Olga Golubnitschaja
    European Association for Predictive, Preventive and Personalised Medicine EPMA, Brussels, Belgium Department of Radiology, Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 2:315-32. 2011
    ..Full analysis of the outcomes will be provided during the next EPMA World Congress in September 2013...
  8. pmc Neurodegeneration: accelerated ageing or inadequate healthcare?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany European Association for Predictive, Preventive and Personalised Medicine, Brussels, Belgium
    EPMA J 1:211-5. 2010
    ....
  9. pmc Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany European Association for Predictive, Preventive and Personalised Medicine, www epmanet eu
    EPMA J 1:237-44. 2010
    ..Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism...
  10. pmc Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures
    Melanie Cebioglu
    Division of Molecular Experimental Radiology, Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    EPMA J 1:130-7. 2010
    ..Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications...
  11. pmc Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany European Association for Predictive, Preventive and Personalised Medicine, www epmanet eu
    EPMA J 1:263-72. 2010
    ..Predictive molecular-profiling in blood can specify individual predisposition for effective prevention...
  12. pmc Position paper of the EPMA and EFLM: a global vision of the consolidated promotion of an integrative medical approach to advance health care
    Olga Golubnitschaja
    European Association for Predictive, Preventive and Personalised Medicine, EPMA, Brussels 1150, Belgium
    EPMA J 4:12. 2013
    ....
  13. pmc Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str, 25, Bonn, 53105, Germany
    EPMA J 4:6. 2013
    ..The absolute necessity to create individual patient profiles and extended medical records is justified for the utilising by routine medical services. Expert recommendations are provided to promote further developments in the field...
  14. pmc Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics?
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str, 25, Bonn, 53105, Germany
    EPMA J 3:11. 2012
    ....
  15. pmc Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics
    Kristina Yeghiazaryan
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Infect Disord Drug Targets 12:332-9. 2012
    ....
  16. pmc General report & recommendations in predictive, preventive and personalised medicine 2012: white paper of the European association for predictive, preventive and personalised medicine
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str, 25, D 53105 Bonn Germany
    EPMA J 3:14. 2012
    ....
  17. ncbi request reprint Diabetes care: risk factors, prediction, prevention, and individualized treatment
    Olga Golubnitschaja
    Division Molecular Experimental Radiology, Department of Radiology, Friedrich Wilhelms University of Bonn, Germany
    Infect Disord Drug Targets 8:68-9. 2008
    ..High potential of an application of novel gene therapy approaches in diabetes care is expected for such advanced technologies as gene repair by gene replacement therapies...
  18. ncbi request reprint Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases
    O Golubnitschaja
    Department of Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 32:359-71. 2007
    ..An application of the most potent detection technologies such as "Disease Proteomics and Transcriptomics" also considered here, allows a most specific selection of diagnostic markers...
  19. doi request reprint Disease proteomics reveals altered basic gene expression regulation in leukocytes of Normal-Tension and Primary Open-Angle glaucoma patients
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Bonn, Germany
    Proteomics Clin Appl 1:1316-23. 2007
    ..Conservative AP-2 up-regulation is of special importance in terms of basic transcriptional dysregulation that might be specific for glaucoma disease...
  20. ncbi request reprint Advanced Diabetes care: three levels of prediction, prevention & personalized treatment
    Olga Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Bonn Germany
    Curr Diabetes Rev 6:42-51. 2010
    ..Communication among the professionals - healthcare providers, policy-makers, educators, etc., obligatory involved in the overall process to improving (pre)Diabetes care is of paramount importance...
  21. ncbi request reprint Activation of genes inducing cell-cycle arrest and of increased DNA repair in the hearts of rats with early streptozotocin-induced diabetes mellitus
    Olga Golubnitschaja
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Germany, and Renal Unit, Department of Internal Medicine, University Hospital, Gent, Belgium
    Med Sci Monit 12:BR68-74. 2006
    ..This study was aimed at elucidating the role of a potent cellular stress-response system of the p53-dependent checkpoint genes, i.e. P21WAF1/CIP1 and 14-3-3 sigma, in the heart in diabetes...
  22. ncbi request reprint Molecular imaging system for possible prediction of active retinopathy in patients with Diabetes mellitus
    O Golubnitschaja
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Bonn, Germany
    Amino Acids 28:229-37. 2005
    ..Because of the central role of activated MBCs, we hypothesised a functional link between specific alterations in gene expression of MBCs, an increased activity of matrix proteases in serum, and the extent of retinal angiopathy in DM...
  23. ncbi request reprint DNA damage and expression of checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in taurine-deficient cardiomyocytes
    Olga Golubnitschaja
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Biochem Pharmacol 66:511-7. 2003
    ..We also carried out quantitative determination of DNA damage...
  24. ncbi request reprint Molecular imaging of perfusion disturbances in glaucoma
    O Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    Amino Acids 23:293-9. 2002
    ..These genes show expression profiles characteristic for adherent leukocytes which could be an important contributor to blood-brain barrier breakdown which has been found in glaucoma patients...
  25. ncbi request reprint p21WAF1/CIP1 and 14-3-3 sigma gene expression in degenerated aortic valves: a link between cell cycle checkpoints and calcification
    O Golubnitschaja
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 31:309-16. 2006
    ..The present findings on degenerated aortic valves show that increased cell density accompanied with consequent calcification might be attributed to the down-regulation of both G1 and G2 checkpoint genes...
  26. ncbi request reprint Non-sufficient cell cycle control as possible clue for the resistance of human malignant glioma cells to clinically relevant treatment conditions
    D Trog
    Department of Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 32:373-9. 2007
    ....
  27. ncbi request reprint Increased DNA breaks and up-regulation of both G(1) and G(2) checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in circulating leukocytes of glaucoma patients and vasospastic individuals
    H Moenkemann
    Department of Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 28:199-205. 2005
    ..Although decreased activity of XPGC-gene leads to insufficient DNA-repair, no leukopenia has been observed in glaucoma. Molecular mechanisms ensuring cell survival have not been elucidated yet for glaucoma with vascular disorder...
  28. ncbi request reprint An enhanced expression of ABC 1 transporter in circulating leukocytes as a potential molecular marker for the diagnostics of glaucoma
    K Yeghiazaryan
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Bonn, Germany
    Amino Acids 28:207-11. 2005
    ..We proposed the enhanced expression of ABC 1 in leukocytes as a potential marker for the diagnostics and ex vivo molecular monitoring of glaucoma...
  29. ncbi request reprint Early molecular events in the development of the diabetic cardiomyopathy
    H Mönkemann
    Department of Radiology, University of Bonn, Germany
    Amino Acids 23:331-6. 2002
    ..This study evaluates possible molecular mechanisms for early events in the development of DM-induced cardiomyopathy...
  30. ncbi request reprint Engineering of clinical glioma treatment: prediction of pro-invasive molecular events in treated gliomas
    D Trog
    Department of Radiology, University of Bonn, Bonn, Germany
    Proc Inst Mech Eng H 222:1149-60. 2008
    ..Individual drug toxicity and response to anti-cancer therapy can be predicted...
  31. ncbi request reprint Could activated tissue remodeling be considered as early marker for progressive valve degeneration? Comparative analysis of checkpoint and ECM remodeling gene expression in native degenerating aortic valves and after bioprosthetic replacement
    K Yeghiazaryan
    Department of Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 32:109-14. 2007
    ..Here we were looking for a possible stage specificity of tissue remodeling and stress responsive checkpoint gene activation in native degenerating human aortic valves and bioprosthetic valvular tissue after replacement...
  32. ncbi request reprint Expression of ABC-1 transporter is elevated in human glioma cells under irradiation and temozolomide treatment
    D Trog
    Department of Radiology, Division of Molecular Experimental Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Amino Acids 28:213-9. 2005
    ..This study investigates an effect of both temozolomide (TMZ) treatment and/or irradiation on the expression of the ABC-1 transporter in human U87-MG glioma cells...
  33. ncbi request reprint What are the biomarkers for glaucoma?
    Olga Golubnitschaja
    Department of Radiology, University of Bonn, Germany
    Surv Ophthalmol 52:S155-61. 2007
    ..New technologies such as disease proteomics and transcriptomics open new perspectives for the development of rapid molecular diagnostics and follow-up in glaucoma...
  34. ncbi request reprint Effects of dietary deficiency of selective amino acids on the function of the cornea and lens in rats
    A Wegener
    Department of Experimental Ophthalmology, Medical Faculty, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Amino Acids 23:337-42. 2002
    ..This observation is supported by lens fresh weight data. DNA staining evidenced that tryptophan deficiency arrested lens fiber maturation in both strains but stimulated corneal neovascularisation only in SD rats...
  35. ncbi request reprint Prediction of degeneration of native and bioprosthetic aortic valves: issue-related particularities of diabetes mellitus
    Kristina Yeghiazaryan
    Department of Radiology and Department of Internal Medicine II Cardiology, Rheinische Friedrich Wilhelms University of Bonn, Germany
    Infect Disord Drug Targets 8:88-99. 2008
    ..This review considers prognostic factors for prediction of progressive degenerative processes and novel targets to prevent calcification of aortic valves...
  36. ncbi request reprint Up-regulation of vimentin expression in low-density malignant glioma cells as immediate and late effects under irradiation and temozolomide treatment
    Daniela Trog
    Department of Radiology, Friedrich Wilhelms University of Bonn, 53105 Bonn, Germany
    Amino Acids 34:539-45. 2008
    ..This is in agreement with the clinical observations of an increased aggressiveness and malignancy grade of post-operatively chemo/radio-treated malignant gliomas...
  37. ncbi request reprint Diabetes mellitus as a risk factor for cancer: stress or viral etiology?
    Melanie Cebioglu
    Department of Radiology, Rheinische Friedrich Wilhelms University of Bonn, Germany
    Infect Disord Drug Targets 8:76-87. 2008
    ..In its turn, viral infections are known to be implicated in cancer pathology. This review considers both stress and viral infections as possible etiology of cancer in diabetes...
  38. ncbi request reprint Down-regulation of microfilamental network-associated proteins in leukocytes of breast cancer patients: potential application to predictive diagnosis
    Michael Braun
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Cancer Genomics Proteomics 6:31-40. 2009
    ..The focus of this study is the creation of a non-invasive predictive diagnostic approach by pathology-specific blood proteome analysis...
  39. ncbi request reprint Irradiated breast cancer patients demonstrate subgroup-specific regularities in protein expression patterns of circulating leukocytes
    Kristina Yeghiazaryan
    Department of Radiology, Friedrich Wilhelms University of Bonn, D 53105, Bonn, Germany
    Cancer Genomics Proteomics 4:411-8. 2007
    ..For these purposes, minimal-invasive molecular blood analysis is considered as a powerful diagnostic tool: molecular interplay in blood is highly informative and may predict individual side-effects of therapy...
  40. ncbi request reprint Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions
    Daniela Trog
    Department of Radiology, Division of Molecular Experimental Radiology, Friedrich Wilhelms University of Bonn, Bonn, Germany
    Proteomics 6:2924-30. 2006
    ....