Stephan Gielen

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
  2. ncbi Exercise-induced modulation of endothelial nitric oxide production
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrabe 39, 04289 Leipzig, Germany
    Curr Pharm Biotechnol 12:1375-84. 2011
  3. doi Risk factor management: antiatherogenic therapies
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009
  4. ncbi Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
  5. ncbi Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
  6. doi Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
  7. ncbi Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
  8. ncbi Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
  9. ncbi Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
  10. doi Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size
    Robert Höllriegel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Int J Cardiol 167:975-80. 2013

Detail Information

Publications39

  1. ncbi Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial
    Sandra Erbs
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 10:336-44. 2003
    ..This analysis was conducted, to evaluate the effects of ET on left ventricular function and haemodynamics in patients with advanced CHF (NYHA class III) fulfilling the inclusion criteria of the COPERNICUS trial...
  2. ncbi Exercise-induced modulation of endothelial nitric oxide production
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrabe 39, 04289 Leipzig, Germany
    Curr Pharm Biotechnol 12:1375-84. 2011
    ....
  3. doi Risk factor management: antiatherogenic therapies
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009
    ..In addition, it is essential not just to treat CV risk factors, but also to treat them to achieve the target values as set by the guidelines of European Society of Cardiology...
  4. ncbi Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....
  5. ncbi Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:393-400. 2005
    ..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF...
  6. doi Maximal exercise, limb ischemia, and endothelial progenitor cells
    Marcus Sandri
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 18:55-64. 2011
    ..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers...
  7. ncbi Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  8. ncbi Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle
    Axel Linke
    Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:1763-70. 2005
    ..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF...
  9. ncbi Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 13:826-31. 2006
    ....
  10. doi Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size
    Robert Höllriegel
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Int J Cardiol 167:975-80. 2013
    ....
  11. doi Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study
    Marcus Sandri
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
    Eur Heart J 33:1758-68. 2012
    ..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)...
  12. ncbi Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure
    Stephan Gielen
    Universitat Leipzig, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    J Am Coll Cardiol 42:861-8. 2003
    ..The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF)...
  13. ncbi Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease
    Volker Adams
    University Leipzig, Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Circulation 111:555-62. 2005
    ..The aim of the present study was to analyze the impact of ET on sources of ROS generation in the left internal mammary artery of patients with symptomatic coronary artery disease...
  14. ncbi Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Am Heart J 146:280-5. 2003
    ..It remains unclear, however, whether the degree of endothelial dysfunction caused by oxidative stress differs between CAD and CHF because of ischemic (ICM) or dilated cardiomyopathy (DCM)...
  15. doi Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure
    Karsten Lenk
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
    Eur J Prev Cardiol 19:404-11. 2012
    ..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome...
  16. ncbi Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  17. ncbi Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction
    Sandra Erbs
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 23:1814-9. 2003
    ..Therefore, we aimed to determine the effects of these polymorphisms on endothelial function and endothelial response to physical exercise in patients with coronary artery disease (CAD)...
  18. doi High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study
    Sandra Erbs
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
    Int J Cardiol 146:56-63. 2011
    ..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF...
  19. pmc Exercise training prevents TNF-α induced loss of force in the diaphragm of mice
    Norman Mangner
    Heart Center Leipzig, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e52274. 2013
    ..Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are elevated in congestive heart failure and are known to induce the production of reactive oxygen species as well as to deteriorate respiratory muscle function...
  20. ncbi Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells
    Nicolle Krankel
    Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
    Arterioscler Thromb Vasc Biol 25:698-703. 2005
    ..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function...
  21. ncbi The effect of exercise training on endothelial function in cardiovascular disease in humans
    Claudia Walther
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Exerc Sport Sci Rev 32:129-34. 2004
    ..Regular exercise training is a nonpharmacological option to improve endothelial dysfunction in patients with cardiovascular disease by increasing NO bioavailability...
  22. ncbi Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions
    Stephan Gielen
    Universitat Leipzig, Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Heart Fail Monit 4:130-6. 2005
    ..In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored...
  23. doi Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trial
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    JACC Cardiovasc Interv 4:452-9. 2011
    ....
  24. doi The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications
    Madlen Uhlemann
    Department of Internal Medicine Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    JACC Cardiovasc Interv 5:36-43. 2012
    ....
  25. doi Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training
    Volker Adams
    Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:293-9. 2008
    ..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx...
  26. ncbi Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia
    Karsten Lenk
    Department of Cardiology, University of Leipzig Heart Center, Strumpellstrasse 39, D 04289 Leipzig, Germany
    Eur Heart J 26:1903-9. 2005
    ..It remains unclear, however, whether an intra-arterial application of autologous CPCs in patients with infrapopliteal PAOD and CLI is safe, feasible, and of potentially beneficial effects...
  27. pmc Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease
    Frank Beutner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 6:e29070. 2011
    ..We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases...
  28. ncbi Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
    ..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF...
  29. ncbi Essay: Hunter-gatherer to sedentary lifestyle
    Rainer Hambrecht
    University of Leipzig, Heart Centre, Department of Internal Medicine Cardiology, 04289 Leipzig, Germany
    Lancet 366:S60-1. 2005
  30. ncbi The childhood obesity epidemic: impact on endothelial function
    Stephan Gielen
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circulation 109:1911-3. 2004
  31. doi Automated photoplethysmography-based determination of ankle-brachial index: a validation study against Doppler sonography
    Frank Beutner
    LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany
    Clin Res Cardiol 101:875-83. 2012
    ..The aim of this study was to determine comparability of automated photoplethysmography (PPG)-derived ABI calculation with the Doppler-ABI algorithm commonly used in cohort studies...
  32. doi Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice
    Volker Adams
    Heart Center Leipzig, University Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
    J Mol Biol 384:48-59. 2008
    ..However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known...
  33. ncbi Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure
    Rainer Hambrecht
    University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
    J Am Coll Cardiol 39:1175-81. 2002
    ..We sought to assess the role of insulin-like growth factor-I (IGF-I) in muscle wasting in chronic heart failure (CHF), serum concentrations and local muscular IGF-I expression were determined in patients with severe CHF...
  34. ncbi Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure
    Rainer Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 12:401-6. 2005
    ..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)...
  35. ncbi Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  36. ncbi Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study
    Volker Adams
    University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
    Cardiovasc Res 54:95-104. 2002
    ..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression...
  37. pmc Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks
    Lesca M Holdt
    LIFE Leipzig Research Center for Civilization Diseases, Universitat Leipzig, Leipzig, Germany
    PLoS Genet 9:e1003588. 2013
    ..Our study provides a molecular mechanism for pro-atherogenic effects of ANRIL at Chr9p21 and suggests a novel role for Alu elements in epigenetic gene regulation by long ncRNAs. ..
  38. ncbi Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotion
    Stephan Gielen
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
    Am Heart J 145:E3. 2003
    ..The aim of this consecutive study was to assess whether a home-based exercise program with reduced average training duration can sustain previously achieved effects on coronary endothelial function...
  39. doi Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    Daniel Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
    Circ Cardiovasc Genet 3:331-9. 2010
    ..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...