Research Topics
| Stephan GielenSummaryAffiliation: University of Leipzig Country: Germany Publications
| Collaborators
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Detail Information
Publications
Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training TrialSandra Erbs
, Herzzentrum GmbH, , Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 10:336-44. 2003..CONCLUSIONS: In patients with advanced CHF (NYHA class III), long-term exercise training is associated with an enhanced physical work capacity, an improvement in stroke volume and a reduction in cardiomegaly...- Exercise-induced modulation of endothelial nitric oxide productionStephan Gielen
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Strumpellstrabe 39, 04289 Leipzig, Germany
Curr Pharm Biotechnol 12:1375-84. 2011.... 
Risk factor management: antiatherogenic therapiesStephan Gielen
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 16:S29-36. 2009..In addition, it is essential not just to treat CV risk factors, but also to treat them to achieve the target values as set by the guidelines of European Society of Cardiology...- Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular functionSandra Erbs
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
Circ Heart Fail 3:486-94. 2010.... - Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscleStephan Gielen
Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 12:393-400. 2005..INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF... - Maximal exercise, limb ischemia, and endothelial progenitor cellsMarcus Sandri
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 18:55-64. 2011..The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers... - Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studiesMarcus Sandri
Heart Center, Department of Internal Medicine/Cardiology, University of Leipzig, Leipzig, Germany
Circulation 111:3391-9. 2005..However, ischemic and subischemic ET programs affect CXCR4 expression of CPCs, which might lead to an improved CPC integration into endothelial networks... - Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscleAxel Linke
Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany
Circulation 111:1763-70. 2005..Moreover, it remains unknown whether exercise training augments the activity of these enzymes in CHF... - Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery diseaseSandra Erbs
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 13:826-31. 2006.... - Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction StudyMarcus Sandri
Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Germany
Eur Heart J 33:1758-68. 2012..We therefore assessed DD in a cohort of referent controls (RCs) and HFREF patients and studied the response of DD to endurance exercise in two age groups (≤55 years and ≥65 years)... - Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failureStephan Gielen
, Herzzentrum GmbH, Department of Internal Medicine and Cardiology, , 04289 Leipzig, Germany
J Am Coll Cardiol 42:861-8. 2003..These local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression of CHF... - Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery diseaseVolker Adams
University Leipzig, Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
Circulation 111:555-62. 2005..7 arbitrary units) mRNA expression. CONCLUSIONS: ET reduces vascular expression of NAD(P)H oxidase and AT1-R, resulting in decreased local ROS generation. These molecular effects converge in a reduced Ang II-mediated vasoconstriction... - Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathySandra Erbs
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany
Am Heart J 146:280-5. 2003..These results suggest that in patients with CHF, factors other than oxidative stress (eg, cytokines) contribute to the pathologic endothelial function... - Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failureKarsten Lenk
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Struempellstrasse 39, Leipzig, Germany
Eur J Prev Cardiol 19:404-11. 2012..In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome... - Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trialRainer Hambrecht
Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
Circulation 109:1371-8. 2004.... - Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunctionSandra Erbs
Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Germany
Arterioscler Thromb Vasc Biol 23:1814-9. 2003..Only the promoter polymorphism might have an adverse effect on training-induced improvement in endothelial function... - High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled studySandra Erbs
University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Struempellstrasse 39, 04289 Leipzig, Germany
Int J Cardiol 146:56-63. 2011..Therefore, we aimed to evaluate the pleiotropic effects of rosuvastatin on vascular and tissue regeneration, its impact on endothelial function and hemodynamics in CHF... - Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cellsNicolle Krankel
Department of Internal Medicine Cardiology, Heart Center Leipzig, University of Leipzig, Germany
Arterioscler Thromb Vasc Biol 25:698-703. 2005..Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function... - The effect of exercise training on endothelial function in cardiovascular disease in humansClaudia Walther
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany
Exerc Sport Sci Rev 32:129-34. 2004..Regular exercise training is a nonpharmacological option to improve endothelial dysfunction in patients with cardiovascular disease by increasing NO bioavailability... - Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventionsStephan Gielen
Universitat Leipzig, Herzzentrum, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
Heart Fail Monit 4:130-6. 2005..In this review, the effects of exercise in aging and in CHF are compared and the parallel mechanisms are explored... - Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemiaKarsten Lenk
Department of Cardiology, University of Leipzig Heart Center, , D-04289 Leipzig, Germany
Eur Heart J 26:1903-9. 2005..CONCLUSION: These preliminary data in a small series of patients with CLI without surgical or interventional options indicate that CPC application is safe, feasible, and may improve both functional and clinical indices... - Randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus: the LIPSIA Yukon trialSteffen Desch
Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
JACC Cardiovasc Interv 4:452-9. 2011.... - The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complicationsMadlen Uhlemann
Department of Internal Medicine Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
JACC Cardiovasc Interv 5:36-43. 2012.... - Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise trainingVolker Adams
Department of Cardiology, University of Leipzig, Leipzig Heart Center, Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 15:293-9. 2008..Exercise training (ET) exhibits great potential to attenuate the development of muscle atrophy and cardiac remodeling. The aim of this study was to investigate the impact of ET on myocardial expression of Murf-1 and MAFbx... 
Exercise training prevents TNF-α induced loss of force in the diaphragm of miceNorman Mangner
Heart Center Leipzig, University of Leipzig, Leipzig, Germany
PLoS ONE 8:e52274. 2013..Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are elevated in congestive heart failure and are known to induce the production of reactive oxygen species as well as to deteriorate respiratory muscle function...- Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery diseaseFrank Beutner
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
PLoS ONE 6:e29070. 2011..We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases... - Essay: Hunter-gatherer to sedentary lifestyleRainer Hambrecht
University of Leipzig, Heart Centre, Department of Internal Medicine/Cardiology, 04289 Leipzig, Germany
Lancet 366:S60-1. 2005 - Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failureP Christian Schulze
Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
Eur J Heart Fail 5:33-40. 2003..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF... - The childhood obesity epidemic: impact on endothelial functionStephan Gielen
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany
Circulation 109:1911-3. 2004 - Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in miceVolker Adams
Heart Center Leipzig, University Leipzig, Strumpellstrasse 39, D 04289 Leipzig, Germany
J Mol Biol 384:48-59. 2008..However, the casual relationships between MuRF1 and TNF-alpha and their relative contributions to muscle function impairment are not known... - Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failureRainer Hambrecht
Heart Center, Department of Cardiology, University of Leipzig, Germany
Eur J Cardiovasc Prev Rehabil 12:401-6. 2005..Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I)... - Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemiaVolker Adams
University Leipzig, Heart Center Leipzig, Germany
Arterioscler Thromb Vasc Biol 24:684-90. 2004..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs... - Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo studyVolker Adams
University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
Cardiovasc Res 54:95-104. 2002..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression... - Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failureRainer Hambrecht
University of Leipzig Heart Center, Department of Cardiology, Leipzig, Germany
J Am Coll Cardiol 39:1175-81. 2002..We sought to assess the role of insulin-like growth factor-I (IGF-I) in muscle wasting in chronic heart failure (CHF), serum concentrations and local muscular IGF-I expression were determined in patients with severe CHF... - Automated photoplethysmography-based determination of ankle-brachial index: a validation study against Doppler sonographyFrank Beutner
LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany
Clin Res Cardiol 101:875-83. 2012..The aim of this study was to determine comparability of automated photoplethysmography (PPG)-derived ABI calculation with the Doppler-ABI algorithm commonly used in cohort studies... - Home-based versus hospital-based exercise programs in patients with coronary artery disease: effects on coronary vasomotionStephan Gielen
Department of Internal Medicine/Cardiology, University of Leipzig, Heart Center, Leipzig, Germany
Am Heart J 145:E3. 2003..However, acetylcholine-induced increases in CBF were lower after home-based ET, suggesting a relation between daily training duration and improvement of coronary vasomotion... - Genetic regulation of serum phytosterol levels and risk of coronary artery diseaseDaniel Teupser
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig, Germany
Circ Cardiovasc Genet 3:331-9. 2010..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...