Dieter Glebe

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Study of the endocytosis and intracellular localization of subviral particles of hepatitis B virus in primary hepatocytes
    Dieter Glebe
    Institute of Medical Virology, University of Giessen, Germany
    Methods Mol Med 96:143-51. 2004
  2. ncbi request reprint Attachment sites and neutralising epitopes of hepatitis B virus
    D Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Minerva Gastroenterol Dietol 52:3-21. 2006
  3. pmc Posttranslational modifications and secretion efficiency of immunogenic hepatitis B virus L protein deletion variants
    Baiba Niedre-Otomere
    Biomedical Research and Study Centre, Ratsupites Street 1, Riga, Latvia
    Virol J 10:63. 2013
  4. pmc Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan
    Mukhlid Yousif
    Hepatitis Virus Diversity Research Programme, Department of Internal Medicine, Faculty of Health Sciences, University of Witwatersrand, Parktown, Johannesburg 2193, South Africa
    BMC Infect Dis 13:328. 2013
  5. doi request reprint The molecular virology of hepatitis B virus
    Dieter Glebe
    Institute of Medical Virology, National Reference Centre for Hepatitis B and D Viruses, Justus Liebig University of Giessen, Giessen, Germany
    Semin Liver Dis 33:103-12. 2013
  6. pmc Correlation of virus and host response markers with circulating immune complexes during acute and chronic woodchuck hepatitis virus infection
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Germany
    J Virol 83:1579-91. 2009
  7. ncbi request reprint Viral and cellular determinants involved in hepadnaviral entry
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University of Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    World J Gastroenterol 13:22-38. 2007
  8. ncbi request reprint Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Germany
    Gastroenterology 129:234-45. 2005
  9. doi request reprint Transient occult hepatitis B virus infection in a blood donor with high viremia
    Corinna M Bremer
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Transfusion 49:1621-9. 2009
  10. doi request reprint Occult hepatitis B virus infection: detection and significance
    Wolfram H Gerlich
    Institute for Medical Virology, Justus Liebig University Giessen, Giessen, Germany
    Dig Dis 28:116-25. 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Study of the endocytosis and intracellular localization of subviral particles of hepatitis B virus in primary hepatocytes
    Dieter Glebe
    Institute of Medical Virology, University of Giessen, Germany
    Methods Mol Med 96:143-51. 2004
  2. ncbi request reprint Attachment sites and neutralising epitopes of hepatitis B virus
    D Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Minerva Gastroenterol Dietol 52:3-21. 2006
    ..Not all S-binding antibodies are able to neutralize the infectivity. This should be considered when the protective efficacy of HBV vaccine induced antibodies is determined...
  3. pmc Posttranslational modifications and secretion efficiency of immunogenic hepatitis B virus L protein deletion variants
    Baiba Niedre-Otomere
    Biomedical Research and Study Centre, Ratsupites Street 1, Riga, Latvia
    Virol J 10:63. 2013
    ..Thus, we studied the effect of preS myristoylation signal suppression on 1-48preS/S secretion efficiency, glycosylation and subcellular distribution...
  4. pmc Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan
    Mukhlid Yousif
    Hepatitis Virus Diversity Research Programme, Department of Internal Medicine, Faculty of Health Sciences, University of Witwatersrand, Parktown, Johannesburg 2193, South Africa
    BMC Infect Dis 13:328. 2013
    ..Our aim was to molecularly characterize hepatitis B virus from Sudanese individuals, with and without liver disease, because genotypes play an important role in clinical manifestation and treatment management...
  5. doi request reprint The molecular virology of hepatitis B virus
    Dieter Glebe
    Institute of Medical Virology, National Reference Centre for Hepatitis B and D Viruses, Justus Liebig University of Giessen, Giessen, Germany
    Semin Liver Dis 33:103-12. 2013
    ....
  6. pmc Correlation of virus and host response markers with circulating immune complexes during acute and chronic woodchuck hepatitis virus infection
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Germany
    J Virol 83:1579-91. 2009
    ....
  7. ncbi request reprint Viral and cellular determinants involved in hepadnaviral entry
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University of Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    World J Gastroenterol 13:22-38. 2007
    ..g. test the fitness of escape mutants), (3) titrate and map neutralizing antibodies, (4) improve current vaccines to combat acute and chronic infections of hepatitis B, and (5) develop entry inhibitors for future clinical applications...
  8. ncbi request reprint Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University Giessen, Germany
    Gastroenterology 129:234-45. 2005
    ..In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection...
  9. doi request reprint Transient occult hepatitis B virus infection in a blood donor with high viremia
    Corinna M Bremer
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Transfusion 49:1621-9. 2009
    ..One month later, anti-HBc and hepatitis B surface antibody (anti-HBs) appeared; HBV DNA disappeared after 2 months. This study asked why HBsAg was undetectable in this rare case of transient occult HBV infection...
  10. doi request reprint Occult hepatitis B virus infection: detection and significance
    Wolfram H Gerlich
    Institute for Medical Virology, Justus Liebig University Giessen, Giessen, Germany
    Dig Dis 28:116-25. 2010
    ..Infection of vaccinated individuals favors development of OBI as we observed in 6 blood donors. HB vaccination may solve the problem of overt HBV infection but may favor OBI...
  11. pmc Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus
    Dieter Glebe
    Institute of Medical Virology Institute of Anatomy and Cell Biology, Justus Liebig University Giessen, 35392 Giessen, Germany
    J Virol 77:9511-21. 2003
    ..The data show that the early steps of HBV infection in Tupaia hepatocyte cultures are comparable to those in the human system...
  12. doi request reprint N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus
    Corinna M Bremer
    Institute of Medical Virology, Justus Liebig University, D 35392 Giessen, Germany
    J Hepatol 55:29-37. 2011
    ..Its B-cell epitopes leading to neutralization of infectivity are not yet characterized...
  13. doi request reprint Inhibition of protein kinase C phosphorylation of hepatitis B virus capsids inhibits virion formation and causes intracellular capsid accumulation
    Linda Wittkop
    Institute of Medical Virology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Cell Microbiol 12:962-75. 2010
    ..Our results imply that different protein kinases have distinct functions within the hepadnaviral life cycle...
  14. ncbi request reprint Role of glycosaminoglycans for binding and infection of hepatitis B virus
    Corinna M Leistner
    Institute of Medical Virology, Justus Liebig University, Frankfurter Str 107, 35392 Giessen, Germany
    Cell Microbiol 10:122-33. 2008
    ..Thereafter, HBV binds via its preS1 attachment site and the N-terminal myristic acid to a yet unknown, high-affinity receptor that confers uptake in a yet unknown compartment...
  15. ncbi request reprint Structure of pre-S2 N- and O-linked glycans in surface proteins from different genotypes of hepatitis B virus
    Sigrid Schmitt
    Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    J Gen Virol 85:2045-53. 2004
    ..The findings may be relevant for the secretion and the immunogenicity of HBV...
  16. doi request reprint Hepatitis B virus infection is dependent on cholesterol in the viral envelope
    Corinna M Bremer
    Institute of Medical Virology, Justus Liebig University, Frankfurter Str 107, 35392, Giessen, Germany
    Cell Microbiol 11:249-60. 2009
    ..g. fusion in a yet unknown compartment...
  17. ncbi request reprint Methods for validation of hepatitis B virus inactivation
    W H Gerlich
    Institute for Medical Virology, National Consulting Laboratory for hepatitis B, C and Blood Transmissible Virus Diseases, Justus Liebig University, Giessen, Germany
    Dev Biol (Basel) 118:113-22. 2004
  18. ncbi request reprint Universal primers for real-time amplification of DNA from all known Orthohepadnavirus species
    Stephan Schaefer
    Institute of Medical Virology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Clin Virol 27:30-7. 2003
    ..By definition, genotypes differ by more than 8% at the nucleotide level. However, some genotypes differ by more than 14% from others...
  19. pmc Lipid-mediated introduction of hepatitis B virus capsids into nonsusceptible cells allows highly efficient replication and facilitates the study of early infection events
    Birgit Rabe
    Institute of Medical Virology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    J Virol 80:5465-73. 2006
    ....
  20. ncbi request reprint Quantitative assay of hepatitis B surface antigen in serum or plasma using laurell electrophoresis
    Wolfram H Gerlich
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Methods Mol Med 95:57-63. 2004
  21. ncbi request reprint Deficiencies in the standardization and sensitivity of diagnostic tests for hepatitis B virus
    W H Gerlich
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    J Viral Hepat 14:16-21. 2007
    ..All tests should be as sensitive as feasible, but even then occult infection may be missed. Reliable detection of occult or mutated HBV is particularly important in blood and organ donors and in patients before or with immunosuppression...
  22. ncbi request reprint Recent advances in hepatitis B virus research: a German point of view
    Dieter Glebe
    World J Gastroenterol 13:8-13. 2007
    ..To overcome these challenging problems new antivirals and optimised vaccines have to be developed...
  23. pmc Combination of an antiviral drug and immunomodulation against hepadnaviral infection in the woodchuck model
    Mengji Lu
    Institut fur Virologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Virol 82:2598-603. 2008
    ....
  24. ncbi request reprint Genotype-dependent activation or repression of HBV enhancer II by transcription factor COUP-TF1
    Silke F Fischer
    Institut fur Medizinische Virologie, Justus Liebig Universitat Giessen, Germany
    World J Gastroenterol 12:6054-8. 2006
    ..To study the expression of HBV enhancer II by transcription factor COUP-TF1...