Ardeschir Ha Ghofrani

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. doi request reprint Riociguat for the treatment of pulmonary arterial hypertension
    Hossein Ardeschir Ghofrani
    University of Giessen and Marburg Lung Center, Giessen, Germany
    N Engl J Med 369:330-40. 2013
  2. doi request reprint Riociguat for the treatment of chronic thromboembolic pulmonary hypertension
    Hossein Ardeschir Ghofrani
    University of Giessen and Marburg Lung Center, Giessen, Germany
    N Engl J Med 369:319-29. 2013
  3. doi request reprint Treatment of pulmonary arterial hypertension (PAH): updated Recommendations of the Cologne Consensus Conference 2011
    H Ardeschir Ghofrani
    Department of Respiratory Medicine, Medical Clinic II, University Hospital Gießen and Marburg, Gießen Branch, Giesen, Germany
    Int J Cardiol 154:S20-33. 2011
  4. pmc Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
    Nicole Pfarr
    Centre for Pulmonary Hypertension Thoraxclinic, University of Heidelberg, Heidelberg, Germany
    Respir Res 12:99. 2011
  5. pmc Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
    Djuro Kosanovic
    University of Giessen Lung Center, Giessen, Germany
    Respir Res 12:87. 2011
  6. pmc Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
    Bhola K Dahal
    University of Giessen Lung Centre, Giessen, Germany
    Respir Res 12:60. 2011
  7. pmc Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
    Beate Fuchs
    Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Giessen, Germany
    Respir Res 12:20. 2011
  8. pmc Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
    Soni Pullamsetti
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Respir Res 6:128. 2005
  9. pmc Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy
    Norbert Weissmann
    Department of Internal Medicine II, Klinikstrasse 36, Justus Liebig University, 35392 Giessen, Germany
    Respir Res 6:86. 2005
  10. pmc Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
    Ralph T Schermuly
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, 35392 Giessen, Germany
    Respir Res 8:4. 2007

Collaborators

Detail Information

Publications60

  1. doi request reprint Riociguat for the treatment of pulmonary arterial hypertension
    Hossein Ardeschir Ghofrani
    University of Giessen and Marburg Lung Center, Giessen, Germany
    N Engl J Med 369:330-40. 2013
    ..Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2 trial to be beneficial in the treatment of pulmonary arterial hypertension...
  2. doi request reprint Riociguat for the treatment of chronic thromboembolic pulmonary hypertension
    Hossein Ardeschir Ghofrani
    University of Giessen and Marburg Lung Center, Giessen, Germany
    N Engl J Med 369:319-29. 2013
    ..Riociguat, a member of a new class of compounds (soluble guanylate cyclase stimulators), has been shown in previous clinical studies to be beneficial in the treatment of chronic thromboembolic pulmonary hypertension...
  3. doi request reprint Treatment of pulmonary arterial hypertension (PAH): updated Recommendations of the Cologne Consensus Conference 2011
    H Ardeschir Ghofrani
    Department of Respiratory Medicine, Medical Clinic II, University Hospital Gießen and Marburg, Gießen Branch, Giesen, Germany
    Int J Cardiol 154:S20-33. 2011
    ..This commentary describes in detail the results and recommendations of the working group on treatment of PAH which were last updated in October 2011...
  4. pmc Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
    Nicole Pfarr
    Centre for Pulmonary Hypertension Thoraxclinic, University of Heidelberg, Heidelberg, Germany
    Respir Res 12:99. 2011
    ..This study prospectively screened for BMPR2 mutations in a large cohort of PAH-patients and compared clinical features between BMPR2 mutation carriers and non-carriers...
  5. pmc Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
    Djuro Kosanovic
    University of Giessen Lung Center, Giessen, Germany
    Respir Res 12:87. 2011
    ..This study aims to investigate the therapeutic efficacy of the selective endothelin-A receptor antagonist TBC3711 in monocrotaline-induced pulmonary hypertension in rats...
  6. pmc Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
    Bhola K Dahal
    University of Giessen Lung Centre, Giessen, Germany
    Respir Res 12:60. 2011
    ....
  7. pmc Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
    Beate Fuchs
    Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Giessen, Germany
    Respir Res 12:20. 2011
    ..However, the mechanism of TRPC6 activation during acute HPV remains elusive. We hypothesize that a diacylglycerol (DAG)-dependent activation of TRPC6 regulates acute HPV...
  8. pmc Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
    Soni Pullamsetti
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Respir Res 6:128. 2005
    ..The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats...
  9. pmc Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy
    Norbert Weissmann
    Department of Internal Medicine II, Klinikstrasse 36, Justus Liebig University, 35392 Giessen, Germany
    Respir Res 6:86. 2005
    ..Electron spin resonance (ESR) with spin trapping is a specific method for ROS detection, and may address some these technical problems...
  10. pmc Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
    Ralph T Schermuly
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, 35392 Giessen, Germany
    Respir Res 8:4. 2007
    ..The rapid desensitization of the human prostacyclin (IP) in response to agonist binding has been shown in cell culture. Phosphorylation of the IP receptor by protein kinase C (PKC) has been suggested to be involved in this process...
  11. pmc Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
    Ralph Theo Schermuly
    Medical Clinic II V, Justus Liebig University Giessen, 35392 Giessen, Germany
    Respir Res 6:76. 2005
    ..The prominent effect of sildenafil may be operative via both PDE1 and PDE5, and is further enhanced by co-application of a PDE3 inhibitor...
  12. pmc Long-term effects of intravenous iloprost in patients with idiopathic pulmonary arterial hypertension deteriorating on non-parenteral therapy
    Lars Knudsen
    Department of Respiratory Medicine, Hannover Medical School, Hanover, Germany
    BMC Pulm Med 11:56. 2011
    ..If these treatments fail, current guidelines recommend the addition of parenteral prostanoid therapy. There is, however, limited evidence for the efficacy of parenteral prostanoids when added to combinations of non-parenteral therapies...
  13. pmc Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
    Sergey Udalov
    University of Giessen, Department of Internal Medicine, Giessen, Germany
    BMC Pulm Med 10:26. 2010
    ..Phosphodiesterase (PDE) 4 is involved in the processes of remodeling and inflammation, which play key role in tissue fibrosis. The aim of the study was, therefore, to investigate the effect of PDE4 inhibition in experimental model of PF...
  14. pmc Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury
    Rio Dumitrascu
    University of Giessen Lung Center, Giessen, Germany
    BMC Pulm Med 8:25. 2008
    ..The injection of monocrotaline is an established model of pulmonary hypertension in rats. The aim of this study was to establish a murine model of pulmonary hypertension by injection of the active metabolite, monocrotaline pyrrole...
  15. ncbi request reprint [Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension]
    H A Ghofrani
    Medizinische Klinik II V, Universitätsklinikum Giessen und Marburg GmbH
    Dtsch Med Wochenschr 131:871-4. 2006
  16. pmc Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy
    Hossein A Ghofrani
    Pulmonary Hypertension Division, Medical Clinic II V, University Hospital Giessen und Marburg GmbH, Giessen, Germany
    Am J Respir Crit Care Med 182:1171-7. 2010
    ..Pulmonary arterial hypertension (PAH) is a progressive condition with a poor prognosis. Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in its pathobiology...
  17. doi request reprint Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study
    H A Ghofrani
    Dept of Internal Medicine, Medical Clinic II V, University Hospital Giessen and Marburg GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Eur Respir J 36:792-9. 2010
    ..These preliminary data show that riociguat has a favourable safety profile and improves exercise capacity, symptoms and pulmonary haemodynamics in CTEPH and PAH. Randomised controlled trials are underway...
  18. doi request reprint [Treatment of pulmonary arterial hypertension (PAH): recommendations of the Cologne Consensus Conference 2010]
    H A Ghofrani
    Abteilung Pneumologie, Medizinische Klink II, Universitätsklinikum Giessen und Marburg, Standort Giessen
    Dtsch Med Wochenschr 135:S87-101. 2010
    ..To this end, a number of working groups was initiated, one of which was specifically dedicated to the treatment of PAH. This commentary summarizes the results and recommendations of the working group on treatment of PAH...
  19. doi request reprint Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension
    Hossein A Ghofrani
    Department of Internal Medicine, Medical Clinic II V, University Hospital Giessen and Marburg GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 118:1195-201. 2008
    ..In addition, we propose guidelines applicable to the conduct of new therapeutic trials in pulmonary arterial hypertension, which aim to provide greater confidence in the efficacy and safety of new treatments currently under development...
  20. ncbi request reprint Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
    Hossein Ardeschir Ghofrani
    Department of Internal Medicine, University Hospital, Justus Liebig University, Klinikstrasse 36, 35392 Giessen, Germany
    Ann Intern Med 136:515-22. 2002
    ..Inhalation of the stable prostacyclin analogue iloprost is being studied for treatment of pulmonary hypertension. The selective phosphodiesterase-5 inhibitor sildenafil has been reported to cause pulmonary vasodilatation...
  21. doi request reprint Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy
    H A Ghofrani
    Dept of Internal Medicine, University Hospital Giessen and Marburg, Germany
    Eur Respir Rev 18:35-41. 2009
    ..Preliminary results indicate that phase-III trials are warranted...
  22. ncbi request reprint Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders
    H A Ghofrani
    Dept of Internal Medicine, Medical Clinic II, Justus Liebig University, Giessen, Germany
    Eur Respir J 19:664-71. 2002
    ..Nitric oxide inhalation provokes a prompt increase in cyclic guanosine monophosphate secretion, but the magnitude of this release is not linked with a decrease in pulmonary vascular resistance...
  23. ncbi request reprint Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension
    Hossein A Ghofrani
    Department of Internal Medicine, University Hospital, Giessen, Germany
    Crit Care Med 30:2489-92. 2002
    ..The aim of the current study was to evaluate if phosphodiesterase type 3 and 4 inhibition might amplify the prostanoid effect on pulmonary vasodilatation by stabilization of intracellular second messenger cyclic adenosine monophosphate...
  24. doi request reprint Riociguat for pulmonary hypertension
    Hossein Ardeschir Ghofrani
    Department of Internal Medicine, Medical Clinic II V, University Hospital Giessen and Marburg GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Future Cardiol 6:155-66. 2010
    ..Further trials in PH have been initiated...
  25. ncbi request reprint Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension
    Hossein A Ghofrani
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, University Hospital, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    J Am Coll Cardiol 42:158-64. 2003
    ....
  26. ncbi request reprint Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
    H A Ghofrani
    Dept of Internal Medicine, University Hospital, Justus Liebig University Giessen, Giessen, Germany
    Eur Respir J 23:321-6. 2004
    ..Future studies are warranted to confirm the encouraging long-term beneficial results observed in the present limited number of patients...
  27. ncbi request reprint [Pulmonary edema]
    H A Ghofrani
    Zentrum fur Innere Medizin, Medizinische Klinik II, Universitatsklinik Giessen
    Internist (Berl) 45:565-72. 2004
    ..This article reviews mainly the pathophysiology of cardiogenic lung edema, while most of the currently discussed therapeutic implications also apply to other entities of lung edema...
  28. ncbi request reprint Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension
    Hossein A Ghofrani
    Department of Internal Medicine Pulmonary Hypertension Center, University Hospital, Giessen, Germany
    J Am Coll Cardiol 43:68S-72S. 2004
    ..The results of such studies have to confirm the current encouraging findings before recommendations regarding the use of PDE-5 inhibitors as a new treatment for PH can be made...
  29. ncbi request reprint [Emerging therapies for the treatment of pulmonary arterial hypertension]
    Hossein Ardeschir Ghofrani
    Medizinische Klinik II, Klinikstrasse 36, 35392, Giessen
    Herz 30:296-302. 2005
    ..However, controlled randomized trials that are currently under consideration have to confirm this notion...
  30. doi request reprint [The treatment of pulmonary arterial hypertension associated with chronic obstructive pulmonary disease makes sense - pro]
    H A Ghofrani
    Medizinische Klinik II V, Universitätsklinikum Giessen und Marburg GmbH
    Dtsch Med Wochenschr 133:720. 2008
  31. pmc Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
    Bakytbek Egemnazarov
    Medical Clinic II, University Hospital Giessen and Marburg, Giessen, Germany
    Respir Res 11:81. 2010
    ..Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebulization of nitrite and different formulations of acidified sodium nitrite on acute HPV...
  32. ncbi request reprint Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction
    Norbert Weissmann
    University Giessen Lung Centre UGLC, Medical Clinic II V, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 34:505-13. 2006
    ....
  33. ncbi request reprint Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies
    Robert Voswinckel
    Department of Internal Medicine, University Hospital Giessen, Giessen, Germany
    J Am Coll Cardiol 48:1672-81. 2006
    ..This study sought to investigate the effects of inhaled treprostinil on pulmonary hemodynamics and gas exchange in severe pulmonary hypertension...
  34. ncbi request reprint Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial
    Hossein A Ghofrani
    University Hospital Giessen and Justus Liebig University, Giessen, Germany
    Ann Intern Med 141:169-77. 2004
    ..Alveolar hypoxia causes pulmonary hypertension and enhanced right ventricular afterload, which may impair exercise tolerance. The phosphodiesterase-5 inhibitor sildenafil has been reported to cause pulmonary vasodilatation...
  35. ncbi request reprint Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study
    Hossein A Ghofrani
    Department of Internal Medicine, University Hospital Giessen, Giessen, Germany
    J Am Coll Cardiol 44:1488-96. 2004
    ..We sought to compare the short-term impact of three different phosphodiesterase-5 (PDE5) inhibitors on pulmonary and systemic hemodynamics and gas exchange parameters in patients with pulmonary arterial hypertension (PAH)...
  36. ncbi request reprint Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury
    Bakytbek Egemnazarov
    Departments of Internal Medicine II, University Hospital Giessen and Marburg, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 296:L462-9. 2009
    ..NO had only marginal effect on I/R injury. Thus BAY 41-2272 protects against I/R-induced lung injury by interfering with the activation of NADPH oxidases...
  37. doi request reprint Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension
    Robert Voswinckel
    University of Giessen Lung Center, Department of Internal Medicine, University Hospital Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Pulm Pharmacol Ther 22:50-6. 2009
    ..Unique drug characteristics may render this prostanoid feasible for inhalation therapy with a metered dose inhaler...
  38. doi request reprint Fhl-1, a new key protein in pulmonary hypertension
    Grazyna Kwapiszewska
    Med Klinik II, University of Giessen Lung Center, Klinik Strasse 36, 35392 Giessen, Germany
    Circulation 118:1183-94. 2008
    ..We hypothesized that underlying key factors can be identified at the onset of the disease. Thus, we screened for alterations to protein expression in lung tissue at the onset of PH in a mouse model of hypoxia-induced PH...
  39. ncbi request reprint Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function
    Frank Reichenberger
    Pulmonary Vascular Diseases Unit, University of Giessen Lung Center UGLC, University Hospital Giessen, Germany
    Respir Physiol Neurobiol 159:196-201. 2007
    ..Sildenafil significantly decreases sPAP and improves right ventricular function...
  40. ncbi request reprint Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia
    Norbert Weissmann
    University of Giessen Lung Center, Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    Thromb Haemost 94:630-8. 2005
    ..In conclusion, congenital over-expression of EPO exerts an "anti-pulmonary hypertensive" effect, both structurally and functionally, particularly obvious upon chronic hypoxia...
  41. ncbi request reprint Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost
    Frank Rose
    Department of Internal Medicine, Justus Leipzig University, Klinikstrasse 36, 35392 Giessen, Germany
    Thromb Haemost 90:1141-9. 2003
    ..Neutrophils might participate in the inflammatory processes in pulmonary arterial hypertension...
  42. ncbi request reprint Measurement of exhaled hydrogen peroxide from rabbit lungs
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, D 35392 Giessen, Germany
    Biol Chem 385:259-64. 2004
    ..When collecting exhaled air via the tracheal tube, the signal represents pulmonary H2O2 generation with the contribution of the remaining body being negligible...
  43. ncbi request reprint Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species
    Parag Goyal
    Department of Internal Medicine 2, Klinikstrasse 36, Giessen, Germany
    Free Radic Biol Med 36:1279-88. 2004
    ..This suggests that H2O2 links Nox1 and HIF-1 activation. We conclude that hypoxic upregulation of Nox1 and subsequently augmented ROS generation may activate HIF-1-dependent pathways...
  44. ncbi request reprint Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats
    Ralph T Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    Am J Respir Crit Care Med 169:39-45. 2004
    ..Moreover, the death rate significantly decreased in those animals treated with sildenafil. We conclude that sildenafil attenuates MCT-induced pulmonary hypertension and cor pulmonale in rats...
  45. ncbi request reprint Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 29:721-32. 2003
    ..Further studies are mandatory to clarify the link between mitochondrial respiratory chain and hypoxic pulmonary vasoconstriction...
  46. ncbi request reprint Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
    Norbert Weissmann
    Department of Internal Medicine, University of Giessen Lung Center UGLC, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Novartis Found Symp 272:196-208; discussion 208-17. 2006
    ..From measurements of intracellular and exhaled H2O2, we hypothesize that total lung ROS release is reduced in alveolar hypoxia, but that in specialized cells or sub-cellular structures an increased ROS release may occur, triggering HPV...
  47. ncbi request reprint Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
    Hossein A Ghofrani
    Medical Clinic II V, Department of Internal Medicine, University Hospital Giessen and Marburg, GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Nat Rev Drug Discov 5:689-702. 2006
    ....
  48. doi request reprint Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension
    Robert Voswinckel
    Department of Internal Medicine, University of Giessen Lung Center, University Hospital Giessen and Marburg GmbH, Giessen, Germany
    Pulm Pharmacol Ther 21:824-32. 2008
    ..We investigated the safety and acute haemodynamic effects of the combination oral sildenafil and inhaled treprostinil in an open label study in patients with precapillary pulmonary hypertension...
  49. ncbi request reprint Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies
    Hossein A Ghofrani
    Medical Clinic II V, Department of Internal Medicine, University Hospital Giessen and Marburg GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Cardiovasc Res 72:30-40. 2006
    ....
  50. ncbi request reprint Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension
    Hossein A Ghofrani
    Department of Internal Medicine, University Hospital, Justus Liebig University Giessen, Germany
    Am J Respir Crit Care Med 167:1139-41. 2003
    ..min-1. m2, p = 0.004, cardiac index 2.4 +/- 0.2 L. min-1. m-2, p = 0.009, 6-minute walking distance 366 +/- 28 m, p = 0.02). Therefore, oral sildenafil may offer a new option for medical treatment of this devastating disease...
  51. ncbi request reprint Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase
    István Vadász
    University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 33:343-54. 2005
    ....
  52. doi request reprint Future perspectives for the treatment of pulmonary arterial hypertension
    Hossein A Ghofrani
    Pulmonary Hypertension Division, University of Giessen Lung Center, University Hospital Giessen, Giessen, Germany
    J Am Coll Cardiol 54:S108-17. 2009
    ....
  53. ncbi request reprint Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
    István Vadász
    University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, D 35392 Giessen, Germany
    Am J Respir Crit Care Med 171:469-79. 2005
    ..Therefore, OA impaired the two essential transepithelial active sodium transport mechanisms of the lung, and could thus promote alveolar edema formation and prevent edema resolution, thereby contributing to the development of ARDS...
  54. doi request reprint The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs
    István Vadász
    University of Giessen Lung Center, Giessen, Germany
    Crit Care Med 36:1543-50. 2008
    ..This study was performed to determine whether the lectin-like domain of tumor necrosis factor-alpha (designated TIP) can improve fluid balance in experimental lung injury by affecting alveolocapillary permeability and/or fluid clearance...
  55. ncbi request reprint Imatinib for the treatment of pulmonary arterial hypertension
    Hossein A Ghofrani
    N Engl J Med 353:1412-3. 2005
  56. ncbi request reprint Sildenafil citrate therapy for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    N Engl J Med 353:2148-57. 2005
    ....
  57. ncbi request reprint Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension
    Robert Voswinckel
    Ann Intern Med 144:149-50. 2006
  58. ncbi request reprint Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    Circulation 117:3010-9. 2008
    ..Ambrisentan is a propanoic acid-based, A-selective endothelin receptor antagonist for the once-daily treatment of pulmonary arterial hypertension...
  59. ncbi request reprint Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 48:2546-52. 2006
    ..This study sought to assess the risks associated with right heart catheter procedures in patients with pulmonary hypertension...
  60. ncbi request reprint Impairment of respiratory muscle function in pulmonary hypertension
    Hans Joachim Kabitz
    Department of Pneumology, University Hospital Freiburg, D 79106 Freiburg Germany
    Clin Sci (Lond) 114:165-71. 2008
    ..Furthermore, the 6-min walking distance is significantly linked to parameters assessing inspiratory muscle strength...