Ines Gockel

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases: a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial
    Carl Christoph Schimanski
    First Deptartment of Internal Medicine, University Medical Center UMC, University Hospital of Mainz, Mainz, Germany
    BMC Cancer 12:144. 2012
  2. doi [Two-stage esophageal resection with ischemic preconditioning of the gastric tube in decompensated dolichomegaesophagus and end-stage achalasia]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 46:1278-82. 2008
  3. pmc Developments in esophageal surgery for adenocarcinoma: a comparison of two decades
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    BMC Cancer 7:114. 2007
  4. ncbi [Appendicitis necessitatis: appendicitis perforating the abdominal wall]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Chirurg 78:840-2. 2007
  5. pmc Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    BMC Cancer 6:290. 2006
  6. ncbi Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysis
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, and the Department of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany
    J Gastrointest Surg 10:1400-8. 2006
  7. ncbi [Nonerosive and erosive gastroesophageal reflux disease. Long-term results of laparoscopic anterior semifundoplication]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Chirurg 78:35-9. 2007
  8. pmc Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Germany
    World J Surg Oncol 5:44. 2007
  9. ncbi [Achalasia in circumscribed scleroderma]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 131:1799-802. 2006
  10. doi Dissection of lymph node metastases in esophageal cancer
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Expert Rev Anticancer Ther 11:571-8. 2011

Detail Information

Publications96

  1. pmc LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases: a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial
    Carl Christoph Schimanski
    First Deptartment of Internal Medicine, University Medical Center UMC, University Hospital of Mainz, Mainz, Germany
    BMC Cancer 12:144. 2012
    ..In a phase IIB trial, L-BLP25 has shown acceptable tolerability and a trend towards longer survival in patients with stage IIIB locoregional NSCLC...
  2. doi [Two-stage esophageal resection with ischemic preconditioning of the gastric tube in decompensated dolichomegaesophagus and end-stage achalasia]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 46:1278-82. 2008
    ....
  3. pmc Developments in esophageal surgery for adenocarcinoma: a comparison of two decades
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    BMC Cancer 7:114. 2007
    ..The objective of this study was to examine outcomes in patients undergoing esophageal resection for adenocarcinoma at our institution during a 20-year period and, in particular, to address temporal trends in long-term survival...
  4. ncbi [Appendicitis necessitatis: appendicitis perforating the abdominal wall]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Chirurg 78:840-2. 2007
    ..In analogy to empyema necessitatis, which would require the pleural empyema to penetrate the thoracic wall, the entity was denoted appendicitis necessitatis...
  5. pmc Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    BMC Cancer 6:290. 2006
    ..The aim of our study was to evaluate the role of CXCR4 in tumor spread of esophageal cancer with a differentiated view of the two predominant histologic types--squamous cell and adenocarcinoma...
  6. ncbi Long-term results of conventional myotomy in patients with achalasia: a prospective 20-year analysis
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, and the Department of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany
    J Gastrointest Surg 10:1400-8. 2006
    ..0-22.5) mm Hg. Conventional myotomy leads in the long run with high efficiency to an improvement of the symptoms evident in achalasia. These results may be regarded as the basis for assessment of the minimal-invasive procedure...
  7. ncbi [Nonerosive and erosive gastroesophageal reflux disease. Long-term results of laparoscopic anterior semifundoplication]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Chirurg 78:35-9. 2007
    ..The aim of this study was to evaluate long-term results of laparoscopic anterior semifundoplication in patients with nonerosive (NERD) and erosive (ERD) gastroesophageal reflux disease...
  8. pmc Resection of the mesopancreas (RMP): a new surgical classification of a known anatomical space
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Germany
    World J Surg Oncol 5:44. 2007
    ..Immunohistochemical investigation of the mesopancreatic-perineural lymphogenic structures was carried out with the purpose of identifying possible routes of metastatic spread...
  9. ncbi [Achalasia in circumscribed scleroderma]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 131:1799-802. 2006
    ..His symptoms had increased markedly 6 months before presenting at our hospital and the patient had lost 15 kg of weight. 2 months ago, a percutaneous endoscopic gastrostomy (PEG) had been inserted at another hospital...
  10. doi Dissection of lymph node metastases in esophageal cancer
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Expert Rev Anticancer Ther 11:571-8. 2011
    ....
  11. ncbi Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Mainz, Germany
    World J Gastroenterol 12:3746-50. 2006
    ..The aim of this study was to investigate the significance of preoperative CRP as a parameter of the perioperative course and long-term prognosis in patients with squamous cell carcinoma and adenocarcinoma of the oesophagus...
  12. ncbi [Retroperitoneal sarcomas: diagnostic and therapy]
    I Gockel
    Klinik für Allgemein und Abdominalchirurgie der Johannes Gutenberg Universität Mainz
    Zentralbl Chir 131:223-9. 2006
    ..It was the aim of this study to analyze diagnosis, therapy and long-term prognosis in patients with retroperitoneal sarcomas over a period of 10 years...
  13. doi [Differentiated surgical therapy for neuroendocrine tumours (NET) of the stomach]
    I Gockel
    Johannes Gutenberg Universitat Mainz, Klinik und Poliklinik fur Allgemein und Abdominalchirurgie, Mainz, Deutschland
    Zentralbl Chir 135:203-9. 2010
    ..Neuroendocrine tumours of the stomach remain a special challenge within the clinical daily routine - not only in the correct classification but also in the optimal surgical therapy...
  14. doi [Squamous cell carcinoma of the oesophagus--impact of surgery within the therapeutic concept]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 48:560-6. 2010
    ..Future research will focus on predictors of the histopathological response, in order to possibly more accurately avoid surgical morbidity in patients with complete pathological responses after multimodal therapy...
  15. ncbi Persistent and recurrent achalasia after Heller myotomy: analysis of different patterns and long-term results of reoperation
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    Arch Surg 142:1093-7. 2007
    ....
  16. doi Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2-40 immunostaining
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Langenbeckstr 1, Mainz D 55131, Germany
    J Surg Oncol 100:191-8. 2009
    ..It was the aim of our study to establish a model for prediction of lymph node metastases in superficial esophageal cancer...
  17. ncbi Necessity of preoperative imaging of the gastro-epiploic arcade prior to esophageal resection
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Germany
    Hepatogastroenterology 56:711-3. 2009
    ....
  18. doi [Surgical therapy for esophageal carcinoma: a prospective 20-year analysis]
    I Gockel
    Klinik und Poliklinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Zentralbl Chir 133:260-6. 2008
    ..The aim of our study was the analysis of long-term developments in the surgical therapy for esophageal carcinoma at our hospital over a period of 20 years with a differentiated view on the two predominant histological tumour types...
  19. doi [Indications for conventional adrenalectomy]
    I Gockel
    Klinik und Poliklinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Zentralbl Chir 133:255-9. 2008
    ..It was the aim of our study to analyse the indications for conventional adrenalectomy in our own patients since the introduction of the minimally invasive technique in the year 1994 - laparoscopically and retroperitoneoscopically...
  20. doi [New perspectives in laparoscopic simulation: from students' skills lab to stress evaluation]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universität Mainz Germany
    Zentralbl Chir 133:244-9. 2008
    ..Application of a LapSim-training model in the Students' Skills Lab as well as the objective evaluation of stress in a virtual operating room scenario offer new perspectives in laparoscopic simulation...
  21. doi Achalasia--if surgical treatment fails: analysis of remedial surgery
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Gastrointest Surg 14:S46-57. 2010
    ..Failure of surgical treatment, however, remains an urgent problem which has been discussed controversially recently...
  22. doi Long-term survivors of esophageal cancer: disease-specific quality of life, general health and complications
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Surg Oncol 102:516-22. 2010
    ..The aim of our study was to assess the quality of life as well as secondary cancers/diseases and esophagectomy-related or unrelated interventions in the long-term course of surgery...
  23. ncbi Laparoscopic anterior semifundoplication in patients with intrathoracic stomach
    Ines Gockel
    Departments of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    Am Surg 74:15-9. 2008
    ..Prospective, randomized long-term studies are essential to gain further information about the "ideal" type of laparoscopic repair in large hiatal hernia with intrathoracic stomach...
  24. doi [Achalasia or pseudoachalasia? Problems of diagnostic and treatment decisions in two cases]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 133:290-4. 2008
    ..Patient 2 (male, aged 84 years) complained of restrosternal dysphagia with each intake of food for one year, weight loss of 12 kg and occasional regurgitation of food...
  25. doi [Technical aspects of laparoscopic Heller myotomy for achalasia]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131, Mainz
    Chirurg 80:840-7. 2009
    ..The pitfalls are incomplete myotomy, especially at its distal, fundic site, with consecutive persistence or recurrence of symptoms, as well as occult mucosal perforations, which can be detected by intraoperative endoscopy...
  26. doi Risk of lymph node metastasis in submucosal esophageal cancer: a review of surgically resected patients
    Ines Gockel
    Johannes Gutenberg University of Mainz, Mainz, Germany
    Expert Rev Gastroenterol Hepatol 5:371-84. 2011
    ..The objective of this article is to determine the risk of nodal metastases in submucosal (sm) esophageal cancer, comparing the two predominating histologic tumor types, squamous cell cancer (SCC) and adenocarcinoma (ADC)...
  27. ncbi Image cytometric DNA analysis of mucosal biopsies in patients with primary achalasia
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    World J Gastroenterol 12:3020-5. 2006
    ..To determine DNA aneuploidy in mucosal biopsies of achalasia patients for subsequent rapid diagnosis...
  28. ncbi Spectrum of histopathologic findings in patients with achalasia reflects different etiologies
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Gastroenterol Hepatol 21:727-33. 2006
    ..The aim of the present study was to elucidate its underlying pathologies and their chronology by investigation of esophageal specimens in patients undergoing surgery (esophageal resection or myotomy) for achalasia...
  29. ncbi [Hamartoma of the duodenum]
    I Gockel
    Klinik und Poliklinik fur Allgemein und Abdominalchirurgie
    Dtsch Med Wochenschr 130:1637-40. 2005
    ..There were no sings of jaundice or gastro-intestinal bleeding. The physical examination was -- apart from epigastric pain -- unremarkable...
  30. ncbi Subtotal esophageal resection in motility disorders of the esophagus
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Dig Dis 22:396-401. 2004
    ..Patient selection in this group is challenging and the operative risk has to be weighted carefully against the poor quality of life with persistent or recurrent dysphagia...
  31. ncbi [Epiphrenic diverticulum: possible causes and surgical therapy]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Chirurg 76:777-82. 2005
    ..Based on our own long-term results, we intended to prove if a treatment concept modeled on the motility disorder is justified...
  32. ncbi Subtotal or total gastrectomy for gastric cancer: impact of the surgical procedure on morbidity and prognosis--analysis of a 10-year experience
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Langenbecks Arch Surg 390:148-55. 2005
    ....
  33. ncbi [Quality of life after subtotal resection and gastrectomy for gastric cancer]
    I Gockel
    Klinik und Poliklinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Chirurg 76:250-7. 2005
    ..The number of meals (4 vs. 5 meals per day) and the loss of weight since surgery (5 vs. 10 kg) were less after subtotal resection than after gastrectomy. However, the latter parameter did not reach statistical significance...
  34. ncbi [Long-term results for Heller-myotomy with anterior semifundoplication in achalasia]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Zentralbl Chir 129:374-80. 2004
    ..Few studies of long-term effects of myotomy concerning the removal of dysphagia and the development of gastroesophageal reflux have been submitted...
  35. ncbi Pseudoachalasia: a case series and analysis of the literature
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Mainz, Germany
    Scand J Gastroenterol 40:378-85. 2005
    ..Mechanisms proposed to explain the clinical features of pseudoachalasia include a circumferential mechanical obstruction of the distal esophagus or a malignant infiltration of inhibitory neurons within the myenteric plexus...
  36. ncbi Influence of splenectomy on perioperative morbidity and long-term survival after esophagectomy in patients with esophageal carcinoma
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Dis Esophagus 18:311-5. 2005
    ..Although it is not yet proven, that splenectomy may have an adverse effect on long-term prognosis, operative procedure should avoid removing the spleen...
  37. ncbi Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstr 1, Mainz 55101, Germany
    Surg Endosc 19:1491-7. 2005
    ....
  38. ncbi [Minimally invasive adrenalectomy for pheochromocytoma: routine or risk?]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Chirurg 77:70-5. 2006
    ..The aim of this study was to examine the relative intraoperative risk of cardiovascular complications with the minimally invasive approach...
  39. ncbi [Dolichomegaesophagus in achalasia. Therapy by esophogectomy in an aged patient]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Mainz
    Dtsch Med Wochenschr 129:735-8. 2004
    ..Currently, the patient presented with dysphagia for liquid and solid food, with permanent retrosternal pain and regurgitation for every meal, leading to a weight loss of 10 kg...
  40. ncbi Endoscopic adrenalectomy for pheochromocytoma: difference between the transperitoneal and retroperitoneal approaches in terms of the operative course
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Surg Endosc 19:1086-92. 2005
    ..The aim of this study was to identify the optimal surgical approach for endoscopic adrenalectomy in patients with pheochromocytoma...
  41. ncbi Incurable esophageal cancer: patterns of tumor spread and therapeutic consequences
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Langenbeckstr 1, Mainz, D 55101, Germany
    World J Surg 30:183-90. 2006
    ..The aim of the study was to determine if the two histologic tumor types in esophageal cancer exhibit different behavior at advanced tumour stages and require a differentiated therapy...
  42. ncbi Impact of minimally invasive surgery in the spectrum of current achalasia treatment options
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Scand J Surg 100:72-7. 2011
    ..Peri-operative mortality should approach 0%, and favorable long-term results can be achieved in > 90%...
  43. ncbi [Esophageal resection for non-specific esophageal motility disorder]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 43:379-83. 2005
    ..Esophageal resection provided the only chance of a long-term benefit for our patient with relief of dysphagia...
  44. doi Analysis of anti-proliferative and chemosensitizing effects of sunitinib on human esophagogastric cancer cells: Synergistic interaction with vandetanib via inhibition of multi-receptor tyrosine kinase pathways
    Orestis Lyros
    First Department of Internal Medicine, Johannes Gutenberg University Hospital, Mainz, Germany
    Int J Cancer 127:1197-208. 2010
    ....
  45. ncbi Does expression of receptor tyrosine kinases in gastric adenocarcinoma correlate with clinicopathological parameters?
    Daniel Drescher
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz 55101, Germany
    Hepatogastroenterology 57:388-94. 2010
    ..This study was initiated in order to define the (co-)expression patterns of target receptor tyrosine kinases (RTKs) in human gastric adenocarcinoma and to correlate them with clinicopathological parameters...
  46. ncbi Co-expression of receptor tyrosine kinases in esophageal adenocarcinoma and squamous cell cancer
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    Oncol Rep 20:845-50. 2008
    ....
  47. doi K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer
    Carl C Schimanski
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz 55101, Germany
    Int J Colorectal Dis 25:181-6. 2010
    ..We initiated this study in order to analyze whether the expression level of targeted receptor tyrosine kinases (RTK) is associated with the K-ras mutation status...
  48. ncbi Effects of pneumatic dilation and myotomy on esophageal function and morphology in patients with achalasia
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany tDepartment of Gastroenterology, German Diagnostic Clinic, Wiesbaden, Germany
    Am Surg 71:128-31. 2005
    ....
  49. doi Low expression of chemokine receptor CCR5 in human colorectal cancer correlates with lymphatic dissemination and reduced CD8+ T-cell infiltration
    Tim Zimmermann
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Int J Colorectal Dis 25:417-24. 2010
    ..The aim of this study was to evaluate the relevance of the chemokine receptor CCR5 expression for the progression of human colorectal cancer...
  50. doi Prognostic scoring system predictive of survival after surgical resection of esophageal carcinoma
    Ines Gockel
    Department of General, Visceral and Transplant Surgery, University Medical Center of Mainz, Germany, Mainz, Germany
    Thorac Cardiovasc Surg 61:470-8. 2013
    ..The aim of our study was to develop a prognostic index score for patients undergoing surgical resection for esophageal cancer that accurately determines survival with specific clinicopathological characteristics...
  51. pmc Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: a systematic review
    George Sgourakis
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital of Mainz, D 55131 Mainz, Germany
    World J Gastroenterol 19:1424-37. 2013
    ..To investigate potential therapeutic recommendations for endoscopic and surgical resection of T1a/T1b esophageal neoplasms...
  52. doi SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer
    Carl C Schimanski
    Interdisciplinary Translational Oncologic Laboratory, Langenbeckstr 1, 55131 Mainz, Germany
    Int J Oncol 39:515-20. 2011
    ..As CXCL12 polymorphisms mediate tumor cell dissemination in esophagogastric cancer, they could represent a marker indicating advanced disease. Antagonists targeting the CXCL12/ CXCR4 axis may be a novel therapeutic option in this entity...
  53. pmc Survival after chemotherapy and/or radiotherapy versus self-expanding metal stent insertion in the setting of inoperable esophageal cancer: a case-control study
    George Sgourakis
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital of Mainz, Mainz, Germany
    BMC Cancer 12:70. 2012
    ..We have made the hypothesis that the administration of combined chemoradiotherapy improves survival in inoperable esophageal cancer patients...
  54. doi Bcl-2 upregulation after 3-nitropropionic acid preconditioning in warm rat liver ischemia
    Friedrich Dünschede
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Shock 30:699-704. 2008
    ..Bcl-2 upregulation might protect against the postischemic burst of reactive oxygen species and therefore reduces apoptotic- and oncotic-related cell death...
  55. doi Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer
    Carl C Schimanski
    Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    J Cancer Res Clin Oncol 137:1139-45. 2011
    ..The aim of this study was to analyze whether CCR5 expression correlates with the presence of hepatic molecular metastases (MM)...
  56. doi VEGF-D correlates with metastatic disease in gastric cancer patients undergoing surgery
    Carl C Schimanski
    First Department of Internal Medicine, University Hospital of Mainz, Mainz, Germany
    World J Surg 35:1010-6. 2011
    ..This is the first study analyzing all these parameters in a homogeneous patient population undergoing surgery...
  57. doi Local excision for more advanced rectal tumors
    Thomas Borschitz
    Clinic of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Acta Oncol 47:1140-7. 2008
    ..In contrast, the situation for T2 tumors is less clear and has only been investigated in small patient collectives. LE for T2 tumors is thus discussed controversially...
  58. pmc Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective
    Thomas C Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Cancer Res Clin Oncol 139:1667-72. 2013
    ..Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or cessation...
  59. ncbi Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease
    Thomas Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Oncol Rep 16:1159-64. 2006
    ..03) and revealed a trend for hematogenous metastasis (P=0.09) and progressed local tumor stages (P=0.15). In summary, strong expression of CXCR4 was significantly associated with advanced pancreatic cancer...
  60. ncbi The use of neural networks in identifying risk factors for lymph node metastasis and recommending management of t1b esophageal cancer
    George Sgourakis
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Am Surg 78:195-206. 2012
    ..Submucosal esophageal cancer should be managed with surgical resection. However, this is subject to the histologic type and presence of specific predictors that could well alter the perspective of multimodality management...
  61. doi Minimally invasive versus open esophagectomy: meta-analysis of outcomes
    George Sgourakis
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Dig Dis Sci 55:3031-40. 2010
    ..A meta-analysis of the current literature was performed to compare the perioperative outcome measures and oncological impact between minimally invasive and open esophagectomy...
  62. pmc High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells
    Carl Christoph Schimanski
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    World J Gastroenterol 15:2089-96. 2009
    ..To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis...
  63. ncbi Endoscopic adrenalectomy: an analysis of the transperitoneal and retroperitoneal approaches and results of a prospective follow-up study
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Surg Endosc 19:569-73. 2005
    ..The aim of this study was to determine which of these is the optimal surgical technique in a prospectively designed analysis of a large series of patients operated on by a single team over a 10-year period...
  64. pmc Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy
    Thomas C Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University Hospital of Mainz, Mainz, Germany
    Int J Colorectal Dis 28:385-98. 2013
    ..We initiated this preclinical study in order to analyze the impact of sorafenib single treatment versus combination treatment in human colorectal cancer...
  65. pmc Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction
    Markus Moehler
    I, Medical Department, Johannes Gutenberg University Mainz, Langenbeckstr, 1, Mainz 55101, Germany
    BMC Cancer 13:75. 2013
    ....
  66. ncbi Electron microscopic studies of esophageal wall structures in patients with achalasia: casting more light on unresolved aspects of pathogenesis
    Juergen R E Bohl
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Germany
    Hepatogastroenterology 57:507-12. 2010
    ....
  67. pmc VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab
    Markus Moehler
    1st Department of Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55101, Germany
    World J Gastroenterol 14:4156-67. 2008
    ..To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC)...
  68. ncbi Adrenalectomy for bilateral and recurrent pheochromocytoma: increased intraoperative risk?
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Am Surg 72:232-7. 2006
    ..The extent to which the adrenergic effect of the increased maximum pCO2 value plays a role on the development of higher maximum blood pressure values and more frequent intraoperative blood pressure crises continues to remain unclear...
  69. ncbi Reduction of interstitial cells of Cajal (ICC) associated with neuronal nitric oxide synthase (n-NOS) in patients with achalasia
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Am J Gastroenterol 103:856-64. 2008
    ..Interstitial cells of Cajal (ICC) have been shown to be involved in nitrergic neurotransmission of the lower esophageal sphincter (LES)...
  70. doi Image of the month. Gastric juvenile polyposis (GJP) in germline SMAD4 mutation accompanied by gastric cancer
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Arch Surg 143:311-2. 2008
  71. ncbi PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy
    Thomas C Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55101 Mainz, Germany
    Oncol Rep 19:697-704. 2008
    ..03). In summary, our results revealed that PDGFRalpha/beta expression significantly correlates with lymphatic dissemination and therefore encourages application of PDGFRalpha/beta RTK-inhibitors within a combination therapy...
  72. doi Oncological outcome after local excision of rectal carcinomas
    Thomas Borschitz
    Clinic of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Surg Oncol 15:3101-8. 2008
    ..However, more frequent recurrences with unknown states of high-risk T1/T2 tumors are risk factors. The purpose of this study was to evaluate if, after LE, immediate reoperation is required, or awaiting salvage surgery is sufficient...
  73. ncbi Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer
    Carl C Schimanski
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, D 55101 Mainz, Germany
    Oncol Rep 16:109-13. 2006
    ..In patients, CCR7 expression was significantly associated with progressed local tumors (P = 0.02) and lymphatic metastasis (P = 0.02). Strong expression of CCR7 promotes intrahepatic and lymphatic HCC dissemination...
  74. doi Detection of lymph node metastases in esophageal cancer
    George Sgourakis
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hopsital of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Expert Rev Anticancer Ther 11:601-12. 2011
    ..Sentinel lymph node navigation may be feasible for cT1N0 or cT2N0 esophageal cancer, and immunohistochemical staining of micrometastatic disease might be feasible in combination with this modality...
  75. ncbi [Childhood achalasia: a separate entity?]
    J Bohl
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Z Gastroenterol 45:1273-80. 2007
    ....
  76. ncbi Three different types of surgeon-specific stress reactions identified by laparoscopic simulation in a virtual scenario
    M Schuetz
    Department of Anaesthesiology, Simulation Center, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
    Surg Endosc 22:1263-7. 2008
    ..This study aimed to investigate whether individual stress responses are associated with intraoperative alterations of manual surgical skills and technical errors of the laparoscopic surgeon...
  77. ncbi Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model
    Friedrich Duenschede
    University Hospital Mainz, Department of General and Abdominal Surgery, Langenbeckstrasse 1, 55131 Mainz, Germany
    World J Gastroenterol 13:3692-8. 2007
    ..Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by alpha-lipoic acid (LA)...
  78. ncbi Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma--a rationale for a molecular targeting strategy?
    Daniel Drescher
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    World J Gastroenterol 13:3605-9. 2007
    ..To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma...
  79. ncbi (Neo)adjuvant strategies of advanced gastric carcinoma: time for a change?
    Markus Moehler
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Dig Dis 22:345-50. 2004
    ....
  80. ncbi A comparison of transhiatal and transthoracic resections on the prognosis in patients with squamous cell carcinoma of the esophagus
    T Junginger
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Eur J Surg Oncol 32:749-55. 2006
    ..The aim of this study was to investigate the long-term prognosis for squamous cell carcinoma of the esophagus treated either by the transhiatal (TH) or by the transthoracic (TT) operative approach...
  81. doi [Palliative care for patients with oesophageal cancer]
    T Junginger
    Universitätsmedizin Mainz, Klinik für Allgemein und Abdominalchirurgie Mainz, Deutschland
    Zentralbl Chir 135:541-6. 2010
    ..Palliative therapy for patients with incurable oesophageal cancer necessitates a broad spectrum of different measures to relieve symptoms...
  82. ncbi The multidisciplinary management of gastrointestinal cancer. Multimodal treatment of gastric cancer
    Markus Moehler
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Best Pract Res Clin Gastroenterol 21:965-81. 2007
    ..This article reviews the most relevant literature on multimodal treatment of gastric cancer, and discusses future strategies to improve locoregional failures...
  83. ncbi Recurrent laryngeal nerve paralysis (RLNP) following esophagectomy for carcinoma
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Eur J Surg Oncol 31:277-81. 2005
    ..The aim of this study was to report the frequency of post-operative recurrent laryngeal nerve paralysis (RLNP) following resection for esophageal carcinoma...
  84. pmc Pneumatic dilation for achalasia: late results of a prospective follow up investigation
    V F Eckardt
    Deutsche Klinik fur Diagnostik, Wiesbaden, Germany
    Gut 53:629-33. 2004
    ....
  85. ncbi Malignant and unclear histological findings in incidentalomas
    F Duenschede
    Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital Mainz, Mainz, Germany
    Eur Surg Res 40:235-8. 2008
    ..The management of incidentalomas with tumor size 3 cm and larger is still under controversial discussion...
  86. pmc Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4
    C C Schimanski
    First Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Br J Cancer 95:210-7. 2006
    ..005) and distant dissemination (M-status; P=0.009), as well as with a decreased 3-year-survival rate (P=0.01). In summary, strong expression of CXCR4 is significantly associated with progressed hepatocellular cancer...
  87. ncbi The value of scoring achalasia: a comparison of current systems and the impact on treatment--the surgeon's viewpoint
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Mainz, Germany
    Am Surg 73:327-31. 2007
    ..The indication for myotomy or dilation therapy can not be set by a specific cut-off point in any system and remains an individual decision, including the aspects of the patient's age and failed prior options...
  88. doi Achalasia: will genetic studies provide insights?
    Henning R Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University, Langenbeckstr 1, 55131, Mainz, Germany
    Hum Genet 128:353-64. 2010
    ..The aim of this review was to summarize current knowledge of the genetics of achalasia. We also discuss the extent to which our understanding of achalasia is likely to be enhanced through future molecular genetic research...
  89. pmc Multidisciplinary management of gastric and gastroesophageal cancers
    Markus Moehler
    World J Gastroenterol 14:3773-80. 2008
    ..This article reviews the most relevant literature on the multidisciplinary management of gastric and gastroesophageal cancer, and discusses future strategies to improve locoregional failures...
  90. ncbi [The Rapunzel syndrome: rare manifestation of a trichobezoar of the upper gastrointestinal tract]
    Ines Gockel
    Klinik für Allgemein und Viszeralchirurgie, Dr Horst Schmidt Kliniken GmbH, Wiesbaden
    Chirurg 74:753-6. 2003
    ..Intensive psychiatric follow-up is mandatory for preventing relapses...
  91. pmc Heller myotomy for failed pneumatic dilation in achalasia: how effective is it?
    Ines Gockel
    Deutsche Klinik für Diagnostik Wiesbaden, Germany
    Ann Surg 239:371-7. 2004
    ..This long-term prospective study describes the effect of myotomy in patients who fail to respond to repeated pneumatic dilations and compares their clinical course with that of patients responding to dilation therapy...
  92. ncbi Novel therapeutic targets in esophageal cancer: impact of chemokine receptor CXCR4
    Ines Gockel
    Future Oncol 3:119-22. 2007
  93. ncbi Achalasia: new insights in pathogenesis
    Ines Gockel
    Am J Gastroenterol 101:202-3. 2006
  94. ncbi The hypertensive lower esophageal sphincter: a motility disorder with manometric features of outflow obstruction
    Ines Gockel
    Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Gastrointest Surg 7:692-700. 2003
    ..Patients with HTLES have significantly elevated intrabolus and residual relaxation pressures on liquid boluses, suggesting that outflow obstruction is present...
  95. ncbi Long-term results of endoscopic adrenalectomy for Conn's syndrome
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany
    Am Surg 73:174-80. 2007
    ..Thus, the coexistence of essential hypertension or, respectively, a long duration of preoperative hypertension with associated renovascular alterations are of significance for the long-term result...
  96. ncbi Superior mesenteric artery (Wilkie) syndrome: different faces
    Ines Gockel
    J Gastroenterol Hepatol 19:720-2. 2004