Robert H Goertsches
Affiliation: University of Rostock
- Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networksRobert H Goertsches
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
J Neurol 255:48-57. 2008....
- Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MSRobert H Goertsches
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18047 Rostock, Germany
Pharmacogenomics 11:147-61. 2010..In multiple sclerosis patients, treatment with recombinant IFN-beta (rIFN-beta) is partially efficient in reducing clinical exacerbations. However, its molecular mechanism of action is still under scrutiny...
- Integrative modeling of transcriptional regulation in response to antirheumatic therapyMichael Hecker
Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
BMC Bioinformatics 10:262. 2009..Etanercept is known to reduce disease symptoms and progression in RA, but the underlying molecular mechanisms have not been fully elucidated...
- Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of multiple sclerosis therapyRobert H Goertsches
University of Rostock, Department of Neurology, Gehlsheimer Strasse 20, 18147 Rostock, Germany
Pharmacogenomics 12:423-32. 2011..We will discuss recurrently reported biomarker candidates, emphasizing those of immunologically meaning, and review studies with network module outputs...
- Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosisRobert Goertsches
Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, 08035 Barcelona, Spain
Mult Scler 14:412-4. 2008..Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis...
- MS therapy research applying genome-wide RNA profiling of peripheral bloodR Goertsches
Department of Immunology, Clinic of Neurology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Int MS J 14:98-107. 2007..This work reviews the state of the art in MS therapy research applying genomewide screening methods at the transcriptome level in peripheral blood cells of humans...
- Detection of apoptotic cells in cerebrospinal fluid of patients suffering from neurological diseaseR Goertsches
Institute of Immunology, University of Rostock, Rostock, Germany
J Neuroimmunol 188:175-80. 2007..In contrast, expression of the anti-apoptotic protein Bcl-2 did not differ between investigated patient groups...
- Multiple sclerosis therapy monitoring based on gene expressionRobert Goertsches
Department of Immunology, University of Rostock, Schillingallee 70, D 18055 Rostock, Germany
Curr Pharm Des 12:3761-79. 2006..It discusses implications in understanding disease pathogenicity, diagnostic markers, the identification of new therapeutic targets and a classification of patients towards the advent of tailored therapies...
- Immunoglobulins--basic considerationsEilhard Mix
University of Rostock, Dept of Neurology, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 253:V9-17. 2006..The generation of genetically engineered monoclonal Abs (mAbs) has revolutionized the diagnostic and therapeutic potential of Abs in almost all disciplines of modern medicine...
- Plasma osteopontin levels in multiple sclerosisManuel Comabella
Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Escola d Infermeria 2a planta, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
J Neuroimmunol 158:231-9. 2005....
- mtDNA nt13708A variant increases the risk of multiple sclerosisXinhua Yu
Section of Immunogenetics, University of Rostock, Rostock, Germany
PLoS ONE 3:e1530. 2008..Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility...
- Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosisRobert Goertsches
Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Escuela de Enfermeria 2 a planta, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
J Neuroimmunol 164:140-7. 2005..No association was detected between different genotypes and disease severity measured by the Multiple Sclerosis Severity Score (MSSS). These findings suggest a potentially important role for the ADAMTS14 gene in predisposition to MS...
- Comparative genomics for the investigation of autoimmune diseasesSteffen Möller
University of Rostock, Institutes of Immunology, Schillingallee 70, 18057 Rostock, Germany
Curr Pharm Des 12:3707-22. 2006....
- Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosisEva Julià
Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
J Neuroimmunol 180:147-58. 2006..To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis...
- Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapyMartin Eggert
Department of Internal Medicine, Rostock Clinic South, Südring 81, 18059 Rostock, Germany
J Neurol Sci 264:145-50. 2008..In summary, pulse therapy resulted in a decreased level of activated p65 NF-kappaB subunits leading to decreased levels of transcriptionally active pro-inflammatory NF-kappaB...
- Association Cluster Detector: a tool for heuristic detection of significance clusters in whole-genome scansTomas Marques-Bonet
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Bioinformatics 21:ii180-1. 2005..AVAILABILITY: The tool can be downloaded from http://www.upf.es/cexs/recerca/bioevo/softanddata.htm..
- Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in EuropeansMaria Ban
University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
J Neuroimmunol 179:108-16. 2006..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1...
- A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the diseaseRobert Goertsches
Neuroimmunology Unit, Hospital Vall d'Hebron, Barcelona, Spain
J Neuroimmunol 143:124-8. 2003..Our results provide support for the presence of multiple coding regions that contain MS susceptibility genes of small or moderate effect...