M Goetz

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Endoscopy 40:554-62. 2008
  2. ncbi Soluble tumor necrosis factor receptor type II in the early diagnosis of fever in neutropenia
    M Goetz
    I Medizinische Klinik, Universitat Mainz, Langenbeckstr 1, Germany
    Ann Hematol 81:382-5. 2002
  3. doi Advances in confocal laser endomicroscopy for the diagnosis of gastrointestinal diseases
    Martin Goetz
    Johannes Gutenberg Universitat Mainz, I Medizinische Klinik und Poliklinik, Langenbeckstr 1, 55131, Mainz, Germany 49 6131 17 1 49 6131 17 5552
    Expert Opin Med Diagn 3:493-500. 2009
  4. doi Colonoscopic surveillance in inflammatory bowel disease: state of the art reduction of biopsies
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Dig Dis 29:36-40. 2011
  5. ncbi In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    J Hepatol 48:91-7. 2008
  6. doi In vivo real-time imaging of the liver with confocal endomicroscopy permits visualization of the temporospatial patterns of hepatocyte apoptosis
    Martin Goetz
    Medical Clinic, University of Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 301:G764-72. 2011
  7. ncbi Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract
    Martin Goetz
    First Med Clinic, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Anticancer Res 28:353-60. 2008
  8. doi Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Eur Surg Res 41:290-7. 2008
  9. ncbi Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    J Hepatol 53:84-90. 2010
  10. doi [Molecular imaging of the small intestine]
    M Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, Mainz, Germany
    Internist (Berl) 51:702-10. 2010

Detail Information

Publications39

  1. doi In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Endoscopy 40:554-62. 2008
    ..We have developed a rigid miniaturized probe for confocal endomicroscopy of the human liver during laparoscopy...
  2. ncbi Soluble tumor necrosis factor receptor type II in the early diagnosis of fever in neutropenia
    M Goetz
    I Medizinische Klinik, Universitat Mainz, Langenbeckstr 1, Germany
    Ann Hematol 81:382-5. 2002
    ..Based on these data, we cannot recommend the routine screening of sTNF-RII for early detection of septic complications in patients undergoing cytoreductive therapy of AML...
  3. doi Advances in confocal laser endomicroscopy for the diagnosis of gastrointestinal diseases
    Martin Goetz
    Johannes Gutenberg Universitat Mainz, I Medizinische Klinik und Poliklinik, Langenbeckstr 1, 55131, Mainz, Germany 49 6131 17 1 49 6131 17 5552
    Expert Opin Med Diagn 3:493-500. 2009
    ..Dynamic imaging of microscopic events in their natural environment and molecular imaging by CLE will open a door for an advanced understanding of tissue function and microarchitecture in vivo...
  4. doi Colonoscopic surveillance in inflammatory bowel disease: state of the art reduction of biopsies
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Dig Dis 29:36-40. 2011
    ....
  5. ncbi In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    J Hepatol 48:91-7. 2008
    ..Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases...
  6. doi In vivo real-time imaging of the liver with confocal endomicroscopy permits visualization of the temporospatial patterns of hepatocyte apoptosis
    Martin Goetz
    Medical Clinic, University of Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 301:G764-72. 2011
    ..Intravital confocal microscopy may be a valuable tool to study the effects of therapeutic intervention on apoptosis in animal models and humans...
  7. ncbi Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract
    Martin Goetz
    First Med Clinic, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Anticancer Res 28:353-60. 2008
    ..Confocal endomicroscopy is evolving as a novel technique for rapid intravital diagnosis of gastrointestinal neoplastic diseases at the microscopic level and bears the potential for molecular imaging in humans in the future...
  8. doi Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Eur Surg Res 41:290-7. 2008
    ..We evaluated a novel miniaturized confocal laser scanning probe for in vivo visualization of blood vessels, blood flow, cell tracking and perfusion in both healthy rodents and disease models...
  9. ncbi Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    J Hepatol 53:84-90. 2010
    ..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy...
  10. doi [Molecular imaging of the small intestine]
    M Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, Mainz, Germany
    Internist (Berl) 51:702-10. 2010
    ..Still, molecular imaging has the potential to greatly enhance our understanding of gastrointestinal pathology and to impact on future clinical algorithms and science in gastroenterology...
  11. doi Advances of endomicroscopy for gastrointestinal physiology and diseases
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 298:G797-806. 2010
    ..Molecular imaging with endomicroscopy applied in clinical and basic science will permit advances in understanding of the cellular basis of gastrointestinal physiology and pathophysiology...
  12. ncbi In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy
    Martin Goetz
    I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
    World J Gastroenterol 13:2160-5. 2007
    ..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents...
  13. ncbi In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseases
    M Goetz
    Medical Clinic I, University of Mainz, Mainz, Germany
    Endoscopy 39:350-6. 2007
    ..In this study we evaluated a newly developed, handheld, miniaturized confocal laser microscopy probe for real-time in-vivo molecular and subsurface imaging in rodent models of human disease...
  14. ncbi Elevation of soluble tumor necrosis factor receptor II in non-febrile patients with acute myeloid leukemia
    M Goetz
    Medizinische Klinik, Universitat Mainz, Munchen, Germany
    Eur J Med Res 7:487-90. 2002
    ..We investigated the serum concentrations of sTNF-RII in previously untreated patients with AML at the onset of cytoreductive therapy and in non-febrile chemotherapy-associated neutropenia...
  15. ncbi Non-fatal acute liver injury possibly related to high-dose ciprofloxacin
    M Goetz
    Medical Clinic I, University of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
    Eur J Clin Microbiol Infect Dis 22:294-6. 2003
    ..Symptoms resolved after cessation of ciprofloxacin therapy. This report highlights an uncommon side effect of a commonly used antimicrobial agent...
  16. ncbi Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitis
    M Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Scand J Immunol 58:533-40. 2003
    ..Our findings suggest that a single initial insult is not sufficient to trigger chronic progressive inflammation. Rather, perpetuation of inflammation probably requires additional stimuli...
  17. pmc Molecular imaging in gastrointestinal endoscopy
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr 1, D 55131 Mainz, Germany
    Gastroenterology 138:828-33.e1. 2010
    ..Even with the limitations of the currently used approaches, molecular imaging has the potential to greatly impact on future endoscopy in gastroenterology...
  18. ncbi Confocal laser endoscopy: new approach to the early diagnosis of tumors of the esophagus and stomach
    Martin Goetz
    Johannes Gutenberg University Mainz, I Med Clinic, Langenbeckstr1, 55131 Mainz, Germany
    Future Oncol 2:469-76. 2006
    ..Based on recent experiences from animal models, future studies will approach in vivo molecular imaging of human cancer...
  19. doi High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial
    A Hoffman
    I Med Clinic, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 42:827-33. 2010
    ..standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma...
  20. doi In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy
    C Fottner
    Department of Endocrinology and Metabolism, I Medical Clinic, University of Mainz, Mainz, Germany
    Endocrinology 151:2179-88. 2010
    ..CLM with OcF permits real-time molecular, functional, and morphological imaging of sstr-expressing cell structures, allowing the specific visualization of pancreatic islet cells and neuroendocrine tumors in vivo...
  21. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
    ..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD...
  22. doi Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy
    A Hoffman
    I Med Clinic, Johannes Gutenberg University Mainz, Germany
    Dig Liver Dis 42:45-50. 2010
    ..1%) in screening for colorectal cancer. We focused on lesions less than 5 mm as a surrogate marker for the optical possibilities of the EPKi system...
  23. doi MedJet--a new CO2-based disposable cleaning device allows safe and effective bowel cleansing during colonoscopy: a pilot study
    R Kiesslich
    I Med Klinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 44:767-71. 2012
    ..The aim of the current pilot study, which was conducted in humans, was to test the safety and efficiency of a newly developed disposable cleaning device, the MedJet, for intraprocedural bowel cleansing...
  24. ncbi Confocal laser endomicroscopy: technical status and current indications
    A Hoffman
    First Dept of Medicine, Johannes Gutenberg University, Mainz, Germany
    Endoscopy 38:1275-83. 2006
    ..Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy (e.g., in vivo receptor analysis)...
  25. doi Imaging techniques in inflammatory bowel disease: recent trends, questions and answers
    M Goetz
    I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Gastroenterol Clin Biol 33:S174-82. 2009
    ..The current data from endoscopic studies should result in an integrated approach to both identify and characterize a suspicious lesion during ongoing endoscopy for reliable, accurate diagnosis and targeted, immediate therapy...
  26. ncbi In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  27. doi In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancer
    M Goetz
    I Medizinische Klinik und Poliklinik, Universtitäsmedizin Mainz, Mainz, Germany
    Endoscopy 45:469-77. 2013
    ....
  28. doi High-definition endoscopy with i-Scan and Lugol's solution for more precise detection of mucosal breaks in patients with reflux symptoms
    A Hoffman
    I Med Clinic, Johannes Gutenberg University Mainz, Germany
    Endoscopy 41:107-12. 2009
    ....
  29. ncbi Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
    ..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy...
  30. ncbi Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 132:874-82. 2007
    ..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial...
  31. doi Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human
    Boris Rainer Haxel
    Department of Otolaryngology, Head and Neck Surgery, Johannes Gutenberg University, 55101 Mainz, Germany
    Eur Arch Otorhinolaryngol 267:443-8. 2010
    ..This is the first report showing that the use of fluorescence confocal endomicroscopy represents a promising method to examine cellular details in vivo in different oropharyngeal regions in human...
  32. doi Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy
    Sebastian Foersch
    Medical Clinic I, University of Mainz, Mainz, Germany
    Gut 59:1046-55. 2010
    ..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC...
  33. doi Confocal laser endomicroscopy for gastrointestinal diseases
    Ralf Kiesslich
    First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Gastrointest Endosc Clin N Am 18:451-66, viii. 2008
    ..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research...
  34. doi Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastrointest Endosc 70:959-68. 2009
    ..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects...
  35. doi In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    Gastroenterology 138:435-46. 2010
    ..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models...
  36. ncbi Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer
    Ralf Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Nat Clin Pract Oncol 4:480-90. 2007
    ..Taken together, CLE has led colorectal cancer endoscopy into a new era. CLE can no longer be regarded as just another endoscopic technique, but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer...
  37. ncbi Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy
    Ralf Kiesslich
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastroenterology 133:1769-78. 2007
    ..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding...
  38. doi Advanced imaging of the gastrointestinal tract: research vs. clinical tools?
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Curr Opin Gastroenterol 25:412-21. 2009
    ..Still, three major needs have to be satisfied: endoscopy should be able to detect a lesion, characterize the lesion, and then its nature should be confirmed. These steps should ideally translate into an immediate therapeutic decision...
  39. ncbi Diagnosing Helicobacter pylori in vivo by confocal laser endoscopy
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 128:2119-23. 2005
    ..Confocal laser endomicroscopy enables subsurface microscopic imaging of living tissue during ongoing endoscopy. This case report describes the in vivo detection of Helicobacter pylori by endomicroscopy...